Search Results - "Lee, Seungbeom"

Structural Congeners of Izenamides Responsible for Cathepsin D Inhibition: Insights from Synthesis-Derived Elucidation by Kim, Hyun Su, Kong, Hyejin, Kim, Taewoo, Lim, Changjin, Lee, Seungbeom, Kim, Seok-Ho, Suh, Young-Ger

“…This study aimed to elucidate the structural congeners of natural izenamides A, B, and C ( - ) responsible for cathepsin D (CTSD) inhibition. Structurally…”
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Identification of a novel circadian clock modulator controlling BMAL1 expression through a ROR/REV-ERB-response element-dependent mechanism by Lee, Jiyeon, Lee, Seungbeom, Chung, Sooyoung, Park, Noheon, Son, Gi Hoon, An, Hongchan, Jang, Jaebong, Chang, Dong-Jo, Suh, Young-Ger, Kim, Kyungjin

“…Circadian rhythms, biological oscillations with a period of about 24 h, are maintained by an innate genetically determined time-keeping system called the…”
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A Michael Acceptor Analogue, SKSI-0412, Down-Regulates Inflammation and Proliferation Factors through Suppressing Signal Transducer and Activator of Transcription 3 Signaling in IL-17A-Induced Human Keratinocyte by Kim, A-Ram, Lee, Seungbeom, Shin, Jung U, Seok, Seung Hui, Suh, Young-Ger, Kim, Dong Hyun

“…The activation of signal transducer and activator of transcription 3 (STAT3), as well as up-regulation of cytokines and growth factors to promote STAT3…”
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Conformation‐Enabled Total Syntheses of Ohmyungsamycins A and B and Structural Revision of Ohmyungsamycin B by Hur, Joonseong, Jang, Jaebong, Sim, Jaehoon, Son, Woo Sung, Ahn, Hee‐Chul, Kim, Tae Sung, Shin, Yern‐Hyerk, Lim, Changjin, Lee, Seungbeom, An, Hongchan, Kim, Seok‐Ho, Oh, Dong‐Chan, Jo, Eun‐Kyeong, Jang, Jichan, Lee, Jeeyeon, Suh, Young‐Ger

“…The first total syntheses of the bioactive cyclodepsipeptides ohmyungsamycin A and B are described. Key features of our synthesis include the concise…”
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Design, Synthesis, and Biological Evaluation of Novel Deguelin-Based Heat Shock Protein 90 (HSP90) Inhibitors Targeting Proliferation and Angiogenesis by Chang, Dong-Jo, An, Hongchan, Kim, Kyoung-suk, Kim, Hyun Ho, Jung, Jinkyung, Lee, Jung Min, Kim, Nam-Jung, Han, Young Taek, Yun, Hwayoung, Lee, Sujin, Lee, Geumwoo, Lee, Seungbeom, Lee, Ju Sung, Cha, Jong-Ho, Park, Ji-Hyeon, Park, Ji Won, Lee, Su-Chan, Kim, Sang Geon, Kim, Jeong Hun, Lee, Ho-Young, Kim, Kyu-Won, Suh, Young-Ger

“…Deguelin exhibits potent apoptotic and antiangiogenic activities in a variety of transformed cells and cancer cells. Deguelin also exhibits potent tumor…”
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15-Keto prostaglandin E2 suppresses STAT3 signaling and inhibits breast cancer cell growth and progression by Lee, Eun Ji, Kim, Su-Jung, Hahn, Young-Il, Yoon, Hyo-Jin, Han, Bitnara, Kim, Kyeojin, Lee, Seungbeom, Kim, Kwang Pyo, Suh, Young Ger, Surh, Young-Joon

“…Overproduction of prostaglandin E 2 (PGE 2 ) has been linked to enhanced tumor cell proliferation, invasiveness and metastasis as well as resistance to…”
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Past, present, and future of WCG technology in display by Kwak, Musun, Kim, Younghoon, Han, Sanghun, Kim, Ahnki, Kim, Sooin, Lee, Seungbeom, Jun, Mike, Kang, Inbyeong

“…We will introduce the development trend of colorant and color technology along the grown of display industry. Wide color gamut (WCG) technology with high…”
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Asymmetric Total Synthesis of (+)-Intricenyne via an Endocyclization Route to Oxocane Skeleton by Ahn, Jungmin, Lim, Changjin, Yun, Hwayoung, Kim, Hyun Su, Kwon, Soonbum, Lee, Jeeyeon, Lee, Seungbeom, An, Hongchan, Park, Hyeong-geun, Suh, Young-Ger

“…The first total synthesis of (+)-intricenyne consisting of an oxocane skeleton was achieved via an extremely selective endocyclization strategy. The key…”
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Development and Validation of Analytical Method for SH-1242 in the Rat and Mouse Plasma by Liquid Chromatography/Tandem Mass Spectrometry by Jeong, Yoo-Seong, Baek, Minjeong, Lee, Seungbeom, Kim, Min-Soo, Maeng, Han-Joo, Lee, Jong-Hwa, Suh, Young-Ger, Chung, Suk-Jae

“…SH-1242, a novel inhibitor of heat shock protein 90 (HSP90), is a synthetic analog of deguelin: It was previously reported that the treatment of SH-1242 led to…”
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Total synthesis of (-)-deguelin via an iterative pyran-ring formation strategy by Lee, Seungbeom, An, Hongchan, Chang, Dong-Jo, Jang, Jaebong, Kim, Kyeojin, Sim, Jaehoon, Lee, Jeeyeon, Suh, Young-Ger

