Search Results - "Lee, Leo T.O."

Understanding the functions of kisspeptin and kisspeptin receptor (Kiss1R) from clinical case studies by Ke, Ran, Ma, Xin, Lee, Leo T.O.

“…•Kisspeptin/Kiss1R mutations can induce endocrine diseases such as CPP and IHH.•Mutations influence kisspeptin/Kiss1R transcription.•Mutations damage…”
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Functional Pairing of Class B1 Ligand-GPCR in Cephalochordate Provides Evidence of the Origin of PTH and PACAP/Glucagon Receptor Family by On, Jason S W, Duan, Cumming, Chow, Billy K C, Lee, Leo T O

“…Several hypotheses have been proposed regarding the origin and evolution of the secretin family of peptides and receptors. However, identification of…”
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Orexins and their receptors from fish to mammals: A comparative approach by Wong, Kari K.Y, Ng, Stephanie Y.L, Lee, Leo T.O, Ng, Hans K.H, Chow, Billy K.C

“…Research highlights ► Orexins’ are under strong evolutionary pressure to preserve structure and functions. ► OX2R is evolutionary more ancient. ► OX1R likely…”
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Secretin as a neurohypophysial factor regulating body water homeostasis by Chu, Jessica Y.S, Lee, Leo T.O, Lai, C.H, Vaudry, H, Chan, Y.S, Yung, W.H, Chow, Billy K.C

“…Hypothalamic magnocellular neurons express either one of the neurohypophysial hormones, vasopressin or oxytocin, along with different neuropeptides or…”
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Discovery of growth hormone-releasing hormones and receptors in nonmammalian vertebrates by Lee, Leo T.O, Siu, Francis K.Y, Tam, Janice K.V, Lau, Ivy T.Y, Wong, Anderson O.L, Lin, Marie C.M, Vaudry, Hubert, Chow, Billy K.C

“…In mammals, growth hormone-releasing hormone (GHRH) is the most important neuroendocrine factor that stimulates the release of growth hormone (GH) from the…”
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Gonadotropin-releasing hormone: regulation of the GnRH gene by Lee, Vien H.Y, Lee, Leo T.O, Chow, Billy K.C

“…As the key regulator of reproduction, gonadotropin-releasing hormone (GnRH) is released by neurons in the hypothalamus, and transported via the…”
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Discovery of a new reproductive hormone in teleosts: Pituitary adenylate cyclase-activating polypeptide-related peptide (PRP) by Tam, Janice K.V, Lee, Leo T.O, Cheng, Christopher H.K, Chow, Billy K.C

“…Highlights ► gfPRP/PACAP and PRPR mRNAs co-expressed in the BPG axis. ► gfPRP stimulation utilizes cAMP signaling pathway. ► gfPRP is unable to stimulate GH…”
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Southwestern blotting in investigating transcriptional regulation by Chow, Billy K C, Siu, Francis K Y, Lee, Leo T O

“…Southwestern blotting is used to investigate DNA–protein interactions. The advantage of this technique over other related methods such as electrophoretic…”
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Molecular cloning of a teleost growth hormone receptor and its functional interaction with human growth hormone by Lee, Leo T.O, Nong, G, Chan, Y.H, Tse, Dicky L.Y, Cheng, Christopher H.K

“…This paper reports the first full-length cDNA sequence of a growth hormone receptor (GHR) from a teleost fish and its functional expression in cultured…”
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Identification of Repressor Element 1 in Secretin/PACAP/VIP Genes by LEE, LEO T.O., LEE, VIEN H.Y., YUAN, PAULA Y., CHOW, BILLY K.C.

“…:  Repressor element 1 (RE‐1) is a negative, cis‐acting regulatory element that interacts with the transcription factor RE‐1‐silencing transcription factor…”
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Abstract 3075: Different roles of EPAC1 and EPAC2 in ovarian cancer: Implications for precision targeting in cancer therapy by Gao, Zhengyin, Yuan, Wanjun, Lee, Leo T.O.

