Search Results - "Lee, Jae K."

Single-cell analysis of the cellular heterogeneity and interactions in the injured mouse spinal cord by Milich, Lindsay M, Choi, James S, Ryan, Christine, Cerqueira, Susana R, Benavides, Sofia, Yahn, Stephanie L, Tsoulfas, Pantelis, Lee, Jae K

“…The wound healing process that occurs after spinal cord injury is critical for maintaining tissue homeostasis and limiting tissue damage, but eventually…”
Get full text

An injectable hydrogel enhances tissue repair after spinal cord injury by promoting extracellular matrix remodeling by Hong, Le Thi Anh, Kim, Young-Min, Park, Hee Hwan, Hwang, Dong Hoon, Cui, Yuexian, Lee, Eun Mi, Yahn, Stephanie, Lee, Jae K., Song, Soo-Chang, Kim, Byung Gon

“…The cystic cavity that develops following injuries to brain or spinal cord is a major obstacle for tissue repair in central nervous system (CNS). Here we…”
Get full text

Perivascular fibroblasts form the fibrotic scar after contusive spinal cord injury by Soderblom, Cynthia, Luo, Xueting, Blumenthal, Ezra, Bray, Eric, Lyapichev, Kirill, Ramos, Jose, Krishnan, Vidhya, Lai-Hsu, Catherine, Park, Kevin K, Tsoulfas, Pantelis, Lee, Jae K

“…Injury to the CNS leads to formation of scar tissue, which is important in sealing the lesion and inhibiting axon regeneration. The fibrotic scar that…”
Get full text

Understanding the NG2 Glial Scar after Spinal Cord Injury by Hackett, Amber R, Lee, Jae K

“…NG2 cells, also known as oligodendrocyte progenitor cells, are located throughout the central nervous system and serve as a pool of progenitors to…”
Get full text

Role of myelin-associated inhibitors in axonal repair after spinal cord injury by Lee, Jae K., Zheng, Binhai

“…Myelin-associated inhibitors of axon growth, including Nogo, MAG and OMgp, have been the subject of intense research. A myriad of experimental approaches have…”
Get full text

Myelin and non-myelin debris contribute to foamy macrophage formation after spinal cord injury by Ryan, Christine B., Choi, James S., Al-Ali, Hassan, Lee, Jae K.

“…Tissue damage after spinal cord injury (SCI) elicits a robust inflammatory cascade that fails to resolve in a timely manner, resulting in impaired wound…”
Get full text

A Surviving Intact Branch Stabilizes Remaining Axon Architecture after Injury as Revealed by In Vivo Imaging in the Mouse Spinal Cord by Lorenzana, Ariana O., Lee, Jae K., Mui, Matthew, Chang, Amy, Zheng, Binhai

“…The complex morphology of axons presents a challenge in understanding axonal responses to injury and disease. By in vivo two-photon imaging of spinal dorsal…”
Get full text

The Impact of Music Therapy (MT) on Anxiety in Cancer Patients Undergoing Simulation for Radiation Therapy (RT) by Rossetti, Andrew, MMT, LCAT, MT-BC, Chadha, Manjeet, MD, FACR, FASTRO, Torres, B. Nelson, MPH, Lee, Jae K., PhD, Hylton, Donald, AAS, RTT, Loewy, Joanne V., DA, LCAT, MT-BC, Harrison, Louis B., MD, FASTRO

“…Abstract Purpose Radiation therapy (RT) is associated with high stress levels. The role of MT in patients receiving RT is not well described. This study…”
Get full text

Fibrotic scar after experimental autoimmune encephalomyelitis inhibits oligodendrocyte differentiation by Yahn, Stephanie L., Li, Jiajun, Goo, Irene, Gao, Han, Brambilla, Roberta, Lee, Jae K.

“…Remyelination failure is a crucial component of disease progression in the autoimmune demyelinating disease Multiple Sclerosis (MS). The regenerative capacity…”
Get full text

Fibronectin Matrix Assembly after Spinal Cord Injury by Zhu, Yunjiao, Soderblom, Cynthia, Trojanowsky, Michelle, Lee, Do-Hun, Lee, Jae K

“…After spinal cord injury (SCI), a fibrotic scar forms at the injury site that is best characterized by the accumulation of perivascular fibroblasts and…”
Get more information

Krüppel-like Factor 7 engineered for transcriptional activation promotes axon regeneration in the adult corticospinal tract by Blackmore, Murray G, Wang, Zimei, Lerch, Jessica K, Motti, Dario, Zhang, Yi Ping, Shields, Christopher B, Lee, Jae K, Goldberg, Jeffrey L, Lemmon, Vance P, Bixby, John L

