Search Results - "Lee, Ernest Y.C."

Loss of the p12 subunit of DNA polymerase delta leads to a defect in HR and sensitization to PARP inhibitors by Zhang, Sufang, Chao, Hsiao Hsiang, Wang, Xiaoxiao, Zhang, Zhongtao, Lee, Ernest Y.C., Lee, Marietta Y.W.T.

“…•p12-knockout generates a HR deficiency phenotype.•Pol δ4 is required for full expression of cellular HR activity.•p12 knockout cells are sensitized to PARP…”
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Discovery of a novel DNA polymerase inhibitor and characterization of its antiproliferative properties by Mishra, Bhanvi, Zhang, Sufang, Zhao, Hong, Darzynkiewicz, Zbigniew, Lee, Ernest Y.C., Lee, Marietta Y.W.T., Zhang, Zhongtao

“…Chromosomal duplication is targeted by various chemotherapeutic agents for the treatment of cancer. However, there is no specific inhibitor of DNA polymerases…”
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Structure of monoubiquitinated PCNA: Implications for DNA polymerase switching and Okazaki fragment maturation by Zhang, Zhongtao, Zhang, Sufang, Lin, Szu Hua Sharon, Wang, Xiaoxiao, Wu, Licheng, Lee, Ernest Y.C., Lee, Marietta Y.W.T.

“…Ubiquitination of proliferating cell nuclear antigen (PCNA) to ub-PCNA is essential for DNA replication across bulky template lesions caused by UV radiation…”
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DNA damage alters DNA polymerase δ to a form that exhibits increased discrimination against modified template bases and mismatched primers by Meng, Xiao, Zhou, Yajing, Zhang, Sufang, Lee, Ernest Y.C, Frick, David N, Lee, Marietta Y.W.T

“…Human DNA polymerase δ (Pol δ4), a key enzyme in chromosomal replication, is a heterotetramer composed of the p125, p50, p68 and p12 subunits. Genotoxic agents…”
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Spatiotemporal recruitment of human DNA polymerase delta to sites of UV damage by Chea, Jennifer, Zhang, Sufang, Zhao, Hong, zhang, Zhongtao, Lee, Ernest Y.C., Darzynkiewicz, Zbigniew, Lee, Marietta Y.W.T.

“…Human DNA polymerase δ (Pol δ) is involved in various DNA damage responses in addition to its central role in DNA replication. The Pol δ4 holoenzyme consists…”
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PCNA is ubiquitinated by RNF8 by Zhang, Sufang, Chea, Jennifer, Meng, Xiao, Zhou, Yajing, Lee, Ernest Y.C., Lee, Marietta Y.W.T.

“…The ubiquitination of PCNA is an essential event in the operation of the DNA Damage Tolerance (DDT) pathway that is activated after DNA damage caused by UV or…”
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Novel DNA Damage Response: RAPID DEGRADATION OF THE p12 SUBUNIT OF DNA POLYMERASE δ by Zhang, Sufang, Zhou, Yajing, Trusa, Sandra, Meng, Xiao, Lee, Ernest Y.C, Lee, Marietta Y.W.T

“…Mammalian DNA polymerase (Pol) δ is essential for DNA replication. It consists of four subunits, p125, p50, p68, and p12. We report the discovery that the p12…”
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Phosphorylation Alters the Properties of Pol η: Implications for Translesion Synthesis by Peddu, Chandana, Zhang, Sufang, Zhao, Hong, Wong, Agnes, Lee, Ernest Y.C., Lee, Marietta Y.W.T., Zhang, Zhongtao

“…There are significant ambiguities regarding how DNA polymerase η is recruited to DNA lesion sites in stressed cells while avoiding normal replication forks in…”
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Initiation and termination of DNA replication during S phase in relation to cyclins D1, E and A, p21WAF1, Cdt1 and the p12 subunit of DNA polymerase δ revealed in individual cells by cytometry by Darzynkiewicz, Zbigniew, Zhao, Hong, Zhang, Sufang, Lee, Marietta Y W T, Lee, Ernest Y C, Zhang, Zhongtao

“…During our recent studies on mechanism of the regulation of human DNA polymerase δ in preparation for DNA replication or repair, multiparameter imaging…”
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Protein Phosphatase-1 Inhibitor-3 Is an in Vivo Target of Caspase-3 and Participates in the Apoptotic Response by Huang, Hua-Shan, Lee, Ernest Y.C.

