Search Results - "Lee, Dongjin R"

Reversion of FMR1 Methylation and Silencing by Editing the Triplet Repeats in Fragile X iPSC-Derived Neurons by Park, Chul-Yong, Halevy, Tomer, Lee, Dongjin R., Sung, Jin Jea, Lee, Jae Souk, Yanuka, Ofra, Benvenisty, Nissim, Kim, Dong-Wook

“…Fragile X syndrome (FXS) is the most common form of inherited intellectual disability, resulting from a CGG repeat expansion in the fragile X mental…”
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An epigenome atlas of neural progenitors within the embryonic mouse forebrain by Rhodes, Christopher T., Thompson, Joyce J., Mitra, Apratim, Asokumar, Dhanya, Lee, Dongjin R., Lee, Daniel J., Zhang, Yajun, Jason, Eva, Dale, Ryan K., Rocha, Pedro P., Petros, Timothy J.

“…A comprehensive characterization of epigenomic organization in the embryonic mouse forebrain will enhance our understanding of neurodevelopment and provide…”
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Transcriptional heterogeneity of ventricular zone cells in the ganglionic eminences of the mouse forebrain by Lee, Dongjin R, Rhodes, Christopher, Mitra, Apratim, Zhang, Yajun, Maric, Dragan, Dale, Ryan K, Petros, Timothy J

“…The ventricular zone (VZ) of the nervous system contains radial glia cells that were originally considered relatively homogenous in their gene expression, but…”
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Defined Conditions for Differentiation of Functional Retinal Ganglion Cells From Human Pluripotent Stem Cells by Lee, Junwon, Choi, Sang-Hwi, Kim, Young-Beom, Jun, Ikhyun, Sung, Jin Jea, Lee, Dongjin R, Kim, Yang In, Cho, Myung Soo, Byeon, Suk Ho, Kim, Dae-Sung, Kim, Dong-Wook

“…We aimed to establish an efficient method for retinal ganglion cell (RGC) differentiation from human pluripotent stem cells (hPSCs) using defined factors. To…”
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Loss of Ezh2 in the medial ganglionic eminence alters interneuron fate, cell morphology and gene expression profiles by Rhodes, Christopher T, Asokumar, Dhanya, Sohn, Mira, Naskar, Shovan, Elisha, Lielle, Stevenson, Parker, Lee, Dongjin R, Zhang, Yajun, Rocha, Pedro P, Dale, Ryan K, Lee, Soohyun, Petros, Timothy J

“…Enhancer of zeste homolog 2 (Ezh2) is responsible for trimethylation of histone 3 at lysine 27 (H3K27me3), resulting in repression of gene expression. Here, we…”
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Modeling and correction of structural variations in patient-derived iPSCs using CRISPR/Cas9 by Park, Chul-Yong, Sung, Jin Jea, Choi, Sang-Hwi, Lee, Dongjin R, Park, In-Hyun, Kim, Dong-Wook

“…This protocol extends the use of genome editing technology to the modeling or correction of large chromosomal rearrangements and short nucleotide repeat…”
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Highly pure and expandable PSA-NCAM-positive neural precursors from human ESC and iPSC-derived neural rosettes by Kim, Dae-Sung, Lee, Dongjin R, Kim, Han-Soo, Yoo, Jeong-Eun, Jung, Sung Jun, Lim, Bo Young, Jang, Jiho, Kang, Hoon-Chul, You, Seungkwon, Hwang, Dong-Youn, Leem, Joong Woo, Nam, Taick Sang, Cho, Sung-Rae, Kim, Dong-Wook

“…Homogeneous culture of neural precursor cells (NPCs) derived from human pluripotent stem cells (hPSCs) would provide a powerful tool for biomedical…”
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Generation of single-cell and single-nuclei suspensions from embryonic and adult mouse brains by Lee, Dongjin R., Zhang, Yajun, Rhodes, Christopher T., Petros, Timothy J.

“…Efficient protocols to generate single-cell and single-nuclei suspensions are critical for the burgeoning field of single-cell/single-nuclei sequencing. Here…”
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Wnt signal activation induces midbrain specification through direct binding of the beta-catenin/TCF4 complex to the EN1 promoter in human pluripotent stem cells by Kim, Ji Young, Lee, Jae Souk, Hwang, Hyun Sub, Lee, Dongjin R., Park, Chul-Yong, Jung, Sung Jun, You, Young Rang, Kim, Dae-Sung, Kim, Dong-Wook

“…The canonical Wnt signal pathway plays a pivotal role in anteroposterior patterning and midbrain specification during early neurogenesis. Activating Wnt signal…”
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Disease-specific induced pluripotent stem cells: a platform for human disease modeling and drug discovery by Jang, Jiho, Yoo, Jeong-Eun, Lee, Jeong-Ah, Lee, Dongjin R, Kim, Ji Young, Huh, Yong Jun, Kim, Dae-Sung, Park, Chul-Yong, Hwang, Dong-Youn, Kim, Han-Soo, Kang, Hoon-Chul, Kim, Dong-Wook