“…There are two distinct functional isoforms of Exchange proteins directly activated by cAMP (EPACs), EPAC1 and EPAC2, which exhibit fundamental distinctions in…”
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Molecular cloning and expression studies of a prolactin receptor in goldfish ( Carassius auratus) by Tse, Dicky L.Y., Chow, Billy K.C., Chan, C.B., Lee, Leo T.O., Cheng, Christopher H.K.

“…A full-length cDNA clone, of a size of 4.6 kb, for the goldfish prolactin receptor has been isolated. This cDNA clone encodes a protein of 600 amino acids…”
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Lipopolysaccharide induces mouse translocator protein by Shimoyama, Shuji, Furukawa, Tomonori, Ogata, Yoshiki, Nikaido, Yoshikazu, Koga, Kohei, Sakamoto, Yui, Ueno, Shinya, Nakamura, Kazuhiko, Lee, Leo T.O

“…It has been reported that neuroinflammation occurs in the central nervous system (CNS) in patients with neuropathic pain, Alzheimer's disease and autism…”
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Lipopolysaccharide induces mouse translocator protein (18 kDa) expression via the AP-1 complex in the microglial cell line, BV-2 by Shimoyama, Shuji, Furukawa, Tomonori, Ogata, Yoshiki, Nikaido, Yoshikazu, Koga, Kohei, Sakamoto, Yui, Ueno, Shinya, Nakamura, Kazuhiko

“…It has been reported that neuroinflammation occurs in the central nervous system (CNS) in patients with neuropathic pain, Alzheimer's disease and autism…”
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GIP receptor suppresses PAC1receptor‐mediated neuronal differentiation via formation of a receptor heterocomplex by Ke, Ran, Lok, Samson I. S., Singh, Kailash, Chow, Billy K. C., Lee, Leo T. O.

“…Pituitary adenylate cyclase‐activating peptide (PACAP) receptor (PAC1R) is a class B Gprotein‐coupled receptor (GPCR) that is widely expressed in the human…”
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Transmembrane peptides as unique tools to demonstrate the in vivo action of a cross‐class GPCR heterocomplex by Lee, Leo T. O., Ng, Stephanie Y. L., Chu, Jessica Y. S., Sekar, Revathi, Harikumar, Kaleeckal G., Miller, Laurence J., Chow, Billy K. C.

“…ABSTRACT Angiotensin (ANGII) and secretin (SCT) share overlapping, interdependent osmoregulatory functions in brain, where SCT peptide/receptor function is…”
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Structure and Function of Cross-class Complexes of G Protein-coupled Secretin and Angiotensin 1a Receptors by Harikumar, Kaleeckal G., Augustine, Mary Lou, Lee, Leo T.O., Chow, Billy K.C., Miller, Laurence J.

“…Complexes of secretin (SecR) and angiotensin 1a (Atr1a) receptors have been proposed to be functionally important in osmoregulation, providing an explanation…”
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Editorial: Neuroendocrine Research in Health and Disease by Wang, Yu-Feng, Chen, Xuequn, Sha, Lei, Kendrick, Keith M, Lee, Leo T O, Cheng, Christopher H K

“…The result confirmed that a genetic predisposition to higher serum morning cortisol levels is associated with an increased depression score. [...]Wu R. et al…”
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An indispensable role of secretin in mediating the osmoregulatory functions of angiotensin II by Lee, Vien H Y, Lee, Leo T O, Chu, Jessica Y S, Lam, Ian P Y, Siu, Francis K Y, Vaudry, Hubert, Chow, Billy K C

“…Fluid balance is critical to life and hence is tightly controlled in the body. Angiotensin II (ANGII), one of the most important components of this regulatory…”
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Agnathan VIP, PACAP and their receptors: ancestral origins of today's highly diversified forms by Ng, Stephanie Y L, Chow, Billy K C, Kasamatsu, Jun, Kasahara, Masanori, Lee, Leo T O

“…VIP and PACAP are pleiotropic peptides belonging to the secretin superfamily of brain-gut peptides and interact specifically with three receptors (VPAC(1),…”
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