Search Results - "Lee, Virginia M.Y"

Distinct α-Synuclein Strains Differentially Promote Tau Inclusions in Neurons by Guo, Jing L., Covell, Dustin J., Daniels, Joshua P., Iba, Michiyo, Stieber, Anna, Zhang, Bin, Riddle, Dawn M., Kwong, Linda K., Xu, Yan, Trojanowski, John Q., Lee, Virginia M.Y.

“…Many neurodegenerative diseases are characterized by the accumulation of insoluble protein aggregates, including neurofibrillary tangles comprised of tau…”
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α-Synuclein Immunotherapy Blocks Uptake and Templated Propagation of Misfolded α-Synuclein and Neurodegeneration by Tran, Hien T., Chung, Charlotte Hiu-Yan, Iba, Michiyo, Zhang, Bin, Trojanowski, John Q., Luk, Kelvin C., Lee, Virginia M.Y.

“…Accumulation of misfolded alpha-synuclein (α-syn) into Lewy bodies (LBs) and Lewy neurites (LNs) is a major hallmark of Parkinson’s disease (PD) and dementia…”
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TDP-43 functions and pathogenic mechanisms implicated in TDP-43 proteinopathies by Cohen, Todd J, Lee, Virginia M.Y, Trojanowski, John Q

“…Given the critical role for TDP-43 in diverse neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration…”
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Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice by Peeraer, Eve, Bottelbergs, Astrid, Van Kolen, Kristof, Stancu, Ilie-Cosmin, Vasconcelos, Bruno, Mahieu, Michel, Duytschaever, Hilde, Ver Donck, Luc, Torremans, An, Sluydts, Ellen, Van Acker, Nathalie, Kemp, John A, Mercken, Marc, Brunden, Kurt R, Trojanowski, John Q, Dewachter, Ilse, Lee, Virginia M.Y, Moechars, Diederik

“…Abstract Neurofibrillary tangles composed of hyperphosphorylated fibrillized tau are found in numerous tauopathies including Alzheimer's disease. Increasing…”
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Vascular disease and dementias: Paradigm shifts to drive research in new directions by Kling, Mitchel A, Trojanowski, John Q, Wolk, David A, Lee, Virginia M.Y, Arnold, Steven E

“…Abstract Vascular disease was once considered the principal cause of aging-related dementia. More recently, however, research emphasis has shifted to studies…”
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Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein by Tuttle, Marcus D, Comellas, Gemma, Nieuwkoop, Andrew J, Covell, Dustin J, Berthold, Deborah A, Kloepper, Kathryn D, Courtney, Joseph M, Kim, Jae K, Barclay, Alexander M, Kendall, Amy, Wan, William, Stubbs, Gerald, Schwieters, Charles D, Lee, Virginia M Y, George, Julia M, Rienstra, Chad M

“…α-synuclein amyloid fibrils are associated with Parkinson's disease. SSNMR analyses now reveal the atomic structure of a pathogenic human α-synuclein fibril,…”
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Unique pathological tau conformers from Alzheimer's brains transmit tau pathology in nontransgenic mice by Guo, Jing L, Narasimhan, Sneha, Changolkar, Lakshmi, He, Zhuohao, Stieber, Anna, Zhang, Bin, Gathagan, Ronald J, Iba, Michiyo, McBride, Jennifer D, Trojanowski, John Q, Lee, Virginia M Y

“…Filamentous tau aggregates are hallmark lesions in numerous neurodegenerative diseases, including Alzheimer's disease (AD). Cell culture and animal studies…”
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Pathological Tau Strains from Human Brains Recapitulate the Diversity of Tauopathies in Nontransgenic Mouse Brain by Narasimhan, Sneha, Guo, Jing L, Changolkar, Lakshmi, Stieber, Anna, McBride, Jennifer D, Silva, Luisa V, He, Zhuohao, Zhang, Bin, Gathagan, Ronald J, Trojanowski, John Q, Lee, Virginia M Y

