Search Results - "Lee, Heon Jeong"

A novel enhancer regulates MGMT expression and promotes temozolomide resistance in glioblastoma by Chen, Xiaoyue, Zhang, Minjie, Gan, Haiyun, Wang, Heping, Lee, Jeong-Heon, Fang, Dong, Kitange, Gaspar J., He, Lihong, Hu, Zeng, Parney, Ian F., Meyer, Fredric B., Giannini, Caterina, Sarkaria, Jann N., Zhang, Zhiguo

“…Temozolomide (TMZ) was used for the treatment of glioblastoma (GBM) for over a decade, but its treatment benefits are limited by acquired resistance, a process…”
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p21 produces a bioactive secretome that places stressed cells under immunosurveillance by Sturmlechner, Ines, Zhang, Cheng, Sine, Chance C, van Deursen, Erik-Jan, Jeganathan, Karthik B, Hamada, Naomi, Grasic, Jan, Friedman, David, Stutchman, Jeremy T, Can, Ismail, Hamada, Masakazu, Lim, Do Young, Lee, Jeong-Heon, Ordog, Tamas, Laberge, Remi-Martin, Shapiro, Virginia, Baker, Darren J, Li, Hu, van Deursen, Jan M

“…Immune cells identify and destroy damaged cells to prevent them from causing cancer or other pathologies by mechanisms that remain poorly understood. Here, we…”
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Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes by Lomberk, Gwen, Blum, Yuna, Nicolle, Rémy, Nair, Asha, Gaonkar, Krutika Satish, Marisa, Laetitia, Mathison, Angela, Sun, Zhifu, Yan, Huihuang, Elarouci, Nabila, Armenoult, Lucile, Ayadi, Mira, Ordog, Tamas, Lee, Jeong-Heon, Oliver, Gavin, Klee, Eric, Moutardier, Vincent, Gayet, Odile, Bian, Benjamin, Duconseil, Pauline, Gilabert, Marine, Bigonnet, Martin, Garcia, Stephane, Turrini, Olivier, Delpero, Jean-Robert, Giovannini, Marc, Grandval, Philippe, Gasmi, Mohamed, Secq, Veronique, De Reyniès, Aurélien, Dusetti, Nelson, Iovanna, Juan, Urrutia, Raul

“…Recent studies have offered ample insight into genome-wide expression patterns to define pancreatic ductal adenocarcinoma (PDAC) subtypes, although there…”
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Integrating the Epigenome to Identify Drivers of Hepatocellular Carcinoma by Hlady, Ryan A., Sathyanarayan, Aishwarya, Thompson, Joyce J., Zhou, Dan, Wu, Qunfeng, Pham, Kien, Lee, Jeong‐Heon, Liu, Chen, Robertson, Keith D.

“…Disruption of epigenetic mechanisms has been intimately linked to the etiology of human cancer. Understanding how these epigenetic mechanisms (including DNA…”
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The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas by Fang, Dong, Gan, Haiyun, Lee, Jeong-Heon, Han, Jing, Wang, Zhiquan, Riester, Scott M., Jin, Long, Chen, Jianji, Zhou, Hui, Wang, Jinglong, Zhang, Honglian, Yang, Na, Bradley, Elizabeth W., Ho, Thai H., Rubin, Brian P., Bridge, Julia A., Thibodeau, Stephen N., Ordog, Tamas, Chen, Yue, van Wijnen, Andre J., Oliveira, Andre M., Xu, Rui-Ming, Westendorf, Jennifer J., Zhang, Zhiguo

“…More than 90% of chondroblastomas contain a heterozygous mutation replacing lysine-36 with methionine-36 (K36M) in the histone H3 variant H3.3. Here we show…”
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Lipid-induced endothelial vascular cell adhesion molecule 1 promotes nonalcoholic steatohepatitis pathogenesis by Furuta, Kunimaro, Guo, Qianqian, Pavelko, Kevin D, Lee, Jeong-Heon, Robertson, Keith D, Nakao, Yasuhiko, Melek, Jan, Shah, Vijay H, Hirsova, Petra, Ibrahim, Samar H

“…Monocyte homing to the liver and adhesion to the liver sinusoidal endothelial cells (LSECs) are key elements in nonalcoholic steatohepatitis (NASH)…”
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Interferon drives HCV scarring of the epigenome and creates targetable vulnerabilities following viral clearance by Hlady, Ryan A., Zhao, Xia, El Khoury, Louis Y., Luna, Aesis, Pham, Kien, Wu, Qunfeng, Lee, Jeong‐Heon, Pyrsopoulos, Nikolaos T., Liu, Chen, Robertson, Keith D.

“…Background and Aims Chronic HCV infection is a leading etiologic driver of cirrhosis and ultimately HCC. Of the approximately 71 million individuals…”
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Cfp1 integrates both CpG content and gene activity for accurate H3K4me3 deposition in embryonic stem cells by Clouaire, Thomas, Webb, Shaun, Skene, Pete, Illingworth, Robert, Kerr, Alastair, Andrews, Robert, Lee, Jeong-Heon, Skalnik, David, Bird, Adrian

“…Trimethylation of histone H3 Lys 4 (H3K4me3) is a mark of active and poised promoters. The Set1 complex is responsible for most somatic H3K4me3 and contains…”
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Ensemble Approach to Combining Episode Prediction Models Using Sequential Circadian Rhythm Sensor Data from Mental Health Patients by Lee, Taek, Lee, Heon-Jeong, Lee, Jung-Been, Kim, Jeong-Dong

