Search Results - "Lee, Shaun W."

Virulence Factor Targeting of the Bacterial Pathogen Staphylococcus aureus for Vaccine and Therapeutics by Kane, Trevor L, Carothers, Katelyn E, Lee, Shaun W

“…Staphylococcus aureus is a major bacterial pathogen capable of causing a range of infections in humans from gastrointestinal disease, skin and soft tissue…”
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Multi-modal Single-Cell Analysis Reveals Brain Immune Landscape Plasticity during Aging and Gut Microbiota Dysbiosis by Golomb, Samantha M., Guldner, Ian H., Zhao, Anqi, Wang, Qingfei, Palakurthi, Bhavana, Aleksandrovic, Emilija A., Lopez, Jacqueline A., Lee, Shaun W., Yang, Kai, Zhang, Siyuan

“…Phenotypic and functional plasticity of brain immune cells contribute to brain tissue homeostasis and disease. Immune cell plasticity is profoundly influenced…”
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The Role of Host-Cellular Responses in COVID-19 Endothelial Dysfunction by Moran, Thomas E, Hammers, Daniel E, Lee, Shaun W

“…SARS-CoV2, Severe acute respiratory syndrome coronavirus 2, is a novel member of the human coronavirus family that has recently emerged worldwide to cause…”
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Editorial: When streptococci seize the opportunity: identifying how manipulation of host inflammatory signaling impacts pathogenesis in streptococcal infections by Flaherty, Rebecca A, Lee, Shaun W, Manning, Shannon D

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Telemedicine for the Management of Glycemic Control and Clinical Outcomes of Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Studies by Lee, Shaun W H, Ooi, Leanne, Lai, Yin K

“…Telemedicine has been shown to be an efficient and effective means of providing care to patients with chronic disease especially in remote and undeserved…”
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Algorithmic assessment of missense mutation severity in the Von-Hippel Lindau protein by Fields, Francisco R, Suresh, Niraja, Hiller, Morgan, Freed, Stefan D, Haldar, Kasturi, Lee, Shaun W

“…Von Hippel-Lindau disease (VHL) is an autosomal dominant rare disease that causes the formation of angiogenic tumors. When functional, pVHL acts as an E3…”
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Discovery of a widely distributed toxin biosynthetic gene cluster by Lee, Shaun W, Mitchell, Douglas A, Markley, Andrew L, Hensler, Mary E, Gonzalez, David, Wohlrab, Aaron, Dorrestein, Pieter C, Nizet, Victor, Dixon, Jack E

“…Bacteriocins represent a large family of ribosomally produced peptide antibiotics. Here we describe the discovery of a widely conserved biosynthetic gene…”
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The M Protein of Streptococcus pyogenes Strain AP53 Retains Cell Surface Functional Plasminogen Binding after Inactivation of the Sortase A Gene by Russo, Brady T, Ayinuola, Yetunde A, Singh, Damini, Carothers, Katelyn, Fischetti, Vincent A, Flores-Mireles, Ana L, Lee, Shaun W, Ploplis, Victoria A, Liang, Zhong, Castellino, Francis J

“…(Lancefield group A [GAS]) is a β-hemolytic human-selective pathogen that is responsible for a large number of morbid and mortal infections in humans. For…”
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Relationships Between Plasminogen-Binding M-Protein and Surface Enolase for Human Plasminogen Acquisition and Activation in Streptococcus pyogenes by Ayinuola, Yetunde A, Tjia-Fleck, Sheiny, Readnour, Bradley M, Liang, Zhong, Ayinuola, Olawole, Paul, Lake N, Lee, Shaun W, Fischetti, Vincent A, Ploplis, Victoria A, Castellino, Francis J

“…The proteolytic activity of human plasmin (hPm) is utilized by various cells to provide a surface protease that increases the potential of cells to migrate and…”
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The wide world of ribosomally encoded bacterial peptides by Flaherty, Rebecca A, Freed, Stefan D, Lee, Shaun W

“…  Bacterial peptides produced by both gram-positive and gram-negative bacteria include antimicrobial peptides such as Nisin and Microcin B17, known host…”
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Streptolysin S targets the sodium-bicarbonate cotransporter NBCn1 to induce inflammation and cytotoxicity in human keratinocytes during Group A Streptococcal infection by Hammers, Daniel E, Donahue, Deborah L, Tucker, Zachary D, Ashfeld, Brandon L, Ploplis, Victoria A, Castellino, Francis J, Lee, Shaun W

