Search Results - "Lee, Rhianna"

SARS-CoV-2 infection of the oral cavity and saliva by Huang, Ni, Pérez, Paola, Kato, Takafumi, Mikami, Yu, Okuda, Kenichi, Gilmore, Rodney C., Conde, Cecilia Domínguez, Gasmi, Billel, Stein, Sydney, Beach, Margaret, Pelayo, Eileen, Maldonado, Jose O., Lafont, Bernard A., Jang, Shyh-Ing, Nasir, Nadia, Padilla, Ricardo J., Murrah, Valerie A., Maile, Robert, Lovell, William, Wallet, Shannon M., Bowman, Natalie M., Meinig, Suzanne L., Wolfgang, Matthew C., Choudhury, Saibyasachi N., Novotny, Mark, Aevermann, Brian D., Scheuermann, Richard H., Cannon, Gabrielle, Anderson, Carlton W., Lee, Rhianna E., Marchesan, Julie T., Bush, Mandy, Freire, Marcelo, Kimple, Adam J., Herr, Daniel L., Rabin, Joseph, Grazioli, Alison, Das, Sanchita, French, Benjamin N., Pranzatelli, Thomas, Chiorini, John A., Kleiner, David E., Pittaluga, Stefania, Hewitt, Stephen M., Burbelo, Peter D., Chertow, Daniel, Frank, Karen, Lee, Janice, Boucher, Richard C., Teichmann, Sarah A., Warner, Blake M., Byrd, Kevin M.

“…Despite signs of infection—including taste loss, dry mouth and mucosal lesions such as ulcerations, enanthema and macules—the involvement of the oral cavity in…”
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Challenges Facing Airway Epithelial Cell-Based Therapy for Cystic Fibrosis by Berical, Andrew, Lee, Rhianna E, Randell, Scott H, Hawkins, Finn

“…Mutations in the cystic fibrosis transmembrane conductance regulator ( ) gene cause the life-limiting hereditary disease, cystic fibrosis (CF). Decreased or…”
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Air-Liquid interface cultures to model drug delivery through the mucociliary epithelial barrier by Lee, Rhianna E, Reidel, Boris, Nelson, Mark R, Macdonald, Jade K, Kesimer, Mehmet, Randell, Scott H

“…[Display omitted] Epithelial cells from mucociliary portions of the airways can be readily grown and expanded in vitro. When grown on a porous membrane at an…”
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A multimodal iPSC platform for cystic fibrosis drug testing by Berical, Andrew, Lee, Rhianna E., Lu, Junjie, Beermann, Mary Lou, Le Suer, Jake A., Mithal, Aditya, Thomas, Dylan, Ranallo, Nicole, Peasley, Megan, Stuffer, Alex, Bukis, Katherine, Seymour, Rebecca, Harrington, Jan, Coote, Kevin, Valley, Hillary, Hurley, Killian, McNally, Paul, Mostoslavsky, Gustavo, Mahoney, John, Randell, Scott H., Hawkins, Finn J.

“…Cystic fibrosis is a monogenic lung disease caused by dysfunction of the cystic fibrosis transmembrane conductance regulator anion channel, resulting in…”
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Assessing Human Airway Epithelial Progenitor Cells for Cystic Fibrosis Cell Therapy by Lee, Rhianna E, Miller, Sean M, Mascenik, Teresa M, Lewis, Catherine A, Dang, Hong, Boggs, Zachary H, Tarran, Robert, Randell, Scott H

“…Cystic fibrosis (CF) is caused by loss-of-function mutations in the (CF transmembrane regulator) gene. Pharmacologic therapies directed at CFTR have been…”
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Small-molecule eRF3a degraders rescue CFTR nonsense mutations by promoting premature termination codon readthrough by Lee, Rhianna E, Lewis, Catherine A, He, Lihua, Bulik-Sullivan, Emily C, Gallant, Samuel C, Mascenik, Teresa M, Dang, Hong, Cholon, Deborah M, Gentzsch, Martina, Morton, Lisa C, Minges, John T, Theile, Jonathan W, Castle, Neil A, Knowles, Michael R, Kimple, Adam J, Randell, Scott H

“…The vast majority of people with cystic fibrosis (CF) are now eligible for CF transmembrane regulator (CFTR) modulator therapy. The remaining individuals with…”
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Long-Term Personalization of an In-Home Socially Assistive Robot for Children With Autism Spectrum Disorders by Clabaugh, Caitlyn, Mahajan, Kartik, Jain, Shomik, Pakkar, Roxanna, Becerra, David, Shi, Zhonghao, Deng, Eric, Lee, Rhianna, Ragusa, Gisele, Matarić, Maja

