Search Results - "Lee, Tom T."

Harnessing features of adaptive NK cells to generate iPSC-derived NK cells for enhanced immunotherapy by Woan, Karrune V., Kim, Hansol, Bjordahl, Ryan, Davis, Zachary B., Gaidarova, Svetlana, Goulding, John, Hancock, Brian, Mahmood, Sajid, Abujarour, Ramzey, Wang, Hongbo, Tuininga, Katie, Zhang, Bin, Wu, Cheng-Ying, Kodal, Behiye, Khaw, Melissa, Bendzick, Laura, Rogers, Paul, Ge, Moyar Qing, Bonello, Greg, Meza, Miguel, Felices, Martin, Huffman, Janel, Dailey, Thomas, Lee, Tom T., Walcheck, Bruce, Malmberg, Karl J., Blazar, Bruce R., Bryceson, Yenan T., Valamehr, Bahram, Miller, Jeffrey S., Cichocki, Frank

“…Select subsets of immune effector cells have the greatest propensity to mediate antitumor responses. However, procuring these subsets is challenging, and…”
Get full text

Quadruple gene-engineered natural killer cells enable multi-antigen targeting for durable antitumor activity against multiple myeloma by Cichocki, Frank, Bjordahl, Ryan, Goodridge, Jodie P., Mahmood, Sajid, Gaidarova, Svetlana, Abujarour, Ramzey, Davis, Zachary B., Merino, Aimee, Tuininga, Katie, Wang, Hongbo, Kumar, Akhilesh, Groff, Brian, Witty, Alec, Bonello, Greg, Huffman, Janel, Dailey, Thomas, Lee, Tom T., Malmberg, Karl-Johan, Walcheck, Bruce, Höpken, Uta, Rehm, Armin, Valamehr, Bahram, Miller, Jeffrey S.

“…Allogeneic natural killer (NK) cell adoptive transfer is a promising treatment for several cancers but is less effective for the treatment of multiple myeloma…”
Get full text

Cardiotrophin 1 stimulates beneficial myogenic and vascular remodeling of the heart by Abdul-Ghani, Mohammad, Suen, Colin, Jiang, Baohua, Deng, Yupu, Weldrick, Jonathan J, Putinski, Charis, Brunette, Steve, Fernando, Pasan, Lee, Tom T, Flynn, Peter, Leenen, Frans H H, Burgon, Patrick G, Stewart, Duncan J, Megeney, Lynn A

“…The post-natal heart adapts to stress and overload through hypertrophic growth, a process that may be pathologic or beneficial （physiologic hypertrophy）…”
Get full text

A Unique RNA Fold in the RumA-RNA-Cofactor Ternary Complex Contributes to Substrate Selectivity and Enzymatic Function by Lee, Tom T., Agarwalla, Sanjay, Stroud, Robert M.

“…A single base (U1939) within E. coli 23S ribosomal RNA is methylated by its dedicated enzyme, RumA. The structure of RumA/RNA/ S-adenosylhomocysteine uncovers…”
Get full text

iPSC-derived NK cells maintain high cytotoxicity and enhance in vivo tumor control in concert with T cells and anti-PD-1 therapy by Cichocki, Frank, Bjordahl, Ryan, Gaidarova, Svetlana, Mahmood, Sajid, Abujarour, Ramzey, Wang, Hongbo, Tuininga, Katie, Felices, Martin, Davis, Zachary B, Bendzick, Laura, Clarke, Raedun, Stokely, Laurel, Rogers, Paul, Ge, Moyar, Robinson, Megan, Rezner, Betsy, Robbins, David L, Lee, Tom T, Kaufman, Dan S, Blazar, Bruce R, Valamehr, Bahram, Miller, Jeffrey S

“…The development of immunotherapeutic monoclonal antibodies targeting checkpoint inhibitory receptors, such as programmed cell death 1 (PD-1), or their ligands,…”
Get more information

Dual antigen–targeted off-the-shelf NK cells show durable response and prevent antigen escape in lymphoma and leukemia by Cichocki, Frank, Goodridge, Jodie P., Bjordahl, Ryan, Mahmood, Sajid, Davis, Zachary B., Gaidarova, Svetlana, Abujarour, Ramzey, Groff, Brian, Witty, Alec, Wang, Hongbo, Tuininga, Katie, Kodal, Behiye, Felices, Martin, Bonello, Greg, Huffman, Janel, Dailey, Thomas, Lee, Tom T., Walcheck, Bruce, Valamehr, Bahram, Miller, Jeffrey S.

