Search Results - "Lee, Matthew R."

Current Status of the Use of Antibiotics and the Antimicrobial Resistance in the Chilean Salmon Farms by Miranda, Claudio D, Godoy, Felix A, Lee, Matthew R

“…The Chilean salmon industry has undergone a rapid development making the country the world's second largest producer of farmed salmon, but this growth has been…”
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Discovery of Selective Small Molecule Degraders of BRAF-V600E by Han, Xiao-Ran, Chen, Liqun, Wei, Yuanqi, Yu, Weihua, Chen, Yanke, Zhang, Chunyan, Jiao, Bingyang, Shi, Tingting, Sun, Lei, Zhang, Chao, Xu, Yang, Lee, Matthew R, Luo, Ying, Plewe, Michael B, Wang, Jialiang

“…BRAF is among the most frequently mutated oncogenes in human cancers. Multiple small molecule BRAF kinase inhibitors have been approved for treating melanoma…”
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Maturing out of alcohol involvement: transitions in latent drinking statuses from late adolescence to adulthood by Lee, Matthew R, Chassin, Laurie, Villalta, Ian K

“…Research has shown a developmental process of "maturing out" of alcohol involvement beginning in young adulthood, but the precise nature of changes…”
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Structural basis for GPR40 allosteric agonism and incretin stimulation by Ho, Joseph D., Chau, Betty, Rodgers, Logan, Lu, Frances, Wilbur, Kelly L., Otto, Keith A., Chen, Yanyun, Song, Min, Riley, Jonathan P., Yang, Hsiu-Chiung, Reynolds, Nichole A., Kahl, Steven D., Lewis, Anjana Patel, Groshong, Christopher, Madsen, Russell E., Conners, Kris, Lineswala, Jayana P., Gheyi, Tarun, Saflor, Melbert-Brian Decipulo, Lee, Matthew R., Benach, Jordi, Baker, Kenton A., Montrose-Rafizadeh, Chahrzad, Genin, Michael J., Miller, Anne R., Hamdouchi, Chafiq

“…Activation of free fatty acid receptor 1 (GPR40) by synthetic partial and full agonists occur via distinct allosteric sites. A crystal structure of…”
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Cortistatin A is a High-Affinity Ligand of Protein Kinases ROCK, CDK8, and CDK11 by Cee, Victor J., Chen, David Y.-K., Lee, Matthew R., Nicolaou, K. C.

“…Antiproliferative alkaloid: Cortistatin A is a high‐affinity ligand for a small set of protein kinases including Rho‐associated, coiled‐coil‐containing protein…”
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Ocean Acidification and Increased Temperature Have Both Positive and Negative Effects on Early Ontogenetic Traits of a Rocky Shore Keystone Predator Species by Manríquez, Patricio H, Jara, María Elisa, Seguel, Mylene E, Torres, Rodrigo, Alarcon, Emilio, Lee, Matthew R

“…The combined effect of ocean acidification and warming is expected to have significant effects on several traits of marine organisms. The gastropod Concholepas…”
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Aquatic Environments as Hotspots of Transferable Low-Level Quinolone Resistance and Their Potential Contribution to High-Level Quinolone Resistance by Miranda, Claudio D, Concha, Christopher, Godoy, Félix A, Lee, Matthew R

“…The disposal of antibiotics in the aquatic environment favors the selection of bacteria exhibiting antibiotic resistance mechanisms. Quinolones are…”
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Making Waves in Academia: Asian/Asian American Feminist Mentoring as Activism by S. Kim, Grace, Okubo, Yuki, R. Lee, Matthew, C. Tolentino, Jean-Arellia, N. Shah, Tanvi, Yi, Sarah

“…Multicultural Feminist Mentoring (MFM) models have provided an important foundation to address the further need for conceptualizing a mentoring model that is…”
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The identification of sympatric cryptic free-living nematode species in the Antarctic intertidal by Lee, Matthew R, Canales-Aguirre, Cristian B, Nuñez, Daniela, Pérez, Karla, Hernández, Crisitan E, Brante, Antonio

“…The diversity of free-living nematodes in the beaches of two Antarctic islands, King George and Deception islands was investigated. We used morphological and…”
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Pharmacological therapy for post-traumatic stress disorder: a systematic review and meta-analysis of monotherapy, augmentation and head-to-head approaches by Hoskins, Mathew D., Bridges, Jack, Sinnerton, Robert, Nakamura, Anna, Underwood, Jack F. G., Slater, Alan, Lee, Matthew R. D., Clarke, Liam, Lewis, Catrin, Roberts, Neil P., Bisson, Jonathan I.

