Search Results - "Lee, Frank J.S."

NCS-1 in the Dentate Gyrus Promotes Exploration, Synaptic Plasticity, and Rapid Acquisition of Spatial Memory by Saab, Bechara J., Georgiou, John, Nath, Arup, Lee, Frank J.S., Wang, Min, Michalon, Aubin, Liu, Fang, Mansuy, Isabelle M., Roder, John C.

“…The molecular underpinnings of exploration and its link to learning and memory remain poorly understood. Here we show that inducible, modest overexpression of…”
Get full text

Dopamine-dependent neurotoxicity of α-synuclein: A mechanism for selective neurodegeneration in Parkinson disease by Yankner, Bruce A, Xu, Jin, Kao, Shyan-Yuan, Lee, Frank J.S, Song, Weihong, Jin, Lee-Way

“…The mechanism by which dopaminergic neurons are selectively lost in Parkinson disease (PD) is unknown. Here we show that accumulation of alpha-synuclein in…”
Get full text

Uncoupling the D1- N- Methyl-D-Aspartate (NMDA) Receptor Complex Promotes NMDA-Dependent Long-Term Potentiation and Working Memory by Nai, Qiang, Li, Shupeng, Wang, Szu-Han, Liu, Jing, Lee, Frank J.S, Frankland, Paul W, Liu, Fang

“…Background Although dopamine D1 receptors are involved in working memory, how D1 receptors contribute to this process remains unclear. Numerous studies have…”
Get full text

The retinoblastoma protein regulates hypoxia-inducible genetic programs, tumor cell invasiveness and neuroendocrine differentiation in prostate cancer cells by Labrecque, Mark P., Takhar, Mandeep K., Nason, Rebecca, Santacruz, Stephanie, Tam, Kevin J., Massah, Shabnam, Haegert, Anne, Bell, Robert H., Altamirano-Dimas, Manuel, Collins, Colin C., Lee, Frank J.S., Prefontaine, Gratien G., Cox, Michael E., Beischlag, Timothy V.

Get full text

Genetic factors involved in the pathogenesis of Parkinson's disease by Lee, Frank J.S, Liu, Fang

“…Abstract Parkinson's disease (PD) is a neurodegenerative disease characterized by a loss of nigrostriatal dopaminergic neurons. Recently, PD research has been…”
Get full text

Protein kinase-mediated bidirectional trafficking and functional regulation of the human dopamine transporter by Pristupa, Zdenek B., McConkey, Fortunata, Liu, Fang, Man, Heng Y., Lee, Frank J.S., Wang, Yu T., Niznik, Hyman B.

“…Modification of the transport velocity of both the native neuronal and cloned presynaptic dopamine transporter (DAT) has been reported following…”
Get full text

Dopamine receptor interacting proteins (DRIPs) of dopamine D1-like receptors in the central nervous system by Wang, Min, Lee, Frank J S, Liu, Fang

“…Dopamine is a major neurotransmitter in the mammalian central nervous system (CNS) that regulates neuroendocrine functions, locomotor activity, cognition and…”
Get more information

Neuroprotective effects of extracellular DJ ‐1 on reperfusion injury in SH ‐ SY 5 Y cells by Han, Jay, Luk, Beryl, Lee, Frank J.S.

“…Abstract Using an in vitro model of ischemic stroke we treated differentiated SH‐SY5Y cells to oxygen‐glucose deprivation (OGD) followed by a reperfusion…”
Get full text

Serum amyloid P component (SAP) modulates antidepressant effects through promoting membrane insertion of the serotonin transporter by Su, Ping, Yan, Shuxin, Yang, Jian, Tong, Junchao, Samsom, James, You, Fan, Li, Yun, Chen, Qiuyue, Jiang, Anlong, Zhai, Dongxu, Chen, Jiahao, Sun, Zuoli, Zhou, Jingjing, Liu, Min, Lee, Frank J S, Xu, Zhi-Qing David, Wang, Xin, Vasdev, Neil, Wong, Albert H C, Liu, Fang

“…Serum amyloid P component (SAP) is a universal constituent of human amyloid deposits including those in Alzheimer's disease. SAP has been observed to be…”
Get full text

Endosomal recycling and dopamine neurotransmission: Exploring the links between the retromer and Parkinson's disease by Gock, Nathan, Follett, Jordan, Rintoul, Gordon L, Beischlag, Timothy V, Lee, Frank J.S.

