Search Results - "Lee, Ernest E."

CRTH2 Antagonist MK-7246: A Synthetic Evolution from Discovery through Development by Molinaro, Carmela, Bulger, Paul G, Lee, Ernest E, Kosjek, Birgit, Lau, Stephen, Gauvreau, Danny, Howard, Melissa E, Wallace, Debra J, O’Shea, Paul D

“…In this paper, we report the development of different synthetic routes to MK-7246 (1) designed by the Process Chemistry group. The syntheses were initially…”
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Enantioselective Synthesis of Indolizidines Bearing Quaternary Substituted Stereocenters via Rhodium-Catalyzed [2 + 2 + 2] Cycloaddition of Alkenyl Isocyanates and Terminal Alkynes by Lee, Ernest E, Rovis, Tomislav

“…An enantioselective synthesis of indolizidines bearing quaternary substituted stereocenters by way of a rhodium-catalyzed [2 + 2 + 2] cycloaddition of…”
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Total Synthesis of Indolizidine Alkaloid (−)‐209D: Overriding Substrate Bias in the Asymmetric Rhodium‐Catalyzed [2+2+2] Cycloaddition by Yu, Robert T., Lee, Ernest E., Malik, Guillaume, Rovis, Tomislav

“…CO! You had me at hello: The use of chiral biphenyl‐based phosphoramidite ligands on rhodium provides an efficient [2+2+2] cycloaddition between terminal alkyl…”
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Enantioselective Palladium(II)-Catalyzed Formal [3,3]-Sigmatropic Rearrangement of 2-Allyloxypyridines and Related Heterocycles by Rodrigues, Alessandro, Lee, Ernest E, Batey, Robert A

“…Enantioselective palladium(II)-catalyzed formal [3,3]-sigmatropic rearrangement of (E)- and (Z)-allyloxy substituted N-heterocycles generates N-allyl…”
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Regioselective rhodium-catalyzed intermolecular [2+2+2] cycloaddition of alkynes and isocyanates to form pyridones by Oberg, Kevin M., Lee, Ernest E., Rovis, Tomislav

“…A highly regioselective rhodium-catalyzed intermolecular [2+2+2] cycloaddition of terminal alkynes with a variety of isocyanates to provide 2- and 4-pyridones…”
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Palladium-Catalyzed Allylic Transposition of (Allyloxy) Iminodiazaphospholidines:  A Formal [3,3]-Aza-phospha-oxa-Cope Sigmatropic Rearrangement for the Stereoselective Synthesis of Allylic Amines by Lee, Ernest E, Batey, Robert A

“…The synthesis of N-protected allylic amines has been achieved utilizing a palladium(II)-catalyzed, [3,3]-rearrangement of (allyloxy) iminodiazaphospholidines…”
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Enantioselective Rhodium-Catalyzed [2 + 2 + 2] Cycloadditions of Terminal Alkynes and Alkenyl Isocyanates: Mechanistic Insights Lead to a Unified Model that Rationalizes Product Selectivity by Dalton, Derek M, Oberg, Kevin M, Yu, Robert T, Lee, Ernest E, Perreault, Stéphane, Oinen, Mark Emil, Pease, Melissa L, Malik, Guillaume, Rovis, Tomislav

“…This manuscript describes the development and scope of the asymmetric rhodium-catalyzed [2 + 2 + 2] cycloaddition of terminal alkynes and alkenyl isocyanates…”
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Diastereoselective synthesis of fluorinated piperidine quinazoline spirocycles as iNOS selective inhibitors by Walpole, Chris, Liu, Ziping, Lee, Ernest E., Yang, Hua, Zhou, Fei, Mackintosh, Nicole, Sjogren, Magnus, Taylor, David, Shen, Jinyu, Batey, Robert A.

“…A diastereoselective synthesis of fluoropiperidine quinazoline spirocycles has been developed through a silyl triflate mediated intermolecular coupling of…”
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Effect of acid catalysis on the direct electrophilic fluorination of ketones, ketals, and enamides using Selectfluor by Liu, Jack, Chan, Johann, Bryant, Craig M., Duspara, Petar A., Lee, Ernest E., Powell, David, Yang, Hua, Liu, Ziping, Walpole, Chris, Roberts, Edward, Batey, Robert A.

“…The fluorination of ketones, ketals, and enamides has been achieved using the electrophilic fluorinating reagent Selectfluor™ (F-TEDA-BF4). For the reactions…”
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Discovery of MK-7246, a selective CRTH2 antagonist for the treatment of respiratory diseases by Gallant, Michel, Beaulieu, Christian, Berthelette, Carl, Colucci, John, Crackower, Michael A., Dalton, Chad, Denis, Danielle, Ducharme, Yves, Friesen, Richard W., Guay, Daniel, Gervais, François G., Hamel, Martine, Houle, Robert, Krawczyk, Connie M., Kosjek, Birgit, Lau, Stephen, Leblanc, Yves, Lee, Ernest E., Levesque, Jean-François, Mellon, Christophe, Molinaro, Carmela, Mullet, Wayne, O’Neill, Gary P., O’Shea, Paul, Sawyer, Nicole, Sillaots, Susan, Simard, Daniel, Slipetz, Deborah, Stocco, Rino, Sørensen, Dan, Truong, Vouy Linh, Wong, Elizabeth, Wu, Jin, Zaghdane, Helmi, Wang, Zhaoyin