“…Background: Pharmacological approaches are widely used for post-traumatic stress disorder (PTSD) despite uncertainty over efficacy. Objectives: To determine…”
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Deep Turbulence as a Novel Main Driver for Multi-Specific Toxic Algal Blooms: The Case of an Anoxic and Heavy Metal-Polluted Submarine Canyon That Harbors Toxic Dinoflagellate Resting Cysts by Rodríguez-Villegas, Camilo, Pérez-Santos, Iván, Díaz, Patricio A, Baldrich, Ángela M, Lee, Matthew R, Saldías, Gonzalo S, Mancilla-Gutiérrez, Guido, Urrutia, Cynthia, Navarro, Claudio R, Varela, Daniel A, Ross, Lauren, Figueroa, Rosa I

“…Over the recent decades, an apparent worldwide rise in Harmful Algae Blooms (HABs) has been observed due to the growing exploitation of the coastal…”
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The Interactive Effects of the Anti-Sea Lice Pesticide Azamethiphos and Temperature on Oxidative Damage and Antioxidant Responses in the Oyster Ostrea chilensis by Montory, Jaime A, Cubillos, Victor M, Chaparro, Oscar R, Gebauer, Paulina, Lee, Matthew R, Ramírez-Kuschel, Eduardo, Paredes-Molina, Francisco, Lara-Sandoval, Valentina, Cumillaf, Juan P, Salas-Yanquin, Luis P, Büchner-Miranda, Joseline A

“…Azamethiphos is used in the salmon industry to treat sea lice and is subsequently discharged into the sea, which may affect non-target species (NTS). A rise in…”
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The Louisiana Community Oil Spill Survey (COSS) dataset by Cope, Michael R., Slack, Tim, Blanchard, Troy C., Lee, Matthew R., Jackson, Jorden E.

“…This article presents an overview of the Louisiana Community Oil Spill Survey (COSS), the dataset used in “Community Sentiment following the Deepwater Horizon…”
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Discovery of Highly Selective and Potent p38 Inhibitors Based on a Phthalazine Scaffold by Herberich, Brad, Cao, Guo-Qiang, Chakrabarti, Partha P, Falsey, James R, Pettus, Liping, Rzasa, Robert M, Reed, Anthony B, Reichelt, Andreas, Sham, Kelvin, Thaman, Maya, Wurz, Ryan P, Xu, Shimin, Zhang, Dawei, Hsieh, Faye, Lee, Matthew R, Syed, Rashid, Li, Vivian, Grosfeld, David, Plant, Matthew H, Henkle, Bradley, Sherman, Lisa, Middleton, Scot, Wong, Lu Min, Tasker, Andrew S

“…Investigations into the structure−activity relationships (SAR) of a series of phthalazine-based inhibitors of p38 are described. These efforts originated from…”
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To know the unknown: The decline in homicide clearance rates, 1980-2000 by Ousey, Graham C., Lee, Matthew R.

“…Against the backdrop of the precipitous decline in urban homicide clearance over the past several decades, this study examines factors that may be linked to…”
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CIVIC COMMUNITY IN THE HINTERLAND: TOWARD A THEORY OF RURAL SOCIAL STRUCTURE AND VIOLENCE by LEE, MATTHEW R.

“…Drawing on the civic community literature, this article explicates a theoretical model to explain variation in rates of violence across rural communities. It…”
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Discovery of Pyridazinopyridinones as Potent and Selective p38 Mitogen-Activated Protein Kinase Inhibitors by Wu, Bin, Wang, Hui-Ling, Pettus, Liping, Wurz, Ryan P, Doherty, Elizabeth M, Henkle, Bradley, McBride, Helen J, Saris, Christiaan J. M, Wong, Lu Min, Plant, Matthew H, Sherman, Lisa, Lee, Matthew R, Hsieh, Faye, Tasker, Andrew S

“…The p38 mitogen-activated protein kinase (MAPK) plays an important role in the production of proinflammatory cytokines, making it an attractive target for the…”
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Role Transitions and Young Adult Maturing Out of Heavy Drinking: Evidence for Larger Effects of Marriage Among More Severe Premarriage Problem Drinkers by Lee, Matthew R., Chassin, Laurie, MacKinnon, David P.

“…Background Research has shown a developmental process of “maturing out” of problem drinking beginning in young adulthood. Perhaps surprisingly, past studies…”
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2-Aminothiadiazole inhibitors of AKT1 as potential cancer therapeutics by Zeng, Qingping, Bourbeau, Matthew P., Wohlhieter, G. Erich, Yao, Guomin, Monenschein, Holger, Rider, James T., Lee, Matthew R., Zhang, Shiwen, Lofgren, Julie, Freeman, Daniel, Li, Chun, Tominey, Elizabeth, Huang, Xin, Hoffman, Douglas, Yamane, Harvey, Tasker, Andrew S., Dominguez, Celia, Viswanadhan, Vellarkad N., Hungate, Randall, Zhang, Xiaoling

“…The development of a series of potent AKT1 inhibitors is reported. A series of 2-aminothiadiazole of inhibitors of AKT1 is described. SAR relationships are…”
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Quinolinone-based agonists of S1P1: Use of a N-scan SAR strategy to optimize in vitro and in vivo activity by Pennington, Lewis D., Croghan, Michael D., Sham, Kelvin K.C., Pickrell, Alexander J., Harrington, Paul E., Frohn, Michael J., Lanman, Brian A., Reed, Anthony B., Lee, Matthew R., Xu, Han, McElvain, Michele, Xu, Yang, Zhang, Xuxia, Fiorino, Michael, Horner, Michelle, Morrison, Henry G., Arnett, Heather A., Fotsch, Christopher, Tasker, Andrew S., Wong, Min, Cee, Victor J.

“…We reveal how a N-scan SAR strategy (systematic substitution of each CH group with a N atom) was employed for quinolinone-based S1P1 agonist 5 to modulate…”
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