Search Results - "Lee, Ka Yee C"
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Antimicrobial Peptides Share a Common Interaction Driven by Membrane Line Tension Reduction
Published in Biophysical journal (15-11-2016)“…Antimicrobial peptides (AMPs) are a class of host-defense molecules that neutralize a broad range of pathogens. Their membrane-permeabilizing behavior has been…”
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Celebrating Soft Matter's 10th anniversary: screening of the calcium-induced spontaneous curvature of lipid membranes
Published in Soft matter (01-01-2015)“…Lipid membranes are key regulators of cellular function. An important step in membrane-related phenomena is the reshaping of the lipid bilayer, often induced…”
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Number of Sialic Acid Residues in Ganglioside Headgroup Affects Interactions with Neighboring Lipids
Published in Biophysical journal (17-09-2013)“…Monolayers of binary mixtures of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and asialo-(GA1), disialo-(GD1b) and trisialo-(GT1b) gangliosides were used…”
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pH-induced metal-ligand cross-links inspired by mussel yield self-healing polymer networks with near-covalent elastic moduli
Published in Proceedings of the National Academy of Sciences - PNAS (15-02-2011)“…Growing evidence supports a critical role of metal-ligand coordination in many attributes of biological materials including adhesion, self-assembly, toughness,…”
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Impact of Surface Amphiphilicity on the Interfacial Behavior of Janus Particle Layers under Compression
Published in Langmuir (03-12-2019)“…Langmuir monolayers of silica/gold Janus particles with two different degrees of amphiphilicity have been examined to study the significance of particle…”
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Glycerol-Induced Membrane Stiffening: The Role of Viscous Fluid Adlayers
Published in Biophysical journal (06-07-2011)“…Lipid interfaces, ranging from cell membranes to thin surfactant layers that stabilize lung alveoli, are integral to living systems. Such interfaces are often…”
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Collapse mechanisms of Langmuir monolayers
Published in Annual review of physical chemistry (01-01-2008)“…When a two-dimensional (2D) film is compressed to its stability limit, it explores the third dimension via collapse. Understanding this 2D-to-3D transition is…”
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Stress and Fold Localization in Thin Elastic Membranes
Published in Science (American Association for the Advancement of Science) (16-05-2008)“…Thin elastic membranes supported on a much softer elastic solid or a fluid deviate from their flat geometries upon compression. We demonstrate that periodic…”
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pH-Based Regulation of Hydrogel Mechanical Properties Through Mussel-Inspired Chemistry and Processing
Published in Advanced functional materials (06-03-2013)“…The mechanical holdfast of the mussel, the byssus, is processed at acidic pH yet functions at alkaline pH. Byssi are enriched in Fe3+ and catechol‐containing…”
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Collapse of Particle-Laden Interfaces under Compression: Buckling vs Particle Expulsion
Published in Langmuir (21-07-2015)“…Colloidal particles can bind to fluid interfaces with a capillary energy that is thousands of times the thermal energy. This phenomenon offers an effective…”
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Nature of Interactions between PEO-PPO-PEO Triblock Copolymers and Lipid Membranes: (I) Effect of Polymer Hydrophobicity on Its Ability to Protect Liposomes from Peroxidation
Published in Biomacromolecules (10-09-2012)“…PEO-PPO-PEO triblock copolymers have opposing effects on lipid membrane integrity: they can behave either as membrane sealants or as membrane permeabilizers…”
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Incommensurate phases of a supported nanoparticle film subjected to uniaxial compression
Published in Proceedings of the National Academy of Sciences - PNAS (15-01-2013)“…We investigate experimentally and theoretically the sequence of phases that occurs when a self-assembled monolayer of gold nanoparticles supported on a fluid…”
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MFG-E8: a model of multiple binding modes associated with ps-binding proteins
Published in The European physical journal. E, Soft matter and biological physics (01-11-2023)“…Membrane-binding proteins often associate with lipid membranes through a singular binding interface which is generally modeled as a two-state system: bound or…”
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Robust Gold Nanoparticle Sheets by Ligand Cross-Linking at the Air–Water Interface
Published in ACS nano (28-02-2017)“…We report the results of cross-linking of two-dimensional gold nanoparticle (Au-NP) assemblies at the air–water interface in situ. We introduce an aqueous…”
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Coupling X-Ray Reflectivity and In Silico Binding to Yield Dynamics of Membrane Recognition by Tim1
Published in Biophysical journal (03-10-2017)“…The dynamic nature of lipid membranes presents significant challenges with respect to understanding the molecular basis of protein/membrane interactions…”
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Molecular mechanism for differential recognition of membrane phosphatidylserine by the immune regulatory receptor Tim4
Published in Proceedings of the National Academy of Sciences - PNAS (15-04-2014)“…Recognition of phosphatidylserine (PS) lipids exposed on the extracellular leaflet of plasma membranes is implicated in both apoptotic cell removal and immune…”
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Headgroup Percolation and Collapse of Condensed Langmuir Monolayers
Published in The journal of physical chemistry. B (09-11-2006)“…We present a study of Langmuir isotherms and 2D bulk moduli of binary lipid mixtures, where changes in monolayer collapse pressure (Πc) are followed while…”
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Mechanism of structural transformations induced by antimicrobial peptides in lipid membranes
Published in Biochimica et biophysica acta (01-02-2012)“…It has long been suggested that pore formation is responsible for the increase in membrane permeability by antimicrobial peptides (AMPs). To better understand…”
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Morphology and Collapse Transitions in Binary Phospholipid Monolayers
Published in The journal of physical chemistry. B (25-10-2001)“…We have concurrently studied the microscopic phase behavior, morphology, and surface pressure−area isotherms of Langmuir monolayers of a 7:3 mixture of DPPC…”
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Amyloid-β Fibrillogenesis Seeded by Interface-Induced Peptide Misfolding and Self-Assembly
Published in Biophysical journal (19-05-2010)“…The amphipathicity of the natively unstructured amyloid-β (Aβ40) peptide may play an important role in its aggregation into β-sheet rich fibrils, which is…”
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