“…Pathological tau aggregates occur in Alzheimer's disease (AD) and other neurodegenerative tauopathies. It is not clearly understood why tauopathies vary…”
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High-Contrast In Vivo Imaging of Tau Pathologies in Alzheimer’s and Non-Alzheimer’s Disease Tauopathies by Tagai, Kenji, Ono, Maiko, Kubota, Manabu, Kitamura, Soichiro, Takahata, Keisuke, Seki, Chie, Takado, Yuhei, Shinotoh, Hitoshi, Sano, Yasunori, Yamamoto, Yasuharu, Matsuoka, Kiwamu, Takuwa, Hiroyuki, Shimojo, Masafumi, Takahashi, Manami, Kawamura, Kazunori, Kikuchi, Tatsuya, Okada, Maki, Akiyama, Haruhiko, Suzuki, Hisaomi, Onaya, Mitsumoto, Takeda, Takahiro, Arai, Kimihito, Arai, Nobutaka, Araki, Nobuyuki, Saito, Yuko, Trojanowski, John Q., Lee, Virginia M.Y., Mishra, Sushil K., Yamaguchi, Yoshiki, Kimura, Yasuyuki, Ichise, Masanori, Tomita, Yutaka, Zhang, Ming-Rong, Suhara, Tetsuya, Shigeta, Masahiro, Sahara, Naruhiko, Higuchi, Makoto, Shimada, Hitoshi

“…A panel of radiochemicals has enabled in vivo positron emission tomography (PET) of tau pathologies in Alzheimer’s disease (AD), although sensitive detection…”
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Humanization of the entire murine Mapt gene provides a murine model of pathological human tau propagation by Saito, Takashi, Mihira, Naomi, Matsuba, Yukio, Sasaguri, Hiroki, Hashimoto, Shoko, Narasimhan, Sneha, Zhang, Bin, Murayama, Shigeo, Higuchi, Makoto, Lee, Virginia M.Y., Trojanowski, John Q., Saido, Takaomi C.

“…In cortical regions of brains from individuals with preclinical or clinical Alzheimer's disease (AD), extracellular β-amyloid (Aβ) deposition precedes the…”
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TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading by Martini-Stoica, Heidi, Cole, Allysa L, Swartzlander, Daniel B, Chen, Fading, Wan, Ying-Wooi, Bajaj, Lakshya, Bader, David A, Lee, Virginia M Y, Trojanowski, John Q, Liu, Zhandong, Sardiello, Marco, Zheng, Hui

“…The progression of tau pathology in Alzheimer's disease follows a stereotyped pattern, and recent evidence suggests a role of synaptic connections in this…”
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Human tau pathology transmits glial tau aggregates in the absence of neuronal tau by Narasimhan, Sneha, Changolkar, Lakshmi, Riddle, Dawn M, Kats, Alexandra, Stieber, Anna, Weitzman, Sarah A, Zhang, Bin, Li, Zhiyong, Roberson, Erik D, Trojanowski, John Q, Lee, Virginia M Y

“…Tauopathies are characterized by abnormal accumulation of tau protein in neurons and glia. In Alzheimer's disease (AD), tau aggregates in neurons, while in…”
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Modulating TRADD to restore cellular homeostasis and inhibit apoptosis by Xu, Daichao, Zhao, Heng, Jin, Minzhi, Zhu, Hong, Shan, Bing, Geng, Jiefei, Dziedzic, Slawomir A., Amin, Palak, Mifflin, Lauren, Naito, Masanori Gomi, Najafov, Ayaz, Xing, Jing, Yan, Lingjie, Liu, Jianping, Qin, Ying, Hu, Xinqian, Wang, Huibing, Zhang, Mengmeng, Manuel, Vica Jean, Tan, Li, He, Zhuohao, Sun, Zhenyu J., Lee, Virginia M. Y., Wagner, Gerhard, Yuan, Junying

“…Cell death in human diseases is often a consequence of disrupted cellular homeostasis. If cell death is prevented without restoring cellular homeostasis, it…”
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High copy wildtype human 1N4R tau expression promotes early pathological tauopathy accompanied by cognitive deficits without progressive neurofibrillary degeneration by Wheeler, Jeanna M, McMillan, Pamela J, Hawk, Michele, Iba, Michiyo, Robinson, Linda, Xu, George J, Dombroski, Beth A, Jeong, Doori, Dichter, Marc A, Juul, Halvor, Loomis, Elaine, Raskind, Murray, Leverenz, James B, Trojanowski, John Q, Lee, Virginia M Y, Schellenberg, Gerard D, Kraemer, Brian C

