Search Results - "Lee, Wheeseong"

Understanding lactate sensing and signalling by Certo, Michelangelo, Llibre, Alba, Lee, Wheeseong, Mauro, Claudio

“…Metabolites generated from cellular and tissue metabolism have been rediscovered in recent years as signalling molecules. They may act as cofactor of enzymes…”
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Thiophene-Anthranilamides as Highly Potent and Orally Available Factor Xa Inhibitors by Ye, Bin, Arnaiz, Damian O, Chou, Yuo-Ling, Griedel, Brian D, Karanjawala, Rushad, Lee, Wheeseong, Morrissey, Michael M, Sacchi, Karna L, Sakata, Steven T, Shaw, Kenneth J, Wu, Shung C, Zhao, Zuchun, Adler, Marc, Cheeseman, Sarah, Dole, William P, Ewing, Janice, Fitch, Richard, Lentz, Dao, Liang, Amy, Light, David, Morser, John, Post, Joseph, Rumennik, Galina, Subramanyam, Babu, Sullivan, Mark E, Vergona, Ron, Walters, Janette, Wang, Yi-Xin, White, Kathy A, Whitlow, Marc, Kochanny, Monica J

“…There remains a high unmet medical need for a safe oral therapy for thrombotic disorders. The serine protease factor Xa (fXa), with its central role in the…”
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LMT503, A NOVEL THERAPY FOR INFLAMMATORY BOWEL DISEASE THROUGH MACROPHAGE POLARIZATIONS BY METABOLIC REPROGRAMMING OF ACTIVATED MACROPHAGE by Lee, Wheeseong, Chung, Hyo Kyun, Kim, Jusik, Ko, Inseok, Yang, Chul-Su, Kim, Hyo Keun

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LMT503, A NOVEL THERAPY FOR INFLAMMATORY BOWEL DISEASE THROUGH MACROPHAGE POLARIZATIONS BY METABOLIC REPROGRAMMING OF ACTIVATED MACROPHAGE by Lee, Wheeseong, Chung, Hyo Kyun, Kim, Jusik, Ko, Inseok, Yang, Chul-Su, Kim, Hyo Keun

“…Macrophages are the first line of defense against self-stimuli and non-self-pathogens and adopt diverse activation states by reprogramming their cell…”
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Synthesis and biological evaluation of piperazine-based derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) by Ye, Bin, Chou, Yuo-Ling, Karanjawala, Rushad, Lee, Wheeseong, Lu, Shou-Fu, Shaw, Kenneth J., Jones, Steven, Lentz, Dao, Liang, Amy, Tseng, Jih-Lie, Wu, Qingyu, Zhao, Zuchun

“…Compound 2 was identified by high throughput screening as a novel PAI-1 inhibitor. Systematic optimization of the A, B, and C segments of 2 resulted in the…”
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Investigations on Transition-State Geometry in the Lewis Acid- (Mukaiyama) and Fluoride-Promoted Aldol Reactions by Denmark, Scott E, Lee, Wheeseong

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Synthesis and biological evaluation of menthol-based derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) by Ye, Bin, Bauer, Shawn, Buckman, Brad O., Ghannam, Ameen, Griedel, Brian D., Khim, Seock-Kyu, Lee, Wheeseong, Sacchi, Karna L., Shaw, Kenneth J., Liang, Amy, Wu, Qingyu, Zhao, Zuchun

“…Compound 1 was identified by high throughput screening as a novel PAI-1 inhibitor. Optimization of the B and C-segments of 1 resulted in a series of…”
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Investigations into Transition-State Geometry in the Mukaiyama Directed Aldol Reaction by Denmark, Scott E., Lee, Wheeseong

“…A model compound was designed to study the relative orientation of enol silane and carbonyl moieties in the Mukaiyama aldol reaction. The cyclization must…”
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Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: Design, synthesis and biological activity by Islam, Imadul, Bryant, Judi, Chou, Yuo-Ling, Kochanny, Monica J., Lee, Wheeseong, Phillips, Gary B., Yu, Hongyi, Adler, Marc, Whitlow, Marc, Ho, Elena, Lentz, Dao, Polokoff, Mark A., Subramanyam, Babu, Wu, James M., Zhu, Daguang, Feldman, Richard I., Arnaiz, Damian O.

“…Optimization of 1 afforded 4i ( BX-517), a potent and selective inhibitor of PDK1. HTS screening identified 1 with micromolar inhibitory activity against PDK1…”
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Catalytic, Enantioselective Aldol Additions with Methyl and Ethyl Acetate O-Silyl Enolates: A Chiral Tridentate Chelate as a Ligand for Titanium(IV) by Carreira, Erick M, Singer, Robert A, Lee, Wheeseong

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Catalytic, Enantioselective Acetone Aldol Additions with 2-Methoxypropene by Carreira, Erick M, Lee, Wheeseong, Singer, Robert A

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CCR5 receptor antagonists: Discovery and SAR study of guanylhydrazone derivatives by Wei, Robert G., Arnaiz, Damian O., Chou, Yuo-Ling, Davey, Dave, Dunning, Laura, Lee, Wheeseong, Lu, Shou-Fu, Onuffer, James, Ye, Bin, Phillips, Gary

“…High throughput screening (HTS) led to the identification of the guanylhydrazone of 2-(4-chlorobenzyloxy)-5-bromobenzaldehyde as a CCR5 receptor antagonist…”
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Substituted thiophene-anthranilamides as potent inhibitors of human factor Xa by Kochanny, Monica J., Adler, Marc, Ewing, Janice, Griedel, Brian D., Ho, Elena, Karanjawala, Rushad, Lee, Wheeseong, Lentz, Dao, Liang, Amy M., Morrissey, Michael M., Phillips, Gary B., Post, Joseph, Sacchi, Karna L., Sakata, Steven T., Subramanyam, Babu, Vergona, Ron, Walters, Janette, White, Kathy A., Whitlow, Marc, Ye, Bin, Zhao, Zuchun, Shaw, Kenneth J.

“…A series of thiophene-anthranilamide fXa inhibitors is reported having subnanomolar inhibitory potency. The pharmacokinetic profile of compound 31 was…”
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Synthesis, Characterization, and Structure−Activity Relationships of Amidine-Substituted (Bis)benzylidene-Cycloketone Olefin Isomers as Potent and Selective Factor Xa Inhibitors by Guilford, William J, Shaw, Kenneth J, Dallas, Jerry L, Koovakkat, Sunil, Lee, Wheeseong, Liang, Amy, Light, David R, McCarrick, Margaret A, Whitlow, Marc, Ye, Bin, Morrissey, Michael M

“…Factor Xa (FXa) is a trypsin-like serine protease that plays a key role in blood coagulation linking the intrinsic and extrinsic pathways to the final common…”
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Investigations on transition state geometry of aldol addition reactions by Lee, Wheeseong

“…The stereochemical course of the aldol reaction has been studied with rationally designed and synthesized model systems. In aqueous medium, the acid-induced…”
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