Search Results - "Lee, Jonathan D."

Genetic fusions favor tumorigenesis through degron loss in oncogenes by Liu, Jing, Tokheim, Collin, Lee, Jonathan D., Gan, Wenjian, North, Brian J., Liu, X. Shirley, Pandolfi, Pier Paolo, Wei, Wenyi

“…Chromosomal rearrangements can generate genetic fusions composed of two distinct gene sequences, many of which have been implicated in tumorigenesis and…”
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Cognition-associated long noncoding RNAs are dysregulated upon severe COVID-19 by Lee, Jonathan D, Solomon, Isaac H, Slack, Frank J, Mavrikaki, Maria

“…Severe COVID-19 leads to widespread transcriptomic changes in the human brain, mimicking diminished cognitive performance. As long noncoding RNAs (lncRNAs)…”
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Differences in syncytia formation by SARS-CoV-2 variants modify host chromatin accessibility and cellular senescence via TP53 by Lee, Jonathan D., Menasche, Bridget L., Mavrikaki, Maria, Uyemura, Madison M., Hong, Su Min, Kozlova, Nina, Wei, Jin, Alfajaro, Mia M., Filler, Renata B., Müller, Arne, Saxena, Tanvi, Posey, Ryan R., Cheung, Priscilla, Muranen, Taru, Heng, Yujing J., Paulo, Joao A., Wilen, Craig B., Slack, Frank J.

“…Coronavirus disease 2019 (COVID-19) remains a significant public health threat due to the ability of severe acute respiratory syndrome coronavirus 2…”
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Patterns and Variation in Benthic Biodiversity in a Large Marine Ecosystem by Piacenza, Susan E, Barner, Allison K, Benkwitt, Cassandra E, Boersma, Kate S, Cerny-Chipman, Elizabeth B, Ingeman, Kurt E, Kindinger, Tye L, Lee, Jonathan D, Lindsley, Amy J, Reimer, Jessica N, Rowe, Jennifer C, Shen, Chenchen, Thompson, Kevin A, Thurman, Lindsey L, Heppell, Selina S

“…While there is a persistent inverse relationship between latitude and species diversity across many taxa and ecosystems, deviations from this norm offer an…”
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Severe COVID-19 is associated with molecular signatures of aging in the human brain by Mavrikaki, Maria, Lee, Jonathan D, Solomon, Isaac H, Slack, Frank J

“…As coronavirus disease 2019 (COVID-19) and aging are both accompanied by cognitive decline, we hypothesized that COVID-19 might lead to molecular signatures…”
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Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway by Lee, Yu-Ru, Chen, Ming, Lee, Jonathan D, Zhang, Jinfang, Lin, Shu-Yu, Fu, Tian-Min, Chen, Hao, Ishikawa, Tomoki, Chiang, Shang-Yin, Katon, Jesse, Zhang, Yang, Shulga, Yulia V, Bester, Assaf C, Fung, Jacqueline, Monteleone, Emanuele, Wan, Lixin, Shen, Chen, Hsu, Chih-Hung, Papa, Antonella, Clohessy, John G, Teruya-Feldstein, Julie, Jain, Suresh, Wu, Hao, Matesic, Lydia, Chen, Ruey-Hwa, Wei, Wenyi, Pandolfi, Pier Paolo

“…Activation of tumor suppressors for the treatment of human cancer has been a long sought, yet elusive, strategy. PTEN is a critical tumor suppressive…”
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Germline NPM1 mutations lead to altered rRNA 2′-O-methylation and cause dyskeratosis congenita by Nachmani, Daphna, Bothmer, Anne H., Grisendi, Silvia, Mele, Aldo, Bothmer, Dietmar, Lee, Jonathan D., Monteleone, Emanuele, Cheng, Ke, Zhang, Yang, Bester, Assaf C., Guzzetti, Alison, Mitchell, Caitlin A., Mendez, Lourdes M., Pozdnyakova, Olga, Sportoletti, Paolo, Martelli, Maria-Paola, Vulliamy, Tom J., Safra, Modi, Schwartz, Schraga, Luzzatto, Lucio, Bluteau, Olivier, Soulier, Jean, Darnell, Robert B., Falini, Brunangelo, Dokal, Inderjeet, Ito, Keisuke, Clohessy, John G., Pandolfi, Pier Paolo

“…RNA modifications are emerging as key determinants of gene expression. However, compelling genetic demonstrations of their relevance to human disease are…”
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The conserved microRNA‐229 family controls low‐insulin signaling and dietary restriction induced longevity through interactions with SKN‐1/NRF2 by Matai, Latika, Stathis, Thalyana, Lee, Jonathan D., Parsons, Christine, Saxena, Tanvi, Shlomchik, Kovi, Slack, Frank J.

