Search Results - "Lee, Katherine S"

SARS-CoV-2 Delta variant induces enhanced pathology and inflammatory responses in K18-hACE2 mice by Lee, Katherine S, Wong, Ting Y, Russ, Brynnan P, Horspool, Alexander M, Miller, Olivia A, Rader, Nathaniel A, Givi, Jerome P, Winters, Michael T, Wong, Zeriel Y A, Cyphert, Holly A, Denvir, James, Stoilov, Peter, Barbier, Mariette, Roan, Nadia R, Amin, Md Shahrier, Martinez, Ivan, Bevere, Justin R, Damron, F Heath

“…The COVID-19 pandemic has been fueled by SARS-CoV-2 novel variants of concern (VOC) that have increased transmissibility, receptor binding affinity, and other…”
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Intranasal COVID-19 vaccine induces respiratory memory T cells and protects K18-hACE mice against SARS-CoV-2 infection by Diallo, Béré K., Ní Chasaide, Caitlín, Wong, Ting Y., Schmitt, Pauline, Lee, Katherine S., Weaver, Kelly, Miller, Olivia, Cooper, Melissa, Jazayeri, Seyed D., Damron, F. Heath, Mills, Kingston H. G.

“…Current COVID-19 vaccines prevent severe disease, but do not induce mucosal immunity or prevent infection with SARS-CoV-2, especially with recent variants…”
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Human sensory neurons derived from induced pluripotent stem cells support varicella-zoster virus infection by Lee, Katherine S, Zhou, Wenbo, Scott-McKean, Jonah J, Emmerling, Kaitlin L, Cai, Guang-yun, Krah, David L, Costa, Alberto C, Freed, Curt R, Levin, Myron J

“…After primary infection, varicella-zoster virus (VZV) establishes latency in neurons of the dorsal root and trigeminal ganglia. Many questions concerning the…”
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Passive immunization with equine RBD-specific Fab protects K18-hACE2-mice against Alpha or Beta variants of SARS-CoV-2 by Barbier, Mariette, Lee, Katherine S., Vikharankar, Mayur S., Rajpathak, Shriram N., Kadam, Nandkumar, Wong, Ting Y., Russ, Brynnan P., Cyphert, Holly A., Miller, Olivia A., Rader, Nathaniel A., Cooper, Melissa, Kang, Jason, Sen-Kilic, Emel, Wong, Zeriel Y., Winters, Michael T., Bevere, Justin R., Martinez, Ivan, Devarumath, Rachayya, Shaligram, Umesh S., Damron, F. Heath

“…Emergence of variants of concern (VOC) during the COVID-19 pandemic has contributed to the decreased efficacy of therapeutic monoclonal antibody treatments for…”
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Intranasal administration of BReC-CoV-2 COVID-19 vaccine protects K18-hACE2 mice against lethal SARS-CoV-2 challenge by Wong, Ting Y., Lee, Katherine S., Russ, Brynnan P., Horspool, Alexander M., Kang, Jason, Winters, Michael T., Allison Wolf, M., Rader, Nathaniel A., Miller, Olivia A., Shiflett, Morgane, Izac, Jerilyn, Varisco, David, Sen-Kilic, Emel, Cunningham, Casey, Cooper, Melissa, Cyphert, Holly A., Barbier, Mariette, Martinez, Ivan, Bevere, Justin R., Ernst, Robert K., Damron, F. Heath

“…SARS-CoV-2 is a viral respiratory pathogen responsible for the current global pandemic and the disease that causes COVID-19. All current WHO approved COVID-19…”
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Influenza virus strains expressing SARS-CoV-2 receptor binding domain protein confer immunity in K18-hACE2 mice by Rader, Nathaniel A., Lee, Katherine S., Loes, Andrea N., Miller-Stump, Olivia A., Cooper, Melissa, Wong, Ting Y., Boehm, Dylan T., Barbier, Mariette, Bevere, Justin R., Heath Damron, F.

