Search Results - "Lee, Meng Huee"

Identification of the Extracellular Matrix (ECM) Binding Motifs of Tissue Inhibitor of Metalloproteinases (TIMP)-3 and Effective Transfer to TIMP-1 by Lee, Meng-Huee, Atkinson, Susan, Murphy, Gillian

“…Tissue inhibitor of metalloproteinases (TIMPs) are the endogenous inhibitors of the zinc-dependent endopeptidases of the matrix metalloproteinase families…”
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Pentosan polysulfate increases affinity between ADAMTS-5 and TIMP-3 through formation of an electrostatically driven trimolecular complex by Troeberg, Linda, Mulloy, Barbara, Ghosh, Peter, Lee, Meng-Huee, Murphy, Gillian, Nagase, Hideaki

“…The semi-synthetic sulfated polysaccharide PPS (pentosan polysulfate) increases affinity between the aggrecan-degrading ADAMTSs (adamalysins with…”
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Selective inhibition of ADAM12 catalytic activity through engineering of tissue inhibitor of metalloproteinase 2 (TIMP-2) by Kveiborg, Marie, Jacobsen, Jonas, Lee, Meng-Huee, Nagase, Hideaki, Wewer, Ulla M, Murphy, Gillian

“…The disintegrin and metalloprotease ADAM12 has important functions in normal physiology as well as in diseases, such as cancer. Little is known about how…”
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Unveiling the Surface Epitopes That Render Tissue Inhibitor of Metalloproteinase-1 Inactive against Membrane Type 1-Matrix Metalloproteinase by Lee, Meng-Huee, Rapti, Magdalini, Murphy, Gillian

“…Membrane type 1-matrix metalloproteinase (MT1-MMP) is a zinc-dependent, membrane-associated endoproteinase of the metzincin family. The enzyme regulates…”
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Targeting a Designer TIMP-1 to the Cell Surface for Effective MT1-MMP Inhibition: A Potential Role for the Prion Protein in Renal Carcinoma Therapy by Jiang, Bingjie, Liu, Jian, Lee, Meng Huee

“…Renal carcinoma cells express Membrane Type 1-Matrix Metalloproteinase (MT1-MMP, MMP-14) to degrade extracellular matrix components and a range of bioactive…”
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Threonine 98, the Pivotal Residue of Tissue Inhibitor of Metalloproteinases (TIMP)-1 in Metalloproteinase Recognition by Lee, Meng-Huee, Rapti, Magdalini, Knaüper, Vera, Murphy, Gillian

“…Tissue inhibitors of metalloproteinases (TIMPs) are the endogenous modulators of the zinc-dependent mammalian matrix metalloproteinases (MMPs) and their close…”
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Modulation of peritumoral fibroblasts with a membrane-tethered tissue inhibitor of metalloproteinase (TIMP) for the elimination of cancer cells by Zhang, Yihe, Liu, Shiyu, Jiang, Bingjie, Chiu, Sung Kay, Lee, Meng Huee

“…Summary Background . Peritumoral fibroblasts are key components of the tumor microenvironment. Through remodeling of the extracellular matrix (ECM) and…”
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A Novel 3D Model for Visualization and Tracking of Fibroblast-Guided Directional Cancer Cell Migration by Zhang, Yihe, Jiang, Bingjie, Lee, Meng Huee

“…Stromal fibroblasts surrounding cancer cells are a major and important constituent of the tumor microenvironment not least because they contain…”
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The Intrinsic Protein Flexibility of Endogenous Protease Inhibitor TIMP-1 Controls Its Binding Interface and Affects Its Function by Grossman, Moran, Tworowski, Dmitry, Dym, Orly, Lee, Meng-Huee, Levy, Yaakov, Murphy, Gillian, Sagi, Irit

“…Protein flexibility is thought to play key roles in numerous biological processes, including antibody affinity maturation, signal transduction, and enzyme…”
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Mapping and characterization of the functional epitopes of tissue inhibitor of metalloproteinases (TIMP)‐3 using TIMP‐1 as the scaffold: A new frontier in TIMP engineering by Lee, Meng‐Huee, Maskos, Klaus, Knäuper, Vera, Dodds, Philippa, Murphy, Gillian