“…Accumulation of insoluble conformationally altered hyperphosphorylated tau occurs as part of the pathogenic process in Alzheimer's disease (AD) and other…”
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A “Clickable” Photoconvertible Small Fluorescent Molecule as a Minimalist Probe for Tracking Individual Biomolecule Complexes by Jun, Joomyung V, Haney, Conor M, Karpowicz, Richard J, Giannakoulias, Sam, Lee, Virginia M.-Y, Petersson, E. James, Chenoweth, David M

“…Photoconvertible fluorophores can enable the visualization and tracking of a specific biomolecules, complexes, and cellular compartments with precise…”
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The microtubule-associated tau protein has intrinsic acetyltransferase activity by Cohen, Todd J, Friedmann, Dave, Hwang, Andrew W, Marmorstein, Ronen, Lee, Virginia M Y

“…Tau is a microbutule-associated protein that can form pathological aggregates in neurodegenerative conditions such as Alzheimer's disease. Tau can undergo…”
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Characterization of tau binding by gosuranemab by Sopko, Richelle, Golonzhka, Olga, Arndt, Joseph, Quan, Chao, Czerkowicz, Julie, Cameron, Andrew, Smith, Benjamin, Murugesan, Yogapriya, Gibbons, Garrett, Kim, Soo-Jung, Trojanowski, John Q., Lee, Virginia M.Y., Brunden, Kurt R., Graham, Danielle L., Weinreb, Paul H., Hering, Heike

“…Deposition of tau aggregates in the brain is a pathological hallmark of several neurodegenerative diseases, termed tauopathies, such as Alzheimer's disease…”
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Cognitive decline and reduced survival in C9orf72 expansion frontotemporal degeneration and amyotrophic lateral sclerosis by Irwin, David J, McMillan, Corey T, Brettschneider, Johannes, Libon, David J, Powers, John, Rascovsky, Katya, Toledo, Jon B, Boller, Ashley, Bekisz, Jonathan, Chandrasekaran, Keerthi, Wood, Elisabeth McCarty, Shaw, Leslie M, Woo, John H, Cook, Philip A, Wolk, David A, Arnold, Steven E, Van Deerlin, Vivianna M, McCluskey, Leo F, Elman, Lauren, Lee, Virginia M-Y, Trojanowski, John Q, Grossman, Murray

“…Background Significant heterogeneity in clinical features of frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) cases with the…”
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Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis by COUTHOUIS, Julien, HART, Michael P, KIM, Cecilia E, FRACKELTON, Edward C, SOLSKI, Jennifer A, WILLIAMS, Kelly L, CLAY-FALCONE, Dana, ELMAN, Lauren, MCCLUSKEY, Leo, GREENE, Robert, HAKONARSON, Hakon, KALB, Robert G, ERION, Renske, LEE, Virginia M. Y, TROJANOWSKI, John Q, NICHOLSON, Garth A, BLAIR, Ian P, BONINI, Nancy M, VAN DEERLIN, Vivianna M, MOURELATOS, Zissimos, SHORTER, James, GITLER, Aaron D, KING, Oliver D, DIAZ, Zamia, NAKAYA, Tadashi, IBRAHIM, Fadia, KIM, Hyung-Jun, MOJSILOVIC-PETROVIC, Jelena, PANOSSIAN, Saarene

“…Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting motor neurons. Mutations in related RNA-binding proteins TDP-43, FUS/TLS and…”
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Characterization of novel conformation-selective α-synuclein antibodies as potential immunotherapeutic agents for Parkinson's disease by Henderson, Michael X., Covell, Dustin J., Chung, Charlotte Hiu-Yan, Pitkin, Rose M., Sandler, Raizel M., Decker, Samantha C., Riddle, Dawn M., Zhang, Bin, Gathagan, Ronald J., James, Michael J., Trojanowski, John Q., Brunden, Kurt R., Lee, Virginia M.Y., Luk, Kelvin C.

“…Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are progressive neurodegenerative diseases for which there is no disease-modifying treatment. PD…”
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