Search Results - "Lee, Richard W J"

New insights into the pathogenesis and nonsurgical management of Graves orbitopathy by Taylor, Peter N., Zhang, Lei, Lee, Richard W. J., Muller, Ilaria, Ezra, Daniel G., Dayan, Colin M., Kahaly, George J., Ludgate, Marian

“…Graves orbitopathy, also known as thyroid eye disease or thyroid-associated orbitopathy, is visually disabling, cosmetically disfiguring and has a substantial…”
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Mycophenolate Mofetil for the Treatment of Uveitis by Teoh, Stephen C, Hogan, Aideen C, Dick, Andrew D, Lee, Richard W.J

“…Purpose To evaluate the efficacy and tolerance of mycophenolate mofetil (MMF) for the treatment of noninfectious uveitis using the methods of analysis…”
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Glucocorticoid-resistant Th17 cells are selectively attenuated by cyclosporine A by Schewitz-Bowers, Lauren P., Lait, Philippa J. P., Copland, David A., Chen, Ping, Wu, Wenting, Dhanda, Ashwin D., Vistica, Barbara P., Williams, Emily L., Liu, Baoying, Jawad, Shayma, Li, Zhiyu, Tucker, William, Hirani, Sima, Wakabayashi, Yoshiyuki, Zhu, Jun, Sen, Nida, Conway-Campbell, Becky L., Gery, Igal, Dick, Andrew D., Wei, Lai, Nussenblatt, Robert B., Lee, Richard W. J.

“…Glucocorticoids remain the cornerstone of treatment for inflammatory conditions, but their utility is limited by a plethora of side effects. One of the key…”
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CytoBinning: Immunological insights from multi-dimensional data by Shen, Yang, Chaigne-Delalande, Benjamin, Lee, Richard W J, Losert, Wolfgang

“…New cytometric techniques continue to push the boundaries of multi-parameter quantitative data acquisition at the single-cell level particularly in immunology…”
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Intravenous indocyanine green dye is insufficient for robust immune cell labelling in the human retina by Bell, Oliver H, Carreño, Ester, Williams, Emily L, Wu, Jiahui, Copland, David A, Bora, Monalisa, Kobayter, Lina, Fruttiger, Marcus, Sim, Dawn A, Lee, Richard W J, Dick, Andrew D, Chu, Colin J

“…It is not currently possible to reliably visualise and track immune cells in the human central nervous system or eye. Previous work demonstrated that…”
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Quantitative Analysis of Peripheral Vasculitis, Ischemia, and Vascular Leakage in Uveitis Using Ultra-Widefield Fluorescein Angiography by Karampelas, Michael, Sim, Dawn A, Chu, Colin, Carreno, Ester, Keane, Pearse A, Zarranz-Ventura, Javier, Westcott, Mark, Lee, Richard W.J, Pavesio, Carlos E

“…Purpose To investigate the relationships between peripheral vasculitis, ischemia, and vascular leakage in uveitis using ultra-widefield fluorescein angiography…”
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CD14++CD16+ Monocytes Are Enriched by Glucocorticoid Treatment and Are Functionally Attenuated in Driving Effector T Cell Responses by Liu, Baoying, Dhanda, Ashwin, Hirani, Sima, Williams, Emily L, Sen, H Nida, Martinez Estrada, Fernando, Ling, Diamond, Thompson, Ian, Casady, Megan, Li, Zhiyu, Si, Han, Tucker, William, Wei, Lai, Jawad, Shayma, Sura, Amol, Dailey, Jennifer, Hannes, Susan, Chen, Ping, Chien, Jason L, Gordon, Siamon, Lee, Richard W J, Nussenblatt, Robert B

“…Human peripheral monocytes have been categorized into three subsets based on differential expression levels of CD14 and CD16. However, the factors that…”
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The DNA Methylation Inhibitor Zebularine Controls CD4 + T Cell Mediated Intraocular Inflammation by Zou, Yanli, Hu, Xiao, Schewitz-Bowers, Lauren P, Stimpson, Madeleine, Miao, Li, Ge, Xiaofei, Yang, Liu, Li, Yan, Bible, Paul W, Wen, Xiaofeng, Li, Jing Jing, Liu, Yizhi, Lee, Richard W J, Wei, Lai

“…CD4 T cell mediated uveitis is conventionally treated with systemic immunosuppressive agents, including corticosteroids and biologics targeting key…”
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SIRT1 activation protects against autoimmune T cell-driven retinal disease in mice via inhibition of IL-2/Stat5 signaling by Gardner, Peter J, Joshi, Lavnish, Lee, Richard W.J, Dick, Andrew D, Adamson, Peter, Calder, Virginia L

“…Abstract Sirtuins are a mammalian family of NAD+ -dependent histone deacetylases that regulate cell function and survival as well as regulating cell responses…”
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Glucocorticoid Receptor-α and MKP-1 as Candidate Biomarkers for Treatment Response and Disease Activity in Vogt-Koyanagi-Harada Disease by Urzua, Cristhian A., Chen, Ping, Chaigne-Delalande, Benjamin, Liu, Baoying, Anguita, Rodrigo, Guerrero, Julia, Sabat, Pablo, Velasquez, Victor, Sen, H. Nida, Lee, Richard W.J., Goecke, Annelise

