Search Results - "Lee, Kyongbum"

Monoethylhexyl Phthalate Elicits an Inflammatory Response in Adipocytes Characterized by Alterations in Lipid and Cytokine Pathways by Manteiga, Sara, Lee, Kyongbum

“…A growing body of evidence links endocrine-disrupting chemicals (EDCs) with obesity-related metabolic diseases. While it has been shown that EDCs can…”
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Gut Microbiota-Derived Tryptophan Metabolites Modulate Inflammatory Response in Hepatocytes and Macrophages by Krishnan, Smitha, Ding, Yufang, Saedi, Nima, Choi, Maria, Sridharan, Gautham V., Sherr, David H., Yarmush, Martin L., Alaniz, Robert C., Jayaraman, Arul, Lee, Kyongbum

“…The gut microbiota plays a significant role in the progression of fatty liver disease; however, the mediators and their mechanisms remain to be elucidated…”
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Engineering Selectively Targeting Antimicrobial Peptides by Lei, Ming, Jayaraman, Arul, Van Deventer, James A, Lee, Kyongbum

“…The rise of antibiotic-resistant strains of bacterial pathogens has necessitated the development of new therapeutics. Antimicrobial peptides (AMPs) are a class…”
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Parabacteroides distasonis attenuates toll‐like receptor 4 signaling and Akt activation and blocks colon tumor formation in high‐fat diet‐fed azoxymethane‐treated mice by Koh, Gar Yee, Kane, Anne, Lee, Kyongbum, Xu, Qiaobing, Wu, Xian, Roper, Jatin, Mason, Joel B., Crott, Jimmy W.

“…Gut dysbiosis may play an etiological role in colorectal tumorigenesis. We previously observed that the abundance of Parabacteroides distasonis (Pd) in stool…”
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Prediction and quantification of bioactive microbiota metabolites in the mouse gut by Sridharan, Gautham V., Choi, Kyungoh, Klemashevich, Cory, Wu, Charmian, Prabakaran, Darshan, Pan, Long Bin, Steinmeyer, Shelby, Mueller, Carrie, Yousofshahi, Mona, Alaniz, Robert C., Lee, Kyongbum, Jayaraman, Arul

“…Metabolites produced by the intestinal microbiota are potentially important physiological modulators. Here we present a metabolomics strategy that models…”
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Endogenous Two-Photon Fluorescence Imaging Elucidates Metabolic Changes Related to Enhanced Glycolysis and Glutamine Consumption in Precancerous Epithelial Tissues by VARONE, Antonio, XYLAS, Joanna, QUINN, Kyle P, POULI, Dimitra, SRIDHARAN, Gautham, MCLAUGHLIN-DRUBIN, Margaret E, ALONZO, Carlo, KYONGBUM LEE, MUNGER, Karl, GEORGAKOUDI, Irene

“…Alterations in the balance between different metabolic pathways used to meet cellular bioenergetic and biosynthetic demands are considered hallmarks of cancer…”
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An algorithm for modularity analysis of directed and weighted biological networks based on edge-betweenness centrality by Yoon, Jeongah, Blumer, Anselm, Lee, Kyongbum

“…Motivation: Modularity analysis is a powerful tool for studying the design of biological networks, offering potential clues for relating the biochemical…”
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Biologically Consistent Annotation of Metabolomics Data by Alden, Nicholas, Krishnan, Smitha, Porokhin, Vladimir, Raju, Ravali, McElearney, Kyle, Gilbert, Alan, Lee, Kyongbum

“…Annotation of metabolites remains a major challenge in liquid chromatography–mass spectrometry (LC–MS) based untargeted metabolomics. The current gold standard…”
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Quantitative metabolic imaging using endogenous fluorescence to detect stem cell differentiation by Quinn, Kyle P., Sridharan, Gautham V., Hayden, Rebecca S., Kaplan, David L., Lee, Kyongbum, Georgakoudi, Irene

“…The non-invasive high-resolution spatial mapping of cell metabolism within tissues could provide substantial advancements in assessing the efficacy of stem…”
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Oral supplementation of gut microbial metabolite indole-3-acetate alleviates diet-induced steatosis and inflammation in mice by Ding, Yufang, Yanagi, Karin, Yang, Fang, Callaway, Evelyn, Cheng, Clint, Hensel, Martha E, Menon, Rani, Alaniz, Robert C, Lee, Kyongbum, Jayaraman, Arul