“…Managing mood disorders poses challenges in counseling and drug treatment, owing to limitations. Counseling is the most effective during hospital visits, and…”
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H3.3K27M mutant proteins reprogram epigenome by sequestering the PRC2 complex to poised enhancers by Fang, Dong, Gan, Haiyun, Cheng, Liang, Lee, Jeong-Heon, Zhou, Hui, Sarkaria, Jann N, Daniels, David J, Zhang, Zhiguo

“…Expression of histone H3.3K27M mutant proteins in human diffuse intrinsic pontine glioma (DIPG) results in a global reduction of tri-methylation of H3K27…”
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CARM1-expressing ovarian cancer depends on the histone methyltransferase EZH2 activity by Karakashev, Sergey, Zhu, Hengrui, Wu, Shuai, Yokoyama, Yuhki, Bitler, Benjamin G., Park, Pyoung-Hwa, Lee, Jeong-Heon, Kossenkov, Andrew V., Gaonkar, Krutika Satish, Yan, Huihuang, Drapkin, Ronny, Conejo-Garcia, Jose R., Speicher, David W., Ordog, Tamas, Zhang, Rugang

“…CARM1 is an arginine methyltransferase that asymmetrically dimethylates protein substrates on arginine residues. CARM1 is often overexpressed in human cancers…”
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Distinctive epigenomes characterize glioma stem cells and their response to differentiation cues by Zhou, Dan, Alver, Bonnie M, Li, Shuang, Hlady, Ryan A, Thompson, Joyce J, Schroeder, Mark A, Lee, Jeong-Heon, Qiu, Jingxin, Schwartz, Philip H, Sarkaria, Jann N, Robertson, Keith D

“…Glioma stem cells (GSCs) are a subpopulation of stem-like cells that contribute to glioblastoma (GBM) aggressiveness, recurrence, and resistance to radiation…”
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USP51 deubiquitylates H2AK13,15ub and regulates DNA damage response by Wang, Zhiquan, Zhang, Honglian, Liu, Ji, Cheruiyot, Abigael, Lee, Jeong-Heon, Ordog, Tamas, Lou, Zhenkun, You, Zhongsheng, Zhang, Zhiguo

“…Dynamic regulation of RNF168-mediated ubiquitylation of histone H2A Lys13,15 (H2AK13,15ub) at DNA double-strand breaks (DSBs) is crucial for preventing…”
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Association between weekend catch-up sleep and high-sensitivity C-reactive protein levels in adults: a population-based study by Han, Kyu-Man, Lee, Heon-Jeong, Kim, Leen, Yoon, Ho-Kyoung

“…Abstract Study Objectives To investigate the association between weekend catch-up sleep (WCS) and the levels of high-sensitivity C-reactive protein (hsCRP)—a…”
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Outdoor artificial light at night, obesity, and sleep health: Cross-sectional analysis in the KoGES study by Koo, Yong Seo, Song, Jin-Young, Joo, Eun-Yeon, Lee, Heon-Jeong, Lee, Eunil, Lee, Sang-kun, Jung, Ki-Young

“…Obesity is a common disorder with many complications. Although chronodisruption plays a role in obesity, few epidemiological studies have investigated the…”
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Wdr82 Is a C-Terminal Domain-Binding Protein That Recruits the Setd1A Histone H3-Lys4 Methyltransferase Complex to Transcription Start Sites of Transcribed Human Genes by Lee, Jeong-Heon, Skalnik, David G.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Measurement of Shear Strengths of Cu Films Using Precise Chip Forming by Lee, Jeong-Heon, Kwak, Jae B

“…The mechanical properties of thin films are under-researched because of the challenges associated with conventional experimental methods. We demonstrate a…”
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Effects of a Rice-Farming Simulation Video Game on Nature Relatedness, Nutritional Status, and Psychological State in Urban-Dwelling Adults During the COVID-19 Pandemic: Randomized Waitlist Controlled Trial by Lee, Seulki, Yuh, Chisung, Shin, Yu-Bin, Lee, Heon-Jeong, Lee, Young-Mee, Lee, Jungsil, Cho, Chul-Hyun

“…During the COVID-19 pandemic, urban inhabitants faced significant challenges in maintaining connections with nature, adhering to nutritional guidelines, and…”
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Vitamin C epigenetically controls osteogenesis and bone mineralization by Thaler, Roman, Khani, Farzaneh, Sturmlechner, Ines, Dehghani, Sharareh S., Denbeigh, Janet M., Zhou, Xianhu, Pichurin, Oksana, Dudakovic, Amel, Jerez, Sofia S., Zhong, Jian, Lee, Jeong-Heon, Natarajan, Ramesh, Kalajzic, Ivo, Jiang, Yong-hui, Deyle, David R., Paschalis, Eleftherios P., Misof, Barbara M., Ordog, Tamas, van Wijnen, Andre J.

“…Vitamin C deficiency disrupts the integrity of connective tissues including bone. For decades this function has been primarily attributed to Vitamin C as a…”
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SETD2 loss in renal epithelial cells drives epithelial‐to‐mesenchymal transition in a TGF‐β‐independent manner by Wang, Tianchu, Wagner, Ryan T., Hlady, Ryan A., Pan, Xiaoyu, Zhao, Xia, Kim, Sungho, Wang, Liguo, Lee, Jeong‐Heon, Luo, Huijun, Castle, Erik P., Lake, Douglas F., Ho, Thai H., Robertson, Keith D.

“…Histone‐lysine N‐methyltransferase SETD2 (SETD2), the sole histone methyltransferase that catalyzes trimethylation of lysine 36 on histone H3 (H3K36me3), is…”
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