“…Axon regeneration in the central nervous system normally fails, in part because of a developmental decline in the intrinsic ability of CNS projection neurons…”
Get full text

Assessing Spinal Axon Regeneration and Sprouting in Nogo-, MAG-, and OMgp-Deficient Mice by Lee, Jae K., Geoffroy, Cédric G., Chan, Andrea F., Tolentino, Kristine E., Crawford, Michael J., Leal, Marisa A., Kang, Brian, Zheng, Binhai

“…A central hypothesis for the limited capacity for adult central nervous system (CNS) axons to regenerate is the presence of myelin-derived axon growth…”
Get full text

Genetic inactivation of IL-1 signaling enhances atherosclerotic plaque instability and reduces outward vessel remodeling in advanced atherosclerosis in mice by Alexander, Matthew R, Moehle, Christopher W, Johnson, Jason L, Yang, Zhengyu, Lee, Jae K, Jackson, Christopher L, Owens, Gary K

“…Clinical complications of atherosclerosis arise primarily as a result of luminal obstruction due to atherosclerotic plaque growth, with inadequate outward…”
Get full text

Neuroinflammation Treatment via Targeted Delivery of Nanoparticles by Cerqueira, Susana R, Ayad, Nagi G, Lee, Jae K

“…The lack of effective treatments for most neurological diseases has prompted the search for novel therapeutic options. Interestingly, neuroinflammation is…”
Get full text

Neoadjuvant radiotherapy of early-stage breast cancer and long-term disease-free survival by Poleszczuk, Jan, Luddy, Kimberly, Chen, Lu, Lee, Jae K, Harrison, Louis B, Czerniecki, Brian J, Soliman, Hatem, Enderling, Heiko

“…Compared with surgery alone, postoperative adjuvant radiotherapy (RT) improves relapse-free survival of patients with early-stage breast cancer. We evaluated…”
Get full text

Multi-gene expression predictors of single drug responses to adjuvant chemotherapy in ovarian carcinoma: predicting platinum resistance by Ferriss, J Stuart, Kim, Youngchul, Duska, Linda, Birrer, Michael, Levine, Douglas A, Moskaluk, Christopher, Theodorescu, Dan, Lee, Jae K

“…Despite advances in radical surgery and chemotherapy delivery, ovarian cancer is the most lethal gynecologic malignancy. Standard therapy includes treatment…”
Get full text

PI3K signaling promotes formation of lipid-laden foamy macrophages at the spinal cord injury site by Ryan, Christine B, Choi, James S, Kang, Brian, Herr, Seth, Pereira, Claudia, Moraes, Carlos T, Al-Ali, Hassan, Lee, Jae K

“…After spinal cord injury (SCI), infiltrating macrophages undergo excessive phagocytosis of myelin and cellular debris, forming lipid-laden foamy macrophages…”
Get full text

Enhanced Transcriptional Activity and Mitochondrial Localization of STAT3 Co-induce Axon Regrowth in the Adult Central Nervous System by Luo, Xueting, Ribeiro, Marcio, Bray, Eric R., Lee, Do-Hun, Yungher, Benjamin J., Mehta, Saloni T., Thakor, Kinjal A., Diaz, Francisca, Lee, Jae K., Moraes, Carlos T., Bixby, John L., Lemmon, Vance P., Park, Kevin K.

“…Signal transducer and activator of transcription 3 (STAT3) is a transcription factor central to axon regrowth with an enigmatic ability to act in different…”
Get full text

STAT3 and SOCS3 regulate NG2 cell proliferation and differentiation after contusive spinal cord injury by Hackett, Amber R, Lee, Do-Hun, Dawood, Abdul, Rodriguez, Mario, Funk, Lucy, Tsoulfas, Pantelis, Lee, Jae K

“…Abstract NG2 cells, also known as oligodendrocyte progenitors or polydendrocytes, are a major component of the glial scar that forms after spinal cord injury…”
Get full text

Interaction between subventricular zone microglia and neural stem cells impacts the neurogenic response in a mouse model of cortical ischemic stroke by Nath, Suvra, Martínez Santamaría, Jose C., Chu, Yu-Hsuan, Choi, James S., Conforti, Pasquale, Lin, Jia-Di, Sankowski, Roman, Amann, Lukas, Galanis, Christos, Wu, Kexin, Deshpande, Sachin S., Vlachos, Andreas, Prinz, Marco, Lee, Jae K., Schachtrup, Christian

“…After a stroke, the neurogenic response from the subventricular zone (SVZ) to repair the brain is limited. Microglia, as an integral part of the distinctive…”
Get full text