Search Results - "Lee, Winnie"
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Molecular Epidemiology of Escherichia coli Producing CTX-M and pAmpC β-Lactamases from Dairy Farms Identifies a Dominant Plasmid Encoding CTX-M-32 but No Evidence for Transmission to Humans in the Same Geographical Region
Published in Applied and environmental microbiology (17-12-2020)“…Third-generation cephalosporin resistance (3GC-R) in is a rising problem in human and farmed-animal populations. We conducted whole-genome sequencing analysis…”
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Harvesting and amplifying gene cassettes confers cross-resistance to critically important antibiotics
Published in PLoS pathogens (01-06-2024)“…Amikacin and piperacillin/tazobactam are frequent antibiotic choices to treat bloodstream infection, which is commonly fatal and most often caused by bacteria…”
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From acute to persistent infection: revealing phylogenomic variations in Salmonella Agona
Published in PLoS pathogens (31-10-2024)“…Salmonella enterica serovar Agona (S. Agona) has been increasingly recognised as a prominent cause of gastroenteritis. This serovar is a strong biofilm former…”
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A global genomic analysis of Salmonella Concord reveals lineages with high antimicrobial resistance in Ethiopia
Published in Nature communications (14-06-2023)“…Antimicrobial resistant Salmonella enterica serovar Concord ( S . Concord) is known to cause severe gastrointestinal and bloodstream infections in patients…”
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Diagnostic MALDI-TOF MS can differentiate between high and low toxic Staphylococcus aureus bacteraemia isolates as a predictor of patient outcome
Published in Microbiology (Society for General Microbiology) (01-08-2022)“…bacteraemia (SAB) is a major cause of blood-stream infection (BSI) in both healthcare and community settings. While the underlying comorbidities of a patient…”
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Barriers to implement extensive green roof systems: A Hong Kong study
Published in Renewable & sustainable energy reviews (2012)“…Air pollution problems caused from the development of infrastructures are getting serious, in which air flow is reduced and heat is trapped among high-rise…”
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A Bayesian Model Based on Local Phenotypic Resistance Data to Inform Empiric Antibiotic Escalation Decisions
Published in Infectious diseases and therapy (01-09-2024)“…Introduction Clinicians commonly escalate empiric antibiotic therapy due to poor clinical progress without microbiology guidance. When escalating, they should…”
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Characterization of a pESI-like plasmid and analysis of multidrug-resistant Salmonella enterica Infantis isolates in England and Wales
Published in Microbial genomics (01-10-2021)“…Salmonella enterica serovar Infantis is the fifth most common Salmonella serovar isolated in England and Wales. Epidemiological, genotyping and…”
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Prevalence of Healthcare-Associated Infections and Antimicrobial Use Among Adult Inpatients in Singapore Acute-Care Hospitals: Results From the First National Point Prevalence Survey
Published in Clinical infectious diseases (15-05-2017)“…Background. We conducted a national point prevalence survey (PPS) to determine the prevalence of healthcare-associated infections (HAIs) and antimicrobial use…”
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Stemming the Rise of Antibiotic Use for Community-Acquired Acute Respiratory Infections during COVID-19 Pandemic
Published in Antibiotics (Basel) (24-06-2022)“…At the start of the COVID-19 pandemic, there was an increase in the use of antibiotics for the treatment of community-acquired respiratory tract infection…”
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Responsiveness to Change of Self-Report and Device-Based Physical Activity Measures in the Living Well With Diabetes Trial
Published in Journal of physical activity & health (01-08-2015)“…This study evaluated the responsiveness to change in physical activity of 2 self-report measures and an accelerometer in the context of a weight loss…”
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In Vitro Pharmacodynamics of Fosfomycin against Carbapenem-Resistant Enterobacter cloacae and Klebsiella aerogenes
Published in Antimicrobial agents and chemotherapy (20-08-2020)“…The increase of carbapenem-resistant (CRE) and lack of therapeutic options due to the scarcity of new antibiotics has sparked interest toward the use of…”
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Family-centered care management strategies for term and near-term neonates with brief hospitalization in a level III NICU in Shenzhen, China during the time of COVID-19 pandemic
Published in The journal of maternal-fetal & neonatal medicine (01-01-2022)“…Adopting the family-centered care (FCC) approach in the neonatal care has been shown to improve breastfeeding rate and parental satisfaction. To minimize the…”
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EP4 Antagonism by E7046 diminishes Myeloid immunosuppression and synergizes with Treg-reducing IL-2-Diphtheria toxin fusion protein in restoring anti-tumor immunity
Published in Oncoimmunology (03-08-2017)“…Reprogramming of immunosuppressive tumor microenvironment (TME) by targeting alternatively activated tumor associated macrophages (M2TAM), myeloid-derived…”
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Importance of control groups when delineating antibiotic use as a risk factor for carbapenem resistance, extreme-drug resistance, and pan-drug resistance in Acinetobacter baumannii and Pseudomonas aeruginosa: A systematic review and meta-analysis
Published in International journal of infectious diseases (01-11-2018)“…•Prior antibiotic exposure predisposes the patient to acquisition of CR/XDR/PDR Acinetobacter baumannii and Pseudomonas aeruginosa.•Selection of control groups…”
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Treatment and Outcomes of Infections Caused by Diverse Carbapenemase-Producing Carbapenem-Resistant Enterobacterales
Published in Frontiers in cellular and infection microbiology (14-10-2020)“…Diverse sequence types (ST) and various carbapenemase-producing carbapenem-resistant (CP-CRE) infections, which complicate treatment strategies, have emerged…”
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Effective antibiotics in combination against extreme drug-resistant Pseudomonas aeruginosa with decreased susceptibility to polymyxin B
Published in PloS one (05-12-2011)“…Extreme drug-resistant Pseudomonas aeruginosa (XDR-PA) with decreased susceptibility to polymyxin B (PB) has emerged in Singapore, causing infections in…”
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From Bench-Top to Bedside: A Prospective In Vitro Antibiotic Combination Testing (iACT) Service to Guide the Selection of Rationally Optimized Antimicrobial Combinations against Extensively Drug Resistant (XDR) Gram Negative Bacteria (GNB)
Published in PloS one (21-07-2016)“…Combination therapy is increasingly utilized against extensively-drug resistant (XDR) Gram negative bacteria (GNB). However, choosing a combination can be…”
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Risk factors, molecular epidemiology and outcomes of ertapenem-resistant, carbapenem-susceptible Enterobacteriaceae: a case-case-control study
Published in PloS one (26-03-2012)“…Increasing prevalence of ertapenem-resistant, carbapenem-susceptible Enterobacteriaceae (ERE) in Singapore presents a major therapeutic problem. Our objective…”
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In-vitro activity of polymyxin B, rifampicin, tigecycline alone and in combination against carbapenem-resistant Acinetobacter baumannii in Singapore
Published in PloS one (21-04-2011)“…Carbapenem-resistant Acinetobacter baumannii (CR-AB) is an emerging cause of nosocomial infections worldwide. Combination therapy may be the only viable option…”
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