Search Results - "Lee, Isac"

Targeted nanopore sequencing with Cas9-guided adapter ligation by Gilpatrick, Timothy, Lee, Isac, Graham, James E., Raimondeau, Etienne, Bowen, Rebecca, Heron, Andrew, Downs, Bradley, Sukumar, Saraswati, Sedlazeck, Fritz J, Timp, Winston

“…Despite recent improvements in sequencing methods, there remains a need for assays that provide high sequencing depth and comprehensive variant detection…”
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Simultaneous profiling of chromatin accessibility and methylation on human cell lines with nanopore sequencing by Lee, Isac, Razaghi, Roham, Gilpatrick, Timothy, Molnar, Michael, Gershman, Ariel, Sadowski, Norah, Sedlazeck, Fritz J., Hansen, Kasper D., Simpson, Jared T., Timp, Winston

“…Probing epigenetic features on DNA has tremendous potential to advance our understanding of the phased epigenome. In this study, we use nanopore sequencing to…”
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Comprehensive analysis of structural variants in breast cancer genomes using single-molecule sequencing by Aganezov, Sergey, Goodwin, Sara, Sherman, Rachel M, Sedlazeck, Fritz J, Arun, Gayatri, Bhatia, Sonam, Lee, Isac, Kirsche, Melanie, Wappel, Robert, Kramer, Melissa, Kostroff, Karen, Spector, David L, Timp, Winston, McCombie, W Richard, Schatz, Michael C

“…Improved identification of structural variants (SVs) in cancer can lead to more targeted and effective treatment options as well as advance our basic…”
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Characterization of human telomerase reverse transcriptase promoter methylation and transcription factor binding in differentiated thyroid cancer cell lines by Avin, Brittany A., Wang, Yongchun, Gilpatrick, Timothy, Workman, Rachael E., Lee, Isac, Timp, Winston, Umbricht, Christopher B., Zeiger, Martha A.

“…Telomerase reverse transcriptase (TERT) activation plays an important role in cancer development by enabling the immortalization of cells. TERT regulation is…”
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Subcloning induces changes in the DNA‐methylation pattern of outgrowing Chinese hamster ovary cell colonies by Weinguny, Marcus, Klanert, Gerald, Eisenhut, Peter, Lee, Isac, Timp, Winston, Borth, Nicole

“…Chinese hamster ovary (CHO) cells are the most extensively used mammalian production system for biologics intended for use in humans. A critical step in the…”
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The influence of HLA genetic variation on plasma protein expression by Krishna, Chirag, Chiou, Joshua, Sakaue, Saori, Kang, Joyce B., Christensen, Stephen M., Lee, Isac, Aksit, Melis Atalar, Kim, Hye In, von Schack, David, Raychaudhuri, Soumya, Ziemek, Daniel, Hu, Xinli

“…Genetic variation in the human leukocyte antigen (HLA) loci is associated with risk of immune-mediated diseases, but the molecular effects of HLA polymorphism…”
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Su1140: PROTEOMIC DIFFERENCES IN COLONIC EPITHELIAL CELLS IN ULCERATIVE COLITIS HAVE AN EPIGENETIC BASIS by Lord, James D., Monetti, Mara, Martz, Flora, Kongala, Ramya, Dickinson, Caitlyn, Culver, Jeffrey A., Lee, Isac, Jelinsky, Scott, Kasaian, Marion

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Coating barium titanate nanoparticles with polyethylenimine improves cellular uptake and allows for coupled imaging and gene delivery by Dempsey, Christopher, Lee, Isac, Cowan, Katie R., Suh, Junghae

“…•Barium titanate nanoparticles were complexed with linear polyethylenimine.•BT-PEI complexes entered cells eight-fold better than BT alone.•Second harmonic…”
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Targeted nanopore sequencing with Cas9-guided adaptor ligation by Gilpatrick, Timothy, Lee, Isac, Graham, James E., Raimondeau, Etienne, Bowen, Rebecca, Heron, Andrew, Downs, Bradley, Sukmar, Saraswati, Sedlazeck, Fritz J, Timp, Winston

“…Despite recent improvements in sequencing methods, there remains a need for assays that provide high sequencing depth and comprehensive variant detection…”
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Proteomic Differences in Colonic Epithelial Cells in Ulcerative Colitis Have an Epigenetic Basis by Jelinsky, Scott, Lee, Isac, Monetti, Mara, Breitkopf, Susanne, Martz, Flora, Kongala, Ramya, Culver, Jeffrey, Vo, Vanessa, Xue, Liang, Gieseck, Richard, Dickinson, Caitlyn, Kasaian, Marion, Lord, James D.

“…The colonic epithelium serves as both a barrier to lumenal contents and a gatekeeper of inflammatory responses. In ulcerative colitis (UC), epithelial…”
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Whole genome DNA methylation sequencing of the chicken retina, cornea and brain by Lee, Isac, Rasoul, Bejan A., Holub, Ashton S., Lejeune, Alannah, Enke, Raymond A., Timp, Winston

“…Whole genome bisulfite sequencing (WGBS) analysis of DNA methylation uses massively parallel next generation sequencing technology to characterize global…”
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Smartphone application for classification of motor impairment severity in Parkinson's disease by Printy, Blake P., Renken, Lindsey M., Herrmann, John P., Lee, Isac, Johnson, Bryant, Knight, Emily, Varga, Georgeta, Whitmer, Diane

“…Advanced hardware components embedded in modern smartphones have the potential to serve as widely available medical diagnostic devices, particularly when used…”
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