Search Results - "Lee, Seung Jae"

Emerging functions of circular RNA in aging by Kim, Eunah, Kim, Yoon Ki, Lee, Seung-Jae V.

“…Circular RNA (circRNA) is a closed, single-stranded transcript widely detected in eukaryotes. Recent studies indicate that the levels of circRNAs change with…”
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Age‐dependent changes and biomarkers of aging in Caenorhabditis elegans by Son, Heehwa G., Altintas, Ozlem, Kim, Eun Ji E., Kwon, Sujeong, Lee, Seung‐Jae V.

“…Caenorhabditis elegans is an exceptionally valuable model for aging research because of many advantages, including its genetic tractability, short lifespan,…”
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Recent Progress in Regulation of Aging by Insulin/IGF-1 Signaling in Caenorhabditis elegans by Lee, Hanseul, Lee, Seung-Jae V

“…has been used as a major model organism to identify genetic factors that regulate organismal aging and longevity. Insulin/insulin-like growth factor 1 (IGF- 1)…”
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Advances in transcriptome analysis of human brain aging by Ham, Seokjin, Lee, Seung-Jae V.

“…Aging is associated with gradual deterioration of physiological and biochemical functions, including cognitive decline. Transcriptome profiling of brain…”
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The role of insulin/IGF-1 signaling in the longevity of model invertebrates, C. elegans and D. melanogaster by Altintas, Ozlem, Park, Sangsoon, Lee, Seung-Jae V

“…Insulin/insulin-like growth factor (IGF)-1 signaling (IIS) pathway regulates aging in many organisms, ranging from simple invertebrates to mammals, including…”
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Assessment of frequency drift on CEST MRI and dynamic correction: application to gagCEST at 7 T by Windschuh, Johannes, Zaiss, Moritz, Ehses, Philipp, Lee, Jae‐Seung, Jerschow, Alexej, Regatte, Ravinder R.

“…Purpose To investigate the effect of a frequency drift of the static magnetic field on 3D CEST MRI based on glycosaminoglycans (GAGs) of articular cartilage at…”
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OASIS 2: online application for survival analysis 2 with features for the analysis of maximal lifespan and healthspan in aging research by Han, Seong Kyu, Lee, Dongyeop, Lee, Heetak, Kim, Donghyo, Son, Heehwa G, Yang, Jae-Seong, Lee, Seung-Jae V, Kim, Sanguk

“…Online application for survival analysis (OASIS) has served as a popular and convenient platform for the statistical analysis of various survival data,…”
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Colorimetric Detection of Mercuric Ion (Hg2+) in Aqueous Media using DNA-Functionalized Gold Nanoparticles by Lee, Jae-Seung, Han, Min Su, Mirkin, Chad A.

“…Color is everything: Hg2+ in aqueous media is detected by the formation of thymidine–Hg2+–thymidine coordination complexes, which raises the melting…”
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Spin currents and spin–orbit torques in ferromagnetic trilayers by Baek, Seung-heon C., Amin, Vivek P., Oh, Young-Wan, Go, Gyungchoon, Lee, Seung-Jae, Lee, Geun-Hee, Kim, Kab-Jin, Stiles, M. D., Park, Byong-Guk, Lee, Kyung-Jin

“…Magnetic torques generated through spin–orbit coupling 1 – 8 promise energy-efficient spintronic devices. For applications, it is important that these torques…”
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The Role of mRNA Quality Control in the Aging of Caenorhabditis elegans by Kwon, Hyunwoo C, Bae, Yunkyu, Lee, Seung-Jae V

“…The proper maintenance of mRNA quality that is regulated by diverse surveillance pathways is essential for cellular homeostasis and is highly conserved among…”
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C. elegans maximum velocity correlates with healthspan and is maintained in worms with an insulin receptor mutation by Hahm, Jeong-Hoon, Kim, Sunhee, DiLoreto, Race, Shi, Cheng, Lee, Seung-Jae V., Murphy, Coleen T., Nam, Hong Gil

