Search Results - "Lee, Jang‐Ik"

New Era in Drug Interaction Evaluation: US Food and Drug Administration Update on CYP Enzymes, Transporters, and the Guidance Process by Huang, Shiew-Mei, Strong, John M., Zhang, Lei, Reynolds, Kellie S., Nallani, Srikanth, Temple, Robert, Abraham, Sophia, Habet, Sayed Al, Baweja, Raman K., Burckart, Gilbert J., Chung, Sang, Colangelo, Philip, Frucht, David, Green, Martin D., Hepp, Paul, Karnaukhova, Elena, Ko, Hon-Sum, Lee, Jang-Ik, Marroum, Patrick J., Norden, Janet M., Qiu, Wei, Rahman, Atiqur, Sobel, Solomon, Stifano, Toni, Thummel, Kenneth, Wei, Xiao-Xiong, Yasuda, Sally, Zheng, Jenny H., Zhao, Hong, Lesko, Lawrence J.

“…Predicting clinically significant drug interactions during drug development is a challenge for the pharmaceutical industry and regulatory agencies. Since the…”
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Nuclear Factor Kappa B: Important Transcription Factor and Therapeutic Target by Lee, Jang-Ik, Burckart, Gilbert J.

“…Nuclear factor kappa B (NF‐κB) is an ubiquitous rapid response transcription factor in cells involved in immune and inflammatory reactions, and exerts its…”
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Application of semisimultaneous midazolam administration for hepatic and intestinal cytochrome P450 3A phenotyping by Lee, Jang‐Ik, Chaves‐Gnecco, Diego, Amico, Janet A., Kroboth, Patricia D., Wilson, John W., Frye, Reginald F.

“…Objectives Determination of hepatic and intestinal cytochrome P450 (CYP) 3A activity is important, because CYP3A substrates show substantial variability in…”
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CYP-Mediated Therapeutic Protein-Drug Interactions: Clinical Findings, Proposed Mechanisms and Regulatory Implications by Lee, Jang-Ik, Zhang, Lei, Men, Angela Y., Kenna, Leslie A., Huang, Shiew-Mei

“…Therapeutic proteins (TPs) may affect the disposition of drugs that are metabolized by cytochrome P450 (CYP) enzymes, as is evident from a review of data in…”
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Drug Interactions/Review: New Era in Drug Interaction Evaluation: US Food and Drug Administration Update on CYP Enzymes, Transporters, and the Guidance Process by Huang, Shiew-Mei, Strong, John M, Reynolds, Kellie S, Nallani, Srikanth, Temple, Robert, Abraham, Sophia, Al Habet, Sayed, Baweja, Raman K, Burckart, Gilbert J, Colangelo, Philip, Frucht, David, Green, Ma, Hepp, Paul, Karnaukhova, Elena, Ko, Hon-Sum, Lee, Jang-Ik, Marroum, Patrick J, Norden, Janet M, Rahman, Atiqur, Sobel, Solomon, Stifano, Toni, Thummel, Kenneth, Wei, Xiao-xiong, Yasuda, Sally, Zheng, Jenny H, Lesko, Lawrence J

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New synthetic aliphatic sulfonamido-quaternary ammonium salts as anticancer chemotherapeutic agents by Song, Doona, Yang, Jee Sun, Oh, Changmok, Cui, Shuolin, Kim, Bo-Kyung, Won, Misun, Lee, Jang-ik, Kim, Hwan Mook, Han, Gyoonhee

“…RhoB is expressed during tumor cell proliferation, survival, invasion, and metastasis. In malignant progression, the expression levels of RhoB are commonly…”
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Analysis of Exposure–Response Relationship in Everolimus–Cyclosporine Combination Regimen by Lee, Jang‐Ik, Tracy, LaRee, Higgins, Karen, Hernandez Cavaille‐Coll, Arturo, Marc

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Cyclosporine A inhibits the expression of costimulatory molecules on in vitro-generated dendritic cells: Association with reduced nuclear translocation of nuclear factor kappa B by LEE, J.-I, GANSTER, R. W, GELLER, D. A, BURCKART, G. J, THOMSON, A. W, LU, L

“…The maturation of dendritic cells (DC) is influenced by various factors, in particular cytokine-mediated signaling events. These include modulation of the…”
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Lactam-Based HDAC Inhibitors for Anticancer Chemotherapy: Restoration of RUNX3 by Posttranslational Modification and Epigenetic Control by Cho, Misun, Choi, Eunhyun, Kim, Jae Hyun, Kim, Hwan, Kim, Hwan Mook, Lee, Jang Ik, Hwang, Ki-Chul, Kim, Hyun-Jung, Han, Gyoonhee

“…Expression and stability of the tumor suppressor runt‐related transcription factor 3 (RUNX3) are regulated by histone deacetylase (HDAC). HDAC inhibition…”
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Information technology at the gate: Faculty perceptions and attitudes about technology-mediated instruction innovation in higher education by Lee, Jang-Ik

“…This study examines why technology-mediated instruction and learning has not been widely adopted by faculty members despite the growing familiarity with…”
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Application of the semi-simultaneous bioavailability approach to hepatic and intestinal CYP3A phenotyping with midazolam by Lee, Jang-Ik

“…Background. Determination of hepatic and intestinal CYP3A activity is important because CYP3A substrates generally show substantial variability in plasma…”
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CYCLOSPORINE A INHIBITS THE EXPRESSION OF COSTIMULATORY MOLECULES ON IN VITRO-GENERATED DENDRITIC CELLS: Association with Reduced Nuclear Translocation of Nuclear Factor Kappa B1 by Lee, Jang-Ik, Ganster, Raymond W., Geller, David A., Burckart, Gilbert J., Thomson, Angus W., Lu, Lina

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Application of the semi-simultaneous bioavailability approach to hepatic and intestinal CYP3A phenotyping with midazolam by Lee, Jang-Ik

“…Background. Determination of hepatic and intestinal CYP3A activity is important because CYP3A substrates generally show substantial variability in plasma…”
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Information technology at the gate: Faculty perceptions and attitudes about technology-mediated instruction innovation in higher education by Lee, Jang-Ik

“…This study examines why technology-mediated instruction and learning has not been widely adopted by faculty members despite the growing familiarity with…”
Get full text