Search Results - "Lee, Fook T."

Radioimmunotherapy with α-Particle–Emitting 213Bi-C-Functionalized trans-Cyclohexyl-Diethylenetriaminepentaacetic Acid-Humanized 3S193 Is Enhanced by Combination with Paclitaxel Chemotherapy by KELLY, Marcus P, LEE, Fook T, TAHTIS, Kiki, SMYTH, Fiona E, BRECHBIEL, Martin W, SCOTT, Andrew M

“…Purpose: Previous experience in solid tumor radioimmunotherapy studies has indicated that greatest therapeutic efficacy is achieved in the treatment of…”
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Molecular Imaging of Death Receptor 5 Occupancy and Saturation Kinetics In Vivo by Humanized Monoclonal Antibody CS-1008 by BURVENICH, Ingrid J. G, LEE, Fook T, BECKMAN, Robert A, FUJIWARA, Kosaku, VON ROEMELING, Reinhard, SCOTT, Andrew M, CARTWRIGHT, Glenn A, O'KEEFE, Graeme J, MAKRIS, Dahna, CAO, Diana, GONG, Sylvia, CHUEH, Anderly C, MARIADASON, John M, BRECHBIEL, Martin W

“…CS-1008 (tigatuzumab; phase I/II), an antihuman death receptor 5 (DR5) agonist, induces apoptosis and has cytotoxic activity against human cancer cell lines…”
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Cross-species analysis of Fc engineered anti-Lewis-Y human IgG1 variants in human neonatal receptor transgenic mice reveal importance of S254 and Y436 in binding human neonatal Fc receptor by Burvenich, Ingrid J G, Farrugia, William, Lee, Fook T, Catimel, Bruno, Liu, Zhanqi, Makris, Dahna, Cao, Diana, O'Keefe, Graeme J, Brechbiel, Martin W, King, Dylan, Spirkoska, Violeta, Allan, Laura C, Ramsland, Paul A, Scott, Andrew M

“…IgG has a long half-life through engagement of its Fc region with the neonatal Fc receptor (FcRn). The FcRn binding site on IgG1 has been shown to contain I253…”
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Enhanced Efficacy of Radioimmunotherapy with 90Y-CHX-A″-DTPA-hu3S193 by Inhibition of Epidermal Growth Factor Receptor (EGFR) Signaling with EGFR Tyrosine Kinase Inhibitor AG1478 by LEE, Fook T, MOUNTAIN, Angela J, SCOTT, Andrew M, KELLY, Marcus P, HALL, Cathrine, RIGOPOULOS, Angela, JOHNS, Terrance G, SMYTH, Fiona E, BRECHBIEL, Martin W, NICE, Edouard C, BURGESS, Antony W

“…Purpose: Monoclonal antibodies and tyrosine kinase inhibitors specific for the epidermal growth factor receptor (EGFR) have been shown to enhance the effect of…”
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l-Tyrosine Confers Residualizing Properties to a d-Amino Acid-Rich Residualizing Peptide for Radioiodination of Internalizing Antibodies by Lee, Fook T., Burvenich, Ingrid J. G., Guo, Nancy, Kocovski, Pece, Tochon-Danguy, Henri, Ackermann, Uwe, O’Keefe, Graeme J., Gong, Sylvia, Rigopoulos, Angela, Liu, Zhanqi, Gan, Hui K., Scott, Andrew M.

“…Purpose: The aims of the study were to develop and evaluate a novel residualizing peptide for labeling internalizing antibodies with 124I to support clinical…”
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Investigation of hypoxia and carbonic anhydrase IX expression in a renal cell carcinoma xenograft model with oxygen tension measurements and 124I-cG250 PET/CT by Lawrentschuk, Nathan, Lee, Fook T., Jones, Gareth, Rigopoulos, Angela, Mountain, Angela, O'Keefe, Graeme, Papenfuss, Anthony T., Bolton, Damien M., Davis, Ian D., Scott, Andrew M.

