Search Results - "Lee, June‐Koo"

Actin remodeling confers BRAF inhibitor resistance to melanoma cells through YAP/TAZ activation by Kim, Min Hwan, Kim, Jongshin, Hong, Hyowon, Lee, Si-Hyung, Lee, June-Koo, Jung, Eunji, Kim, Joon

“…The activation of transcriptional coactivators YAP and its paralog TAZ has been shown to promote resistance to anti‐cancer therapies. YAP/TAZ activity is…”
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Clinicopathological and Preclinical Findings of NUT Carcinoma: A Multicenter Study by Jung, Minsun, Kim, Soyeon, Lee, June‐Koo, Yoon, Sun Och, Park, Heae Surng, Hong, Soon Won, Park, Weon‐Seo, Kim, Ji Eun, Kim, Joon, Keam, Bhumsuk, Kim, Hyun Jik, Kang, Hyoung Jin, Kim, Dong‐Wan, Jung, Kyeong Cheon, Kim, Young Tae, Heo, Dae Seog, Kim, Tae Min, Jeon, Yoon Kyung

“…Background NUT carcinoma is a rare aggressive disease caused by BRD4/3‐NUT fusion, and C‐MYC upregulation plays a key role in the pathogenesis. Here, we report…”
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Mutalisk: a web-based somatic MUTation AnaLyIS toolKit for genomic, transcriptional and epigenomic signatures by Lee, Jongkeun, Lee, Andy Jinseok, Lee, June-Koo, Park, Jongkeun, Kwon, Youngoh, Park, Seongyeol, Chun, Hyonho, Ju, Young Seok, Hong, Dongwan

“…Abstract Somatic genome mutations occur due to combinations of various intrinsic/extrinsic mutational processes and DNA repair mechanisms. Different molecular…”
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The genome-wide landscape of C:G > T:A polymorphism at the CpG contexts in the human population by Youk, Jeonghwan, An, Yohan, Park, Seongyeol, Lee, June-Koo, Ju, Young Seok

“…The C:G > T:A substitution at the CpG dinucleotide contexts is the most frequent substitution type in genome evolution. The mutational process is obviously…”
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Detecting the mutational signature of homologous recombination deficiency in clinical samples by Gulhan, Doga C., Lee, Jake June-Koo, Melloni, Giorgio E. M., Cortés-Ciriano, Isidro, Park, Peter J.

“…Mutations in BRCA1 and/or BRCA2 ( BRCA1/2 ) are the most common indication of deficiency in the homologous recombination (HR) DNA repair pathway. However,…”
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Tracing Oncogene Rearrangements in the Mutational History of Lung Adenocarcinoma by Lee, Jake June-Koo, Park, Seongyeol, Park, Hansol, Kim, Sehui, Lee, Jongkeun, Lee, Junehawk, Youk, Jeonghwan, Yi, Kijong, An, Yohan, Park, In Kyu, Kang, Chang Hyun, Chung, Doo Hyun, Kim, Tae Min, Jeon, Yoon Kyung, Hong, Dongwan, Park, Peter J., Ju, Young Seok, Kim, Young Tae

“…Mutational processes giving rise to lung adenocarcinomas (LADCs) in non-smokers remain elusive. We analyzed 138 LADC whole genomes, including 83 cases with…”
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An enhanced genetic model of colorectal cancer progression history by Yang, Lixing, Wang, Su, Lee, Jake June-Koo, Lee, Semin, Lee, Eunjung, Shinbrot, Eve, Wheeler, David A, Kucherlapati, Raju, Park, Peter J

“…The classical genetic model of colorectal cancer presents APC mutations as the earliest genomic alterations, followed by KRAS and TP53 mutations. However, the…”
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A systematic review and meta-analysis of individual patient data on the impact of the BIM deletion polymorphism on treatment outcomes in epidermal growth factor receptor mutant lung cancer by Soh, Sheila X, Siddiqui, Fahad J, Allen, John C, Kim, Go Woon, Lee, Jae Cheol, Yatabe, Yasushi, Soda, Manabu, Mano, Hiroyuki, Soo, Ross A, Chin, Tan-Min, Ebi, Hiromichi, Yano, Seiji, Matsuo, Keitaro, Niu, Xiaomin, Lu, Shun, Isobe, Kazutoshi, Lee, Jih-Hsiang, Yang, James C, Zhao, Mingchuan, Zhou, Caicun, Lee, June-Koo, Lee, Se-Hoon, Lee, Ji Yun, Ahn, Myung-Ju, Tan, Tira J, Tan, Daniel S, Tan, Eng-Huat, Ong, S Tiong, Lim, Wan-Teck

“…A germline deletion in the BIM (BCL2L11) gene has been shown to impair the apoptotic response to tyrosine kinase inhibitors (TKIs) in vitro but its association…”
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Actin remodelling factors control ciliogenesis by regulating YAP/TAZ activity and vesicle trafficking by Kim, Jongshin, Jo, Haiin, Hong, Hyowon, Kim, Min Hwan, Kim, Jin Man, Lee, June-Koo, Heo, Won Do, Kim, Joon

