Search Results - "Lee, S Hong"

Genetic correlations of polygenic disease traits: from theory to practice by van Rheenen, Wouter, Peyrot, Wouter J., Schork, Andrew J., Lee, S. Hong, Wray, Naomi R.

“…The genetic correlation describes the genetic relationship between two traits and can contribute to a better understanding of the shared biological pathways…”
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An integrative analysis of genomic and exposomic data for complex traits and phenotypic prediction by Zhou, Xuan, Lee, S. Hong

“…Complementary to the genome, the concept of exposome has been proposed to capture the totality of human environmental exposures. While there has been some…”
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GCTA: A Tool for Genome-wide Complex Trait Analysis by Yang, Jian, Lee, S. Hong, Goddard, Michael E., Visscher, Peter M.

“…For most human complex diseases and traits, SNPs identified by genome-wide association studies (GWAS) explain only a small fraction of the heritability. Here…”
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CORE GREML for estimating covariance between random effects in linear mixed models for complex trait analyses by Zhou, Xuan, Im, Hae Kyung, Lee, S. Hong

“…As a key variance partitioning tool, linear mixed models (LMMs) using genome-based restricted maximum likelihood (GREML) allow both fixed and random effects…”
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RICOPILI: Rapid Imputation for COnsortias PIpeLIne by Lam, Max, Awasthi, Swapnil, Watson, Hunna J, Goldstein, Jackie, Panagiotaropoulou, Georgia, Trubetskoy, Vassily, Karlsson, Robert, Frei, Oleksander, Fan, Chun-Chieh, De Witte, Ward, Mota, Nina R, Mullins, Niamh, Brügger, Kim, Lee, S Hong, Wray, Naomi R, Skarabis, Nora, Huang, Hailiang, Neale, Benjamin, Daly, Mark J, Mattheisen, Manuel, Walters, Raymond, Ripke, Stephan

“…Abstract Summary Genome-wide association study (GWAS) analyses, at sufficient sample sizes and power, have successfully revealed biological insights for…”
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Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs by Lee, S Hong, DeCandia, Teresa R, Ripke, Stephan, Yang, Jian, Sullivan, Patrick F, Goddard, Michael E, Keller, Matthew C, Visscher, Peter M, Wray, Naomi R

“…Naomi Wray, Peter Visscher and colleagues report analyses of the common variation that contributes to schizophrenia risk within three independent case-control…”
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Genotype–covariate correlation and interaction disentangled by a whole-genome multivariate reaction norm model by Ni, Guiyan, van der Werf, Julius, Zhou, Xuan, Hyppönen, Elina, Wray, Naomi R., Lee, S. Hong

“…The genomics era has brought useful tools to dissect the genetic architecture of complex traits. Here we propose a multivariate reaction norm model (MRNM) to…”
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Host genetic determinants of COVID-19 susceptibility and severity: A systematic review and meta-analysis by Eshetie, Setegn, Jullian, Pastor, Benyamin, Beben, Lee, S Hong

“…Genome-wide association studies (GWASs) have identified single nucleotide polymorphisms (SNPs) associated with susceptibility and severity of coronavirus…”
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Phenotypic variance partitioning by transcriptomic gene expression levels and environmental variables for anthropometric traits using GTEx data by Jullian Fabres, Pastor, Lee, S Hong

“…Phenotypic variation in human is the results of genetic variation and environmental influences. Understanding the contribution of genetic and environmental…”
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Adiposity and cancer: a Mendelian randomization analysis in the UK biobank by Ahmed, Muktar, Mulugeta, Anwar, Lee, S. Hong, Mäkinen, Ville-Petteri, Boyle, Terry, Hyppönen, Elina

“…Background Observational and Mendelian randomization (MR) studies link obesity and cancer, but it remains unclear whether these depend upon related metabolic…”
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Integrative analysis of genomic and exposomic influences on youth mental health by Choi, Karmel W., Wilson, Marina, Ge, Tian, Kandola, Aaron, Patel, Chirag J., Lee, S. Hong, Smoller, Jordan W.