“…In tumors, hypoxia stimulates angiogenesis and correlates with treatment resistance and poor prognosis. We have previously demonstrated hypoxia in human renal…”
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Immuno-PET quantitation of de2-7 epidermal growth factor receptor expression in glioma using 124I-IMP-R4-labeled antibody ch806 by Lee, Fook T, O'Keefe, Graeme J, Gan, Hui K, Mountain, Angela J, Jones, Gareth R, Saunder, Timothy H, Sagona, Jessica, Rigopoulos, Angela, Smyth, Fiona E, Johns, Terrance G, Govindan, Serengulam V, Goldenberg, David M, Old, Lloyd J, Scott, Andrew M

“…Overexpression, activation, and mutations of the epidermal growth factor receptor (EGFR) are commonly found in solid tumors. The aim of this study was to…”
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Immuno-PET for tumor targeting by LEE, Fook T, SCOTT, Andrew M

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Abstract 1174: A phase I imaging and pharmacodynamic trial of CS-1008 in patients (pts) with metastatic colorectal cancer (mCRC) by Ciprotti, Marika, Tebbutt, Niall C., Lee, Fook T., Lee, Sze T., McKee, Dave C., O'Keefe, Graeme J., Gong, Sylvia J., Chong, Geoffrey, Gan, Hui K., Hopkins, Wendie, Chappell, Bridget, Guo, Nancy Y., Smyth, Fiona E., Tse, Archie N., Jansen, Mendel, Matsumura, Manabu, Watanabe, Rira, Beckman, Robert A., Greenberg, Jon, Scott, Andrew M.

“…Background: Death receptor 5 (DR5) is a member of the TNFR superfamily that initiates the extrinsic apoptotic pathway by activating caspases. CS-1008 is a…”
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Immuno-PET Quantitation of de2-7 Epidermal Growth Factor Receptor Expression in Glioma Using ^sup 124^I-IMP-R4-Labeled Antibody ch806 by Lee, Fook T, O'Keefe, Graeme J, Gan, Hui K, Mountain, Angela J, Jones, Gareth R, Saunder, Timothy H, Sagona, Jessica, Rigopoulos, Angela, Smyth, Fiona E, Johns, Terrance G, Giovindan, Serengulam V, Goldenberg, David M, Old, Lloyd J, Scott, Andrew M

“…Overexpression, activation, and mutations of the epidermal growth factor receptor (EGFR) are commonly found in solid tumors. The aim of this study was to…”
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Immuno-PET Quantitation of de2-7 Epidermal Growth Factor Receptor Expression in Glioma Using 124 I-IMP-R4–Labeled Antibody ch806 by Lee, Fook T., O'Keefe, Graeme J., Gan, Hui K., Mountain, Angela J., Jones, Gareth R., Saunder, Timothy H., Sagona, Jessica, Rigopoulos, Angela, Smyth, Fiona E., Johns, Terrance G., Govindan, Serengulam V., Goldenberg, David M., Old, Lloyd J., Scott, Andrew M.

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Detection of Malignant Tumors Using Tc-99m Labeled Fab' Fragments From a Monoclonal Antibody With Specificity for D-Dimer of Cross-Linked Fibrin by ANGELIDES, SOCRATES, LEE, FOOK T, BASTEN, ANTHONY, LAMBRECHT, RICHARD M, WALKER, KAREN Z, BUNDESEN, PETER G, BAUTOVICH, GEORGE J

“…The authors present the case studies of two patients whose malignant tumors were detected with a Tc-99m labeled antifibrin monoclonal antibody (DD-3B6/22),…”
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Radioimmunotherapy with alpha -Particle-Emitting super(213)Bi-C-Functionalized trans-Cyclohexyl-Diethylenetriaminepentaacetic Acid-Humanized 3S193 Is Enhanced by Combination with Paclitaxel Chemotherapy by Kelly, Marcus P, Lee, Fook T, Tahtis, Kiki, Smyth, Fiona E, Brechbiel, Martin W, Scott, Andrew M

