Search Results - "Lee, Matt R."

Imaging Mutant Huntingtin Aggregates: Development of a Potential PET Ligand by Liu, Longbin, Prime, Michael E, Lee, Matt R, Khetarpal, Vinod, Brown, Christopher J, Johnson, Peter D, Miranda-Azpiazu, Patricia, Chen, Xuemei, Clark-Frew, Daniel, Coe, Samuel, Davis, Randall, Dickie, Anthony, Ebneth, Andreas, Esposito, Simone, Gadouleau, Elise, Gai, Xinjie, Galan, Sebastien, Green, Samantha, Greenaway, Catherine, Giles, Paul, Halldin, Christer, Hayes, Sarah, Herbst, Todd, Herrmann, Frank, Heßmann, Manuela, Jia, Zhisheng, Kiselyov, Alexander, Kotey, Adrian, Krulle, Thomas, Mangette, John E, Marston, Richard W, Menta, Sergio, Mills, Matthew R, Monteagudo, Edith, Nag, Sangram, Nibbio, Martina, Orsatti, Laura, Schaertl, Sabine, Scheich, Christoph, Sproston, Joanne, Stepanov, Vladimir, Svedberg, Marie, Takano, Akihiro, Taylor, Malcolm, Thomas, Wayne, Toth, Miklós, Vaidya, Darshan, Vanräs, Katarina, Weddell, Derek, Wigginton, Ian, Wityak, John, Mrzljak, Ladislav, Munoz-Sanjuan, Ignacio, Bard, Jonathan A, Dominguez, Celia

“…Mutant huntingtin (mHTT) protein carrying the elongated N-terminal polyglutamine (polyQ) tract misfolds and forms protein aggregates characteristic of…”
Get full text

Discovery of AMG 369, a Thiazolo[5,4-b]pyridine Agonist of S1P1 and S1P5 by Cee, Victor J, Frohn, Mike, Lanman, Brian A, Golden, Jennifer, Muller, Kristine, Neira, Susana, Pickrell, Alex, Arnett, Heather, Buys, Janet, Gore, Anu, Fiorino, Mike, Horner, Michelle, Itano, Andrea, Lee, Matt R, McElvain, Michele, Middleton, Scot, Schrag, Michael, Rivenzon-Segal, Dalia, Vargas, Hugo M, Xu, Han, Xu, Yang, Zhang, Xuxia, Siu, Jerry, Wong, Min, Bürli, Roland W

“…The optimization of a series of thiazolopyridine S1P1 agonists with limited activity at the S1P3 receptor is reported. These efforts resulted in the discovery…”
Get full text

Discovery of AMG 369, a Thiazolo[5,4- b ]pyridine Agonist of S1P 1 and S1P 5 by Cee, Victor J., Frohn, Mike, Lanman, Brian A., Golden, Jennifer, Muller, Kristine, Neira, Susana, Pickrell, Alex, Arnett, Heather, Buys, Janet, Gore, Anu, Fiorino, Mike, Horner, Michelle, Itano, Andrea, Lee, Matt R., McElvain, Michele, Middleton, Scot, Schrag, Michael, Rivenzon-Segal, Dalia, Vargas, Hugo M., Xu, Han, Xu, Yang, Zhang, Xuxia, Siu, Jerry, Wong, Min, Bürli, Roland W.

Get full text