Search Results - "Lee, Hyung‐Ok"

Examination of two different proteasome inhibitors in reactivating mutant human cystathionine β-synthase in mice by Gupta, Sapna, Lee, Hyung-Ok, Wang, Liqun, Kruger, Warren D

“…Classic homocystinuria is an inborn error of metabolism caused mainly by missense mutations leading to misfolded and/or unstable human cystathionine β-synthase…”
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Long‐term functional correction of cystathionine β‐synthase deficiency in mice by adeno‐associated viral gene therapy by Lee, Hyung‐Ok, Salami, Christiana O., Sondhi, Dolan, Kaminsky, Stephen M., Crystal, Ronald G., Kruger, Warren D.

“…Cystathionine β‐synthase (CBS) deficiency is a recessive inborn error of sulfur metabolism characterized by elevated blood levels of total homocysteine (tHcy)…”
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Specific Targeting of MTAP -Deleted Tumors with a Combination of 2'-Fluoroadenine and 5'-Methylthioadenosine by Tang, Baiqing, Lee, Hyung-Ok, An, Serim S, Cai, Kathy Q, Kruger, Warren D

“…Homozygous deletion of the methylthioadenosine phosphorylase ( gene is a frequent event in a wide variety of human cancers and is a possible molecular target…”
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FAP-overexpressing fibroblasts produce an extracellular matrix that enhances invasive velocity and directionality of pancreatic cancer cells by Lee, Hyung-Ok, Mullins, Stefanie R, Franco-Barraza, Janusz, Valianou, Matthildi, Cukierman, Edna, Cheng, Jonathan D

“…Alterations towards a permissive stromal microenvironment provide important cues for tumor growth, invasion, and metastasis. In this study, Fibroblast…”
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Hydroxychloroquine Destabilizes Phospho-S6 in Human Renal Carcinoma Cells by Lee, Hyung-Ok, Mustafa, Aladdin, Hudes, Gary R, Kruger, Warren D

“…mTOR inhibitors are used to treat metastatic renal cell cancer (RCC), but most patients eventually become resistant. One possible mechanism for resistance is…”
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Treatment of Cystathionine β-Synthase Deficiency in Mice Using a Minicircle-Based Naked DNA Vector by Lee, Hyung-Ok, Gallego-Villar, Lorena, Grisch-Chan, Hiu Man, Häberle, Johannes, Thöny, Beat, Kruger, Warren D

“…Cystathionine β-synthase ( ) deficiency is a recessive inborn error of metabolism characterized by extremely elevated total homocysteine (tHcy) in the blood…”
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Clinical Implications of Fibroblast Activation Protein in Patients with Colon Cancer by HENRY, Leonard R, LEE, Hyung-Ok, LEE, John S, KLEIN-SZANTO, Andres, WATTS, Perry, ROSS, Eric A, CHEN, Wen-Tien, CHENG, Jonathan D

“…Purpose: Human fibroblast activation protein (FAP)/seprase is a 97-kDa surface glycoprotein expressed on tumor associated fibroblasts in the majority of…”
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Combination of serum histidine and plasma tryptophan as a potential biomarker to detect clear cell renal cell carcinoma by Lee, Hyung-Ok, Uzzo, Robert G, Kister, Debra, Kruger, Warren D

“…In previous work, we showed that serum-free amino acid (SFAA) profiles were different between kidney cancer patients and age and sex matched controls. The…”
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NEDD9 sustains hexokinase expression to promote glycolysis by Deneka, Alexander Y., Nikonova, Anna S., Lee, Hyung-Ok, Kruger, Warren D., Golemis, Erica A.

“…Elevated rates of glycolysis in cancer cells support tumor growth, in a process that typically depends on oncogene-induced increases in the expression and/or…”
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Analysis of the Qatari R336C cystathionine β‐synthase protein in mice by Gupta, Sapna, Gallego‐Villar, Lorena, Wang, Liqun, Lee, Hyung‐Ok, Nasrallah, Gheyath, Al‐Dewik, Nader, Häberle, Johannes, Thöny, Beat, Blom, Henk J., Ben‐Omran, Tawfeg, Kruger, Warren D.

