Search Results - "Lee, Simon P"

The burden of disease associated with filaggrin mutations: A population-based, longitudinal birth cohort study by Henderson, John, MD, Northstone, Kate, MSc, Lee, Simon P., MSc, Liao, Haihui, MD, Zhao, Yiwei, MD, Pembrey, Marcus, MD, Mukhopadhyay, Somnath, MD, Smith, George Davey, MD, DSc, Palmer, Colin N.A., PhD, McLean, W. H. Irwin, PhD, DSc, Irvine, Alan D., MD

“…Background Atopic disease is a major health problem. Mutations in the filaggrin gene (FLG) confer major susceptibility to eczema and related asthma. Objective…”
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Filaggrin null mutations are associated with increased asthma severity in children and young adults by Palmer, Colin N.A., PhD, Ismail, Tahmina, MBBS, MSc, Lee, Simon P., MSc, Terron-Kwiatkowski, Ana, PhD, Zhao, Yiwei, MD, Liao, Haihui, MD, Smith, Frances J.D., PhD, McLean, W.H. Irwin, PhD, DSc, FRSE, Mukhopadhyay, Somnath, FRCPCH, PhD

“…Background Filaggrin is a key protein involved in skin barrier function. Filaggrin ( FLG ) null mutations are important genetic predisposing factors for atopic…”
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Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations by Weidinger, Stephan, Illig, Thomas, Baurecht, Hansjörg, Irvine, Alan D., Rodriguez, Elke, Diaz-Lacava, Amalia, Klopp, Norman, Wagenpfeil, Stefan, Zhao, Yiwei, Liao, Haihui, Lee, Simon P., Palmer, Colin N.A., Jenneck, Claudia, Maintz, Laura, Hagemann, Tobias, Behrendt, Heidrun, Ring, Johannes, Nothen, Markus M., McLean, W. H. Irwin, Novak, Natalija

“…Atopic dermatitis (AD) is a chronic inflammatory skin disease with a strong genetic background. One of the characteristic features of AD and causative factor…”
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Null Mutations in the Filaggrin Gene (FLG) Determine Major Susceptibility to Early-Onset Atopic Dermatitis that Persists into Adulthood by Barker, Jonathan N.W.N., Palmer, Colin N.A., Zhao, Yiwei, Liao, Haihui, Hull, Peter R., Lee, Simon P., Allen, Michael H., Meggitt, Simon J., Reynolds, Nicholas J., Trembath, Richard C., Irwin McLean, W.H.

“…Atopic dermatitis (AD) is a common disease with a complex etiology in childhood and adult life. A significant proportion of childhood AD is transient, but in…”
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Glutathione S-Transferase M1 and P1 Genotype, Passive Smoking, and Peak Expiratory Flow in Asthma by Palmer, Colin N.A, Doney, Alex S.F, Lee, Simon P, Murrie, Inez, Ismail, Tahmina, Macgregor, Donald F, Mukhopadhyay, Somnath

“…Our purpose with this work was to assess the contribution of glutathione S-transferase gene variants to asthma susceptibility and pulmonary function in…”
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Loss-of-function Variants of the Filaggrin Gene are Associated with Atopic Eczema and Associated Phenotypes in Swedish Families by EKELUND, Elisabeth, LIEDEN, Agne, LINK, Jenny, LEE, Simon P, D'AMATO, Mauro, PALMER, Colin N. A, KOCKUM, Ingrid, BRADLEY, Maria

“…Recent studies have identified 2 loss-of-function variants, R501X and 2282del4, in the filaggrin gene as predisposing factors in the development of eczema. In…”
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Filaggrin Null Alleles Are Not Associated with Psoriasis by Zhao, Yiwei, Terron-Kwiatkowski, Ana, Liao, Haihui, Lee, Simon P., Allen, Michael H., Hull, Peter R., Campbell, Linda E., Trembath, Richard C., Capon, Francesca, Griffiths, Christopher E.M., Burden, David, McManus, Ross, Hughes, Rosalind, Kirby, Brian, Rogers, Sarah F., Fitzgerald, Oliver, Kane, David, Barker, Jonathan N.W.N., Palmer, Colin N.A., Irvine, Alan D., Irwin McLean, W.H.

“…Psoriasis is a common skin disease with an etiology consistent with a multifactorial trait. Several psoriasis susceptibility loci are known, a number of which…”
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A Discussion on the Impact of CFC12 Emission Rate from XPS Insulation on Atmospheric Banks by Paquet, Andrew N., Mutton, John, Lee, Simon P.

“…This report presents new information regarding emissions of CFC12 used to make extruded polystyrene foam products. Earlier reports identified a significant…”
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Global Atmospheric Emissions Model of HCFC142b with Respect to Extruded Polystyrene Foam Applications by Paquet, Andrew N., Mutton, John, Lee, Simon P.

“…This paper will address significant issues related to discrepancies between the atmospheric measurements of HCFC142b and estimated emissions from production…”
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Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis by McLean, W H Irwin, Palmer, Colin N A, Irvine, Alan D, Terron-Kwiatkowski, Ana, Zhao, Yiwei, Liao, Haihui, Lee, Simon P, Goudie, David R, Sandilands, Aileen, Campbell, Linda E, Smith, Frances J D, O'Regan, Gráinne M, Watson, Rosemarie M, Cecil, Jo E, Bale, Sherri J, Compton, John G, DiGiovanna, John J, Fleckman, Philip, Lewis-Jones, Sue, Arseculeratne, Gehan, Sergeant, Ann, Munro, Colin S, El Houate, Brahim, McElreavey, Ken, Halkjaer, Liselotte B, Bisgaard, Hans, Mukhopadhyay, Somnath

“…Atopic disease, including atopic dermatitis (eczema), allergy and asthma, has increased in frequency in recent decades and now affects ∼20% of the population…”
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A Discussion on the Impact of CFC 12 Emission Rate from XPS Insulation on Atmospheric Banks by PAQUET, Andrew N, MUTTON, John, LEE, Simon P

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Null mutations in the filaggrin gene (FLG) determine major susceptibility to early-onset atopic dermatitis that persists into adulthood. Commentary by IRVINE, Alan D, BARKER, Jonathan N. W. N, TREMBATH, Richard C, IRWIN MCLEAN, W. H, PALMER, Colin N. A, YIWEI ZHAO, HAIHUI LIAO, HULL, Peter R, LEE, Simon P, ALLEN, Michael H, MEGGITT, Simon J, REYNOLDS, Nicholas J

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Association of common variation in the PPARA gene with incident myocardial infarction in individuals with type 2 diabetes: a Go-DARTS study by Doney, Alex S F, Fischer, Bettina, Lee, Simon P, Morris, Andrew D, Leese, Graham, Palmer, Colin N A

“…Common variants of the PPARA gene have been found to associate with ischaemic heart disease in non diabetic men. The L162V variant was found to be protective…”
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Association of common variation in the PPARAgene with incident myocardial infarction in individuals with type 2 diabetes: A Go-DARTS study by Doney, Alex SF, Fischer, Bettina, Lee, Simon P, Morris, Andrew D, Leese, Graham, Palmer, Colin NA

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