Search Results - "Lee, Marietta Y. W. T."

Characterization of human DNA polymerase delta and its subassemblies reconstituted by expression in the MultiBac system by Zhou, Yajing, Meng, Xiao, Zhang, Sufang, Lee, Ernest Y C, Lee, Marietta Y W T

“…Mammalian DNA polymerase δ (Pol δ), a four-subunit enzyme, plays a crucial and versatile role in DNA replication and DNA repair processes. We have…”
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Production of recombinant human DNA polymerase delta in a Bombyx mori bioreactor by Zhou, Yajing, Chen, Huiqing, Li, Xiao, Wang, Yujue, Chen, Keping, Zhang, Sufang, Meng, Xiao, Lee, Ernest Y C, Lee, Marietta Y W T

“…Eukaryotic DNA polymerase δ (pol δ) plays a crucial role in chromosomal DNA replication and various DNA repair processes. It is thought to consist of p125, p66…”
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Special Issue "DNA Replication/Repair, and the DNA Damage Response in Human Disease" by Zhang, Dong, Eckert, Kristin A, Lee, Marietta Y W T

“…Mutations of numerous genes involved in DNA replication, DNA repair, and DNA damage response (DDR) pathways lead to a variety of human diseases, including…”
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POLDIP3: At the Crossroad of RNA and DNA Metabolism by Singh, Manrose, Zhang, Sufang, Perez, Alexis M, Lee, Ernest Y C, Lee, Marietta Y W T, Zhang, Dong

“…POLDIP3 was initially identified as a DNA polymerase delta (Pol δ) interacting protein almost twenty years ago. Intriguingly, it also interacts with proteins…”
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P50, the small subunit of DNA polymerase delta, is required for mediation of the interaction of polymerase delta subassemblies with PCNA by Wang, Yujue, Zhang, Qian, Chen, Huiqing, Li, Xiao, Mai, Weijun, Chen, Keping, Zhang, Sufang, Lee, Ernest Y C, Lee, Marietta Y W T, Zhou, Yajing

“…Mammalian DNA polymerase δ (pol δ), a four-subunit enzyme, plays a crucial and versatile role in DNA replication and various DNA repair processes. Its function…”
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DNA structure and the Werner protein modulate human DNA polymerase delta-dependent replication dynamics within the common fragile site FRA16D by Shah, Sandeep N, Opresko, Patricia L, Meng, Xiao, Lee, Marietta Y.W.T, Eckert, Kristin A

“…Common fragile sites (CFS) are chromosomal regions that exhibit instability during DNA replication stress. Although the mechanism of CFS expression has not…”
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DNA polymerase delta interacting protein 3 facilitates the activation and maintenance of DNA damage checkpoint in response to replication stress by Zhang, Sufang, Lee, Ernest Y. C., Lee, Marietta Y. W. T., Zhang, Dong

“…Background Replication stress response is crucial for the maintenance of a stable genome. POLDIP3 (DNA polymerase delta interacting protein 3) was initially…”
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The p12 Subunit of Human Polymerase δ Modulates the Rate and Fidelity of DNA Synthesis by Meng, Xiao, Zhou, Yajing, Lee, Ernest Y. C, Lee, Marietta Y. W. T, Frick, David N

“…This study examines the role of the p12 subunit in the function of the human DNA polymerase δ (Pol δ) holoenzyme by comparing the kinetics of DNA synthesis and…”
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Phosphorylation of the p68 Subunit of Pol δ Acts as a Molecular Switch To Regulate Its Interaction with PCNA by Rahmeh, Amal A, Zhou, Yajing, Xie, Bin, Li, Hao, Lee, Ernest Y. C, Lee, Marietta Y. W. T

“…DNA polymerase delta (Pol δ) is a central enzyme for eukaryotic DNA replication and repair. Pol δ is a complex of four subunits p125, p68, p50, and p12. The…”
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A slipped-CAG DNA-binding small molecule induces trinucleotide-repeat contractions in vivo by Nakamori, Masayuki, Panigrahi, Gagan B., Lanni, Stella, Gall-Duncan, Terence, Hayakawa, Hideki, Tanaka, Hana, Luo, Jennifer, Otabe, Takahiro, Li, Jinxing, Sakata, Akihiro, Caron, Marie-Christine, Joshi, Niraj, Prasolava, Tanya, Chiang, Karen, Masson, Jean-Yves, Wold, Marc S., Wang, Xiaoxiao, Lee, Marietta Y. W. T., Huddleston, John, Munson, Katherine M., Davidson, Scott, Layeghifard, Mehdi, Edward, Lisa-Monique, Gallon, Richard, Santibanez-Koref, Mauro, Murata, Asako, Takahashi, Masanori P., Eichler, Evan E., Shlien, Adam, Nakatani, Kazuhiko, Mochizuki, Hideki, Pearson, Christopher E.