“…Socially assistive robots (SAR) have shown great potential to augment the social and educational development of children with autism spectrum disorders (ASD)…”
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A MERS-CoV antibody neutralizes a pre-emerging group 2c bat coronavirus by Tse, Longping V, Hou, Yixuan J, McFadden, Elizabeth, Lee, Rhianna E, Scobey, Trevor D, Leist, Sarah R, Martinez, David R, Meganck, Rita M, Schäfer, Alexandra, Yount, Boyd L, Mascenik, Teresa, Powers, John M, Randell, Scott H, Zhang, Yi, Wang, Lingshu, Mascola, John, McLellan, Jason S, Baric, Ralph S

“…The repeated emergence of zoonotic human betacoronaviruses (β-CoVs) dictates the need for broad therapeutics and conserved epitope targets for countermeasure…”
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SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo by Hou, Yixuan J, Chiba, Shiho, Halfmann, Peter, Ehre, Camille, Kuroda, Makoto, Dinnon, 3rd, Kenneth H, Leist, Sarah R, Schäfer, Alexandra, Nakajima, Noriko, Takahashi, Kenta, Lee, Rhianna E, Mascenik, Teresa M, Graham, Rachel, Edwards, Caitlin E, Tse, Longping V, Okuda, Kenichi, Markmann, Alena J, Bartelt, Luther, de Silva, Aravinda, Margolis, David M, Boucher, Richard C, Randell, Scott H, Suzuki, Tadaki, Gralinski, Lisa E, Kawaoka, Yoshihiro, Baric, Ralph S

“…The spike aspartic acid-614 to glycine (D614G) substitution is prevalent in global severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains, but…”
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Epigenome editing of the CFTR-locus for treatment of cystic fibrosis by Kabadi, Ami M., Machlin, Leah, Dalal, Nikita, Lee, Rhianna E., McDowell, Ian, Shah, Nirav N., Drowley, Lauren, Randell, Scott H., Reddy, Timothy E.

“…•Genomic regions surrounding the CFTR locus were interrogated for enhancer function using dCas9-based epigenome editing.•Multiple enhancers were identified…”
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SARS-CoV-2 variant of concern fitness and adaptation in primary human airway epithelia by Meganck, Rita M., Edwards, Caitlin E., Mallory, Michael L., Lee, Rhianna E., Dang, Hong, Bailey, Alexis B., Wykoff, Jason A., Gallant, Samuel C., Zhu, Deanna R., Yount, Boyd L., Kato, Takafumi, Shaffer, Kendall M., Nakano, Satoko, Cawley, Anne Marie, Sontake, Vishwaraj, Wang, Jeremy R., Hagan, Robert S., Miller, Melissa B., Tata, Purushothama Rao, Randell, Scott H., Tse, Longping V., Ehre, Camille, Okuda, Kenichi, Boucher, Richard C., Baric, Ralph S.

“…The severe acute respiratory syndrome coronavirus 2 pandemic is characterized by the emergence of novel variants of concern (VOCs) that replace ancestral…”
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Secretory Cells Dominate Airway CFTR Expression and Function in Human Airway Superficial Epithelia by Okuda, Kenichi, Dang, Hong, Kobayashi, Yoshihiko, Carraro, Gianni, Nakano, Satoko, Chen, Gang, Kato, Takafumi, Asakura, Takanori, Gilmore, Rodney C, Morton, Lisa C, Lee, Rhianna E, Mascenik, Teresa, Yin, Wei-Ning, Barbosa Cardenas, Selene Margarita, O'Neal, Yvonne K, Minnick, Caroline E, Chua, Michael, Quinney, Nancy L, Gentzsch, Martina, Anderson, Carlton W, Ghio, Andrew, Matsui, Hirotoshi, Nagase, Takahide, Ostrowski, Lawrence E, Grubb, Barbara R, Olsen, John C, Randell, Scott H, Stripp, Barry R, Tata, Purushothama Rao, O'Neal, Wanda K, Boucher, Richard C

“…Identification of the specific cell types expressing CFTR (cystic fibrosis [CF] transmembrane conductance regulator) is required for precision medicine…”
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Expression of gain-of-function CFTR in cystic fibrosis airway cells restores epithelial function better than wild-type or codon-optimized CFTR by Woodall, Maximillian, Tarran, Robert, Lee, Rhianna, Anfishi, Hafssa, Prins, Stella, Counsell, John, Vergani, Paola, Hart, Stephen, Baines, Deborah