“…•iDuo NK cells prevent antigen escape by targeting both CD19+ and CD19− lymphoma cells.•iDuo NK cells demonstrate enhanced anti-tumor activity and persistence…”
Get full text

Synthesis and SAR of thiophene containing kinesin spindle protein (KSP) inhibitors by Pinkerton, Anthony B., Lee, Tom T., Hoffman, Timothy Z., Wang, Yan, Kahraman, Mehmet, Cook, Travis G., Severance, Daniel, Gahman, Timothy C., Noble, Stewart A., Shiau, Andrew K., Davis, Robert L.

“…We have identified and synthesized a series of thiophene containing inhibitors of kinesin spindle protein. SAR studies led to the synthesis of 33, which was…”
Get full text

The Role of Protein Dynamics in Thymidylate Synthase Catalysis:  Variants of Conserved 2‘-Deoxyuridine 5‘-Monophosphate (dUMP)-Binding Tyr-261 by Newby, Zachary, Lee, Tom T, Morse, Richard J, Liu, Yaoquan, Liu, Lu, Venkatraman, Prasanna, Santi, Daniel V, Finer-Moore, Janet S, Stroud, Robert M

“…The enzyme thymidylate synthase (TS) catalyzes the reductive methylation of 2‘-deoxyuridine 5‘-monophosphate (dUMP) to 2‘-deoxythymidine 5‘-monophosphate…”
Get full text

A Single Mutation Traps a Half-Sites Reactive Enzyme in Midstream, Explaining Asymmetry in Hydride Transfer by Finer-Moore, Janet S, Lee, Tom T, Stroud, Robert M

“…In Escherichia coli thymidylate synthase (EcTS), rate-determining hydride transfer from the cofactor 5,10-methylene-5,6,7,8-tetrahydrofolate to the…”
Get full text

Crystal Structure of RumA, an Iron-Sulfur Cluster Containing E. coli Ribosomal RNA 5-Methyluridine Methyltransferase by Lee, Tom T, Agarwalla, Sanjay, Stroud, Robert M

“…RumA catalyzes transfer of a methyl group from S-adenosylmethionine (SAM) specifically to uridine 1939 of 23S ribosomal RNA in Escherichia coli to yield…”
Get full text

KLYP956 is a non-imidazole-based orally active inhibitor of nitric-oxide synthase dimerization by Symons, Kent T, Massari, Mark E, Nguyen, Phan M, Lee, Tom T, Roppe, Jeffrey, Bonnefous, Céline, Payne, Joseph E, Smith, Nicholas D, Noble, Stewart A, Sablad, Marciano, Rozenkrants, Natasha, Zhang, Yan, Rao, Tadimeti S, Shiau, Andrew K, Hassig, Christian A

“…Nitric-oxide synthases (NOS) generate nitric oxide (NO) through the oxidation of l-arginine. Inappropriate or excessive production of NO by NOS is associated…”
Get more information

Structure of a TrmA-RNA complex: A consensus RNA fold contributes to substrate selectivity and catalysis in m⁵U methyltransferases by Alian, Akram, Lee, Tom T, Griner, Sarah L, Stroud, Robert M, Finer-Moore, Janet

“…TrmA catalyzes S-adenosylmethionine (AdoMet)-dependent methylation of U54 in most tRNAs. We solved the structure of the Escherichia coli 5-methyluridine (m⁵U)…”
Get full text

A chemical approach facilitates CRISPRa-only human iPSC generation and minimizes the number of targeted loci required by Abujarour, Ramzey, Dinella, Jason, Pribadi, Mochtar, Fong, Lauren K, Denholtz, Matthew, Gutierrez, Alma, Haynes, Matt, Mahmood, Enaaya, Lee, Tom T, Ding, Sheng, Valamehr, Bahram

