Search Results - "Lee, Jennifer C."

Cysteine cathepsins are essential in lysosomal degradation of α-synuclein by McGlinchey, Ryan P., Lee, Jennifer C.

“…A cellular feature of Parkinson’s disease is cytosolic accumulation and amyloid formation of α-synuclein (α-syn), implicating a misregulation or impairment of…”
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pH-Dependent fibril maturation of a Pmel17 repeat domain isoform revealed by tryptophan fluorescence by Dean, Dexter N., Lee, Jennifer C.

“…The pre-melanosomal protein (Pmel17) aggregates within melanosomes to form functional amyloid fibrils that facilitate melanin polymerization. The repeat domain…”
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Why Study Functional Amyloids? Lessons from the Repeat Domain of Pmel17 by McGlinchey, Ryan P., Lee, Jennifer C.

“…One of the current challenges facing biomedical researchers is the need to develop new approaches in preventing amyloid formation that is associated with…”
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Lipid-Chaperone Hypothesis: A Common Molecular Mechanism of Membrane Disruption by Intrinsically Disordered Proteins by Sciacca, Michele F, Lolicato, Fabio, Tempra, Carmelo, Scollo, Federica, Sahoo, Bikash R, Watson, Matthew D, García-Viñuales, Sara, Milardi, Danilo, Raudino, Antonio, Lee, Jennifer C, Ramamoorthy, Ayyalusamy, La Rosa, Carmelo

“…An increasing number of human diseases has been shown to be linked to aggregation and amyloid formation by intrinsically disordered proteins (IDPs). Amylin,…”
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In situ differentiation of iridophore crystallotypes underlies zebrafish stripe patterning by Gur, Dvir, Bain, Emily J., Johnson, Kory R., Aman, Andy J., Pasolli, H. Amalia, Flynn, Jessica D., Allen, Michael C., Deheyn, Dimitri D., Lee, Jennifer C., Lippincott-Schwartz, Jennifer, Parichy, David M.

“…Skin color patterns are ubiquitous in nature, impact social behavior, predator avoidance, and protection from ultraviolet irradiation. A leading model system…”
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Depth of α-Synuclein in a Bilayer Determined by Fluorescence, Neutron Reflectometry, and Computation by Pfefferkorn, Candace M., Heinrich, Frank, Sodt, Alexander J., Maltsev, Alexander S., Pastor, Richard W., Lee, Jennifer C.

“…α-Synuclein (α-syn) membrane interactions are implicated in the pathogenesis of Parkinson's disease. Fluorescence and neutron reflectometry (NR) measurements…”
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Effects of pH on aggregation kinetics of the repeat domain of a functional amyloid, Pmel17 by Pfefferkorn, Candace M., McGlinchey, Ryan P., Lee, Jennifer C., Gray, Harry B.

“…Pmel17 is a functional amyloidogenic protein whose fibrils act as scaffolds for pigment deposition in human skin and eyes. We have used the repeat domain (RPT,…”
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Author Correction: In situ differentiation of iridophore crystallotypes underlies zebrafish stripe patterning by Gur, Dvir, Bain, Emily J., Johnson, Kory R., Aman, Andy J., Pasolli, H. Amalia, Flynn, Jessica D., Allen, Michael C., Deheyn, Dimitri D., Lee, Jennifer C., Lippincott-Schwartz, Jennifer, Parichy, David M.

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Comparative Safety of Antidepressant Agents for Children and Adolescents Regarding Suicidal Acts by SCHNEEWEISS, Sebastian, PATRICK, Amanda R, SOLOMON, Daniel H, DORMUTH, Colin R, MILLER, Matt, MEHTA, Jyotsna, LEE, Jennifer C, WANG, Philip S

“…The objective of this study was to assess the risk of suicide attempts and suicides after initiation of antidepressant medication use by children and…”
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Mechanism of Assembly of the Non-Covalent Spectrin Tetramerization Domain from Intrinsically Disordered Partners by Hill, Stephanie A., Kwa, Lee Gyan, Shammas, Sarah L., Lee, Jennifer C., Clarke, Jane

“…Interdomain interactions of spectrin are critical for maintenance of the erythrocyte cytoskeleton. In particular, “head-to-head” dimerization occurs when the…”
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Income Inequality in College Enrollment and Degree Attainment During and After the Great Recession Years by Klugman, Joshua, Arteta, Genesis D., Lee, Jennifer C.