“…Class Ia/b cystic fibrosis transmembrane regulator (CFTR) variants cause severe lung disease in 10% of cystic fibrosis (CF) patients and are untreatable with…”
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Host range, transmissibility and antigenicity of a pangolin coronavirus by Hou, Yixuan J., Chiba, Shiho, Leist, Sarah R., Meganck, Rita M., Martinez, David R., Schäfer, Alexandra, Catanzaro, Nicholas J., Sontake, Vishwaraj, West, Ande, Edwards, Catlin E., Yount, Boyd, Lee, Rhianna E., Gallant, Samuel C., Zost, Seth J., Powers, John, Adams, Lily, Kong, Edgar F., Mattocks, Melissa, Tata, Aleksandra, Randell, Scott H., Tata, Purushothama R., Halfmann, Peter, Crowe, James E., Kawaoka, Yoshihiro, Baric, Ralph S.

“…The pathogenic and cross-species transmission potential of SARS-CoV-2-related coronaviruses (CoVs) remain poorly characterized. Here we recovered a wild-type…”
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Mometasone absorption in cultured airway epithelium by Nguyen, Tuong T., Soma, Paul S., Mascenik, Teresa, Lewis, Catherine A., Lee, Rhianna E., Thorp, Brian D., Zanation, Adam M., Ebert, Charles S., Senior, Brent A., Randell, Scott H., Ehrmann, Brandie M., Kimple, Adam J.

“…Background Topical mometasone is frequently used as an intranasal spray, on drug‐eluting stents, and compounded by specialty pharmacies as a sinus rinse. A…”
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Characterizing Exogenous Cell Engraftment for Cystic Fibrosis Cell Therapy by Lee, Rhianna Elizabeth, Miller, Sean Michael, Mascenik, Teresa Mary, Tarran, Robert, Randell, Scott Howard

“…Cell therapy is a potential method for treating cystic fibrosis (CF), although cell engraftment into the highly resistive, pseudostratified human bronchial…”
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Small-molecule eRF3a degraders rescue CFTR nonsense mutations by promoting premature termination codon readthrough by Lee, Rhianna E, Lewis, Catherine A, He, Lihua, Bulik-Sullivan, Emily C, Gallant, Samuel C, Mascenik, Teresa M, Dang, Hong, Cholon, Deborah M, Gentzsch, Martina, Morton, Lisa C, Minges, John T, Theile, Jonathan W, Castle, Neil A, Knowles, Michael R, Kimple, Adam J, Randell, Scott H

“…The vast majority of people with cystic fibrosis (CF) are now eligible for CF transmembrane regulator (CFTR) modulator therapy. The remaining individuals with…”
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SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract by Hou, Yixuan J., Okuda, Kenichi, Edwards, Caitlin E., Martinez, David R., Asakura, Takanori, Dinnon, Kenneth H., Kato, Takafumi, Lee, Rhianna E., Yount, Boyd L., Mascenik, Teresa M., Chen, Gang, Olivier, Kenneth N., Ghio, Andrew, Tse, Longping V., Leist, Sarah R., Gralinski, Lisa E., Schäfer, Alexandra, Dang, Hong, Gilmore, Rodney, Nakano, Satoko, Sun, Ling, Fulcher, M. Leslie, Livraghi-Butrico, Alessandra, Nicely, Nathan I., Cameron, Mark, Cameron, Cheryl, Kelvin, David J., de Silva, Aravinda, Margolis, David M., Markmann, Alena, Bartelt, Luther, Zumwalt, Ross, Martinez, Fernando J., Salvatore, Steven P., Borczuk, Alain, Tata, Purushothama R., Sontake, Vishwaraj, Kimple, Adam, Jaspers, Ilona, O’Neal, Wanda K., Randell, Scott H., Boucher, Richard C., Baric, Ralph S.

“…The mode of acquisition and causes for the variable clinical spectrum of coronavirus disease 2019 (COVID-19) remain unknown. We utilized a reverse genetics…”
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Designing a Socially Assistive Robot for Long-Term In-Home Use for Children with Autism Spectrum Disorders by Pakkar, Roxanna, Clabaugh, Caitlyn, Lee, Rhianna, Deng, Eric, Mataricc, Maja J

“…Socially assistive robotics (SAR) research has shown great potential for supplementing and augmenting therapy for children with autism spectrum disorders…”
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Designing a Socially Assistive Robot for Long-Term In-Home Use for Children with Autism Spectrum Disorders by Pakkar, Roxanna, Clabaugh, Caitlyn, Lee, Rhianna, Deng, Eric, Mataric, Maja J

“…Socially assistive robotics (SAR) research has shown great potential for supplementing and augmenting therapy for children with autism spectrum disorders…”
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