Search Results - "Lee, Stuart M C."
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Association of Long-Duration Spaceflight With Anterior and Posterior Ocular Structure Changes in Astronauts and Their Recovery
Published in JAMA ophthalmology (01-05-2020)“…During long-duration spaceflights, nearly all astronauts exhibit some change in ocular structure within the spectrum of spaceflight-associated neuro-ocular…”
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Optic Disc Edema and Choroidal Engorgement in Astronauts During Spaceflight and Individuals Exposed to Bed Rest
Published in JAMA ophthalmology (01-02-2020)“…Optic disc edema develops in astronauts during long-duration spaceflight and is a risk for all future astronauts during spaceflight. Having a ground-based…”
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Association of Structural Changes in the Brain and Retina After Long-Duration Spaceflight
Published in JAMA ophthalmology (01-07-2021)“…Long-duration spaceflight induces structural changes in the brain and eye. Identification of an association between cerebral and ocular changes could help…”
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Artificial gravity training reduces bed rest-induced cardiovascular deconditioning
Published in European journal of applied physiology (01-02-2012)“…We studied 15 men (8 treatment, 7 control) before and after 21 days of 6º head-down tilt to determine whether daily, 1-h exposures to 1.0 G z (at the heart)…”
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Early-phase musculoskeletal adaptations to different levels of eccentric resistance after 8 weeks of lower body training
Published in European journal of applied physiology (01-11-2014)“…Purpose Eccentric muscle actions are important to the development of muscle mass and strength and may affect bone mineral density (BMD). This study’s purpose…”
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Physiological and Functional Alterations after Spaceflight and Bed Rest
Published in Medicine and science in sports and exercise (01-09-2018)“…INTRODUCTIONExposure to microgravity causes alterations in multiple physiological systems, potentially impacting the ability of astronauts to perform critical…”
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Peak exercise oxygen uptake during and following long-duration spaceflight
Published in Journal of applied physiology (1985) (01-08-2014)“…This investigation was designed to measure aerobic capacity (V̇o2peak) during and after long-duration International Space Station (ISS) missions. Astronauts (9…”
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Assessment of Jugular Venous Blood Flow Stasis and Thrombosis During Spaceflight
Published in JAMA network open (01-11-2019)“…Exposure to a weightless environment during spaceflight results in a chronic headward blood and tissue fluid shift compared with the upright posture on Earth,…”
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Arterial structure and function during and after long-duration spaceflight
Published in Journal of applied physiology (1985) (01-07-2020)“…Spaceflight missions expose astronauts to increased risk of oxidative stress and inflammatory damage that might accelerate the development of asymptomatic…”
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Left ventricular remodeling during and after 60 days of sedentary head-down bed rest
Published in Journal of applied physiology (1985) (15-04-2016)“…Short periods of weightlessness are associated with reduced stroke volume and left ventricular (LV) mass that appear rapidly and are thought to be largely…”
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Changes in the Optic Nerve Head and Choroid Over 1 Year of Spaceflight
Published in JAMA ophthalmology (01-06-2021)“…While 6-month data are available regarding spaceflight-associated neuro-ocular syndrome, manned missions for 1 year and beyond are planned, warranting…”
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Lower body negative pressure exercise plus brief postexercise lower body negative pressure improve post-bed rest orthostatic tolerance
Published in Journal of applied physiology (1985) (01-12-2007)“…1 Department of Integrative Physiology, University of North Texas Health Science Center, Fort Worth, Texas; 2 Department of Community Health Sciences, Brock…”
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Orthostatic Intolerance After ISS and Space Shuttle Missions
Published in Aerospace medicine and human performance (01-12-2015)“…Cardiovascular deconditioning apparently progresses with flight duration, resulting in a greater incidence of orthostatic intolerance following long-duration…”
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Computational modelling of cardiovascular pathophysiology to risk stratify commercial spaceflight
Published in Nature reviews cardiology (01-10-2024)“…For more than 60 years, humans have travelled into space. Until now, the majority of astronauts have been professional, government agency astronauts selected,…”
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Unchanged cerebrovascular CO2 reactivity and hypercapnic ventilatory response during strict head‐down tilt bed rest in a mild hypercapnic environment
Published in The Journal of physiology (01-06-2020)“…Key points Carbon dioxide levels are mildly elevated on the International Space Station and it is unknown whether this chronic exposure causes physiological…”
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Mechanical Countermeasures to Headward Fluid Shifts
Published in Journal of applied physiology (1985) (01-06-2021)“…Head-to-foot gravitationally-induced hydrostatic pressure gradients in the upright posture on Earth are absent in weightlessness. This results in a relative…”
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Near infrared spectroscopy-derived interstitial hydrogen ion concentration and tissue oxygen saturation during ambulation
Published in European journal of applied physiology (01-08-2011)“…The objective of this study was to determine whether walking and running at different treadmill speeds resulted in different metabolic and cardiovascular…”
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Musculoskeletal Adaptations to Training with the Advanced Resistive Exercise Device
Published in Medicine and science in sports and exercise (2011)“…Resistance exercise has been used as a means to prevent the musculoskeletal losses associated with spaceflight. Therefore, the National Aeronautics and Space…”
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Impact of Daily Lower-Body Negative Pressure or Cycling Followed by Venous Constrictive Thigh Cuffs on Bedrest-Induced Orthostatic Intolerance
Published in Journal of the American Heart Association (05-11-2024)“…Orthostatic intolerance occurs following immobilization in patients on Earth and in astronauts after spaceflight. Head-down tilt bedrest is a terrestrial model…”
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Self-Generated Lower Body Negative Pressure Exercise: A Low Power Countermeasure for Acute Space Missions
Published in Life (Basel, Switzerland) (24-06-2024)“…Microgravity in spaceflight produces headward fluid shifts which probably contribute to Spaceflight-Associated Neuro-Ocular Syndrome (SANS). Developing new…”
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