“…Tumor necrosis factor‐α (TNF‐α) converting enzyme (TACE/ADAM‐17) is responsible for the release of TNF‐α, a potent proinflammatory cytokine associated with…”
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Expanding the Activity of Tissue Inhibitors of Metalloproteinase (TIMP)-1 against Surface-Anchored Metalloproteinases by the Replacement of Its C-Terminal Domain: Implications for Anti-Cancer Effects by Duan, Jing Xian, Rapti, Magdalini, Tsigkou, Anastasia, Lee, Meng Huee

“…Tissue inhibitors of metalloproteinases (TIMPs) are the endogenous inhibitors of the matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinases…”
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Matrix metalloproteinases at a glance by Lee, Meng-Huee, Murphy, Gillian

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The activity of a designer tissue inhibitor of metalloproteinases (TIMP)-1 against native membrane type 1 matrix metalloproteinase (MT1-MMP) in a cell-based environment by Lee, Meng-Huee, Atkinson, Susan, Rapti, Magdalini, Handsley, Madeleine, Curry, Valerie, Edwards, Dylan, Murphy, Gillian

“…Abstract The surface-anchored membrane type 1 matrix metalloproteinase (MT1-MMP) degrades a wide range of extracellular matrix components that includes…”
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The isolated N-terminal domains of TIMP-1 and TIMP-3 are insufficient for ADAM10 inhibition by Rapti, Magdalini, Atkinson, Susan J, Lee, Meng-Huee, Trim, Andrew, Moss, Marcia, Murphy, Gillian

“…ADAM (a disintegrin and metalloproteinase) 10 is a key member of the ADAM family of disintegrin and metalloproteinases which process membrane-associated…”
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Delineating the molecular basis of the inactivity of tissue inhibitor of metalloproteinase-2 against tumor necrosis factor-alpha-converting enzyme by Lee, Meng-Huee, Rapti, Magdalini, Murphy, Gillian

“…Tumor necrosis factor-alpha (TNF-alpha)-converting enzyme (TACE, ADAM-17) is a zinc-dependent ADAM (a disintegrin and metalloproteinase) metalloproteinase (MP)…”
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Engineering N-terminal domain of tissue inhibitor of metalloproteinase (TIMP)-3 to be a better inhibitor against tumour necrosis factor-alpha-converting enzyme by Lee, Meng-Huee, Verma, Vandana, Maskos, Klaus, Nath, Deepa, Knäuper, Vera, Dodds, Philippa, Amour, Augustin, Murphy, Gillian

“…We previously reported that full-length tissue inhibitor of metalloproteinase-3 (TIMP-3) and its N-terminal domain form (N-TIMP-3) displayed equal binding…”
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Full-Length and N-TIMP-3 Display Equal Inhibitory Activities toward TNF-α Convertase by Lee, Meng-Huee, Knäuper, Vera, Becherer, J.David, Murphy, Gillian

“…We previously reported that tumor necrosis factor-α converting enzyme (TACE) was specifically inhibited by TIMP-3 but not TIMP-1, -2, and -4. Further…”
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Total Conversion of Tissue Inhibitor of Metalloproteinase (TIMP) for Specific Metalloproteinase Targeting by Lee, Meng-Huee, Rapti, Magdalini, Murphy, Gillian

“…Tissue inhibitors of metalloproteinases (TIMPs) are the endogenous inhibitors of the matrix metalloproteinases, the ADAMs (adisintegrin and metalloproteinase)…”
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Tailoring tissue inhibitor of metalloproteinases-3 to overcome the weakening effects of the cysteine-rich domains of tumour necrosis factor-alpha converting enzyme by Lee, Meng-Huee, Dodds, Philippa, Verma, Vandana, Maskos, Klaus, Knäuper, Vera, Murphy, Gillian

“…Tumour necrosis factor-alpha (TNF-alpha) converting enzyme (TACE) is a membrane-anchored, multiple-domain zinc metalloproteinase responsible for the release of…”
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The C-terminal domains of TACE weaken the inhibitory action of N-TIMP-3 by Lee, Meng-Huee, Verma, Vandana, Maskos, Klaus, Becherer, J.David, Knäuper, Vera, Dodds, Philippa, Amour, Augustin, Murphy, Gillian

“…Tumor necrosis factor-α converting enzyme (TACE) is an ADAM ( a d isintegrin a nd m etalloproteinases) that comprises an active catalytic domain and several…”
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