Search Results - "Lee, Edgar L."

Amyloid Fiber Formation and Membrane Disruption are Separate Processes Localized in Two Distinct Regions of IAPP, the Type-2-Diabetes-Related Peptide by Brender, Jeffrey R, Lee, Edgar L, Cavitt, Marchello A, Gafni, Ari, Steel, Duncan G, Ramamoorthy, Ayyalusamy

“…Aggregation of Islet Amyloid Polypeptide (IAPP) has been implicated in the development of type II diabetes. Because IAPP is a highly amyloidogenic peptide, it…”
Get full text

Biphasic Effects of Insulin on Islet Amyloid Polypeptide Membrane Disruption by Brender, Jeffrey R., Lee, Edgar L., Hartman, Kevin, Wong, Pamela T., Ramamoorthy, Ayyalusamy, Steel, Duncan G., Gafni, Ari

“…Type II diabetes, in its late stages, is often associated with the formation of extracellular islet amyloid deposits composed of islet amyloid polypeptide…”
Get full text

Amyloid-β Membrane Binding and Permeabilization are Distinct Processes Influenced Separately by Membrane Charge and Fluidity by Wong, Pamela T., Schauerte, Joseph A., Wisser, Kathleen C., Ding, Hao, Lee, Edgar L., Steel, Duncan G., Gafni, Ari

“…The 40 and 42 residue amyloid-β (Aβ) peptides are major components of the proteinaceous plaques prevalent in the Alzheimer's disease-afflicted brain and have…”
Get full text

Determination of the Oligomer Size of Amyloidogenic Protein β-Amyloid(1–40) by Single-Molecule Spectroscopy by Ding, Hao, Wong, Pamela T., Lee, Edgar L., Gafni, Ari, Steel, Duncan G.

“…Amyloid diseases are traditionally characterized by the appearance of inter- and intracellular fibrillar protein deposits, termed amyloid. Historically, these…”
Get full text

Determination of the Oligomer Size of Amyloidogenic Protein b-Amyloid(1-40) by Single-Molecule Spectroscopy by Ding, Hao, Wong, Pamela T, Lee, Edgar L, Gafni, Ari, Steel, Duncan G

“…Amyloid diseases are traditionally characterized by the appearance of inter- and intracellular fibrillar protein deposits, termed amyloid. Historically, these…”
Get full text

Determination of the Oligomer Size of Amyloidogenic Protein [beta]-Amyloid (1-40) by Single-Molecule Spectroscopy by Ding, Hao, Wong, Pamela T, Lee, Edgar L, Gafni, Ari, Steel, Duncan G

“…Amyloid diseases are traditionally characterized by the appearance of inter- and intracellular fibrillar protein deposits, termed amyloid. Historically, these…”
Get full text

A Single Mutation in the Non-Amyloidogenic Region of IAPP Greatly Reduces Toxicity by Hartman, Kevin, Brender, Jeffrey R., Reid, Kendra R., Smith, Pieter E.S., Nanga, Ravi P.R., Cavitt, Marchello A., Lee, Edgar L., Steel, Duncan G., Gafni, Ari, Kennedy, Robert T., Ramamoorthy, Ayyalusamy

Get full text

Pancreatic islet amyloid polypeptide membrane binding and permeabilization by Lee, Edgar L

“…Type II diabetes is often associated with the presence of islet amyloid. Islet amyloid is aggregated fibrils composed primarily of the hormone peptide, islet…”
Get full text

Pancreatic islet amyloid polypeptide membrane binding and permeabilization by Lee, Edgar L

“…Type II diabetes is often associated with the presence of islet amyloid. Islet amyloid is aggregated fibrils composed primarily of the hormone peptide, islet…”
Get full text