Search Results - "Lee, Dong Kuk"

Solid-State NMR Investigation of the Membrane-Disrupting Mechanism of Antimicrobial Peptides MSI-78 and MSI-594 Derived from Magainin 2 and Melittin by Ramamoorthy, Ayyalusamy, Thennarasu, Sathiah, Lee, Dong-Kuk, Tan, Anmin, Maloy, Lee

“…The mechanism of membrane interaction of two amphipathic antimicrobial peptides, MSI-78 and MSI-594, derived from magainin-2 and melittin, is presented. Both…”
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Magnetic Alignment of Polymer Nanodiscs Probed by Solid-State NMR Spectroscopy by Ravula, Thirupathi, Kim, JaeWoong, Lee, Dong-Kuk, Ramamoorthy, Ayyalusamy

“…The ability of amphipathic polymers to self-assemble with lipids and form nanodiscs has been a boon for the field of functional reconstitution of membrane…”
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Role of Cationic Group Structure in Membrane Binding and Disruption by Amphiphilic Copolymers by Palermo, Edmund F, Lee, Dong-Kuk, Ramamoorthy, Ayyalusamy, Kuroda, Kenichi

“…Cationic, amphiphilic polymers are currently being used as antimicrobial agents that disrupt biomembranes, although their mechanisms remain poorly understood…”
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Determining the Effects of Lipophilic Drugs on Membrane Structure by Solid-State NMR Spectroscopy: The Case of the Antioxidant Curcumin by Barry, Jeffrey, Fritz, Michelle, Brender, Jeffrey R, Smith, Pieter E. S, Lee, Dong-Kuk, Ramamoorthy, Ayyalusamy

“…Curcumin is the active ingredient of turmeric powder, a natural spice used for generations in traditional medicines. Curcumin’s broad spectrum of antioxidant,…”
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Phosphatidylethanolamine Enhances Amyloid Fiber-Dependent Membrane Fragmentation by Sciacca, Michele F. M, Brender, Jeffrey R, Lee, Dong-Kuk, Ramamoorthy, Ayyalusamy

“…The toxicity of amyloid-forming peptides has been hypothesized to reside in the ability of protein oligomers to interact with and disrupt the cell membrane…”
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Membrane Thinning Due to Antimicrobial Peptide Binding: An Atomic Force Microscopy Study of MSI-78 in Lipid Bilayers by Mecke, Almut, Lee, Dong-Kuk, Ramamoorthy, Ayyalusamy, Orr, Bradford G., Banaszak Holl, Mark M.

“…The interaction of an antimicrobial peptide, MSI-78, with phospholipid bilayers has been investigated using atomic force microscopy, circular dichroism, and…”
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MSI-78, an Analogue of the Magainin Antimicrobial Peptides, Disrupts Lipid Bilayer Structure via Positive Curvature Strain by Hallock, Kevin J., Lee, Dong-Kuk, Ramamoorthy, A.

“…In this work, we present the first characterization of the cell lysing mechanism of MSI-78, an antimicrobial peptide. MSI-78 is an amphipathic α-helical…”
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Mechanism of Lipid Bilayer Disruption by the Human Antimicrobial Peptide, LL-37 by Henzler Wildman, Katherine A, Lee, Dong-Kuk, Ramamoorthy, A

“…LL-37 is an amphipathic, α-helical, antimicrobial peptide. 15N chemical shift and 15N dipolar−shift spectroscopy of site-specifically labeled LL-37 in oriented…”
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Lipid Composition-Dependent Membrane Fragmentation and Pore-Forming Mechanisms of Membrane Disruption by Pexiganan (MSI-78) by Lee, Dong-Kuk, Brender, Jeffrey R, Sciacca, Michele F. M, Krishnamoorthy, Janarthanan, Yu, Changsu, Ramamoorthy, Ayyalusamy

“…The potency and selectivity of many antimicrobial peptides (AMPs) are correlated with their ability to interact with and disrupt the bacterial cell membrane…”
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Limiting an Antimicrobial Peptide to the Lipid−Water Interface Enhances Its Bacterial Membrane Selectivity: A Case Study of MSI-367 by Thennarasu, Sathiah, Huang, Rui, Lee, Dong-Kuk, Yang, Pei, Maloy, Lee, Chen, Zhan, Ramamoorthy, Ayyalusamy

