Search Results - "Lee, Linus H"

Selective mTORC2 Inhibitor Therapeutically Blocks Breast Cancer Cell Growth and Survival by Werfel, Thomas A, Wang, Shan, Jackson, Meredith A, Kavanaugh, Taylor E, Joly, Meghan Morrison, Lee, Linus H, Hicks, Donna J, Sanchez, Violeta, Ericsson, Paula Gonzalez, Kilchrist, Kameron V, Dimobi, Somtochukwu C, Sarett, Samantha M, Brantley-Sieders, Dana M, Cook, Rebecca S, Duvall, Craig L

“…Small-molecule inhibitors of the mTORC2 kinase (torkinibs) have shown efficacy in early clinical trials. However, the torkinibs under study also inhibit the…”
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Structural optimization of siRNA conjugates for albumin binding achieves effective MCL1-directed cancer therapy by Hoogenboezem, Ella N., Patel, Shrusti S., Lo, Justin H., Cavnar, Ashley B., Babb, Lauren M., Francini, Nora, Gbur, Eva F., Patil, Prarthana, Colazo, Juan M., Michell, Danielle L., Sanchez, Violeta M., McCune, Joshua T., Ma, Jinqi, DeJulius, Carlisle R., Lee, Linus H., Rosch, Jonah C., Allen, Ryan M., Stokes, Larry D., Hill, Jordan L., Vickers, Kasey C., Cook, Rebecca S., Duvall, Craig L.

“…The high potential of siRNAs to silence oncogenic drivers remains largely untapped due to the challenges of tumor cell delivery. Here, divalent…”
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