Search Results - "Lee, Sun Ku"

Population Pharmacokinetics and Pharmacodynamics of Burosumab in Adult and Pediatric Patients With X‐linked Hypophosphatemia by Lee, Sun Ku, Gosselin, Nathalie H., Taylor, Julie, Roberts, Mary Scott, McKeever, Kathleen, Shi, Jack

“…Burosumab is a fully human monoclonal antibody against fibroblast growth factor 23, which has been approved to treat X‐linked hypophosphatemia (XLH) in adult…”
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Novel lung imaging biomarkers and skin gene expression subsetting in dasatinib treatment of systemic sclerosis-associated interstitial lung disease by Martyanov, Viktor, Kim, Grace-Hyun J, Hayes, Wendy, Du, Shuyan, Ganguly, Bishu J, Sy, Oumar, Lee, Sun Ku, Bogatkevich, Galina S, Schieven, Gary L, Schiopu, Elena, Marangoni, Roberta Gonçalves, Goldin, Jonathan, Whitfield, Michael L, Varga, John

“…There are no effective treatments or validated clinical response markers in systemic sclerosis (SSc). We assessed imaging biomarkers and performed gene…”
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The Pharmacokinetics of Triheptanoin and Its Metabolites in Healthy Subjects and Patients With Long‐Chain Fatty Acid Oxidation Disorders by Lee, Sun Ku, Gupta, Manju, Shi, Jack, McKeever, Kathleen

“…Long‐chain fatty acid oxidation disorders (LC‐FAODs) are a group of life‐threatening autosomal recessive disorders caused by defects in nuclear genes encoding…”
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Population Pharmacokinetics of Heptanoate in Healthy Subjects and Patients With Long‐Chain Fatty Acid Oxidation Disorders Treated With Triheptanoin by Lee, Sun Ku, Gosselin, Nathalie H., Jomphe, Claudia, McKeever, Kathleen, Putnam, Wendy

“…Triheptanoin is an odd‐carbon, medium‐chain triglyceride consisting of three fatty acids with seven carbons each on a glycerol backbone, indicated for the…”
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Resting energy expenditure and the clearance of therapeutic proteins in pediatric subjects by Lee, Sun Ku

“…The effect of age on the clearance (CL) of therapeutic proteins has not been explored extensively in pediatric subjects. Recently, resting energy expenditure…”
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Model‐Informed Approach to Recommend Burosumab Dosing Regimens for Pediatric and Adult Patients With the Ultrarare Disease Tumor‐Induced Osteomalacia by Hruska, Matthew W., Sid‐Otmane, Lamia, Gosselin, Nathalie H., Quattrocchi, Emilia, Lee, Sun Ku, Mascelli, Mary Ann, Mehta, Krina, Jan de Beur, Suzanne M., Marsteller, Douglas

“…Burosumab is approved for the treatment of hypophosphatemia in persistent tumor‐induced osteomalacia. This work exemplifies a model‐informed drug development…”
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Safety, pharmacokinetics, and pharmacodynamics of BMS-986142, a novel reversible BTK inhibitor, in healthy participants by Lee, Sun Ku, Xing, Jun, Catlett, Ian M., Adamczyk, Robert, Griffies, Amber, Liu, Ang, Murthy, Bindu, Nowak, Miroslawa

“…Purpose BMS-986142 is an oral, small-molecule reversible inhibitor of Bruton’s tyrosine kinase. The main objectives of our phase I studies were to characterize…”
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Population Pharmacokinetics of the BTK Inhibitor Acalabrutinib and its Active Metabolite in Healthy Volunteers and Patients with B-Cell Malignancies by Edlund, Helena, Lee, Sun Ku, Andrew, Marilee A., Slatter, J. Greg, Aksenov, Sergey, Al-Huniti, Nidal

“…Introduction Bruton tyrosine kinase (BTK) is a key component of B-cell receptor signalling, critical for cell proliferation. Acalabrutinib, a selective,…”
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Acalabrutinib monotherapy in patients with Waldenström macroglobulinemia: a single-arm, multicentre, phase 2 study by Owen, Roger G, McCarthy, Helen, Rule, Simon, D'Sa, Shirley, Thomas, Sheeba K, Tournilhac, Olivier, Forconi, Francesco, Kersten, Marie José, Zinzani, Pier Luigi, Iyengar, Sunil, Kothari, Jaimal, Minnema, Monique C, Kastritis, Efstathios, Aurran-Schleinitz, Thérèse, Cheson, Bruce D, Walter, Harriet, Greenwald, Daniel, Chen, Dih-Yih, Frigault, Melanie M, Hamdy, Ahmed, Izumi, Raquel, Patel, Priti, Wei, Helen, Lee, Sun Ku, Mittag, Diana, Furman, Richard R

“…Chemoimmunotherapy is typically the standard of care for patients with Waldenström macroglobulinemia; however, infectious and hematologic toxic effects are…”
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A physiologically based pharmacokinetic model for lactational transfer of PCB 153 with or without PCB 126 in mice by SUN KU LEE, OU, Ying C, ANDERSEN, Melvin E, YANG, Raymond S. H