“…Ageing is marked by physical decline. Caenorhabditis elegans is a valuable model for identifying genetic regulatory mechanisms of ageing and longevity. Here we…”
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Structural heterogeneity of α-synuclein fibrils amplified from patient brain extracts by Strohäker, Timo, Jung, Byung Chul, Liou, Shu-Hao, Fernandez, Claudio O., Riedel, Dietmar, Becker, Stefan, Halliday, Glenda M., Bennati, Marina, Kim, Woojin S., Lee, Seung-Jae, Zweckstetter, Markus

“…Parkinson’s disease (PD) and Multiple System Atrophy (MSA) are clinically distinctive diseases that feature a common neuropathological hallmark of aggregated…”
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Insights into Characterization Methods and Biomedical Applications of Nanoparticle-Protein Corona by Li, Yan, Lee, Jae-Seung

“…Nanoparticles (NPs) exposed to a biological milieu will strongly interact with proteins, forming "coronas" on the surfaces of the NPs. The protein coronas…”
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MDT-15/MED15 permits longevity at low temperature via enhancing lipidostasis and proteostasis by Lee, Dongyeop, An, Seon Woo A, Jung, Yoonji, Yamaoka, Yasuyo, Ryu, Youngjae, Goh, Grace Ying Shyen, Beigi, Arshia, Yang, Jae-Seong, Jung, Gyoo Yeol, Ma, Dengke K, Ha, Chang Man, Taubert, Stefan, Lee, Youngsook, Lee, Seung-Jae V

“…Low temperatures delay aging and promote longevity in many organisms. However, the metabolic and homeostatic aspects of low-temperature-induced longevity…”
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Neuroinflammation in Synucleinopathies by Lim, Somin, Chun, Yewon, Lee, Jun Sung, Lee, Seung-Jae

“…The causes of most neurodegenerative diseases are attributed to multiple genetic and environmental factors interacting with one another. Above all,…”
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Lewy Body–like Inclusions in Human Midbrain Organoids Carrying Glucocerebrosidase and α‐Synuclein Mutations by Jo, Junghyun, Yang, Lin, Tran, Hoang‐Dai, Yu, Weonjin, Sun, Alfred Xuyang, Chang, Ya Yin, Jung, Byung Chul, Lee, Seung‐Jae, Saw, Tzuen Yih, Xiao, Bin, Khoo, Audrey Tze Ting, Yaw, Lai‐Ping, Xie, Jessica Jiaxin, Lokman, Hidayat, Ong, Wei‐Yi, Lim, Grace Gui Yin, Lim, Kah‐Leong, Tan, Eng‐King, Ng, Huck‐Hui, Je, Hyunsoo Shawn

“…Objective We utilized human midbrain‐like organoids (hMLOs) generated from human pluripotent stem cells carrying glucocerebrosidase gene (GBA1) and α‐synuclein…”
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Mechanism of neuroprotection by trehalose: controversy surrounding autophagy induction by Lee, He-Jin, Yoon, Ye-Seul, Lee, Seung-Jae

“…Trehalose is a non-reducing disaccharide with two glucose molecules linked through an α, α-1,1-glucosidic bond. Trehalose has received attention for the past…”
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Synthesized tissue‐equivalent dielectric phantoms using salt and polyvinylpyrrolidone solutions by Ianniello, Carlotta, de Zwart, Jacco A., Duan, Qi, Deniz, Cem M., Alon, Leeor, Lee, Jae‐Seung, Lattanzi, Riccardo, Brown, Ryan

“…Purpose To explore the use of polyvinylpyrrolidone (PVP) for simulated materials with tissue‐equivalent dielectric properties. Methods PVP and salt were used…”
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Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans by Hansen, Malene, Taubert, Stefan, Crawford, Douglas, Libina, Nataliya, Lee, Seung‐Jae, Kenyon, Cynthia

“…Summary Many conditions that shift cells from states of nutrient utilization and growth to states of cell maintenance extend lifespan. We have carried out a…”
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Sex differences in the evaluation and treatment of acute ischaemic stroke by Bushnell, Cheryl, Howard, Virginia J, Lisabeth, Lynda, Caso, Valeria, Gall, Seana, Kleindorfer, Dawn, Chaturvedi, Seemant, Madsen, Tracy E, Demel, Stacie L, Lee, Seung-Jae, Reeves, Mathew

“…With the greater availability of treatments for acute ischaemic stroke, including advances in endovascular therapy, personalised assessment of patients before…”
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