Search Results - "Lee, Sarah E."

Mimicry of Antimicrobial Host-Defense Peptides by Random Copolymers by Mowery, Brendan P, Lee, Sarah E, Kissounko, Denis A, Epand, Raquel F, Epand, Richard M, Weisblum, Bernard, Stahl, Shannon S, Gellman, Samuel H

“…Efforts to generate antibacterial agents via mimicry of host-defense peptides have focused on discrete oligomers that can adopt a regular globally amphiphilic…”
Get full text

Postnatal developmental expression of regulator of G protein signaling 14 (RGS14) in the mouse brain by Evans, Paul R., Lee, Sarah E., Smith, Yoland, Hepler, John R.

“…ABSTRACT Regulator of G protein signaling 14 (RGS14) is a multifunctional scaffolding protein that integrates G protein and mitogen‐activated protein kinase…”
Get full text

Delays in commitment and treatment court proceedings worsen psychiatric and other medical conditions by Biswas, Jhilam, Lee, Sarah E., Muñoz, Carla G., Armstrong, Natalie E.

“…Adversarial hearings in hospital commitment and de novo treatment proceedings, or court hearings, delay psychiatric treatment in many jurisdictions. In…”
Get full text

Strongly Coordinating Ligands To Form Weakly Coordinating Yet Functional Organometallic Anions by Fisher, Steven P, McArthur, Scott G, Tej, Varun, Lee, Sarah E, Chan, Allen L, Banda, Isaac, Gregory, Aaron, Berkley, Kevin, Tsay, Charlene, Rheingold, Arnold L, Guisado-Barrios, Gregorio, Lavallo, Vincent

“…Weakly coordinating anions (WCAs) are generally tailored to act as spectators with little or no function. Here we describe the implementation of strongly…”
Get full text

The Presence of Physical Medicine and Rehabilitation Across Social Media Platforms: Content Analysis by Anderson, Austin S., Crandall, Cody S., Samimi, Alhan, Thompson, Hunter S., Weed, Mallory K., Hawatmeh, Serena S., Lee, Sarah E., Chamberlain, Brandon H., Rachdi, Omar D.

Get full text

Reversible Silver Electrodeposition from Boron Cluster Ionic Liquid (BCIL) Electrolytes by Dziedzic, Rafal M, Waddington, Mary A, Lee, Sarah E, Kleinsasser, Jack, Plumley, John B, Ewing, William C, Bosley, Beth D, Lavallo, Vincent, Peng, Thomas L, Spokoyny, Alexander M

“…Electrochemical systems offer a versatile means for creating adaptive devices. However, the utility of electrochemical deposition is inherently limited by the…”
Get full text

Dual Mechanism of Bacterial Lethality for a Cationic Sequence-Random Copolymer that Mimics Host-Defense Antimicrobial Peptides by Epand, Raquel F., Mowery, Brendan P., Lee, Sarah E., Stahl, Shannon S., Lehrer, Robert I., Gellman, Samuel H., Epand, Richard M.

“…Flexible sequence-random polymers containing cationic and lipophilic subunits that act as functional mimics of host-defense peptides have recently been…”
Get full text

Access to Poly-β-Peptides with Functionalized Side Chains and End Groups via Controlled Ring-Opening Polymerization of β-Lactams by Zhang, Jihua, Kissounko, Denis A, Lee, Sarah E, Gellman, Samuel H, Stahl, Shannon S

“…Poly-β-peptides are attractive for biomedical applications because the backbone is similar enough to that of proteins for biocompatibility, but the backbone is…”
Get full text

Challenges and Opportunities for Translation of Therapies to Improve Cognition in Down Syndrome by Lee, Sarah E., Duran-Martinez, Monica, Khantsis, Sabina, Bianchi, Diana W., Guedj, Faycal

“…While preclinical studies have reported improvement of behavioral deficits in the Ts65Dn mouse model of Down syndrome (DS), translation to human clinical…”
Get full text

Paclitaxel nanosuspensions for targeted chemotherapy - nanosuspension preparation, characterization, and use by Lee, Sarah E., Bairstow, Shawn F., Werling, Jane O., Chaubal, Mahesh V., Lin, Lawrence, Murphy, Mary Ann, DiOrio, James P., Gass, Jerome, Rabinow, Barrett, Wang, Xiaoen, Zhang, Yong, Yang, Zhijian, Hoffman, Robert M.