“…Inh3 (inhibitor-3) is a potent inhibitor of protein phosphatase-1 that selectively associates with PP1γ1 and PP1α but not the PP1β isoform. We demonstrate that…”
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A Protein Phosphatase-1-binding Motif Identified by the Panning of a Random Peptide Display Library by Zhao, Sumin, Lee, Ernest Y.C.

“…An unusually large number of regulatory or targeting proteins that bind to the catalytic subunit of protein phosphatase-1 have been recently reported. This can…”
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Colorimetric protein phosphatase inhibition assay of laboratory strains and natural blooms of cyanobacteria: comparisons with high-performance liquid chromatographic analysis for microcystins by Ward, Clive J, Beattie, Kenneth A, Lee, Ernest Y.C, Codd, Geoffrey A

“…Microcystins are cyclic heptapeptide hepatotoxins commonly produced by bloom-forming genera of cyanobacteria. These toxins are potent and specific inhibitors…”
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The DHX9 helicase interacts with human DNA polymerase δ4 and stimulates its activity in D-loop extension synthesis by Wang, Xiaoxiao, Zhang, Sufang, Zhang, Zhongtao, Mazloum, Nayef A., Lee, Ernest Y.C., Lee, Marietta Y.W.

“…The extension of the invading strand within a displacement loop (D-loop) is a key step in homology directed repair (HDR) of doubled stranded DNA breaks. The…”
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Characterization of human DNA polymerase delta and its subassemblies reconstituted by expression in the MultiBac system by Zhou, Yajing, Meng, Xiao, Zhang, Sufang, Lee, Ernest Y C, Lee, Marietta Y W T

“…Mammalian DNA polymerase δ (Pol δ), a four-subunit enzyme, plays a crucial and versatile role in DNA replication and DNA repair processes. We have…”
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Two forms of human DNA polymerase δ: Who does what and why? by Lee, Marietta Y.W.T., Zhang, Sufang, Wang, Xiaoxiao, Chao, Hsiao Hsiang, Zhao, Hong, Darzynkiewicz, Zbigniew, Zhang, Zhongtao, Lee, Ernest Y.C.

“…DNA polymerase δ (Pol δ) plays a central role in lagging strand DNA synthesis in eukaryotic cells, as well as an important role in DNA repair processes. Human…”
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A novel function of CRL4(Cdt2): regulation of the subunit structure of DNA polymerase δ in response to DNA damage and during the S phase by Zhang, Sufang, Zhao, Hong, Darzynkiewicz, Zbiegniew, Zhou, Pengbo, Zhang, Zhongtao, Lee, Ernest Y C, Lee, Marietta Y W T

“…DNA polymerase δ (Pol δ4) is a heterotetrameric enzyme, whose p12 subunit is degraded in response to DNA damage, leaving behind a trimer (Pol δ3) with altered…”
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Expression of the p12 subunit of human DNA polymerase δ (Pol δ), CDK inhibitor p21WAF1, Cdt1, cyclin A, PCNA and Ki-67 in relation to DNA replication in individual cells by Zhao, Hong, Zhang, Sufang, Xu, Dazhong, Lee, Marietta YWT, Zhang, Zhongtao, Lee, Ernest YC, Darzynkiewicz, Zbigniew

“…We recently reported that the p12 subunit of human DNA polymerase δ (Pol δ4) is degraded by CRL4 Cdt2 which regulates the licensing factor Cdt1 and p21 WAF1…”
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Regulation and Modulation of Human DNA Polymerase δ Activity and Function by Lee, Marietta Y W T, Wang, Xiaoxiao, Zhang, Sufang, Zhang, Zhongtao, Lee, Ernest Y C

“…This review focuses on the regulation and modulation of human DNA polymerase δ (Pol δ). The emphasis is on the mechanisms that regulate the activity and…”
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POLDIP3: At the Crossroad of RNA and DNA Metabolism by Singh, Manrose, Zhang, Sufang, Perez, Alexis M, Lee, Ernest Y C, Lee, Marietta Y W T, Zhang, Dong

“…POLDIP3 was initially identified as a DNA polymerase delta (Pol δ) interacting protein almost twenty years ago. Intriguingly, it also interacts with proteins…”
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A Novel Function of CRL4Cdt2 by Zhang, Sufang, Zhao, Hong, Darzynkiewicz, Zbiegniew, Zhou, Pengbo, Zhang, Zhongtao, Lee, Ernest Y.C., Lee, Marietta Y.W.T.

“…DNA polymerase δ (Pol δ4) is a heterotetrameric enzyme, whose p12 subunit is degraded in response to DNA damage, leaving behind a trimer (Pol δ3) with altered…”
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