Search Results - "Lee, Marcus C. S."

Insights into the intracellular localization, protein associations and artemisinin resistance properties of Plasmodium falciparum K13 by Gnädig, Nina F, Stokes, Barbara H, Edwards, Rachel L, Kalantarov, Gavreel F, Heimsch, Kim C, Kuderjavy, Michal, Crane, Audrey, Lee, Marcus C S, Straimer, Judith, Becker, Katja, Trakht, Ilya N, Odom John, Audrey R, Mok, Sachel, Fidock, David A

“…The emergence of artemisinin (ART) resistance in Plasmodium falciparum intra-erythrocytic parasites has led to increasing treatment failure rates with…”
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A manually curated annotation characterises genomic features of P. falciparum lncRNAs by Hoshizaki, Johanna, Adjalley, Sophie H, Thathy, Vandana, Judge, Kim, Berriman, Matthew, Reid, Adam J, Lee, Marcus C S

“…Important regulation occurs at the level of transcription in Plasmodium falciparum and growing evidence suggests that these apicomplexan parasites have complex…”
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Propensity of selecting mutant parasites for the antimalarial drug cabamiquine by Stadler, Eva, Maiga, Mohamed, Friedrich, Lukas, Thathy, Vandana, Demarta-Gatsi, Claudia, Dara, Antoine, Sogore, Fanta, Striepen, Josefine, Oeuvray, Claude, Djimdé, Abdoulaye A., Lee, Marcus C. S., Dembélé, Laurent, Fidock, David A., Khoury, David S., Spangenberg, Thomas

“…We report an analysis of the propensity of the antimalarial agent cabamiquine, a Plasmodium -specific eukaryotic elongation factor 2 inhibitor, to select for…”
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Correction: A manually curated annotation characterises genomic features of P. falciparum lncRNAs by Hoshizaki, Johanna, Adjalley, Sophie H, Thathy, Vandana, Judge, Kim, Berriman, Matthew, Reid, Adam J, Lee, Marcus C S

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Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue by Adjalley, Sophie H., Johnston, Geoffrey L., Li, Tao, Eastman, Richard T., Ekland, Eric H., Eappen, Abraham G., Richman, Adam, Sim, B. Kim Lee, Lee, Marcus C. S., Hoffman, Stephen L., Fidock, David A.

“…Clinical studies and mathematical models predict that, to achieve malaria elimination, combination therapies will need to incorporate drugs that block the…”
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Generation of a mutator parasite to drive resistome discovery in Plasmodium falciparum by Kümpornsin, Krittikorn, Kochakarn, Theerarat, Yeo, Tomas, Okombo, John, Luth, Madeline R., Hoshizaki, Johanna, Rawat, Mukul, Pearson, Richard D., Schindler, Kyra A., Mok, Sachel, Park, Heekuk, Uhlemann, Anne-Catrin, Jana, Gouranga P., Maity, Bikash C., Laleu, Benoît, Chenu, Elodie, Duffy, James, Moliner Cubel, Sonia, Franco, Virginia, Gomez-Lorenzo, Maria G., Gamo, Francisco Javier, Winzeler, Elizabeth A., Fidock, David A., Chookajorn, Thanat, Lee, Marcus C. S.

“…In vitro evolution of drug resistance is a powerful approach for identifying antimalarial targets, however, key obstacles to eliciting resistance are the…”
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Author Correction: Propensity of selecting mutant parasites for the antimalarial drug cabamiquine by Stadler, Eva, Maiga, Mohamed, Friedrich, Lukas, Thathy, Vandana, Demarta-Gatsi, Claudia, Dara, Antoine, Sogore, Fanta, Striepen, Josefine, Oeuvray, Claude, Djimdé, Abdoulaye A., Lee, Marcus C. S., Dembélé, Laurent, Fidock, David A., Khoury, David S., Spangenberg, Thomas

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Nedd8 hydrolysis by UCH proteases in Plasmodium parasites by Karpiyevich, Maryia, Adjalley, Sophie, Mol, Marco, Ascher, David B, Mason, Bethany, van der Heden van Noort, Gerbrand J, Laman, Heike, Ovaa, Huib, Lee, Marcus C S, Artavanis-Tsakonas, Katerina

“…Plasmodium parasites are the causative agents of malaria, a disease with wide public health repercussions. Increasing drug resistance and the absence of a…”
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CRISPR‐Cas9‐modified pfmdr1 protects Plasmodium falciparum asexual blood stages and gametocytes against a class of piperazine‐containing compounds but potentiates artemisinin‐based combination therapy partner drugs by Ng, Caroline L., Siciliano, Giulia, Lee, Marcus C. S., de Almeida, Mariana J., Corey, Victoria C., Bopp, Selina E., Bertuccini, Lucia, Wittlin, Sergio, Kasdin, Rachel G., Le Bihan, Amélie, Clozel, Martine, Winzeler, Elizabeth A., Alano, Pietro, Fidock, David A.