“…Classical homocystinuria is a recessive inborn error of metabolism caused by mutations in the cystathionine beta‐synthase (CBS) gene. The highest incidence of…”
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Author Correction: Highly recurrent CBS epimutations in gastric cancer CpG island methylator phenotypes and inflammation by Padmanabhan, Nisha, Kyon, Huang Kie, Boot, Arnoud, Lim, Kevin, Srivastava, Supriya, Chen, Shuwen, Wu, Zhiyuan, Lee, Hyung-Ok, Mukundan, Vineeth T., Chan, Charlene, Chan, Yarn Kit, Xuewen, Ong, Pitt, Jason J., Isa, Zul Fazreen Adam, Xing, Manjie, Lee, Ming Hui, Tan, Angie Lay Keng, Ting, Shamaine Ho Wei, Luftig, Micah A., Kappei, Dennis, Kruger, Warren D., Bian, Jinsong, Ho, Ying Swan, Teh, Ming, Rozen, Steve George, Tan, Patrick

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Phase II trial of single agent Val-boroPro (talabostat) inhibiting fibroblast activation protein in patients with metastatic colorectal cancer by Narra, Kalyani, Mullins, Stefanie R., Lee, Hyung-Ok, Strzemkowski-Brun, Brenda, Magalong, Kimberly, Christiansen, Victoria J., McKee, Patrick A., Egleston, Brian, Cohen, Steven J., Weiner, Louis M., Meropol, Neal J., Cheng, Jonathan D.

“…Purpose: Fibroblast Activation Protein (FAP) is a tumor fibroblast protease that has been shown to potentiate colorectal cancer growth. The clinical impact of…”
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Lack of global epigenetic methylation defects in CBS deficient mice by Lee, Hyung-Ok, Wang, Liqun, Kuo, Yin-Ming, Gupta, Sapna, Slifker, Michael J., Li, Yue-sheng, Andrews, Andrew J., Kruger, Warren D.

“…Cystathionine β-synthase (CBS) deficiency is a recessive inborn error of metabolism in which patients have extremely elevated plasma total homocysteine and…”
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The endothelin receptor-B is required for the migration of neural crest-derived melanocyte and enteric neuron precursors by Lee, Hyung-Ok, Levorse, John M., Shin, Myung K.

“…Mutations in the genes encoding endothelin receptor-B ( Ednrb) and its ligand endothelin-3 ( Edn3) affect the development of two neural crest-derived cell…”
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Spatiotemporal regulation of endothelin receptor-B by SOX10 in neural crest-derived enteric neuron precursors by Shin, Myung K, Zhu, Lei, Lee, Hyung-Ok, Jordan, ChaRandle S, Cantrell, V Ashley, Southard-Smith, E Michelle

“…Hirschsprung disease (HSCR) is a multigenic, congenital disorder that affects 1 in 5,000 newborns and is characterized by the absence of neural crest-derived…”
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Aberrant cyclin C nuclear release induces mitochondrial fragmentation and dysfunction in MED13L syndrome fibroblasts by Chang, Kai-Ti, Jezek, Jan, Campbell, Alicia N., Stieg, David C., Kiss, Zachary A., Kemper, Kevin, Jiang, Ping, Lee, Hyung-Ok, Kruger, Warren D., van Hasselt, Peter M., Strich, Randy

“…MED13L syndrome is a haploinsufficiency developmental disorder characterized by intellectual disability, heart malformation, and hypotonia. MED13L controls…”
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Identification of inhibitory scFv antibodies targeting fibroblast activation protein utilizing phage display functional screens by Zhang, Jiping, Valianou, Matthildi, Simmons, Heidi, Robinson, Matthew K., Lee, Hyung‐Ok, Mullins, Stefanie R., Marasco, Wayne A., Adams, Gregory P., Weiner, Louis M., Cheng, Jonathan D.

“…Fibroblast activation protein (FAP) is a serine protease selectively expressed on tumor stromal fibroblasts in epithelial carcinomas and is important in cancer…”
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S-adenosylhomocysteine hydrolase over-expression does not alter S-adenosylmethionine or S-adenosylhomocysteine levels in CBS deficient mice by Lee, Hyung-Ok, Wang, Liqun, Kuo, Yin-Ming, Andrews, Andrew J., Gupta, Sapna, Kruger, Warren D.

“…Elevated plasma total homocysteine (tHcy) is associated with a number of human diseases including coronary artery disease, stroke, osteoporosis and dementia…”
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Abrogation of fibroblast activation protein enzymatic activity attenuates tumor growth by Cheng, Jonathan D, Valianou, Matthildi, Canutescu, Adrian A, Jaffe, Eileen K, Lee, Hyung-Ok, Wang, Hao, Lai, Jack H, Bachovchin, William W, Weiner, Louis M

“…Tumor-associated fibroblasts are functionally and phenotypically distinct from normal fibroblasts that are not in the tumor microenvironment. Fibroblast…”
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