Search Results - "Lee, Henry H"

Terminator-free template-independent enzymatic DNA synthesis for digital information storage by Lee, Henry H., Kalhor, Reza, Goela, Naveen, Bolot, Jean, Church, George M.

“…DNA is an emerging medium for digital data and its adoption can be accelerated by synthesis processes specialized for storage applications. Here, we describe a…”
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Antibiotic treatment expands the resistance reservoir and ecological network of the phage metagenome by Modi, Sheetal R., Lee, Henry H., Spina, Catherine S., Collins, James J.

“…By exploring the phageome in mice, antibiotic treatment is shown to lead to enrichment of phage-encoded genes that are related to antibiotic resistance. Gut…”
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Bacterial charity work leads to population-wide resistance by Collins, James J, Lee, Henry H, Molla, Michael N, Cantor, Charles R

“…Bacteria show remarkable adaptability in the face of antibiotic therapeutics. Resistance alleles in drug target-specific sites and general stress responses…”
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Detection and characterization of the SARS-CoV-2 lineage B.1.526 in New York by West, Anthony P., Wertheim, Joel O., Wang, Jade C., Vasylyeva, Tetyana I., Havens, Jennifer L., Chowdhury, Moinuddin A., Gonzalez, Edimarlyn, Fang, Courtney E., Di Lonardo, Steve S., Hughes, Scott, Rakeman, Jennifer L., Lee, Henry H., Barnes, Christopher O., Gnanapragasam, Priyanthi N. P., Yang, Zhi, Gaebler, Christian, Caskey, Marina, Nussenzweig, Michel C., Keeffe, Jennifer R., Bjorkman, Pamela J.

“…Wide-scale SARS-CoV-2 genome sequencing is critical to tracking viral evolution during the ongoing pandemic. We develop the software tool, Variant Database…”
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Phenotypic correlates of structural and functional protein impairments resultant from ALDH5A1 variants by Tokatly Latzer, Itay, Roullet, Jean-Baptiste, Cesaro, Samuele, DiBacco, Melissa L., Arning, Erland, Rotenberg, Alexander, Lee, Henry H. C., Opladen, Thomas, Jeltsch, Kathrin, García-Cazorla, Àngels, Juliá-Palacios, Natalia, Gibson, K. Michael, Bertoldi, Mariarita, Pearl, Phillip L.

“…To investigate the genotype-to-protein-to-phenotype correlations of succinic semialdehyde dehydrogenase deficiency (SSADHD), an inherited metabolic disorder of…”
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Establishing a Cell-Free Vibrio natriegens Expression System by Wiegand, Daniel J, Lee, Henry H, Ostrov, Nili, Church, George M

“…The fast growing bacterium Vibrio natriegens is an emerging microbial host for biotechnology. Harnessing its productive cellular components may offer a…”
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New Therapeutic Approaches to Inherited Metabolic Pediatric Epilepsies by Pearl, Phillip L., Tokatly-Latzer, Itay, Lee, Henry HC, Rotenberg, Alexander

“…Treatment options for inherited metabolic epilepsies are rapidly expanding with advances in molecular biology and the genomic revolution. Traditional dietary…”
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Direct Protein Kinase C-dependent Phosphorylation Regulates the Cell Surface Stability and Activity of the Potassium Chloride Cotransporter KCC2 by Lee, Henry H.C., Walker, Joshua A., Williams, Jeffery R., Goodier, Richard J., Payne, John A., Moss, Stephen J.

“…The potassium chloride cotransporter KCC2 plays a major role in the maintenance of transmembrane chloride potential in mature neurons; thus KCC2 activity is…”
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Technological challenges and milestones for writing genomes by Ostrov, Nili, Beal, Jacob, Ellis, Tom, Gordon, D Benjamin, Karas, Bogumil J, Lee, Henry H, Lenaghan, Scott C, Schloss, Jeffery A, Stracquadanio, Giovanni, Trefzer, Axel, Bader, Joel S, Church, George M, Coelho, Cintia M, Efcavitch, J William, Güell, Marc, Mitchell, Leslie A, Nielsen, Alec A K, Peck, Bill, Smith, Alexander C, Stewart, Jr, C Neal, Tekotte, Hille

“…Synthetic genomics requires improved technologies Engineering biology with recombinant DNA, broadly called synthetic biology, has progressed tremendously in…”
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Understanding the Molecular Mechanisms of Succinic Semialdehyde Dehydrogenase Deficiency (SSADHD): Towards the Development of SSADH-Targeted Medicine by Lee, Henry H C, McGinty, Gabrielle E, Pearl, Phillip L, Rotenberg, Alexander