“…The retromer complex is an evolutionarily conserved protein complex involved in the endosomal recycling of various cargo proteins. It is ubiquitously expressed…”
Get full text

Dopamine transporter cell surface localization facilitated by a direct interaction with the dopamine D2 receptor by Lee, Frank JS, Pei, Lin, Moszczynska, Anna, Vukusic, Brian, Fletcher, Paul J, Liu, Fang

“…Altered synaptic dopamine levels have been implicated in several neurological/neuropsychiatric disorders, including drug addiction and schizophrenia. However,…”
Get full text

Neuroprotective effects of extracellular DJ‐1 on reperfusion injury in SH‐SY5Y cells by Han, Jay, Luk, Beryl, Lee, Frank J.S.

“…Using an in vitro model of ischemic stroke we treated differentiated SH‐SY5Y cells to oxygen‐glucose deprivation (OGD) followed by a reperfusion period where…”
Get full text

Delineation of Domains Within the Cannabinoid CB1 and Dopamine D2 Receptors That Mediate the Formation of the Heterodimer Complex by Khan, Shazina S., Lee, Frank J. S.

“…Both the cannabinoid CB1 receptor (CB1) and dopamine D2 receptor (D2R) are G protein-coupled receptors that are linked to inhibitory Gαi/o protein, whereby…”
Get full text

Dual Regulation of NMDA Receptor Functions by Direct Protein-Protein Interactions with the Dopamine D1 Receptor by Lee, Frank J.S., Xue, Sheng, Pei, Lin, Vukusic, Brian, Chéry, Nadege, Wang, Yushan, Wang, Yu Tian, Niznik, Hyman B., Yu, Xian-min, Liu, Fang

“…Dopamine D1-like receptors, composed of D1 and D5 receptors, have been documented to modulate glutamate-mediated fast excitatory synaptic neurotransmission…”
Get full text

Direct binding and functional coupling of alpha-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis by Lee, F J, Liu, F, Pristupa, Z B, Niznik, H B

“…Mutations in alpha-synuclein, a protein highly enriched in presynaptic terminals, have been implicated in the expression of familial forms of Parkinson's…”
Get full text

A Physical Interaction between the Dopamine Transporter and DJ-1 Facilitates Increased Dopamine Reuptake by Luk, Beryl, Mohammed, Mohinuddin, Liu, Fang, Lee, Frank J S

“…The regulation of the dopamine transporter (DAT) impacts extracellular dopamine levels after release from dopaminergic neurons. Furthermore, a variety of…”
Get full text

Regulation of Dopamine D1 Receptor Function by Physical Interaction with the NMDA Receptors by Pei, Lin, Lee, Frank J. S, Moszczynska, Anna, Vukusic, Brian, Liu, Fang

“…Functional interactions between dopamine D1-like receptors and NMDA subtype glutamate receptors have been implicated in the maintenance of normal brain…”
Get full text

Disruption of the dopamine transporter-dopamine D2 receptor interaction in schizophrenia by Lee, Frank J.S., Pei, Lin, Liu, Fang

“…No abstract is available for this article…”
Get full text

FMRP Acts as a Key Messenger for Dopamine Modulation in the Forebrain by Wang, Hansen, Wu, Long-Jun, Kim, Susan S., Lee, Frank J.S., Gong, Bo, Toyoda, Hiroki, Ren, Ming, Shang, Yu-Ze, Xu, Hui, Liu, Fang, Zhao, Ming-Gao, Zhuo, Min

“…The fragile X mental retardation protein (FMRP) is an RNA-binding protein that controls translational efficiency and regulates synaptic plasticity. Here, we…”
Get full text

Direct interaction between GluR2 and GAPDH regulates AMPAR-mediated excitotoxicity by Wang, Min, Li, Shupeng, Zhang, Hongyu, Pei, Lin, Zou, Shengwei, Lee, Frank J S, Wang, Yu Tian, Liu, Fang

“…Over-activation of AMPARs (α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid subtype glutamate receptors) is implicated in excitotoxic neuronal death…”
Get full text