“…The generation of disease-specific induced pluripotent stem cell (iPSC) lines from patients with incurable diseases is a promising approach for studying…”
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Establishment of PITX3-mCherry knock-in reporter human embryonic stem cell line (WAe009-A-23) by Park, Sanghyun, Yoo, Jeong-Eun, Lee, Dongjin R., Jang, Jiho, Cho, Myung Soo, Kim, Dae-Sung, Kim, Dong-Wook

“…Pituitary homeobox 3 (Pitx3) is a key transcription factor that plays an important role in the development and maintenance of midbrain dopaminergic (mDA)…”
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Trophoblast glycoprotein is a marker for efficient sorting of ventral mesencephalic dopaminergic precursors derived from human pluripotent stem cells by Yoo, Jeong-Eun, Lee, Dongjin R., Park, Sanghyun, Shin, Hye-Rim, Lee, Kun Gu, Kim, Dae-Sung, Jo, Mi-Young, Eom, Jang-Hyeon, Cho, Myung Soo, Hwang, Dong-Youn, Kim, Dong-Wook

“…Successful cell therapy for Parkinson’s disease (PD) requires large numbers of homogeneous ventral mesencephalic dopaminergic (vmDA) precursors. Enrichment of…”
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PSA-NCAM-Negative Neural Crest Cells Emerging during Neural Induction of Pluripotent Stem Cells Cause Mesodermal Tumors and Unwanted Grafts by Lee, Dongjin R., Yoo, Jeong-Eun, Lee, Jae Souk, Park, Sanghyun, Lee, Junwon, Park, Chul-Yong, Ji, Eunhyun, Kim, Han-Soo, Hwang, Dong-Youn, Kim, Dae-Sung, Kim, Dong-Wook

“…Tumorigenic potential of human pluripotent stem cells (hPSCs) is an important issue in clinical applications. Despite many efforts, PSC-derived neural…”
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Transplantation of GABAergic Neurons from ESCs Attenuates Tactile Hypersensitivity Following Spinal Cord Injury by Kim, Dae‐Sung, Jung, Se Jung, Nam, Taick Sang, Jeon, Young Hoon, Lee, Dongjin R., Lee, Jae Souk, Leem, Joong Woo, Kim, Dong‐Wook

“…We investigated the therapeutic potential of mouse ESC‐derived gamma‐amino butyric acid (GABA)ergic neurons (∼74% of total neurons in vitro) to reduce…”
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ABCD2 is a direct target of β-catenin and TCF-4: implications for X-linked adrenoleukodystrophy therapy by Park, Chul-Yong, Kim, Han-Soo, Jang, Jiho, Lee, Hyunji, Lee, Jae Souk, Yoo, Jeong-Eun, Lee, Dongjin R, Kim, Dong-Wook

“…X-linked adrenoleukodystrophy (X-ALD) is a peroxisomal disorder caused by mutations in the ABCD1 gene that encodes the peroxisomal ATP-binding cassette (ABC)…”
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Generation of Isthmic Organizer-Like Cells from Human Embryonic Stem Cells by Lee, Junwon, Choi, Sang-Hwi, Lee, Dongjin R, Kim, Dae-Sung, Kim, Dong-Wook

“…The objective of this study was to induce the production of isthmic organizer (IsO)-like cells capable of secreting fibroblast growth factor (FGF) 8 and WNT1…”
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Genome-editing technologies for gene correction of hemophilia by Park, Chul-Yong, Lee, Dongjin R., Sung, Jin Jea, Kim, Dong-Wook

“…Hemophilia is caused by various mutations in blood coagulation factor genes, including factor VIII ( FVIII ) and factor IX ( FIX ), that encode key proteins in…”
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Generation of Isthmic Organizer-Like Cells from Human Embryonic Stem Cells by Lee, Junwon, Choi, Sang-Hwi, Lee, Dongjin R, Kim, Dae-Sung, Kim, Dong-Wook

“…The objective of this study was to induce the production of isthmic organizer (IsO)-like cells capable of secreting fibroblast growth factor (FGF) 8 and WNT1…”
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PSA-NCAM+ Neural Precursor Cells from Human Embryonic Stem Cells Promote Neural Tissue Integrity and Behavioral Performance in A Rat Stroke Model by Kim, Han-Soo, Choi, Seong-Mi, Yang, Wonsuk, Kim, Dae-Sung, Lee, Dongjin R., Cho, Sung-Rae, Kim, Dong-Wook

“…Recently, cell-based therapy has been highlighted as an alternative to treating ischemic brain damage in stroke patients. The present study addresses the…”
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Thermodynamic Role of Glutathione Oxidation by Peroxide and Peroxybicarbonate in the Prevention of Alzheimer’s Disease and Cancer by Galant, Natalie J, Wang, Hui, Lee, DongJin R, Mucsi, Zoltan, Setiadi, David H, Viskolcz, Bela, Csizmadia, Imre G

“…First principle quantum molecular computations have been carried out at the B3LYP/6-31G(d,p) and G3MP2B3 levels of theory on ethyl mercaptan and diethyl…”
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