Search Results - "Lee, Robin E."

Parallel Tempering with Lasso for model reduction in systems biology by Gupta, Sanjana, Lee, Robin E C, Faeder, James R

“…Systems Biology models reveal relationships between signaling inputs and observable molecular or cellular behaviors. The complexity of these models, however,…”
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A network-centric approach to drugging TNF-induced NF-κB signaling by Pabon, Nicolas A., Zhang, Qiuhong, Cruz, J. Agustin, Schipper, David L., Camacho, Carlos J., Lee, Robin E. C.

“…Target-centric drug development strategies prioritize single-target potency in vitro and do not account for connectivity and multi-target effects within a…”
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Genome-Wide Expression Profiling of the Response to Azole, Polyene, Echinocandin, and Pyrimidine Antifungal Agents in Candida albicans by LIU, Teresa T, LEE, Robin E. B, BARKER, Katherine S, LEE, Richard E, LAI WEI, HOMAYOUNI, Ramin, ROGERS, P. David

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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A non-death role of the yeast metacaspase: Yca1p alters cell cycle dynamics by Lee, Robin E C, Puente, Lawrence G, Kaern, Mads, Megeney, Lynn A

“…Caspase proteases are a conserved protein family predominantly known for engaging and executing apoptotic cell death. Nevertheless, in higher eukaryotes,…”
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Metacaspase Yca1 is required for clearance of insoluble protein aggregates by Lee, Robin E. C., Brunette, Steve, Puente, Lawrence G., Megeney, Lynn A., Olson, Eric N.

“…In complex organisms, caspase proteases mediate a variety of cell behaviors, including proliferation, differentiation, and programmed cell death/apoptosis…”
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Discovery of novel isoxazolines as anti-tuberculosis agents by Tangallapally, Rajendra P., Sun, Dianqing, Rakesh, Budha, Nageshwar, Lee, Robin E.B., Lenaerts, Anne J.M., Meibohm, Bernd, Lee, Richard E.

“…Discovery of isoxazoline compound 12 as novel anti-tuberculosis agent (MIC 90 = 1.56 μg/mL) is reported. Nitrofuranyl isoxazolines with increased proteolytic…”
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Ubiquitin: Not just a one‐way ticket to the proteasome, but a therapeutic dial to fine‐tune the molecular landscape of disease by Kim, A. Hyun, Chiknas, P. Murdo, Lee, Robin E. C.

“…Recently, there is a rise in studies that recognize the importance of targeting ubiquitin and related molecular machinery in various therapeutic contexts. Here…”
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Shift from stochastic to spatially-ordered expression of serine-glycine synthesis enzymes in 3D microtumors by Singh, Manjulata, Warita, Katsuhiko, Warita, Tomoko, Faeder, James R., Lee, Robin E. C., Sant, Shilpa, Oltvai, Zoltán N.

“…Cell-to-cell differences in protein expression in normal tissues and tumors are a common phenomenon, but the underlying principles that govern this…”
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Synthesis and Evaluation of Cyclic Secondary Amine Substituted Phenyl and Benzyl Nitrofuranyl Amides as Novel Antituberculosis Agents by Tangallapally, Rajendra P, Yendapally, Raghunandan, Lee, Robin E, Lenaerts, Anne J. M, Lee, Richard E

“…In an ongoing effort to develop new and potent antituberculosis agents, a second-generation series of nitrofuranyl amides was synthesized on the basis of the…”
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Syntheses and evaluation of macrocyclic engelhardione analogs as antitubercular and antibacterial agents by Shen, Li, M Maddox, Marcus, Adhikari, Sudip, Bruhn, David F, Kumar, Manish, Lee, Robin E, Hurdle, Julian G, Lee, Richard E, Sun, Dianqing

“…The natural product engelhardione is an underexplored chemotype for developing novel treatments for bacterial infections; we therefore explored this natural…”
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Fold Change of Nuclear NF-κB Determines TNF-Induced Transcription in Single Cells by Lee, Robin E.C., Walker, Sarah R., Savery, Kate, Frank, David A., Gaudet, Suzanne