“…Succinic semialdehyde dehydrogenase deficiency (SSADHD) is a rare genetic disorder caused by inefficient metabolic breakdown of the major inhibitory…”
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Otx2 binding to perineuronal nets persistently regulates plasticity in the mature visual cortex by Beurdeley, Marine, Spatazza, Julien, Lee, Henry H C, Sugiyama, Sayaka, Bernard, Clémence, Di Nardo, Ariel A, Hensch, Takao K, Prochiantz, Alain

“…Specific transfer of (orthodenticle homeobox 2) Otx2 homeoprotein into GABAergic interneurons expressing parvalbumin (PV) is necessary and sufficient to open,…”
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NMDA receptor activity downregulates KCC2 resulting in depolarizing GABAA receptor–mediated currents by Lee, Henry H C, Deeb, Tarek Z, Walker, Joshua A, Davies, Paul A, Moss, Stephen J

“…The authors show that NMDA receptor activation induces a rapid protein phosphatase 1–dependent dephosphorylation and downregulation of the neuron-specific…”
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KCC2 activity is critical in limiting the onset and severity of status epilepticus by Silayeva, Liliya, Deeb, Tarek Z., Hines, Rochelle M., Kelley, Matt R., Munoz, Michaelanne B., Lee, Henry H. C., Brandon, Nicholas J., Dunlop, John, Maguire, Jaime, Davies, Paul A., Moss, Stephen J.

“…Significance Status epilepticus (SE) is defined as a state of continuous unremitting seizures that often exhibits underlying deficits in neuronal inhibition…”
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Clinical and molecular outcomes from the 5-Year natural history study of SSADH Deficiency, a model metabolic neurodevelopmental disorder by Tokatly Latzer, Itay, Roullet, Jean-Baptiste, Afshar-Saber, Wardiya, Lee, Henry H C, Bertoldi, Mariarita, McGinty, Gabrielle E, DiBacco, Melissa L, Arning, Erland, Tsuboyama, Melissa, Rotenberg, Alexander, Opladen, Thomas, Jeltsch, Kathrin, García-Cazorla, Àngels, Juliá-Palacios, Natalia, Gibson, K Michael, Sahin, Mustafa, Pearl, Phillip L

“…Succinic semialdehyde dehydrogenase deficiency (SSADHD) represents a model neurometabolic disease at the fulcrum of translational research within the Boston…”
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Tyrosine phosphorylation regulates the membrane trafficking of the potassium chloride co-transporter KCC2 by Lee, Henry H.C., Jurd, Rachel, Moss, Stephen J.

“…The activity of the neuronal-specific potassium chloride co-transporter KCC2 allows neurons to maintain low intracellular Cl − concentrations. These low Cl −…”
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Choroid-Plexus-Derived Otx2 Homeoprotein Constrains Adult Cortical Plasticity by Spatazza, Julien, Lee, Henry H.C., Di Nardo, Ariel A., Tibaldi, Lorenzo, Joliot, Alain, Hensch, Takao K., Prochiantz, Alain

“…Brain plasticity is often restricted to critical periods in early life. Here, we show that a key regulator of this process in the visual cortex, Otx2…”
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Assessment of potential SARS-CoV-2 virus integration into human genome reveals no significant impact on RT-qPCR COVID-19 testing by Briggs, Erica, Ward, William, Rey, Sol, Law, Dylan, Nelson, Katharine, Bois, Michael, Ostrov, Nili, Lee, Henry H., Laurent, Jon M., Mita, Paolo

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Functional genomics of the rapidly replicating bacterium Vibrio natriegens by CRISPRi by Lee, Henry H., Ostrov, Nili, Wong, Brandon G., Gold, Michaela A., Khalil, Ahmad S., Church, George M.

“…The fast-growing Gram-negative bacterium Vibrio natriegens is an attractive microbial system for molecular biology and biotechnology due to its remarkably…”
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Glymphatic dysfunction coincides with lower GABA levels and sleep disturbances in succinic semialdehyde dehydrogenase deficiency by Tokatly Latzer, Itay, Yang, Edward, Afacan, Onur, Arning, Erland, Rotenberg, Alexander, Lee, Henry H. C., Roullet, Jean‐Baptiste, Pearl, Phillip L.

“…Summary Succinic semialdehyde dehydrogenase deficiency (SSADHD) is an inherited metabolic disorder of γ‐aminobutyrate (GABA) catabolism. Cerebral waste…”
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Microbial environments confound antibiotic efficacy by Lee, Henry H, Collins, James J

“…Despite our continued efforts to assert control over pathogens, more and more bacteria are saying “no” to drugs. It is becoming increasingly apparent that…”
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