“…Chemical exposure via breast milk is one of the great concerns in public health. Previously, we demonstrated that most body burden of PCB 153 can be…”
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Advantages of Calcium Green-1 over Other Fluorescent Dyes in Measuring Cytosolic Calcium in Platelets by Lee, Sun-Ku, Lee, Joo-Young, Lee, Moo-Yeol, Chung, Seung-Min, Chung, Jin-Ho

“…Fluorescent indicators are widely used in the measurements of cytosolic calcium in many cell types for many purposes because they are relatively easy to use…”
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Pharmacokinetic, Pharmacodynamic, and Safety Profile of a Novel Anti‐CD28 Domain Antibody Antagonist in Healthy Subjects by Shi, Rong, Honczarenko, Marek, Zhang, Sean, Fleener, Catherine, Mora, Johanna, Lee, Sun Ku, Wang, Reena, Liu, Xiaoni, Shevell, Diane E., Yang, Zheng, Wang, Haiqing, Murthy, Bindu

“…We report pharmacokinetics, pharmacodynamics, and safety of a novel anti‐CD28 domain antibody antagonist (lulizumab pegol) in healthy subjects following…”
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The roles of ATP and calcium in morphological changes and cytotoxicity induced by 1,4-benzoquinone in platelets by Lee, Sun-Ku, Chung, Seung-Min, Lee, Moo-Yoel, Lee, Joo-Young, Ok-Nam Bae, Chung, Jin-Ho

“…To understand the mechanism of 1,4-benzoquinone-induced cytotoxicity in platelets, the roles of ATP and calcium in platelet toxicity and morphological changes…”
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Comparison of pharmacokinetic interactions and physiologically based pharmacokinetic modeling of PCB 153 and PCB 126 in nonpregnant mice, lactating mice, and suckling pups by SUN KU LEE, OU, Ying C, YANG, Raymond S. H

“…Polychlorinated biphenyls (PCBs) are ubiquitous environmental contaminants that can induce neurological defects in infants and children via placental and…”
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Safety and Efficacy of Acalabrutinib Plus Bendamustine and Rituximab (BR) in Patients with Treatment-Naive (TN) or Relapsed/Refractory (R/R) Mantle Cell Lymphoma (MCL) by Phillips, Tycel J., Smith, Stephen D., Jurczak, Wojciech, Robak, Tadeusz, Stevens, Don, Farber, Charles M., Pagel, John M., Maddocks, Kami J., Flinn, Ian W., Jedrzejczak, Wieslaw W., Goy, Andre, Zinzani, Pier Luigi, Zaucha, Jan, Coleman, Morton, Chen, Tianling, Lee, Sun Ku, Liang, Wei, Seto, Anna, Wang, Michael

“…Background: MCL is a subtype of NHL that remains largely incurable with conventional therapies; BR is standard first-line therapy. Acalabrutinib is a potent,…”
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Pharmacokinetic, Pharmacodynamic, and Safety Profile of a Novel Anti-CD28 Domain Antibody Antagonist in Healthy Subjects: Novel Anti-CD28 Domain Antibody Antagonist by Shi, Rong, Honczarenko, Marek, Zhang, Sean, Fleener, Catherine, Mora, Johanna, Lee, Sun Ku, Wang, Reena, Liu, Xiaoni, Shevell, Diane E., Yang, Zheng, Wang, Haiqing, Murthy, Bindu

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Safety and Efficacy of Acalabrutinib Plus Bendamustine and Rituximab (BR) in Patients with Treatment-Naive (TN) or Relapsed/Refractory (R/R) Mantle Cell Lymphoma (MCL) by Phillips, Tycel, Smith, Stephen D., Jurczak, Wojciech, Robak, Tadeusz, Stevens, Don A., Farber, Charles M., Pagel, John M., Maddocks, Kami, Flinn, Ian, Jedrzejczak, Wieslaw W., Goy, Andre, Zinzani, Pier Luigi, Zaucha, Jan, Coleman, Morton, Chen, Tianling, Lee, Sun Ku, Liang, Wei, Seto, Anna, Wang, Michael

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Pharmacokinetic/pharmacodynamic (PK/PD) modeling for the respiratory effect of aminophylline in rats by Lee, Sun Ku, Jenkins, Angela C., Hoffman, Kathy, Abdelhameed, Magdy, Beck, T.W., Sarazan, R. Dustan

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Effect of PCBs on the lactational transfer of methyl mercury in mice: PBPK modeling by Lee, Sun Ku, Hamer, Dwayne, Bedwell, Cathy L, Lohitnavy, Manupat, Yang, Raymond S.H

“…Abstract MeHg and PCB exposure to lactating mice were analyzed and a physiologically based pharmacokinetic (PBPK) model was developed to describe the…”
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An integrative study for developmental neurotoxicities of methylmercury and PCBs: Combination of computational modeling with experimental toxicology by Lee, Sun Ku

“…The underlying purpose of the study is to investigate the potential whether MeHg and PCBs can induce interactive effects in the developing brain using…”
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