Search Results - "Lee, Erinna F"

BECLIN1: Protein Structure, Function and Regulation by Tran, Sharon, Fairlie, W. Douglas, Lee, Erinna F.

“…BECLIN1 is a well-established regulator of autophagy, a process essential for mammalian survival. It functions in conjunction with other proteins to form Class…”
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Bax Crystal Structures Reveal How BH3 Domains Activate Bax and Nucleate Its Oligomerization to Induce Apoptosis by Czabotar, Peter E., Westphal, Dana, Dewson, Grant, Ma, Stephen, Hockings, Colin, Fairlie, W. Douglas, Lee, Erinna F., Yao, Shenggen, Robin, Adeline Y., Smith, Brian J., Huang, David C.S., Kluck, Ruth M., Adams, Jerry M., Colman, Peter M.

“…In stressed cells, apoptosis ensues when Bcl-2 family members Bax or Bak oligomerize and permeabilize the mitochondrial outer membrane. Certain BH3-only…”
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Co-Operativity between MYC and BCL-2 Pro-Survival Proteins in Cancer by Fairlie, Walter Douglas, Lee, Erinna F

“…B-Cell Lymphoma 2 (BCL-2), c-MYC and related proteins are arguably amongst the most widely studied in all of biology. Every year there are thousands of papers…”
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The Structural Biology of Bcl-xL by Lee, Erinna F., Fairlie, W. Douglas

“…Interactions between the pro-survival and pro-apoptotic members of the Bcl-2 family of proteins dictate whether a cell lives or dies. Much of our knowledge of…”
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Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia by Glaser, Stefan P, Lee, Erinna F, Trounson, Evelyn, Bouillet, Philippe, Wei, Andrew, Fairlie, W Douglas, Izon, David J, Zuber, Johannes, Rappaport, Amy R, Herold, Marco J, Alexander, Warren S, Lowe, Scott W, Robb, Lorraine, Strasser, Andreas

“…Acute myeloid leukemia (AML) frequently relapses after initial treatment. Drug resistance in AML has been attributed to high levels of the anti-apoptotic Bcl-2…”
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Osteosarcoma cells depend on MCL-1 for survival, and osteosarcoma metastases respond to MCL-1 antagonism plus regorafenib in vivo by Ji, Yanhao, Harris, Michael A, Newton, Lucas M, Harris, Tiffany J, Fairlie, W. Douglas, Lee, Erinna F, Hawkins, Christine J

“…Abstract Osteosarcoma is the most common form of primary bone cancer, which primarily afflicts children and adolescents. Chemotherapy, consisting of…”
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Structural insights into the degradation of Mcl-1 induced by BH3 domains by Czabotar, Peter E, Lee, Erinna F, van Delft, Mark F, Day, Catherine L, Smith, Brian J, Huang, David C.S, Fairlie, W. Douglas, Hinds, Mark G, Colman, Peter M

“…Apoptosis is held in check by prosurvival proteins of the Bcl-2 family. The distantly related BH3-only proteins bind to and antagonize them, thereby promoting…”
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ATF3 Repression of BCL-XL Determines Apoptotic Sensitivity to HDAC Inhibitors across Tumor Types by Chüeh, Anderly C., Tse, Janson W.T., Dickinson, Michael, Ioannidis, Paul, Jenkins, Laura, Togel, Lars, Tan, BeeShin, Luk, Ian, Davalos-Salas, Mercedes, Nightingale, Rebecca, Thompson, Matthew R., Williams, Bryan R.G., Lessene, Guillaume, Lee, Erinna F., Fairlie, Walter D., Dhillon, Amardeep S., Mariadason, John M.

“…Abstract Purpose: Histone deacetylase inhibitors (HDACi) are epigenome-targeting small molecules approved for the treatment of cutaneous T-cell lymphoma and…”
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In situ visualization of endothelial cell-derived extracellular vesicle formation in steady state and malignant conditions by Atkin-Smith, Georgia K., Santavanond, Jascinta P., Light, Amanda, Rimes, Joel S., Samson, Andre L., Er, Jeremy, Liu, Joy, Johnson, Darryl N., Le Page, Mélanie, Rajasekhar, Pradeep, Yip, Raymond K. H., Geoghegan, Niall D., Rogers, Kelly L., Chang, Catherine, Bryant, Vanessa L., Margetts, Mai, Keightley, M. Cristina, Kilpatrick, Trevor J., Binder, Michele D., Tran, Sharon, Lee, Erinna F., Fairlie, Walter D., Ozkocak, Dilara C., Wei, Andrew H., Hawkins, Edwin D., Poon, Ivan K. H.

“…Endothelial cells are integral components of all vasculature within complex organisms. As they line the blood vessel wall, endothelial cells are constantly…”
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role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins by Mérino, Delphine, Giam, Maybelline, Hughes, Peter D, Siggs, Owen M, Heger, Klaus, O'Reilly, Lorraine A, Adams, Jerry M, Strasser, Andreas, Lee, Erinna F, Fairlie, Walter D, Bouillet, Philippe

“…Proteins of the Bcl-2 family are critical regulators of apoptosis, but how its BH3-only members activate the essential effectors Bax and Bak remains…”
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MCL-1 inhibition provides a new way to suppress breast cancer metastasis and increase sensitivity to dasatinib by Young, Adelaide I J, Law, Andrew M K, Castillo, Lesley, Chong, Sabrina, Cullen, Hayley D, Koehler, Martin, Herzog, Sebastian, Brummer, Tilman, Lee, Erinna F, Fairlie, Walter D, Lucas, Morghan C, Herrmann, David, Allam, Amr, Timpson, Paul, Watkins, D Neil, Millar, Ewan K A, O'Toole, Sandra A, Gallego-Ortega, David, Ormandy, Christopher J, Oakes, Samantha R