“…In many repeat diseases, such as Huntington’s disease (HD), ongoing repeat expansions in affected tissues contribute to disease onset, progression and…”
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DNA synthesis by Pol η promotes fragile site stability by preventing under-replicated DNA in mitosis by Bergoglio, Valérie, Boyer, Anne-Sophie, Walsh, Erin, Naim, Valeria, Legube, Gaëlle, Lee, Marietta Y W T, Rey, Laurie, Rosselli, Filippo, Cazaux, Christophe, Eckert, Kristin A, Hoffmann, Jean-Sébastien

“…Human DNA polymerase η (Pol η) is best known for its role in responding to UV irradiation-induced genome damage. We have recently observed that Pol η is also…”
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Reconstitution and Characterization of the Human DNA Polymerase Delta Four-Subunit Holoenzyme by Xie, Bin, Mazloum, Nayef, Liu, Li, Rahmeh, Amal, Li, Hao, Lee, Marietta Y. W. T

“…Mammalian DNA polymerase δ was originally characterized as a tightly associated heterodimer consisting of the catalytic subunit, p125, and the p50 subunit…”
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Protein Phosphatase-1 Is Targeted to DNA Polymerase δ via an Interaction with the p68 Subunit by Gao, Yan, Zhou, Yajing, Xie, Bin, Zhang, Sufang, Rahmeh, Amal, Huang, Hua-shan, Lee, Marietta Y. W. T, Lee, Ernest Y. C

“…Protein phosphatase-1 (PP1) is a Ser/Thr protein phosphatase that participates in the phosphorylation/dephosphorylation regulation of a diverse range of…”
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A novel function of CRL4(Cdt2): regulation of the subunit structure of DNA polymerase δ in response to DNA damage and during the S phase by Zhang, Sufang, Zhao, Hong, Darzynkiewicz, Zbiegniew, Zhou, Pengbo, Zhang, Zhongtao, Lee, Ernest Y C, Lee, Marietta Y W T

“…DNA polymerase δ (Pol δ4) is a heterotetrameric enzyme, whose p12 subunit is degraded in response to DNA damage, leaving behind a trimer (Pol δ3) with altered…”
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Distinctive activities of DNA polymerases during human DNA replication by Rytkönen, Anna K., Vaara, Markku, Nethanel, Tamar, Kaufmann, Gabriel, Sormunen, Raija, Läärä, Esa, Nasheuer, Heinz‐Peter, Rahmeh, Amal, Lee, Marietta Y. W. T., Syväoja, Juhani E., Pospiech, Helmut

“…The contributions of human DNA polymerases (pols) α, δ and ε during S‐phase progression were studied in order to elaborate how these enzymes co‐ordinate their…”
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The PCNA-associated protein PARI negatively regulates homologous recombination via the inhibition of DNA repair synthesis by Burkovics, Peter, Dome, Lili, Juhasz, Szilvia, Altmannova, Veronika, Sebesta, Marek, Pacesa, Martin, Fugger, Kasper, Sorensen, Claus Storgaard, Lee, Marietta Y W T, Haracska, Lajos, Krejci, Lumir

“…Successful and accurate completion of the replication of damage-containing DNA requires mainly recombination and RAD18-dependent DNA damage tolerance pathways…”
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Loss of the p12 subunit of DNA polymerase delta leads to a defect in HR and sensitization to PARP inhibitors by Zhang, Sufang, Chao, Hsiao Hsiang, Wang, Xiaoxiao, Zhang, Zhongtao, Lee, Ernest Y.C., Lee, Marietta Y.W.T.

“…•p12-knockout generates a HR deficiency phenotype.•Pol δ4 is required for full expression of cellular HR activity.•p12 knockout cells are sensitized to PARP…”
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Role of PCNA and TLS polymerases in D-loop extension during homologous recombination in humans by Sebesta, Marek, Burkovics, Peter, Juhasz, Szilvia, Zhang, Sufang, Szabo, Judit E., Lee, Marietta Y.W.T., Haracska, Lajos, Krejci, Lumir

“…Homologous recombination (HR) is essential for maintaining genomic integrity, which is challenged by a wide variety of potentially lethal DNA lesions…”
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Discovery of a novel DNA polymerase inhibitor and characterization of its antiproliferative properties by Mishra, Bhanvi, Zhang, Sufang, Zhao, Hong, Darzynkiewicz, Zbigniew, Lee, Ernest Y.C., Lee, Marietta Y.W.T., Zhang, Zhongtao

“…Chromosomal duplication is targeted by various chemotherapeutic agents for the treatment of cancer. However, there is no specific inhibitor of DNA polymerases…”
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Regulation and Modulation of Human DNA Polymerase δ Activity and Function by Lee, Marietta Y W T, Wang, Xiaoxiao, Zhang, Sufang, Zhang, Zhongtao, Lee, Ernest Y C

“…This review focuses on the regulation and modulation of human DNA polymerase δ (Pol δ). The emphasis is on the mechanisms that regulate the activity and…”
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