“…Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in Western countries. There is growing evidence that dysbiosis of the…”
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Novel In Vivo-Degradable Cellulose-Chitin Copolymer from Metabolically Engineered Gluconacetobacter xylinus by Yadav, Vikas, Paniliatis, Bruce J, Shi, Hai, Lee, Kyongbum, Cebe, Peggy, Kaplan, David L

“…Despite excellent biocompatibility and mechanical properties, the poor in vitro and in vivo degradability of cellulose has limited its biomedical and biomass…”
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Flavone and Hydroxyflavones Are Ligands That Bind the Orphan Nuclear Receptor 4A1 (NR4A1) by Lee, Miok, Upadhyay, Srijana, Mariyam, Fuada, Martin, Greg, Hailemariam, Amanuel, Lee, Kyongbum, Jayaraman, Arul, Chapkin, Robert S, Lee, Syng-Ook, Safe, Stephen

“…It was recently reported that the hydroxyflavones quercetin and kaempferol bind the orphan nuclear receptor 4A1 (NR4A1, Nur77) and act as antagonists in cancer…”
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Isoflavones as Ah Receptor Agonists in Colon-Derived Cell Lines: Structure–Activity Relationships by Park, Hyejin, Jin, Un-Ho, Orr, Asuka A, Echegaray, Stephanie P, Davidson, Laurie A, Allred, Clinton D, Chapkin, Robert S, Jayaraman, Arul, Lee, Kyongbum, Tamamis, Phanourios, Safe, Stephen

“…Many of the protective responses observed for flavonoids in the gastrointestinal track resemble aryl hydrocarbon receptor (AhR)-mediated effects. Therefore, we…”
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Effect of diet and intestinal AhR expression on fecal microbiome and metabolomic profiles by Yang, Fang, DeLuca, Jennifer A A, Menon, Rani, Garcia-Vilarato, Erika, Callaway, Evelyn, Landrock, Kerstin K, Lee, Kyongbum, Safe, Stephen H, Chapkin, Robert S, Allred, Clinton D, Jayaraman, Arul

“…Diet, loss of aryl hydrocarbon receptor (AhR) expression and their modification of the gut microbiota community composition and its metabolites affect the…”
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A Metabolomics Approach to Increasing Chinese Hamster Ovary (CHO) Cell Productivity by Yao, Grace, Aron, Kathryn, Borys, Michael, Li, Zhengjian, Pendse, Girish, Lee, Kyongbum

“…Much progress has been made in improving the viable cell density of bioreactor cultures in monoclonal antibody production from Chinese hamster ovary (CHO)…”
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Dietary spinach reshapes the gut microbiome in an Apc-mutant genetic background: mechanistic insights from integrated multi-omics by Chen, Ying-Shiuan, Li, Jia, Menon, Rani, Jayaraman, Arul, Lee, Kyongbum, Huang, Yun, Dashwood, Wan Mohaiza, Zhang, Ke, Sun, Deqiang, Dashwood, Roderick H.

“…Complex interrelationships govern the dynamic interactions between gut microbes, the host, and exogenous drivers of disease outcome. A multi-omics approach to…”
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PreProPath: An Uncertainty-Aware Algorithm for Identifying Predictable Profitable Pathways in Biochemical Networks by Ullah, Ehsan, Walker, Mark, Kyongbum Lee, Hassoun, Soha

“…Pathway analysis is a powerful approach to enable rational design or redesign of biochemical networks for optimizing metabolic engineering and synthetic…”
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Using Metabolomics to Identify Cell Line-Independent Indicators of Growth Inhibition for Chinese Hamster Ovary Cell-based Bioprocesses by Alden, Nicholas, Raju, Ravali, McElearney, Kyle, Lambropoulos, James, Kshirsagar, Rashmi, Gilbert, Alan, Lee, Kyongbum

“…Chinese hamster ovary (CHO) cells are widely used for the production of biopharmaceuticals. Efforts to improve productivity through medium design and feeding…”
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Towards high resolution analysis of metabolic flux in cells and tissues by Sims, James K, Manteiga, Sara, Lee, Kyongbum

“…Graphical abstract…”
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Biological Filtering and Substrate Promiscuity Prediction for Annotating Untargeted Metabolomics by Hassanpour, Neda, Alden, Nicholas, Menon, Rani, Jayaraman, Arul, Lee, Kyongbum, Hassoun, Soha

“…Mass spectrometry coupled with chromatography separation techniques provides a powerful platform for untargeted metabolomics. Determining the chemical…”
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