“…Enantioselective synthesis of (-)-deguelin was accomplished via an iterative pyran-ring formation approach. The key features involve the anionic addition of a…”
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An Electrophilic Deguelin Analogue Inhibits STAT3 Signaling in H-Ras-Transformed Human Mammary Epithelial Cells: The Cysteine 259 Residue as a Potential Target by Hong, Sung-Jun, Kim, Jin-Tae, Kim, Su-Jung, Cho, Nam-Chul, Kim, Kyeojin, Lee, Seungbeom, Suh, Young-Ger, Cho, Kyung-Cho, Kim, Kwang Pyo, Surh, Young-Joon

“…Signal transducer and activator of transcription 3 (STAT3) is a point of convergence for numerous oncogenic signals that are often constitutively activated in…”
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Natural biomaterials for sustainable flexible neuromorphic devices by Zhao, Yanfei, Lee, Seungbeom, Long, Tingyu, Park, Hea-Lim, Lee, Tae-Woo

“…Neuromorphic electronics use neural models in hardware to emulate brain-like behavior, and provide power-efficient, extremely compact, and massively-parallel…”
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Recent advances in development of hetero-bivalent kinase inhibitors by Lee, Seungbeom, Kim, Jisu, Jo, Jeyun, Chang, Jae Won, Sim, Jaehoon, Yun, Hwayoung

“…Identifying a pharmacological agent that targets only one of more than 500 kinases present in humans is an important challenge. One potential solution to this…”
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A High-Speed Pipelined Degree-Computationless Modified Euclidean Algorithm Architecture for Reed-Solomon Decoders by Lee, Seungbeom, Lee, Hanho, Shin, Jongyoon, Ko, Je-Soo

“…This paper presents a novel high-speed low-complexity pipelined degree-computationless modified Euclidean (pDCME) algorithm architecture for high-speed RS…”
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Outcomes of lipectomy in patients with advanced unilateral upper extremity lymphedema with regard to the difference in time required for indocyanine green to reach the axilla: A retrospective cohort study in a single center by Kim, Ryuck Seong, Yi, Changryul Claud, Lee, Jae Woo, Yoon, Jin A, Lee, Seungbeom, Kim, Joo Hyoung

“…This study aimed to compare and analyze the prognosis after lipectomy with respect to the difference in time required for indocyanine green (ICG) to reach the…”
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Long-term Results and Efficacy of Intermediate Rhinoplasty in Patients With Unilateral Cleft Lip: A Single Surgeon's Experience by Bae, Yong Chan, Lee, Chi Hyun, Seo, Hyung Joon, Park, Min Suk, Lee, Seungbeom, Kim, Ryuck Seong

“…Intermediate rhinoplasty, the correction of cleft lip nose deformities, is performed between the time of primary and secondary rhinoplasties, which is at ~6…”
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A novel small molecule STAT3 inhibitor SLSI-1216 suppresses proliferation and tumor growth of triple-negative breast cancer cells through apoptotic induction by Park, Soo Kyung, Byun, Woong Sub, Lee, Seungbeom, Han, Young Taek, Jeong, Yoo-Seong, Jang, Kyungkuk, Chung, Suk-Jae, Lee, Jeeyeon, Suh, Young-Ger, Lee, Sang Kook

“…[Display omitted] Triple-negative breast cancer (TNBC) is the most aggressive type of breast cancer, characterized by the lack of expression of estrogen…”
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S-lactoyl modification of KEAP1 by a reactive glycolytic metabolite activates NRF2 signaling by Ko, Yeonjin, Hong, Mannkyu, Lee, Seungbeom, Kumar, Manoj, Ibrahim, Lara, Nutsch, Kayla, Stanton, Caroline, Sondermann, Phillip, Sandoval, Braddock, Bulos, Maya L, Iaconelli, Jonathan, Chatterjee, Arnab K, Wiseman, R Luke, Schultz, Peter G, Bollong, Michael J

“…KEAP1 (Kelch-like ECH-associated protein), a cytoplasmic repressor of the oxidative stress responsive transcription factor Nuclear factor erythroid 2-related…”
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An Efficient Admission Control Algorithm for IEEE 802.11e WLAN by Min Li Huang, Seungbeom Lee, Sin-Chong Park

“…The IEEE 802.1 le standard allows an admission control (AC) criteria based on medium time calculation for contention-based wireless access. In this standard,…”
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Synthesis and Structure–Activity Relationships of Arylsulfonamides as AIMP2-DX2 Inhibitors for the Development of a Novel Anticancer Therapy by Sivaraman, Aneesh, Kim, Dae Gyu, Bhattarai, Deepak, Kim, Minkyoung, Lee, Hwa Young, Lim, Semi, Kong, Jiwon, Goo, Ja-il, Shim, Seunghwan, Lee, Seungbeom, Suh, Young-Ger, Choi, Yongseok, Kim, Sunghoon, Lee, Kyeong

“…AIMP2-DX2, a splicing variant of AIMP2, is up-regulated in lung cancer, possesses oncogenic activity, and results in tumorigenesis. Specifically inhibiting the…”
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