Search Results - "Lee, M. Douglas"

The aquaporin family of water channel proteins in clinical medicine by Lee, M D, King, L S, Agre, P

“…The aquaporins are a family of membrane channel proteins that serve as selective pores through which water crosses the plasma membranes of many human tissues…”
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Keratinocyte Growth Factor Modulates Alveolar Epithelial Cell Phenotype In Vitro: Expression of Aquaporin 5 by Borok, Zea, Lubman, Richard L, Danto, Spencer I, Zhang, Xiao-Ling, Zabski, Stephanie M, King, Landon S, Lee, Douglas M, Agre, Peter, Crandall, Edward D

“…We investigated the role of keratinocyte growth factor (KGF) in regulation of alveolar epithelial cell (AEC) phenotype in vitro. Effects of KGF on cell…”
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Aquaporins and Ion Conductance by Agre, Peter, Lee, M. Douglas, Devidas, Sreenivas, Guggino, William B., Sasaki, Sei, Uchida, Shinichi, Kuwahara, Michio, Fushimi, Kiyohide, Marumo, Fumiaki, Verkman, A. S., Yang, Baoxue, Deen, P. M. T., Mulders, S. M., Kansen, S. M., van Os, C. H., Fischbarg, Jorge, Kuang, Kunyan, Li, Jun, Iserovich, Pavel, Wen, Qian, Patil, Rajkumar V., Han, Zhiquang, Wax, Martin B., Regan, John W., Stamer, W. Daniel, Yool, Andrea J.

“…A study of membrane conductance in Xenopus Laevis oocytes injected with aquaporin1 (AQP1) complementary RNA observed ion conductance in the AQPI protein…”
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Effect of Endotoxin-Induced Monokines on Glucose Metabolism in the Muscle Cell Line L6 by Lee, M. Douglas, Zentella, Alejandro, Pekala, Phillip H., Cerami, Anthony

“…Exposure of fully differentiated L6 myotubes to a crude monokine preparation from endotoxin-stimulated RAW 264.7 cells resulted in a rapid and substantial…”
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The Human Aquaporin-5 Gene by Lee, M. Douglas, Bhakta, Kushal Y., Raina, Surabhi, Yonescu, Raluca, Griffin, Constance A., Copeland, Neal G., Gilbert, Debra J., Jenkins, Nancy A., Preston, Gregory M., Agre, Peter

“…The cDNA for the fifth mammalian aquaporin (AQP5) was isolated from rat, and expression was demonstrated in rat salivary and lacrimal glands, cornea, and lung…”
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Are Guidelines Mantra? Musings About Uncertainty in Medicine by Lee, Douglas, MD, PhD

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Reversal of COPD-associated weight loss using the anabolic agent oxandrolone by Yeh, Shing-Shing, DeGuzman, Bernadette, Kramer, Ted

“…Weight loss is a common complication of COPD, associated with negative outcomes. Weight restoration has been associated with improved outcomes. The effects of…”
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The Human AQP4 Gene: Definition of the Locus Encoding Two Water Channel Polypeptides in Brain by Lu, Mingqi, Lee, M. Douglas, Smith, Barbara L., Jung, Jin Sup, Agre, Peter, Marian A. J. Verdijk, Merkx, Gerard, Johan P. L. Rijss, Peter M. T. Deen

“…The aquaporin family of membrane water transport proteins are expressed in diverse tissues, and in brain the predominant water channel protein is AQP4. Here we…”
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Left Ventricular Hypertrophy Patterns and Incidence of Heart Failure With Preserved Versus Reduced Ejection Fraction by Velagaleti, Raghava S., MD, Gona, Philimon, PhD, Pencina, Michael J., PhD, Aragam, Jayashri, MD, Wang, Thomas J., MD, Levy, Daniel, MD, D'Agostino, Ralph B., PhD, Lee, Douglas S., MD, Kannel, William B., MD, Benjamin, Emelia J., MD, ScM, Vasan, Ramachandran S., MD

“…Higher left ventricular (LV) mass, wall thickness, and internal dimension are associated with increased heart failure (HF) risk. Whether different LV…”
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Patient engagement in a trial testing a new strategy of care for acute heart failure by Lee, Douglas S., MD PhD, Armstrong, Robert, RN BScN, Mohamed, Shanas

“…About 1 million emergency department visits for heart failure occur annually in North America. After initial stabilization and symptom control, a decision must…”
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Associations Between Short or Long Length of Stay and 30-Day Readmission and Mortality in Hospitalized Patients With Heart Failure by Sud, Maneesh, MD, Yu, Bing, PhD, Wijeysundera, Harindra C., MD, PhD, Austin, Peter C., PhD, Ko, Dennis T., MD, MSc, Braga, Juarez, MD, Cram, Peter, MD, MBA, Spertus, John A., MD, MPH, Domanski, Michael, MD, Lee, Douglas S., MD, PhD