“…•ΔNA(RBD) is an influenza virus-based vaccine for SARS-CoV-2.•ΔNA(RBD) is genetically engineered to express RBD in the NA gene locus.•Infected mice vaccinated…”
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Obesity and metabolic dysfunction drive sex-associated differential disease profiles in hACE2-mice challenged with SARS-CoV-2 by Lee, Katherine S., Russ, Brynnan P., Wong, Ting Y., Horspool, Alexander M., Winters, Michael T., Barbier, Mariette, Bevere, Justin R., Martinez, Ivan, Damron, F. Heath, Cyphert, Holly A.

“…Severe outcomes from SARS-CoV-2 infection are highly associated with preexisting comorbid conditions like hypertension, diabetes, and obesity. We utilized the…”
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Murine Gammaherpesvirus 68 Infection of Gamma Interferon-Deficient Mice on a BALB/c Background Results in Acute Lethal Pneumonia That Is Dependent on Specific Viral Genes by LEE, Katherine S, COOL, Carlyne D, VAN DYK, Linda F

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Viral cyclins mediate separate phases of infection by integrating functions of distinct mammalian cyclins by Lee, Katherine S, Suarez, Andrea L, Claypool, David J, Armstrong, Taylor K, Buckingham, Erin M, van Dyk, Linda F

“…Gammaherpesvirus cyclins have expanded biochemical features relative to mammalian cyclins, and promote infection and pathogenesis including acute lung…”
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Varicella-zoster virus inhibits autophagosome-lysosome fusion and the degradation stage of mTOR-mediated autophagic flux by Graybill, Chiharu, Morgan, Michael J., Levin, Myron J., Lee, Katherine S.

“…Macroautophagy (herein referred to as autophagy) is a lysosomal degradation mechanism that is important for maintaining homeostasis and for coping with…”
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Intranasal VLP-RBD vaccine adjuvanted with BECC470 confers immunity against Delta SARS-CoV-2 challenge in K18-hACE2-mice by Lee, Katherine S., Rader, Nathaniel A., Miller-Stump, Olivia A., Cooper, Melissa, Wong, Ting Y., Shahrier Amin, Md, Barbier, Mariette, Bevere, Justin R., Ernst, Robert K., Heath Damron, F.

“…As the COVID-19 pandemic transitions into endemicity, seasonal boosters are a plausible reality across the globe. We hypothesize that intranasal vaccines can…”
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Evaluating Antibody Mediated Protection against Alpha, Beta, and Delta SARS-CoV-2 Variants of Concern in K18-hACE2 Transgenic Mice by Wong, Ting Y, Horspool, Alexander M, Russ, Brynnan P, Ye, Chengjin, Lee, Katherine S, Winters, Michael T, Bevere, Justin R, Miller, Olivia A, Rader, Nathaniel A, Cooper, Melissa, Kieffer, Theodore, Sourimant, Julien, Greninger, Alexander L, Plemper, Richard K, Denvir, James, Cyphert, Holly A, Barbier, Mariette, Torrelles, Jordi B, Martinez, Ivan, Martinez-Sobrido, Luis, Damron, F Heath

“…SARS-CoV-2 variants of concern (VoC) are impacting responses to the COVID-19 pandemic. Here, we utilized passive immunization using human convalescent plasma…”
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Cytokines Produced in Response to Varicella-Zoster Virus Infection of ARPE-19 Cells Stimulate Lymphocyte Chemotaxis by Graybill, Chiharu, Claypool, David J., Brinton, John T., Levin, Myron J., Lee, Katherine S.

“…Posterior uveitis is an ocular complication that can occur with reactivation of varicella-zoster virus (VZV). It may lead to loss of vision due to retinal…”
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Varicella-Zoster Virus DNA in Blood After Administration of Herpes Zoster Vaccine by Levin, Myron J, Cai, Guang-Yun, Lee, Katherine S, Rouphael, Nadine G, Mehta, Aneesh K, Canniff, Jennifer, Mulligan, Mark J, Weinberg, Adriana

“…Varicella-zoster virus (VZV) DNA is common in the blood after administration of live-attenuated herpes zoster vaccine. The extent that this reflects viral…”
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SARS-CoV-2 Delta variant induces enhanced pathology and inflammatory responses in K18-hACE2 mice by Katherine S. Lee, Ting Y. Wong, Brynnan P. Russ, Alexander M. Horspool, Olivia A. Miller, Nathaniel A. Rader, Jerome P. Givi, Michael T. Winters, Zeriel Y. A. Wong, Holly A. Cyphert, James Denvir, Peter Stoilov, Mariette Barbier, Nadia R. Roan, Md. Shahrier Amin, Ivan Martinez, Justin R. Bevere, F. Heath Damron