“…Group A (GAS, ) is a Gram-positive human pathogen that employs several secreted and surface-bound virulence factors to manipulate its environment, allowing it…”
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Dynamics of Neisseria gonorrhoeae Attachment: Microcolony Development, Cortical Plaque Formation, and Cytoprotection by Higashi, Dustin L, Lee, Shaun W, Snyder, Aurelie, Weyand, Nathan J, Bakke, Antony, So, Magdalene

“…Neisseria gonorrhoeae is the bacterium that causes gonorrhea, a major sexually transmitted disease and a significant cofactor for human immunodeficiency virus…”
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Mutations in the control of virulence sensor gene from Streptococcus pyogenes after infection in mice lead to clonal bacterial variants with altered gene regulatory activity and virulence by Mayfield, Jeffrey A, Liang, Zhong, Agrahari, Garima, Lee, Shaun W, Donahue, Deborah L, Ploplis, Victoria A, Castellino, Francis J

“…The cluster of virulence sensor (CovS)/responder (CovR) two-component operon (CovRS) regulates ∼15% of the genes of the Group A Streptococcal pyogenes (GAS)…”
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Rationally Designed Minimal Bioactive Domains of AS-48 Bacteriocin Homologs Possess Potent Antileishmanial Properties by Corman, Hannah N, Ross, Jessica N, Fields, Francisco R, Shoue, Douglas A, McDowell, Mary Ann, Lee, Shaun W

“…Leishmaniasis, a category I neglected tropical disease, is a group of diseases caused by the protozoan parasite species with a wide range of clinical…”
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A Seed-Endophytic Bacillus safensis Strain With Antimicrobial Activity Has Genes for Novel Bacteriocin-Like Antimicrobial Peptides by Romero-Severson, Jeanne, Moran, Thomas E., Shrader, Donna G., Fields, Francisco R., Pandey-Joshi, Susan, Thomas, Clayton L., Palmer, Emily C., Shrout, Joshua D., Pfrender, Michael E., Lee, Shaun W.

“…Bacteriocins are a highly diverse group of antimicrobial peptides that have been identified in a wide range of commensal and probiotic organisms, especially…”
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Efficacy of Pharmacist Based Diabetes Educational Interventions on Clinical Outcomes of Adults With Type 2 Diabetes Mellitus: A Network Meta-Analysis by Bukhsh, Allah, Khan, Tahir M, Lee, Shaun W H, Lee, Learn-Han, Chan, Kok-Gan, Goh, Bey-Hing

“…Comparative efficacy of different pharmacist based interventions on glycemic control of type 2 diabetes patients is unclear. This review aimed to evaluate and…”
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Synthetic Peptide Libraries Designed From a Minimal Alpha-Helical Domain of AS-48-Bacteriocin Homologs Exhibit Potent Antibacterial Activity by Ross, Jessica N, Fields, Francisco R, Kalwajtys, Veronica R, Gonzalez, Alejandro J, O'Connor, Samantha, Zhang, Angela, Moran, Thomas E, Hammers, Daniel E, Carothers, Katelyn E, Lee, Shaun W

“…The circularized bacteriocin enterocin AS-48 produced by sp. exhibits antibacterial activity through membrane disruption. The membrane-penetrating activity of…”
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Rational design of syn-safencin, a novel linear antimicrobial peptide derived from the circular bacteriocin safencin AS-48 by Fields, Francisco R., Carothers, Katelyn E., Balsara, Rashna D., Ploplis, Victoria A., Castellino, Francis J., Lee, Shaun W.

“…Bacteriocins hold unprecedented promise as a largely untapped source of antibiotic alternatives in the age of multidrug resistance. Here, we describe the first…”
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Directly Acting Antivirals for COVID-19: Where Do We Stand? by Teoh, Siew L., Lim, Yi H., Lai, Nai M., Lee, Shaun W. H.

“…The outbreak of a novel coronavirus (SARS-CoV-2) in Wuhan, China in December 2019 has now become a pandemic with no approved therapeutic agent. At the moment,…”
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Structural and Functional Dissection of the Heterocyclic Peptide Cytotoxin Streptolysin S by Mitchell, Douglas A., Lee, Shaun W., Pence, Morgan A., Markley, Andrew L., Limm, Joyce D., Nizet, Victor, Dixon, Jack E.

“…The human pathogen Streptococcus pyogenes secretes a highly cytolytic toxin known as streptolysin S (SLS). SLS is a key virulence determinant and responsible…”
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