“…Summary Emerging resistance to first‐line antimalarial combination therapies threatens malaria treatment and the global elimination campaign. Improved…”
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A novel multiple-stage antimalarial agent that inhibits protein synthesis by Baragaña, Beatriz, Hallyburton, Irene, Lee, Marcus C. S., Norcross, Neil R., Grimaldi, Raffaella, Otto, Thomas D., Proto, William R., Blagborough, Andrew M., Meister, Stephan, Wirjanata, Grennady, Ruecker, Andrea, Upton, Leanna M., Abraham, Tara S., Almeida, Mariana J., Pradhan, Anupam, Porzelle, Achim, Martínez, María Santos, Bolscher, Judith M., Woodland, Andrew, Luksch, Torsten, Norval, Suzanne, Zuccotto, Fabio, Thomas, John, Simeons, Frederick, Stojanovski, Laste, Osuna-Cabello, Maria, Brock, Paddy M., Churcher, Tom S., Sala, Katarzyna A., Zakutansky, Sara E., Jiménez-Díaz, María Belén, Sanz, Laura Maria, Riley, Jennifer, Basak, Rajshekhar, Campbell, Michael, Avery, Vicky M., Sauerwein, Robert W., Dechering, Koen J., Noviyanti, Rintis, Campo, Brice, Frearson, Julie A., Angulo-Barturen, Iñigo, Ferrer-Bazaga, Santiago, Gamo, Francisco Javier, Wyatt, Paul G., Leroy, Didier, Siegl, Peter, Delves, Michael J., Kyle, Dennis E., Wittlin, Sergio, Marfurt, Jutta, Price, Ric N., Sinden, Robert E., Winzeler, Elizabeth A., Charman, Susan A., Bebrevska, Lidiya, Gray, David W., Campbell, Simon, Fairlamb, Alan H., Willis, Paul A., Rayner, Julian C., Fidock, David A., Read, Kevin D., Gilbert, Ian H.

“…There is an urgent need for new drugs to treat malaria, with broad therapeutic potential and novel modes of action, to widen the scope of treatment and to…”
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Scientists on a RAMPAGE to find apicomplexan transcription start sites by Hoshizaki, Johanna, Lee, Marcus C. S.

“…This month’s Genome Watch highlights approaches that enable high-resolution mapping of transcription start sites in apicomplexan parasites…”
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A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue by Sonoiki, Ebere, Ng, Caroline L., Lee, Marcus C. S., Guo, Denghui, Zhang, Yong-Kang, Zhou, Yasheen, Alley, M. R. K., Ahyong, Vida, Sanz, Laura M., Lafuente-Monasterio, Maria Jose, Dong, Chen, Schupp, Patrick G., Gut, Jiri, Legac, Jenny, Cooper, Roland A., Gamo, Francisco-Javier, DeRisi, Joseph, Freund, Yvonne R., Fidock, David A., Rosenthal, Philip J.

“…Benzoxaboroles are effective against bacterial, fungal and protozoan pathogens. We report potent activity of the benzoxaborole AN3661 against Plasmodium…”
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A novel 4-aminoquinoline chemotype with multistage antimalarial activity and lack of cross-resistance with PfCRT and PfMDR1 mutants by Ferreira, Letícia Tiburcio, Cassiano, Gustavo Capatti, Alvarez, Luis Carlos Salazar, Okombo, John, Calit, Juliana, Fontinha, Diana, Gil-Iturbe, Eva, Coyle, Rachael, Andrade, Carolina Horta, Sunnerhagen, Per, Bargieri, Daniel Youssef, Prudêncio, Miguel, Quick, Matthias, Cravo, Pedro V, Lee, Marcus C S, Fidock, David A, Costa, Fabio Trindade Maranhão