“…We explored the generation of human induced pluripotent stem cells (iPSCs) solely through the transcriptional activation of endogenous genes by CRISPR…”
Get full text

A chimeric antigen receptor uniquely recognizing MICA/B stress proteins provides an effective approach to target solid tumors by Goulding, John, Yeh, Wen-I, Hancock, Bryan, Blum, Robert, Xu, Tianhao, Yang, Bi-Huei, Chang, Chia-Wei, Groff, Brian, Avramis, Earl, Pribadi, Mochtar, Pan, Yijia, Chu, Hui-Yi, Sikaroodi, Shohreh, Fong, Lauren, Brookhouser, Nicholas, Dailey, Thomas, Meza, Miguel, Denholtz, Matthew, Diaz, Evelyn, Martin, Judy, Szabo, Peter, Cooley, Sarah, Ferrari de Andrade, Lucas, Lee, Tom T, Bjordahl, Ryan, Wucherpfennig, Kai W, Valamehr, Bahram

“…The advent of chimeric antigen receptor (CAR) T cell therapies has transformed the treatment of hematological malignancies; however, broader therapeutic…”
Get more information

A Single Mutation Traps a Half-sites Reactive Enzyme in Mid-stream, Explaining Asymmetry in Hydride Transfer by Finer-Moore, Janet S., Lee, Tom T., Stroud, Robert M.

“…In Escherichia coli thymidylate synthase (EcTS), rate-determining hydride transfer from the cofactor, 5,10-methylene-5,6,7,8-tetrahydrofolate, to the…”
Get full text

Abstract 1539: Development of off-the-shelf B7H3 chimeric antigen receptor NK cell therapeutic with broad applicability across many solid tumors by Bjordahl, Ryan, Goulding, John, Chu, Hui-Yi, Cichocki, Frank, Zorko, Nicholas, Davis, Zachary, Felices, Martin, Garcia, Alex, Gaidarova, Svetlana, Yeh, Wen-I, Lee, Tom T., Miller, Jeffrey S., Valamehr, Bahram

“…Although chimeric antigen receptor (CAR) T cell therapies have demonstrated impressive efficacy in a number of hematological malignancies, successful…”
Get full text

Effects of Subunit Occupancy on Partitioning of an Intermediate in Thymidylate Synthase Mutants by Variath, Prasanna, Liu, Yaoquan, Lee, Tom T, Stroud, Robert M, Santi, Daniel V

“…Experimental evidence for a 5-exocyclic methylene-dUMP intermediate in the thymidylate synthase reaction was recently obtained by demonstrating that tryptophan…”
Get full text

Abstract 3574: Cytokine-autonomous, CAR-directed, off-the-shelf natural killer cells derived from a clonal engineered master pluripotent cell line by Lee, Tom T., Li, Ye E., Bjordahl, Ryan, Blum, Robert, Mahmood, Sajid, Zhu, Huang, Bonello, Gregory B., Valamehr, Bahram, Kaufman, Dan S.

“…Natural killer (NK) cells are potent antitumor effectors that play an important role in innate and adaptive immunity. Despite recent clinical advances in the…”
Get full text

His68 and His141 Are Critical Contributors to the Intersubunit Catalytic Site of Adenylosuccinate Lyase of Bacillus subtilis by Lee, Tom T, Worby, Carolyn, Bao, Zhao-Qin, Dixon, Jack E, Colman, Roberta F

“…Mutant adenylosuccinate lyases of Bacillus subtilis were prepared by site-directed mutagenesis with replacements for His141, previously identified by affinity…”
Get full text

Implication of His68 in the Substrate Site of Bacillus subtilis Adenylosuccinate Lyase by Mutagenesis and Affinity Labeling with 2-[(4-Bromo-2,3-dioxobutyl)thio]adenosine 5‘-monophosphate by Lee, Tom T, Worby, Carolyn, Bao, Zhao-Qin, Dixon, Jack E, Colman, Roberta F

“…Adenylosuccinate lyase of Bacillus subtilis is inactivated by 2-[(4-bromo-2,3-dioxobutyl)thio]adenosine 5‘-monophosphate (2-BDB-TAMP) at pH 7.0. As the reagent…”
Get full text