“…PURPOSE: Previous experience in solid tumor radioimmunotherapy studies has indicated that greatest therapeutic efficacy is achieved in the treatment of…”
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Tyrosine Confers Residualizing Properties to a -Amino Acid-Rich Residualizing Peptide for Radioiodination of Internalizing Antibodies by Fook T. Lee PhD, Ingrid J. G. Burvenich PhD, Nancy Guo MBBS, MSc, Pece Kocovski BSc (Honors), Henri Tochon-Danguy PhD, Uwe Ackermann PhD, Graeme J. O’Keefe PhD, Sylvia Gong PhD, Angela Rigopoulos BSc, MSc, Zhanqi Liu MBBS, PhD, Hui K. Gan MBBS, FRACP, PhD, Andrew M. Scott MBBS, FRACP, MD

“…Purpose: The aims of the study were to develop and evaluate a novel residualizing peptide for labeling internalizing antibodies with 124 I to support clinical…”
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Immuno-PET of human colon xenograft-bearing BALB/c nude mice using (124)I-CDR-grafted humanized A33 monoclonal antibody by Lee, Fook T, Hall, Cathrine, Rigopoulos, Angela, Zweit, Jamal

“…Radiolabeling monoclonal antibodies (mAbs) allows the evaluation of biodistribution of constructs in vivo through gamma camera imaging and also permits…”
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Enhanced Efficacy of 90Y-Radiolabeled Anti-Lewis Y Humanized Monoclonal Antibody hu3S193 and Paclitaxel Combined-Modality Radioimmunotherapy in a Breast Cancer Model by Kelly, Marcus P, Lee, Fook T, Smyth, Fiona E, Brechbiel, Martin W, Scott, Andrew M

“…Radioimmunotherapy (RIT) of solid tumor is often limited in efficacy because of restrictions in achieved tumor dose. In an effort to overcome this, the…”
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Enhanced Efficacy of ^sup 90^Y-Radiolabeled Anti-Lewis Y Humanized Monoclonal Antibody hu3S193 and Paclitaxel Combined-Modality Radioimmunotherapy in a Breast Cancer Model by Kelly, Marcus P, Lee, Fook T, Smyth, Fiona E, Brechbiel, Martin W, Scott, Andrew M

“…Radioimmunotherapy (RIT) of solid tumor is often limited in efficacy because of restrictions in achieved tumor dose. In an effort to overcome this, the…”
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Investigation of hypoxia and carbonic anhydrase IX expression in a renal cell carcinoma xenograft model with oxygen tension measurements and124 I-cG250 PET/CT by Lawrentschuk, Nathan, F.R.A.C.S, Lee, Fook T., Ph.D, Jones, Gareth, B.Sc (Hons), Rigopoulos, Angela, M.Sc, Mountain, Angela, B.App.Sci, O'Keefe, Graeme, Ph.D, Papenfuss, Anthony T., Ph.D, Bolton, Damien M., M.D, Davis, Ian D., Ph.D, Scott, Andrew M., M.D

“…Abstract Objectives In tumors, hypoxia stimulates angiogenesis and correlates with treatment resistance and poor prognosis. We have previously demonstrated…”
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Enhanced Efficacy of Radioimmunotherapy with super(90)Y-CHX-A''-DTPA-hu3S193 by Inhibition of Epidermal Growth Factor Receptor (EGFR) Signaling with EGFR Tyrosine Kinase Inhibitor AG1478 by Lee, Fook T, Mountain, Angela J, Kelly, Marcus P, Hall, Cathrine, Rigopoulos, Angela, Johns, Terrance G, Smyth, Fiona E, Brechbiel, Martin W, Nice, Edouard C, Burgess, Antony W, Scott, Andrew M

“…PURPOSE: Monoclonal antibodies and tyrosine kinase inhibitors specific for the epidermal growth factor receptor (EGFR) have been shown to enhance the effect of…”
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PET Imaging of 86Y-Labeled Anti-Lewis Y Monoclonal Antibodies in a Nude Mouse Model: Comparison Between 86Y and 111In Radiolabels by Lovqvist, Anna, Humm, John L, Sheikh, Arif, Finn, Ron D, Koziorowski, Jacek, Ruan, Shutian, Pentlow, Keith S, Jungbluth, Achim, Welt, Sydney, Lee, Fook T, Brechbiel, Martin W, Larson, Steven M

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