“…In a minimalist design approach, a synthetic peptide MSI-367 [(KFAKKFA)3-NH2] was designed and synthesized with the objective of generating cell-selective…”
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Temperature-Resistant Bicelles for Structural Studies by Solid-State NMR Spectroscopy by Yamamoto, Kazutoshi, Pearcy, Paige, Lee, Dong-Kuk, Yu, Changsu, Im, Sang-Choul, Waskell, Lucy, Ramamoorthy, Ayyalusamy

“…Three-dimensional structure determination of membrane proteins is important to fully understand their biological functions. However, obtaining a…”
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Membrane Composition Determines Pardaxin's Mechanism of Lipid Bilayer Disruption by Hallock, Kevin J., Lee, Dong-Kuk, Omnaas, John, Mosberg, Henry I., Ramamoorthy, A.

“…Pardaxin is a membrane-lysing peptide originally isolated from the fish Pardachirus marmoratus. The effect of the carboxy-amide of pardaxin (P1a) on bilayers…”
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Structure and Orientation of Pardaxin Determined by NMR Experiments in Model Membranes by Porcelli, Fernando, Buck, Bethany, Lee, Dong-Kuk, Hallock, Kevin J, Ramamoorthy, Ayyalusamy, Veglia, Gianluigi

“…Pardaxins are a class of ichthyotoxic peptides isolated from fish mucous glands. Pardaxins physically interact with cell membranes by forming pores or…”
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Solid-state NMR and molecular dynamics simulations reveal the oligomeric ion-channels of TM2-GABAA stabilized by intermolecular hydrogen bonding by Kandasamy, Senthil K., Lee, Dong-Kuk, Nanga, Ravi P.R., Xu, Jiadi, Santos, Jose S., Larson, Ronald G., Ramamoorthy, Ayyalusamy

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Direct observation of lipid bilayer disruption by poly(amidoamine) dendrimers by Mecke, Almut, Uppuluri, Srinivas, Sassanella, Timothy M., Lee, Dong-Kuk, Ramamoorthy, A., Baker, James R., Orr, Bradford G., Banaszak Holl, Mark M.

“…Atomic force microscopy (AFM) is employed to observe the effect of poly(amidoamine) (PAMAM) dendrimers on 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC)…”
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Antimicrobial activity and membrane selective interactions of a synthetic lipopeptide MSI-843 by Thennarasu, Sathiah, Lee, Dong-Kuk, Tan, Anmin, Prasad Kari, U., Ramamoorthy, Ayyalusamy

“…Lipopeptide MSI-843 consisting of the nonstandard amino acid ornithine (Oct–OOLLOOLOOL–NH 2) was designed with an objective towards generating non-lytic short…”
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An Innovative Procedure Using a Sublimable Solid to Align Lipid Bilayers for Solid-State NMR Studies by Hallock, Kevin J., Henzler Wildman, Katherine, Lee, Dong-Kuk, Ramamoorthy, Ayyalusamy

“…Uniaxially aligned phospholipid bilayers are often used as model membranes to obtain structural details of membrane-associated molecules, such as peptides,…”
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Detergent-Type Membrane Fragmentation by MSI-78, MSI-367, MSI-594, and MSI-843 Antimicrobial Peptides and Inhibition by Cholesterol: A Solid-State Nuclear Magnetic Resonance Study by Lee, Dong-Kuk, Bhunia, Anirban, Kotler, Samuel A, Ramamoorthy, Ayyalusamy

“…Multidrug resistance against the existing antibiotics is becoming a global threat, and any potential drug that can be designed using cationic antimicrobial…”
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Two-Step Mechanism of Membrane Disruption by Aβ through Membrane Fragmentation and Pore Formation by Sciacca, Michele F.M., Kotler, Samuel A., Brender, Jeffrey R., Chen, Jennifer, Lee, Dong-kuk, Ramamoorthy, Ayyalusamy

“…Disruption of cell membranes by Aβ is believed to be one of the key components of Aβ toxicity. However, the mechanism by which this occurs is not fully…”
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Effects of antidepressants on the conformation of phospholipid headgroups studied by solid-state NMR by Santos, Jose S., Lee, Dong-Kuk, Ramamoorthy, Ayyalusamy

“…The effect of tricyclic antidepressants (TCA) on phospholipid bilayer structure and dynamics was studied to provide insight into the mechanism of TCA‐induced…”
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