“…In this manuscript we wish to report the discovery of MK-7246 (4), a potent and selective CRTH2 (DP2) antagonist. SAR studies leading to MK-7246 along with two…”
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Effect of ethnicity on the risk of developing nonmelanoma skin cancer following long-term PUVA therapy by Murase, Jenny E., Lee, Ernest E., Koo, John

“…Background  Research demonstrating an increased incidence of skin cancer with psoralen plus ultraviolet A (PUVA) therapy has reflected the Caucasian…”
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Palladium-Catalyzed [3,3] Sigmatropic Rearrangement of (Allyloxy)iminodiazaphospholidines: Allylic Transposition of CO and CN Functionality by Lee, Ernest E., Batey, Robert A.

“…A PVN to PVO interconversion is the thermodynamic driving force for the title reaction. Iminodiazaphospholidines 1 give phosphoramides 2, which are…”
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Is contact allergy in man lifelong? An overview of patch test follow-ups by LEE, Ernest E, MAIBACH, Howard I

“…In contradistinction from certain strains of mice, contact allergy in man is hypothesized to be either lifelong or at least to last for years. We examined…”
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Synthesis of oligosaccharide fragments of the glycosylinositolphospholipid of Trypanosoma cruzi: a new selenoglycoside glycosyl donor for the preparation of 4-thiogalactofuranosyl analogues by Randell, Karla D, Johnston, Blair D, Lee, Ernest E, Pinto, B.Mario

“…A new selenoglycoside, phenyl 2,3,5,6-tetra- O-acetyl-4-thio-1-selenogalactofuranose, has been synthesized. This 4-thiogalactofuranosyl donor was used in the…”
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Effect of acid catalysis on the direct electrophilic fluorination of ketones, ketals, and enamides using Selectfluorac by Liu, Jack, Chan, Johann, Bryant, Craig M, Duspara, Petar A, Lee, Ernest E, Powell, David, Yang, Hua, Liu, Ziping, Walpole, Chris, Roberts, Edward, Batey, Robert A

“…The fluorination of ketones, ketals, and enamides has been achieved using the electrophilic fluorinating reagent Selectfluorac (F-TEDA-BF4). For the reactions…”
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Discovery of Mix-7246, a selective CRTH2 antagonist for the treatment of respiratory diseases by GALLANT, Michel, BEAULIEU, Christian, GERVAIS, François G, HAMEL, Martine, HOULE, Robert, KRAWCZYK, Connie M, KOSJEK, Birgit, LAU, Stephen, LEBLANC, Yves, LEE, Ernest E, LEVESQUE, Jean-François, MELLON, Christophe, BERTHELETTE, Carl, MOLINARO, Carmela, MULLET, Wayne, O'NEILL, Gary P, O'SHEA, Paul, SAWYER, Nicole, SILLAOTS, Susan, SIMARD, Daniel, SLIPETZ, Deborah, STOCCO, Rino, SØRENSEN, Dan, COLUCCI, John, VOUY LINH TRUONG, WONG, Elizabeth, JIN WU, ZAGHDANE, Helmi, ZHAOYIN WANG, CRACKOWER, Michael A, DALTON, Chad, DENIS, Danielle, DUCHARME, Yves, FRIESEN, Richard W, GUAY, Daniel

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Treatment of urticaria. An evidence-based evaluation of antihistamines by Lee, E E, Maibach, H I

“…Urticaria is a cutaneous syndrome characterized by dermal edema (wheal) and erythema (flare) that blanches with pressure. The lesions typically last less than…”
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Total Synthesis of Indolizidine Alkaloid (−)‐209D: Overriding Substrate Bias in the Asymmetric Rhodium‐Catalyzed [2+2+2] Cycloaddition by Yu, Robert T., Lee, Ernest E., Malik, Guillaume, Rovis, Tomislav

“…CO auf Wanderschaft: Mit chiralen Biphenyl‐basierten Phosphoramiditliganden an Rhodium lässt sich eine effiziente [2+2+2]‐Cycloaddition zwischen endständigen…”
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Is contact allergy in man lifelong? by Lee, Ernest E., Maibach, Howard I.

“…In contradistinction from certain strains of mice, contact allergy in man is hypothesized to be either lifelong or at least to last for years. We examined…”
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Palladium-Catalyzed [3,3] Sigmatropic Rearrangement of (Allyloxy)iminodiazaphospholidines: Allylic Transposition of CO and CN Functionality by Lee, Ernest E., Batey, Robert A.

“…Die thermodynamische Triebkraft der Titelreaktion ist die Umwandlung einer PVN‐ in eine PVO‐Gruppe: Iminodiazaphospholidine 1 liefern Phosphorsäuretriamide…”
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