“…Background Understanding complex influences on mental health problems in young people is needed to inform early prevention strategies. Both genetic and…”
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A method for an unbiased estimate of cross-ancestry genetic correlation using individual-level data by Momin, Md. Moksedul, Shin, Jisu, Lee, Soohyun, Truong, Buu, Benyamin, Beben, Lee, S. Hong

“…Cross-ancestry genetic correlation is an important parameter to understand the genetic relationship between two ancestry groups. However, existing methods…”
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Contextualizing genetic risk score for disease screening and rare variant discovery by Zhou, Dan, Yu, Dongmei, Scharf, Jeremiah M., Mathews, Carol A., McGrath, Lauren, Cook, Edwin, Lee, S. Hong, Davis, Lea K., Gamazon, Eric R.

“…Studies of the genetic basis of complex traits have demonstrated a substantial role for common, small-effect variant polygenic burden (PB) as well as…”
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Mitigating type 1 error inflation and power loss in GxE PRS: Genotype–environment interaction in polygenic risk score models by Jayasinghe, Dovini, Momin, Md. Moksedul, Beckmann, Kerri, Hyppönen, Elina, Benyamin, Beben, Lee, S. Hong

“…The use of polygenic risk score (PRS) models has transformed the field of genetics by enabling the prediction of complex traits and diseases based on an…”
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Efficient polygenic risk scores for biobank scale data by exploiting phenotypes from inferred relatives by Truong, Buu, Zhou, Xuan, Shin, Jisu, Li, Jiuyong, van der Werf, Julius H. J., Le, Thuc D., Lee, S. Hong

“…Polygenic risk scores are emerging as a potentially powerful tool to predict future phenotypes of target individuals, typically using unrelated individuals,…”
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The genetic relationship between female reproductive traits and six psychiatric disorders by Ni, Guiyan, Amare, Azmeraw T., Zhou, Xuan, Mills, Natalie, Gratten, Jacob, Lee, S. Hong

“…Female reproductive behaviours have important implications for evolutionary fitness and health of offspring. Here we used the second release of UK Biobank data…”
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Estimation of genomic prediction accuracy from reference populations with varying degrees of relationship by Lee, S Hong, Clark, Sam, van der Werf, Julius H J

“…Genomic prediction is emerging in a wide range of fields including animal and plant breeding, risk prediction in human precision medicine and forensic. It is…”
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Circulating Phylloquinone and the Risk of Four Female-Specific Cancers: A Mendelian Randomization Study by Yalew, Melaku, Mulugeta, Anwar, Lumsden, Amanda L., Madakkatel, Iqbal, Lee, S. Hong, Oehler, Martin K., Mäenpää, Johanna, Hyppönen, Elina

“…Background: Observational studies have linked vitamin K and cancer, but the causality of this association remains unknown. This Mendelian randomization (MR)…”
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Estimation of SNP Heritability from Dense Genotype Data by Lee, S. Hong, Yang, Jian, Chen, Guo-Bo, Ripke, Stephan, Stahl, Eli A., Hultman, Christina M., Sklar, Pamela, Visscher, Peter M., Sullivan, Patrick F., Goddard, Michael E., Wray, Naomi R.

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Additive Genetic Variation in Schizophrenia Risk Is Shared by Populations of African and European Descent by de Candia, Teresa R., Lee, S. Hong, Yang, Jian, Browning, Brian L., Gejman, Pablo V., Levinson, Douglas F., Mowry, Bryan J., Hewitt, John K., Goddard, Michael E., O’Donovan, Michael C., Purcell, Shaun M., Posthuma, Danielle, Visscher, Peter M., Wray, Naomi R., Keller, Matthew C.

“…To investigate the extent to which the proportion of schizophrenia’s additive genetic variation tagged by SNPs is shared by populations of European and African…”
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