“…Abstract Objectives This study sought to examine the associations between heart failure (HF)-related hospital length of stay and 30-day readmissions and HF…”
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Implementation of the Comparison of Outcomes and Access to Care for Heart Failure (COACH) TrialKey Findings by Christine Fahim, PhD, MSc, Ayaat T. Hassan, MSc, Elikem Togo, MPH, Heather Ross, Sharon E. Straus, MD, Msc, Douglas S. Lee, MD, PhD

“…Background: The Comparison of Outcomes and Access to Care for Heart Failure (COACH) trial demonstrated that use of a point-of-care risk assessment tool and a…”
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Effect of early physician follow-up on mortality and subsequent hospital admissions after emergency care for heart failure: a retrospective cohort study by Atzema, Clare L., MD MSc, Austin, Peter C., PhD, Yu, Bing, PhD, Schull, Michael J., MD MSc, Jackevicius, Cynthia A., PharmD MSc, Ivers, Noah M., MD PhD, Rochon, Paula A., MD MPH, Lee, Douglas S., MD PhD

“…ABSTRACT BACKGROUND The 1-year mortality rate in patients with heart failure who are discharged from an emergency department is 20%. We sought to determine…”
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The Canadian Alliance for Healthy Hearts and Minds: How Well Does It Reflect the Canadian Population? by Hall, Ruth E., Tusevljak, Natasa, Wu, C. Fangyun, Ibrahim, Quazi, Schulze, Karleen, Khan, Anam M., Desai, Dipika, Awadalla, Philip, Broet, Philippe, Dummer, Trevor J.B., Hicks, Jason, Tardif, Jean-Claude, Teo, Koon K., Vena, Jennifer, Lee, Douglas, Friedrich, Matthias, Anand, Sonia S., Tu, Jack V.

“…The intent of the Canadian Alliance for Healthy Hearts and Minds (CAHHM) cohort is to understand the early determinants of subclinical cardiac and vascular…”
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Risk Stratification in Acute Heart Failure by Lee, Douglas S., MD, PhD, Ezekowitz, Justin A., MBBCh, MSc

“…Abstract Acute heart failure is a leading reason for emergency department visits, hospital admissions, and readmissions. Despite the high rate of…”
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The human Aquaporin-5 gene. Molecular characterization and chromosomal localization by Lee, M D, Bhakta, K Y, Raina, S, Yonescu, R, Griffin, C A, Copeland, N G, Gilbert, D J, Jenkins, N A, Preston, G M, Agre, P

“…The cDNA for the fifth mammalian aquaporin (AQP5) was isolated from rat, and expression was demonstrated in rat salivary and lacrimal glands, cornea, and lung…”
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Long-term mortality risk stratification of liver transplant recipients: real-time application of deep learning algorithms on longitudinal data by Nitski, Osvald, Azhie, Amirhossein, Qazi-Arisar, Fakhar Ali, Wang, Xueqi, Ma, Shihao, Lilly, Leslie, Watt, Kymberly D, Levitsky, Josh, Asrani, Sumeet K, Lee, Douglas S, Rubin, Barry B, Bhat, Mamatha, Wang, Bo

“…Survival of liver transplant recipients beyond 1 year since transplantation is compromised by an increased risk of cancer, cardiovascular events, infection,…”
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Comparison of processes of care and clinical outcomes for patients newly hospitalized for heart failure attended by different physician specialists by Boom, Nicole K., MSc, Lee, Douglas S., MD, PhD, Tu, Jack V., MD, PhD

“…Background Previous studies suggest that patients with heart failure (HF) treated by cardiologists have improved outcomes compared with patients treated by…”
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Reinitiation of Anticoagulation After Warfarin-Associated Intracranial Hemorrhage and Mortality Risk: The Best Practice for Reinitiating Anticoagulation Therapy After Intracranial Bleeding (BRAIN) Study by Yung, Derek, MD, Kapral, Moira K., MD, MSc, Asllani, Eriola, MSc, Fang, Jiming, PhD, Lee, Douglas S., MD, PhD

“…Abstract Background While warfarin-related intracranial hemorrhage (ICH) occurs in 0.25%-1.1% patients per year, little is known about the practice and…”
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Diuretic dose and long-term outcomes in elderly patients with heart failure after hospitalization by Abdel-Qadir, Husam M., MD, Tu, Jack V., MD, PhD, Yun, Lingsong, MSc, Austin, Peter C., PhD, Newton, Gary E., MD, Lee, Douglas S., MD, PhD

“…Background The array of outcomes according to longitudinal furosemide doses in heart failure (HF) have not been evaluated. We examined the relationship of…”
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