Search Results - "Lee, Susie A"

Increased Lipogenesis, Induced by AKT-mTORC1-RPS6 Signaling, Promotes Development of Human Hepatocellular Carcinoma by Calvisi, Diego F, Wang, Chunmei, Ho, Coral, Ladu, Sara, Lee, Susie A, Mattu, Sandra, Destefanis, Giulia, Delogu, Salvatore, Zimmermann, Antje, Ericsson, Johan, Brozzetti, Stefania, Staniscia, Tommaso, Chen, Xin, Dombrowski, Frank, Evert, Matthias

“…Background & Aims De novo lipogenesis is believed to be involved in oncogenesis. We investigated the role of aberrant lipid biosynthesis in the pathogenesis of…”
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AKT (v-akt murine thymoma viral oncogene homolog 1) and N-Ras (neuroblastoma ras viral oncogene homolog) coactivation in the mouse liver promotes rapid carcinogenesis by way of mTOR (mammalian target of rapamycin complex 1), FOXM1 (forkhead box M1)/SKP2, and c-Myc pathways by Ho, Coral, Wang, Chunmei, Mattu, Sandra, Destefanis, Giulia, Ladu, Sara, Delogu, Salvatore, Armbruster, Julia, Fan, Lingling, Lee, Susie A., Jiang, Lijie, Dombrowski, Frank, Evert, Matthias, Chen, Xin, Calvisi, Diego F.

“…Activation of v‐akt murine thymoma viral oncogene homolog (AKT) and Ras pathways is often implicated in carcinogenesis. However, the oncogenic cooperation…”
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Synergistic role of sprouty2 inactivation and c‐Met up‐regulation in mouse and human hepatocarcinogenesis by Lee, Susie A., Ladu, Sara, Evert, Matthias, Dombrowski, Frank, De Murtas, Valentina, Chen, Xin, Calvisi, Diego F.

“…Sprouty2 (Spry2), a negative feedback regulator of the Ras/mitogen‐activated protein kinase (MAPK) pathway, is frequently down‐regulated in human…”
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RNA interference as therapeutics for hepatocellular carcinoma by Xu, Chuanrui, Lee, Susie A, Chen, Xin

“…Hepatocellular carcinoma (HCC), a major form of primary liver cancer, is one of the leading causes of cancer related deaths worldwide. Hepatitis B and C…”
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Inactivation of Spry2 accelerates AKT-driven hepatocarcinogenesis via activation of MAPK and PKM2 pathways by Wang, Chunmei, Delogu, Salvatore, Ho, Coral, Lee, Susie A, Gui, Bing, Jiang, Lijie, Ladu, Sara, Cigliano, Antonio, Dombrowski, Frank, Evert, Matthias, Calvisi, Diego F, Chen, Xin

“…Background & Aims Aberrant activation of the AKT oncogenic pathway and downregulation of the Sprouty 2 ( Spry2 ) tumor suppressor gene are frequently observed…”
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Integration of genomic analysis and in vivo transfection to identify sprouty 2 as a candidate tumor suppressor in liver cancer by Lee, Susie A., Ho, Coral, Roy, Ritu, Kosinski, Cynthia, Patil, Mohini A., Tward, Aaron D., Fridlyand, Jane, Chen, Xin

“…Hepatocellular carcinoma (HCC) is 1 of the leading causes of cancer‐related deaths worldwide, yet the molecular genetics underlying this malignancy are still…”
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The zebrafish forkhead transcription factor Foxi1 specifies epibranchial placode-derived sensory neurons by Lee, Susie A, Shen, Ellen L, Fiser, Andras, Sali, Andrej, Guo, Su

“…Vertebrate epibranchial placodes give rise to visceral sensory neurons that transmit vital information such as heart rate, blood pressure and visceral…”
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Role of cyclin D1 as a mediator of c-Met- and beta-catenin-induced hepatocarcinogenesis by Patil, Mohini A, Lee, Susie A, Macias, Everardo, Lam, Ernest T, Xu, Chuanrui, Jones, Kirk D, Ho, Coral, Rodriguez-Puebla, Marcelo, Chen, Xin

“…Activation of c-Met signaling and beta-catenin mutations are frequent genetic events observed in liver cancer development. Recently, we demonstrated that…”
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Synergistic role of Spry2 inactivation and c-Met upregulation in mouse and human hepatocarcinogenesis by Lee, Susie A., Ladu, Sara, Evert, Matthias, Dombrowski, Frank, De Murtas, Valentina, Chen, Xin, Calvisi, Diego F.

“…Sprouty2 (Spry2), a negative feedback regulator of the Ras/MAPK pathway, is frequently downregulated in human hepatocellular carcinoma (HCC). In the present…”
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AKT and N-Ras co-activation in the mouse liver promotes rapid carcinogenesis via mTORC1, FOXM1/SKP2, and c-Myc pathways by Ho, Coral, Wang, Chunmei, Mattu, Sandra, Destefanis, Giulia, Ladu, Sara, Delogu, Salvatore, Armbruster, Julia, Fan, Lingling, Lee, Susie A., Jiang, Lijie, Dombrowski, Frank, Evert, Matthias, Chen, Xin, Calvisi, Diego F.

“…Activation of v-akt murine thymoma viral oncogene homolog (AKT) and Ras pathways is often implicated in carcinogenesis. However, the oncogenic cooperation…”
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Role of Cyclin D1 as a Mediator of c-Met- and β-Catenin-lnduced Hepatocarcinogenesis by PATIL, Mohini A, LEE, Susie A, MACIAS, Everardo, LAM, Ernest T, CHUANRUI XU, JONES, Kirk D, HO, Coral, RODRIGUEZ-PUEBLA, Marcelo, XIN CHEN

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