“…Metastatic disease is largely resistant to therapy and accounts for almost all cancer deaths. Myeloid cell leukemia-1 (MCL-1) is an important regulator of cell…”
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Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax by Fletcher, Jamie I, Meusburger, Sarina, Hawkins, Christine J, Riglar, David T, Lee, Erinna F, Fairlie, W. Douglas, Huang, David C.S, Adams, Jerry M

“…A central issue in the control of apoptosis is whether its essential mediators Bax and Bak must be restrained by Bcl-2-like prosurvival relatives to prevent…”
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Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer by Berger, Stephanie, Procko, Erik, Margineantu, Daciana, Lee, Erinna F, Shen, Betty W, Zelter, Alex, Silva, Daniel-Adriano, Chawla, Kusum, Herold, Marco J, Garnier, Jean-Marc, Johnson, Richard, MacCoss, Michael J, Lessene, Guillaume, Davis, Trisha N, Stayton, Patrick S, Stoddard, Barry L, Fairlie, W Douglas, Hockenbery, David M, Baker, David

“…Many cancers overexpress one or more of the six human pro-survival BCL2 family proteins to evade apoptosis. To determine which BCL2 protein or proteins block…”
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High-Resolution Structural Characterization of a Helical α/β-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-xL by Lee, Erinna F, Sadowsky, Jack D, Smith, Brian J, Czabotar, Peter E, Peterson-Kaufman, Kimberly J, Colman, Peter M, Gellman, Samuel H, Fairlie, W. Douglas

“…Get into the groove: The first high-resolution structure of a foldamer bound to a protein target is described (see picture; foldamer in sticks). The foldamer…”
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Physiological restraint of Bak by Bcl-xL is essential for cell survival by Lee, Erinna F, Grabow, Stephanie, Chappaz, Stephane, Dewson, Grant, Hockings, Colin, Kluck, Ruth M, Debrincat, Marlyse A, Gray, Daniel H, Witkowski, Matthew T, Evangelista, Marco, Pettikiriarachchi, Anne, Bouillet, Philippe, Lane, Rachael M, Czabotar, Peter E, Colman, Peter M, Smith, Brian J, Kile, Benjamin T, Fairlie, W Douglas

“…Due to the myriad interactions between prosurvival and proapoptotic members of the Bcl-2 family of proteins, establishing the mechanisms that regulate the…”
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Combination of bazedoxifene with chemotherapy and SMAC-mimetics for the treatment of colorectal cancer by Dmello, Rhynelle S., Palmieri, Michelle, Thilakasiri, Pathum S., Doughty, Larissa, Nero, Tracy L., Poh, Ashleigh R., To, Sarah Q., Lee, Erinna F., Douglas Fairlie, W., Mielke, Lisa, Parker, Michael W., Poon, Ivan K. H., Batlle, Eduard, Ernst, Matthias, Chand, Ashwini L.

“…Excessive STAT3 signalling via gp130, the shared receptor subunit for IL-6 and IL-11, contributes to disease progression and poor survival outcomes in patients…”
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Prosurvival Bcl-2 family members reveal a distinct apoptotic identity between conventional and plasmacytoid dendritic cells by Carrington, Emma M., Zhang, Jian-Guo, Sutherland, Robyn M., Vikstrom, Ingela B., Brady, Jamie L., Soo, Priscilla, Vremec, David, Allison, Cody, Lee, Erinna F., Fairlie, W. Douglas, Bouillet, Philippe, Grabow, Stephanie, Ottina, Eleonora, Herold, Marco J., Pellegrini, Marc, Huang, David C. S., Tarlinton, David M., Strasser, Andreas, Lew, Andrew M., Zhan, Yifan

“…Dendritic cells (DCs) are heterogeneous, comprising subsets with functional specializations that play distinct roles in immunity as well as immunopathology. We…”
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Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands by Lee, Erinna F., Czabotar, Peter E., Yang, Hong, Sleebs, Brad E., Lessene, Guillaume, Colman, Peter M., Smith, Brian J., Fairlie, W.Douglas

“…Antagonists of anti-apoptotic Bcl-2 family members hold promise as cancer therapeutics. Apoptosis is triggered when a peptide containing a BH3 motif or a small…”
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Induction of endoplasmic reticulum stress is associated with the anti‐tumor activity of monepantel across cancer types by Harris, Tiffany J., Liao, Yang, Shi, Wei, Evangelista, Marco, Pal, Bhupinder, Puthalakath, Hamsa, Aston, Roger, Mollard, Richard, Mariadason, John M., Lee, Erinna F., Fairlie, Walter D.

“…Background Monepantel is an anti‐helminthic drug that also has anti‐cancer properties. Despite several studies over the years, the molecular target of…”
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A novel BH3-mimetic, AZD0466, targeting BCL-XL and BCL-2 is effective in pre-clinical models of malignant pleural mesothelioma by Arulananda, Surein, O’Brien, Megan, Evangelista, Marco, Jenkins, Laura J., Poh, Ashleigh R., Walkiewicz, Marzena, Leong, Trishe, Mariadason, John M., Cebon, Jonathan, Balachander, Srividya B., Cidado, Justin R., Lee, Erinna F., John, Thomas, Fairlie, Walter D.

“…Malignant pleural mesothelioma (MPM) is an aggressive cancer with treatment limited to Cisplatin and Pemetrexed chemotherapy. Recently, we showed that drugs…”
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