“…To investigate the potential of utilizing the expression of genes for glucocorticoid receptor (GR) and mitogen-activated protein kinase phosphatase-1 (MKP-1)…”
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Identification of an intraocular microbiota by Deng, Yuhua, Ge, Xiaofei, Li, Yan, Zou, Bin, Wen, Xiaofeng, Chen, Weirong, Lu, Lin, Zhang, Meifen, Zhang, Xiaomin, Li, Chunmei, Zhao, Chan, Lin, Xiaofeng, Zhang, Xiulan, Huang, Xinhua, Li, Xiaorong, Jin, Ming, Peng, Guang-Hua, Wang, Dongni, Wang, Xun, Lai, Weiyi, Liang, Juanran, Li, Jing Jing, Liang, Qiaoxing, Yang, Liu, Zhang, Qinfen, Li, Yinyin, Lu, Ping, Hu, Xiao, Li, Xifang, Deng, Xiuli, Liu, Yu, Zou, Yanli, Guo, Shixin, Chen, Tingting, Qin, Yali, Yang, Fuhua, Miao, Li, Chen, Wei, Chan, Chi-Chao, Lin, Haotian, Liu, Yizhi, Lee, Richard W. J., Wei, Lai

“…The current dogma in ophthalmology and vision research presumes the intraocular environment to be sterile. However, recent evidence of intestinal bacterial…”
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Ex Vivo T Cell Cytokine Expression Predicts Survival in Patients with Severe Alcoholic Hepatitis by Dhanda, Ashwin D, Yates, Euan, Schewitz-Bowers, Lauren P, Lait, Philippa J, Lee, Richard W J, Cramp, Matthew E

“…Alcoholic hepatitis (AH) is an acute inflammatory liver condition with high early mortality rate. Steroids improve short-term survival but nonresponders have…”
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Annexin-A1 restricts Th17 cells and attenuates the severity of autoimmune disease by Yazid, Samia, Gardner, Peter J, Carvalho, Livia, Chu, Colin J, Flower, Roderick J, Solito, Egle, Lee, Richard W.J, Ali, Robin R, Dick, Andrew D

“…Abstract Annexin-A1 (Anx-A1) is an endogenous anti-inflammatory molecule and while described as a repressor of innate immune responses, the role of Anx-A1 in…”
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Multimodal Imaging in Acute Posterior Multifocal Placoid Pigment Epitheliopathy Demonstrating Obstruction of the Choriocapillaris by Salvatore, Serena, Steeples, Laura R, Ross, Adam H, Bailey, Clare, Lee, Richard W J, Carreño, Ester

“…Optical coherence tomography angiography (OCTA) provides noninvasive in vivo vascular imaging of the retina and choriocapillaris. To highlight OCTA utility,…”
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Alemtuzumab-induced remission of multiple sclerosis-associated uveitis by Willis, Mark D., Pickersgill, Trevor P., Robertson, Neil P., Lee, Richard W. J., Dick, Andrew D., Carreño, Ester

“…Purpose The purpose of the study was to report a case of multiple sclerosis (MS)-associated uveitis refractory to conventional immunosuppressants, with…”
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The Safety and Efficacy of Noncorticosteroid Triple Immunosuppressive Therapy in the Treatment of Refractory Chronic Noninfectious Uveitis in Childhood by LITTLE, Jessica A, SEN, Ethan S, STRIKE, Helen, HINCHCLIFFE, Annie, GULY, Catherine M, LEE, Richard W. J, DICK, Andrew D, RAMANAN, Athimalaipet V

“…To assess the safety and efficacy of noncorticosteroid triple immunosuppressive therapy in the treatment of refractory chronic noninfectious childhood uveitis…”
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Author Correction: Identification of an intraocular microbiota by Deng, Yuhua, Ge, Xiaofei, Li, Yan, Zou, Bin, Wen, Xiaofeng, Chen, Weirong, Lu, Lin, Zhang, Meifen, Zhang, Xiaomin, Li, Chunmei, Zhao, Chan, Lin, Xiaofeng, Zhang, Xiulan, Huang, Xinhua, Li, Xiaorong, Jin, Ming, Peng, Guang-Hua, Wang, Dongni, Wang, Xun, Lai, Weiyi, Liang, Juanran, Li, Jing Jing, Liang, Qiaoxing, Yang, Liu, Zhang, Qinfen, Li, Yinyin, Lu, Ping, Hu, Xiao, Li, Xifang, Deng, Xiuli, Liu, Yu, Zou, Yanli, Guo, Shixin, Chen, Tingting, Qin, Yali, Yang, Fuhua, Miao, Li, Chen, Wei, Chan, Chi-Chao, Lin, Haotian, Liu, Yizhi, Lee, Richard W. J., Wei, Lai

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A Randomized Trial of Tacrolimus versus Tacrolimus and Prednisone for the Maintenance of Disease Remission in Noninfectious Uveitis by Lee, Richard W.J., MRCOphth, PhD, Greenwood, Rosemary, MSc, Taylor, Hazel, MSc, Amer, Radgonde, MD, Biester, Sabine, FEBO, Heissigerova, Jarka, MD, PhD, Forrester, John V., MD, FMedSci, Dick, Andrew D., MD, FMedSci

“…Purpose To compare tacrolimus monotherapy with tacrolimus and prednisone therapy for the maintenance of disease remission in subjects with noninfectious…”
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Orbital radiotherapy for adult thyroid eye disease by Rajendram, Rathie, Bunce, Catey, Lee, Richard W J, Morley, Ana M S

“…Thyroid eye disease is an autoimmune inflammatory condition of the orbital and periorbital tissues. Orbital radiotherapy is an anti-inflammatory treatment used…”
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Optical Coherence Tomography Angiography Findings in Dengue-Related Maculopathy: A Case Report by Tavassoli, Shokufeh, Carreño, Ester, Teoh, Stephen C, Theodoropoulou, Sofia, Bailey, Clare, Lee, Richard W J, Dick, Andrew D

“…The ophthalmic manifestations of dengue fever include a visually impairing maculopathy, where patients are left with a central or paracentral relative scotoma…”
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