“…Prior research using the Current Population Surveys (CPS) documents a dramatic equalization in U.S. college enrollments based on family income starting in…”
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Emerging insights into the mechanistic link between α-synuclein and glucocerebrosidase in Parkinson's disease by McGlinchey, Ryan P, Lee, Jennifer C

“…Mutations in the GBA1 gene, encoding the enzyme glucocerebrosidase, cause the lysosomal storage disorder GD (Gaucher's disease), and are associated with the…”
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Racialized Assimilation of Asian Americans by Lee, Jennifer C, Kye, Samuel

“…Because of the generally high socioeconomic attainments and high intermarriage rates of Asian Americans, it has been suggested that Asian Americans are…”
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When Work Matters: The Varying Impact of Work Intensity on High School Dropout by Lee, Jennifer C., Staff, Jeremy

“…While the association between teenagers' work and academic performance continues to be debated in studies of adolescent employment, many researchers have found…”
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Dissociation of glucocerebrosidase dimer in solution by its co-factor, saposin C by Gruschus, James M., Jiang, Zhiping, Yap, Thai Leong, Hill, Stephanie A., Grishaev, Alexander, Piszczek, Grzegorz, Sidransky, Ellen, Lee, Jennifer C.

“…Mutations in the gene for the lysosomal enzyme glucocerebrosidase (GCase) cause Gaucher disease and are the most common risk factor for Parkinson disease (PD)…”
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Structural Insights into α-Synuclein Fibril Polymorphism: Effects of Parkinson's Disease-Related C-Terminal Truncations by Ni, Xiaodan, McGlinchey, Ryan P., Jiang, Jiansen, Lee, Jennifer C.

“…Lewy bodies, hallmarks of Parkinson's disease, contain C-terminally truncated (ΔC) α-synuclein (α-syn). Here, we report fibril structures of three N-terminally…”
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Unroofing site-specific α-synuclein–lipid interactions at the plasma membrane by Kaur, Upneet, Lee, Jennifer C.

“…Parkinson’s disease is associated with α-synuclein (α-syn), a cytosolic protein enriched in presynaptic terminals. The biological function of α-syn remains…”
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Water bend–libration as a cellular Raman imaging probe of hydration by Ramos, Sashary, Lee, Jennifer C.

“…Water is a ubiquitous and vital component of living systems. Hydration, which is the interaction between water and intracellular biomolecules, plays an…”
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Alpha-Synuclein Lipid-Dependent Membrane Binding and Translocation through the α-Hemolysin Channel by Gurnev, Philip A., Yap, Thai Leong, Pfefferkorn, Candace M., Rostovtseva, Tatiana K., Berezhkovskii, Alexander M., Lee, Jennifer C., Parsegian, V. Adrian, Bezrukov, Sergey M.

“…Gauging the interactions of a natively unfolded Parkinson disease-related protein, alpha-synuclein (α-syn) with membranes and its pathways between and within…”
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Pilot study of Doppler optical coherence tomography of retinal blood flow following laser photocoagulation in poorly controlled diabetic patients by Lee, Jennifer C, Wong, Brandon J, Tan, Ou, Srinivas, Sowmya, Sadda, Srinivas R, Huang, David, Fawzi, Amani A

“…To investigate the effect of panretinal photocoagulation (PRP) on retinal blood flow and shear rate using Doppler Fourier-domain optical coherence tomography…”
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