“…Abstract Objective: The purpose of this work was to prepare a stable paclitaxel nanosuspension and test it for potential use as a targeted chemotherapeutic…”
Get full text

Using Chemical Genetics and ATP Analogues To Dissect Protein Kinase Function by Elphick, Lucy M, Lee, Sarah E, Gouverneur, Véronique, Mann, David J

“…Protein kinases catalyze the transfer of the γ-phosphate of ATP to a protein substrate and thereby profoundly alter the properties of the phosphorylated…”
Get full text

Synthesis and reactivity of novel γ-phosphate modified ATP analogues by Lee, Sarah E., Elphick, Lucy M., Anderson, Alexandra A., Bonnac, Laurent, Child, Emma S., Mann, David J., Gouverneur, Véronique

“…We hereby present a simple yet novel chemical synthesis of a family of γ-modified ATPs bearing functional groups on the γ-phosphate that are amenable to…”
Get full text

Synthesis and O-phosphorylation of 3,3,4,4-tetrafluoroaryl-C-nucleoside analogues by Bonnac, Laurent, Lee, Sarah E, Giuffredi, Guy T, Elphick, Lucy M, Anderson, Alexandra A, Child, Emma S, Mann, David J, Gouverneur, Véronique

“…Enantioenriched tetrafluorinated aryl-C-nucleosides were synthesised in four steps from 1-benzyloxy-4-bromo-3,3,4,4-tetrafluorobutan-2-ol. The presence of the…”
Get more information

The Relationship of Authoritarianism and Related Constructs to Attitudes Toward Homosexuality by WHITLEY JR, BERNARD E., LEE, SARAH E.

Get full text

NMR of heparin API: investigation of unidentified signals in the USP-specified range of 2.12-3.00 ppm by Lee, Sarah E, Chess, Edward K, Rabinow, Barrett, Ray, G. Joseph, Szabo, Christina M, Melnick, Bennett, Miller, Reagan L, Nair, Lakshmy M, Moore, Edwin G

“…This article addresses the identification and quantification of the chemical species resulting in resonances at 2.17 and 2.25 ppm in the ¹H nuclear magnetic…”
Get full text

Chemoselective One-Step Alkylation and Isolation of Thiophosphorylated Cdk2 Substrates in the Presence of Native Cysteine by Lee, Sarah E, Elphick, Lucy M, Kramer, Holger B, Jones, Alexandra M.E, Child, Emma S, Anderson, Alexandra A, Bonnac, Laurent, Suwaki, Natsuko, Kessler, Benedikt M, Gouverneur, Véronique, Mann, David J

“…The elucidation of signalling pathways relies heavily upon the identification of protein kinase substrates. Recent investigations have demonstrated the…”
Get full text

Quantitative Comparison of Wild-Type and Gatekeeper Mutant Cdk2 for Chemical Genetic Studies with ATP Analogues by Elphick, Lucy M, Lee, Sarah E, Child, Emma S, Prasad, Aarathi, Pignocchi, Cristina, Thibaudeau, Sébastien, Anderson, Alexandra A, Bonnac, Laurent, Gouverneur, Véronique, Mann, David J

“…Mutant kinase kinetics: Protein kinases with enlarged ATP binding sites are increasingly being used as tools to probe the functioning signal transduction…”
Get full text

Enhancing the catalytic repertoire of nucleic acids. II. Simultaneous incorporation of amino and imidazolyl functionalities by two modified triphosphates during PCR by Gourlain, T, Sidorov, A, Mignet, N, Thorpe, S J, Lee, S E, Grasby, J A, Williams, D M

“…The incorporation of potentially catalytic groups into DNA is of interest for the in vitro selection of novel deoxyribozymes. We have devised synthetic routes…”
Get full text

Enhancing the catalytic repertoire of nucleic acids: a systematic study of linker length and rigidity by Lee, S E, Sidorov, A, Gourlain, T, Mignet, N, Thorpe, S J, Brazier, J A, Dickman, M J, Hornby, D P, Grasby, J A, Williams, D M

“…The incorporation of potentially catalytic groups in DNA is of interest for the in vitro selection of novel deoxyribozymes. A series of 10 C5-modified…”
Get full text

The Bub2-dependent mitotic pathway in yeast acts every cell cycle and regulates cytokinesis by Lee, S E, Jensen, S, Frenz, L M, Johnson, A L, Fesquet, D, Johnston, L H

“…In eukaryotes an abnormal spindle activates a conserved checkpoint consisting of the MAD and BUB genes that results in mitotic arrest at metaphase. Recently,…”
Get full text