“…In response to tumor necrosis factor (TNF), NF-κB enters the nucleus and promotes inflammatory and stress-responsive gene transcription. Because NF-κB…”
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Genome-wide expression profiling of the response to ciclopirox olamine in Candida albicans by Lee, Robin E. B., Liu, Teresa T., Barker, Katherine S., Lee, Richard E., Rogers, P. David

“…Objectives: The aim of this study was to identify changes in the gene expression profile of Candida albicans upon exposure to the hydroxypyridone…”
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Solid-phase synthesis and biological evaluation of a uridinyl branched peptide urea library by Sun, Dianqing, Jones, Victoria, Carson, Elizabeth I., Lee, Robin E.B., Scherman, Michael S., McNeil, Michael R., Lee, Richard E.

“…Solid-phase synthesis and biological evaluation of a uridinyl branched peptide urea library 1 as Mureidomycin mimetics are described. A 1000-member uridinyl…”
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Methods for Acquisition and Assignment of Multidimensional High-Resolution Magic Angle Spinning NMR of Whole Cell Bacteria by Li, Wei, Lee, Robin E. B, Lee, Richard E, Li, Jinghu

“…High-resolution magic-angle spinning (HR-MAS) NMR was developed in late 1990s, and it has evolved quickly for the study of a variety of biological matrixes…”
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NF-κB signalling and cell fate decisions in response to a short pulse of tumour necrosis factor by Lee, Robin E. C., Qasaimeh, Mohammad A., Xia, Xianfang, Juncker, David, Gaudet, Suzanne

“…In tissues and tumours, cell behaviours are regulated by multiple time-varying signals. While in the laboratory cells are often exposed to a stimulus for the…”
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dNEMO: a tool for quantification of mRNA and punctate structures in time-lapse images of single cells by Kowalczyk, Gabriel J, Cruz, J Agustin, Guo, Yue, Zhang, Qiuhong, Sauerwald, Natalie, Lee, Robin E C

“…Abstract Motivation Many biological processes are regulated by single molecules and molecular assemblies within cells that are visible by microscopy as…”
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Demystifying the cytokine network: Mathematical models point the way by Morel, Penelope A., Lee, Robin E.C., Faeder, James R.

“…Cytokines provide the means by which immune cells communicate with each other and with parenchymal cells. There are over one hundred cytokines and many exist…”
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Nitrofurans as novel anti-tuberculosis agents: identification, development and evaluation by Tangallapally, Rajendra P, Yendapally, Raghunandan, Daniels, AnTawan J, Lee, Robin E B, Lee, Richard E

“…During a search for new anti-tuberculosis agents, a screen of a commercially available library provided a hit nitrofuranyl amide. This hit was selected for…”
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Synthesis of new and potent analogues of anti-tuberculosis agent 5-nitro-furan-2-carboxylic acid 4-(4-benzyl-piperazin-1-yl)-benzylamide with improved bioavailability by Tangallapally, Rajendra P., Lee, Robin E.B., Lenaerts, Anne J.M., Lee, Richard E.

“…The synthesis of lead optimized analogues, their anti-tuberculosis activity, and bioavailability are reported. Previously, the lead compound…”
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Dopamine D2 receptor modulates Wnt expression and control of cell proliferation by Han, Fei, Konkalmatt, Prasad, Mokashi, Chaitanya, Kumar, Megha, Zhang, Yanrong, Ko, Allen, Farino, Zachary J., Asico, Laureano D., Xu, Gaosi, Gildea, John, Zheng, Xiaoxu, Felder, Robin A., Lee, Robin E. C., Jose, Pedro A., Freyberg, Zachary, Armando, Ines

“…The Wnt/β-catenin pathway is one of the most conserved signaling pathways across species with essential roles in development, cell proliferation, and disease…”
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