“…Several microRNAs have emerged as regulators of pathways that control aging. For example, miR‐228 is required for normal lifespan and dietary restriction (DR)…”
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Case report: Duplicated appendicitis with history of cloacal exstrophy causing bowel obstruction by Lee, Jonathan D., Sacks, Marla A., Radulescu, Andrei, Moores, Donald

“…Cloacal and bladder exstrophy are rare embryological defects that can cause developmental disruption of surrounding organ structures, the pelvis, spinal cord,…”
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Zinc Finger Protein SALL4 Functions through an AT-Rich Motif to Regulate Gene Expression by Kong, Nikki R., Bassal, Mahmoud A., Tan, Hong Kee, Kurland, Jesse V., Yong, Kol Jia, Young, John J., Yang, Yang, Li, Fudong, Lee, Jonathan D., Liu, Yue, Wu, Chan-Shuo, Stein, Alicia, Luo, Hongbo R., Silberstein, Leslie E., Bulyk, Martha L., Tenen, Daniel G., Chai, Li

“…The zinc finger transcription factor SALL4 is highly expressed in embryonic stem cells, downregulated in most adult tissues, but reactivated in many aggressive…”
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Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci by Miller, Clint L., Pjanic, Milos, Wang, Ting, Nguyen, Trieu, Cohain, Ariella, Lee, Jonathan D., Perisic, Ljubica, Hedin, Ulf, Kundu, Ramendra K., Majmudar, Deshna, Kim, Juyong B., Wang, Oliver, Betsholtz, Christer, Ruusalepp, Arno, Franzén, Oscar, Assimes, Themistocles L., Montgomery, Stephen B., Schadt, Eric E., Björkegren, Johan L.M., Quertermous, Thomas

“…Coronary artery disease (CAD) is the leading cause of mortality and morbidity, driven by both genetic and environmental risk factors. Meta-analyses of…”
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An Integrated Genome-wide CRISPRa Approach to Functionalize lncRNAs in Drug Resistance by Bester, Assaf C., Lee, Jonathan D., Chavez, Alejandro, Lee, Yu-Ru, Nachmani, Daphna, Vora, Suhani, Victor, Joshua, Sauvageau, Martin, Monteleone, Emanuele, Rinn, John L., Provero, Paolo, Church, George M., Clohessy, John G., Pandolfi, Pier Paolo

“…Resistance to chemotherapy plays a significant role in cancer mortality. To identify genetic units affecting sensitivity to cytarabine, the mainstay of…”
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Dual DNA and protein tagging of open chromatin unveils dynamics of epigenomic landscapes in leukemia by Lee, Jonathan D., Paulo, Joao A., Posey, Ryan R., Mugoni, Vera, Kong, Nikki R., Cheloni, Giulia, Lee, Yu-Ru, Slack, Frank J., Tenen, Daniel G., Clohessy, John G., Gygi, Steven P., Pandolfi, Pier Paolo

“…The architecture of chromatin regulates eukaryotic cell states by controlling transcription factor access to sites of gene regulation. Here we describe a dual…”
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A note on Linnik’s theorem on quadratic non-residues by Balister, Paul, Bollobás, Béla, Lee, Jonathan D., Morris, Robert, Riordan, Oliver

“…We present a short and purely combinatorial proof of Linnik’s theorem: for any ε > 0 there exists a constant C ε such that for any N , there are at most C ε…”
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Anxiety and neural responses to infant and adult faces during pregnancy by Rutherford, Helena J.V., Byrne, Simon P., Austin, Grace M., Lee, Jonathan D., Crowley, Michael J., Mayes, Linda C.

“…•Event-related potentials elicited by face stimuli were measured during pregnancy.•Antenatal anxiety correlated with the LPP elicited by neutral infant…”
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Murine model of femoral artery wire injury with implantation of a perivascular drug delivery patch by Le, Victoria, Johnson, Collin G, Lee, Jonathan D, Baker, Aaron B

“…Percutaneous interventions including balloon angioplasty and stenting have been used to restore blood flow in vessels with occlusive vascular disease. While…”
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Abstract 1694: CHIP and AML mutations dictate the composition of hematopoietic microenvironments by Posey, Ryan R., Mendez, Lourdes M., Lee, Jonathan D., Clohessy, John G., Pandolfi, Pier Paolo

“…Abstract Clonal Hematopoiesis of Indeterminate Potential (CHIP) is the age-associated acquisition of detectable stem cell mutations, known to predispose…”
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A Suspicious Formula Involving Pi: 12006 [2017, 970] by Lee, Jonathan D., Wagon, Stan, Stadler, Albert

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Abstract 19076: ATAC-seq Implicates Epigenome-wide CTCF Dissociation in the Progression of Cardiac Ischemia by Lee, Jonathan D, Lin, Shin, Snyder, Michael P

“…IntroductionHeart disease is currently the most common cause of death in the United States. In 2010 alone, over 375,000 people died of coronary heart disease,…”
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F-saturation games by Lee, Jonathan D., Riet, Ago-Erik

“…We study F-saturation games, first introduced by Füredi, Reimer and Seress in 1991, and named as such by West (2009). The main question is to determine the…”
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