“…Primary cilia exert a profound impact on cell signalling and cell cycle progression. Recently, actin cytoskeleton destabilization has been recognized as a…”
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Human glioblastoma arises from subventricular zone cells with low-level driver mutations by Lee, Joo Ho, Lee, Jeong Eun, Kahng, Jee Ye, Kim, Se Hoon, Park, Jun Sung, Yoon, Seon Jin, Um, Ji-Yong, Kim, Woo Kyeong, Lee, June-Koo, Park, Junseong, Kim, Eui Hyun, Lee, Ji-Hyun, Lee, Joon-Hyuk, Chung, Won-Suk, Ju, Young Seok, Park, Sung-Hong, Chang, Jong Hee, Kang, Seok-Gu, Lee, Jeong Ho

“…Glioblastoma (GBM) is a devastating and incurable brain tumour, with a median overall survival of fifteen months 1 , 2 . Identifying the cell of origin that…”
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Mechanisms and Consequences of Cancer Genome Instability: Lessons from Genome Sequencing Studies by Lee, June-Koo, Choi, Yoon-La, Kwon, Mijung, Park, Peter J

“…During tumor evolution, cancer cells can accumulate numerous genetic alterations, ranging from single nucleotide mutations to whole-chromosomal changes…”
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The transcriptional landscape and mutational profile of lung adenocarcinoma by Seo, Jeong-Sun, Ju, Young Seok, Lee, Won-Chul, Shin, Jong-Yeon, Lee, June Koo, Bleazard, Thomas, Lee, Junho, Jung, Yoo Jin, Kim, Jung-Oh, Shin, Jung-Young, Yu, Saet-Byeol, Kim, Jihye, Lee, Eung-Ryoung, Kang, Chang-Hyun, Park, In-Kyu, Rhee, Hwanseok, Lee, Se-Hoon, Kim, Jong-Il, Kang, Jin-Hyoung, Kim, Young Tae

“…All cancers harbor molecular alterations in their genomes. The transcriptional consequences of these somatic mutations have not yet been comprehensively…”
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Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors vs Conventional Chemotherapy in Non–Small Cell Lung Cancer Harboring Wild-Type Epidermal Growth Factor Receptor: A Meta-analysis by Lee, June-Koo, Hahn, Seokyung, Kim, Dong-Wan, Suh, Koung Jin, Keam, Bhumsuk, Kim, Tae Min, Lee, Se-Hoon, Heo, Dae Seog

“…IMPORTANCE Current guidelines recommend both epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) and cytotoxic chemotherapy drugs as…”
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Immunohistochemical screening for anaplastic lymphoma kinase (ALK) rearrangement in advanced non-small cell lung cancer patients by Park, Heae Surng, Lee, June Koo, Kim, Dong-Wan, Kulig, Kimary, Kim, Tae Min, Lee, Se-Hoon, Jeon, Yoon-Kyung, Chung, Doo Hyun, Heo, Dae Seog

“…Abstract Fluorescence in situ hybridization (FISH) is currently used to detect non-small cell lung cancer (NSCLC) patients with anaplastic lymphoma kinase…”
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Terminal cancer patients’ and their primary caregivers’ attitudes toward hospice/palliative care and their effects on actual utilization: A prospective cohort study by An, Ah Reum, Lee, June-Koo, Yun, Young Ho, Heo, Dae Seog

“…Background: Previous studies on hospice/palliative care indicated that patients’ socio-demographic factors, disease status, and availability of health-care…”
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Metabolic and metastatic characteristics of ALK -rearranged lung adenocarcinoma on FDG PET/CT by Choi, Hongyoon, Paeng, Jin Chul, Kim, Dong-Wan, Lee, June Koo, Park, Chang Min, Kang, Keon Wook, Chung, June-Key, Lee, Dong Soo

“…Abstract Introduction ALK rearrangement in lung cancer has been identified as a novel molecular target in lung adenocarcinoma. In this study, we evaluated…”
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Two recent phase 2 trials of vandetanib in RET -rearranged NSCLC by Lee, Se-Hoon, Lee, June-Koo

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Comparative analyses of overall survival in patients with anaplastic lymphoma kinase‐positive and matched wild‐type advanced nonsmall cell lung cancer by Lee, June Koo, Park, Heae Surng, Kim, Dong‐Wan, Kulig, Kimary, Kim, Tae Min, Lee, Se‐Hoon, Jeon, Yoon‐Kyung, Chung, Doo Hyun, Heo, Dae Seog, Kim, Woo‐Ho, Bang, Yung‐Jue

“…BACKGROUND: The purpose of this study was to investigate the overall survival (OS) of patients with advanced ALK‐positive nonsmall cell lung cancer (NSCLC) who…”
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Computational analysis of cancer genome sequencing data by Cortés-Ciriano, Isidro, Gulhan, Doga C., Lee, Jake June-Koo, Melloni, Giorgio E. M., Park, Peter J.

“…Distilling biologically meaningful information from cancer genome sequencing data requires comprehensive identification of somatic alterations using rigorous…”
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ERα-associated translocations underlie oncogene amplifications in breast cancer by Lee, Jake June-Koo, Jung, Youngsook Lucy, Cheong, Taek-Chin, Espejo Valle-Inclan, Jose, Chu, Chong, Gulhan, Doga C., Ljungström, Viktor, Jin, Hu, Viswanadham, Vinayak V., Watson, Emma V., Cortés-Ciriano, Isidro, Elledge, Stephen J., Chiarle, Roberto, Pellman, David, Park, Peter J.

“…Focal copy-number amplification is an oncogenic event. Although recent studies have revealed the complex structure 1 – 3 and the evolutionary trajectories 4 of…”
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