Does Glaucoma Share Common Pathogenesis with Branch Retinal Vein Occlusion?

To evaluate the observed prevalence and the optic nerve head (ONH) characteristics of normal tension glaucoma (NTG)-suspect eyes in branch retinal vein occulusion (BRVO) eyes in Korean population. This was a retrospective observational study. We investigated 445 BRVO eyes that were diagnosed in the...

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Bibliographic Details
Published in:	PloS one Vol. 11; no. 6; p. e0156966
Main Authors:	Han, Jong Chul, Eo, Doo Ri, Lee, Taek Kwan, Shin, Jong Hoon, Kee, Changwon
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01-06-2016 Public Library of Science (PLoS)
Subjects:	Aged Biology and Life Sciences Diabetes Eye Eye (anatomy) Female Glaucoma Glaucoma - diagnosis Glaucoma - epidemiology Health care facilities Hemorrhage Humans Intraocular Pressure Male Medicine Medicine and Health Sciences Middle Aged Morphology Occlusion Ocular Hypertension - diagnosis Ocular Hypertension - epidemiology Optic Disk - pathology Optic Disk - physiopathology Optic nerve Optic Nerve - pathology Optic Nerve - physiopathology Optic Nerve Diseases - diagnosis Optic Nerve Diseases - epidemiology Pathogenesis Physical characteristics Population studies Prevalence Republic of Korea - epidemiology Retina Retinal Vein - pathology Retinal Vein - physiopathology Retinal Vein Occlusion - diagnosis Retinal Vein Occlusion - epidemiology Retrospective Studies Thinning Veins & arteries Visual Acuity United States > US South Korea
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Summary:	To evaluate the observed prevalence and the optic nerve head (ONH) characteristics of normal tension glaucoma (NTG)-suspect eyes in branch retinal vein occulusion (BRVO) eyes in Korean population. This was a retrospective observational study. We investigated 445 BRVO eyes that were diagnosed in the retina clinic of Samsung Medical Center between March 2005 and December 2011. The observed prevalence of NTG-suspect in BRVO eyes was evaluated compared to the previous population based study. In addition, NTG-suspect cases in BRVO were divided into three groups based on the characteristics of optic disc morphology. In 445 BRVO eyes, 30 eyes were excluded from the present study. In 415 BRVO eyes, 4.3% (18 eyes) (95% confident interval [CI], 2.4-6.3%) were diagnosed with suspect glaucoma and this is not significantly different from the result in the general Korean population (P = 0.09). We classified the NTG-suspect eyes into three groups such as disc rim notching and thinning type (Group 1; 55.6%), optic cup-sited hemorrhage type (Group 2; 16.7%) and disc rim thinning and pallor type (Group 3; 27.8%). NTG-suspect in the fellow eye were only found in group 1 (80%) and group 2 (67%), but not in group 3 (P = 0.01). BRVO and glaucoma seem to have no common vascular pathogenesis in consideration of the prevalence of NTG-suspect in BRVO eyes compared to general Korean population.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Undefined-1 ObjectType-Feature-3 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 Competing Interests: The authors have declared that no competing interests exist. Conceived and designed the experiments: JCH CK. Performed the experiments: JCH DRE. Analyzed the data: JCH JHS. Contributed reagents/materials/analysis tools: TKL JCH. Wrote the paper: JCH.
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0156966