Effect-site concentration of remifentanil for preventing propofol injection pain during induction of balanced anesthesia
Background: Despite various strategies designed for preventing pain from propofol injection, it is still common and distressing to the patients. The purpose of the present study was to investigate the adequate effect-site concentration (Ce) of remifentanil to prevent pain due to propofol injection....
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| Published in: | Anesthesia and pain medicine (Korean society of anesthesiologists) Vol. 15; no. 2; pp. 152 - 156 |
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| Main Authors: | , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Korean Society of Anesthesiologists
30-04-2020
대한마취통증의학회 |
| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Background: Despite various strategies designed for preventing pain from propofol injection, it is still common and distressing to the patients. The purpose of the present study was to investigate the adequate effect-site concentration (Ce) of remifentanil to prevent pain due to propofol injection. Methods: A total of 160 adults scheduled for elective surgery were randomly assigned to one of four groups receiving normal saline (group S) or remifentanil at a Ce of 2 (group R2), 3 (group R3), or 4 (group R4), administered via target-controlled infusion, followed by the injection of 2 mg/kg of propofol (delivered with 1% lipid propofol). The severity and incidence of injection pain were assessed on a four-point scale. Results: The incidence of propofol injection pain was significantly lower in group R2, R3, or R4 than in group S (30%, 5%, or 2.5% vs. 70%, respectively). Moreover, the intensity of the pain was lesser in group R2, R3, or R4 than in group S. However, the incidence or severity of injection was not different between groups R3 and R4. Conclusions: During the induction of balanced anesthesia using propofol injection, pretreatment with remifentanil at a target Ce of 3 ng/ml effectively reduced propofol injection pain in adults. |
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| Bibliography: | https://doi.org/10.17085/apm.2020.15.2.152 |
| ISSN: | 1975-5171 2383-7977 |
| DOI: | 10.17085/apm.2020.15.2.152 |