“…The COVID-19 pandemic has been fueled by SARS-CoV-2 novel variants of concern (VOC) that have increased transmissibility, receptor binding affinity, and other…”
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Molecular engineering of a cryptic epitope in Spike RBD improves manufacturability and neutralizing breadth against SARS-CoV-2 variants by Rodriguez-Aponte, Sergio A., Dalvie, Neil C., Wong, Ting Y., Johnston, Ryan S., Naranjo, Christopher A., Bajoria, Sakshi, Kumru, Ozan S., Kaur, Kawaljit, Russ, Brynnan P., Lee, Katherine S., Cyphert, Holly A., Barbier, Mariette, Rao, Harish D., Rajurkar, Meghraj P., Lothe, Rakesh R., Shaligram, Umesh S., Batwal, Saurabh, Chandrasekaran, Rahul, Nagar, Gaurav, Kleanthous, Harry, Biswas, Sumi, Bevere, Justin R., Joshi, Sangeeta B., Volkin, David B., Damron, F. Heath, Love, J. Christopher

“…•RDB-J6 (RBD-S383D-L452K-F490W-L518D) exhibits improved manufacturability.•RBD-J6 is recognized by human convalescent sera and neutralizing antibodies.•A…”
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Endogenous CD4⁺ CD25⁺ Regulatory T Cells Play No Apparent Role in the Acute Humoral Response to Intact Streptococcus pneumoniae by Lee, Katherine S, Sen, Goutam, Snapper, Clifford M

“…Immunoglobulin G (IgG) antiprotein and antipolysaccharide responses to intact Streptococcus pneumoniae are CD4⁺-T-cell dependent and therefore might be under…”
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Targeted Genome Sequencing Reveals Varicella-Zoster Virus Open Reading Frame 12 Deletion by Cohrs, Randall J, Lee, Katherine S, Beach, Addilynn, Sanford, Bridget, Baird, Nicholas L, Como, Christina, Graybill, Chiharu, Jones, Dallas, Tekeste, Eden, Ballard, Mitchell, Chen, Xiaomi, Yalacki, David, Frietze, Seth, Jones, Kenneth, Lenac Rovis, Tihana, Jonjić, Stipan, Haas, Jürgen, Gilden, Don

“…The neurotropic herpesvirus varicella-zoster virus (VZV) establishes a lifelong latent infection in humans following primary infection. The low abundance of…”
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RBD-VLP Vaccines Adjuvanted with Alum or SWE Protect K18-hACE2 Mice against SARS-CoV-2 VOC Challenge by Wong, Ting Y, Russ, Brynnan P, Lee, Katherine S, Miller, Olivia A, Kang, Jason, Cooper, Melissa, Winters, Michael T, Rodriguez-Aponte, Sergio A, Dalvie, Neil C, Johnston, Ryan S, Rader, Nathaniel A, Wong, Zeriel Y, Cyphert, Holly A, Martinez, Ivan, Shaligram, Umesh, Batwal, Saurabh, Lothe, Rakesh, Chandrasekaran, Rahul, Nagar, Gaurav, Rajurkar, Meghraj, Rao, Harish, Bevere, Justin R, Barbier, Mariette, Love, J Christopher, Damron, F Heath

“…The ongoing COVID-19 pandemic has contributed largely to the global vaccine disparity. Development of protein subunit vaccines can help alleviate shortages of…”
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Murine Gammaherpesvirus 68 Infection of IFNγ Unresponsive Mice: A Small Animal Model for Gammaherpesvirus-Associated B-Cell Lymphoproliferative Disease by LEE, Katherine S, GROSHONG, Steve D, COOL, Carlyne D, KLEINSCHMIDT-DEMASTERS, Bette K, VAN DYK, Linda F

“…Abstract Gammaherpesviruses are tightly controlled by the host immune response, with gammaherpesvirus-associated malignancies prevalent in immune-suppressed…”
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