“…Artemisinin-based combination therapy (ACT) is the mainstay of effective treatment of Plasmodium falciparum malaria. However, the long-term utility of ACTs is…”
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KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission by Kuhen, Kelli L, Chatterjee, Arnab K, Rottmann, Matthias, Gagaring, Kerstin, Borboa, Rachel, Buenviaje, Jennifer, Chen, Zhong, Francek, Carolyn, Wu, Tao, Nagle, Advait, Barnes, S Whitney, Plouffe, David, Lee, Marcus C S, Fidock, David A, Graumans, Wouter, van de Vegte-Bolmer, Marga, van Gemert, Geert J, Wirjanata, Grennady, Sebayang, Boni, Marfurt, Jutta, Russell, Bruce, Suwanarusk, Rossarin, Price, Ric N, Nosten, Francois, Tungtaeng, Anchalee, Gettayacamin, Montip, Sattabongkot, Jetsumon, Taylor, Jennifer, Walker, John R, Tully, David, Patra, Kailash P, Flannery, Erika L, Vinetz, Joseph M, Renia, Laurent, Sauerwein, Robert W, Winzeler, Elizabeth A, Glynne, Richard J, Diagana, Thierry T

“…Renewed global efforts toward malaria eradication have highlighted the need for novel antimalarial agents with activity against multiple stages of the parasite…”
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Cytoplasmic isoleucyl tRNA synthetase as an attractive multistage antimalarial drug target by Istvan, Eva S, Guerra, Francisco, Abraham, Matthew, Huang, Kuo-Sen, Rocamora, Frances, Zhao, Haoshuang, Xu, Lan, Pasaje, Charisse, Kumpornsin, Krittikorn, Luth, Madeline R, Cui, Haissi, Yang, Tuo, Palomo Diaz, Sara, Gomez-Lorenzo, Maria G, Qahash, Tarrick, Mittal, Nimisha, Ottilie, Sabine, Niles, Jacquin, Lee, Marcus C S, Llinas, Manuel, Kato, Nobutaka, Okombo, John, Fidock, David A, Schimmel, Paul, Gamo, Francisco Javier, Goldberg, Daniel E, Winzeler, Elizabeth A

“…Development of antimalarial compounds into clinical candidates remains costly and arduous without detailed knowledge of the target. As resistance increases and…”
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Site-specific genome editing in Plasmodium falciparum using engineered zinc-finger nucleases by Straimer, Judith, Lee, Marcus C S, Lee, Andrew H, Zeitler, Bryan, Williams, April E, Pearl, Jocelynn R, Zhang, Lei, Rebar, Edward J, Gregory, Philip D, Llinás, Manuel, Urnov, Fyodor D, Fidock, David A

“…This paper reports genetic manipulation of the malaria parasite Plasmodium falciparum with zinc-finger nucleases. It demonstrates gene disruption as well as…”
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Cutting back malaria: CRISPR/Cas9 genome editing of Plasmodium by Lee, Marcus C S, Lindner, Scott E, Lopez-Rubio, Jose-Juan, Llinás, Manuel

“…CRISPR/Cas9 approaches are revolutionizing our ability to perform functional genomics across a wide range of organisms, including the Plasmodium parasites that…”
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A broad analysis of resistance development in the malaria parasite by Corey, Victoria C., Lukens, Amanda K., Istvan, Eva S., Lee, Marcus C. S., Franco, Virginia, Magistrado, Pamela, Coburn-Flynn, Olivia, Sakata-Kato, Tomoyo, Fuchs, Olivia, Gnädig, Nina F., Goldgof, Greg, Linares, Maria, Gomez-Lorenzo, Maria G., De Cózar, Cristina, Lafuente-Monasterio, Maria Jose, Prats, Sara, Meister, Stephan, Tanaseichuk, Olga, Wree, Melanie, Zhou, Yingyao, Willis, Paul A., Gamo, Francisco-Javier, Goldberg, Daniel E., Fidock, David A., Wirth, Dyann F., Winzeler, Elizabeth A.

“…Microbial resistance to chemotherapy has caused countless deaths where malaria is endemic. Chemotherapy may fail either due to pre-existing resistance or…”
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Plasmodium falciparum Sec24 marks transitional ER that exports a model cargo via a diacidic motif by Lee, Marcus C.S, Moura, Pedro A, Miller, Elizabeth A, Fidock, David A

“…Exit from the endoplasmic reticulum (ER) often occurs at distinct sites of vesicle formation known as transitional ER (tER) that are enriched for COPII vesicle…”
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Efficient generation of mNeonGreen Plasmodium falciparum reporter lines enables quantitative fitness analysis by Hoshizaki, Johanna, Jagoe, Hannah, Lee, Marcus C. S.

“…CRISPR editing has enabled the rapid creation of fluorescent Plasmodium transgenic lines, facilitating a deeper understanding of parasite biology. The impact…”
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