Search Results - "Lee, Doheon"

Identifying prognostic subgroups of luminal-A breast cancer using deep autoencoders and gene expressions by Wang, Seunghyun, Lee, Doheon

“…Luminal-A breast cancer is the most frequently occurring subtype which is characterized by high expression levels of hormone receptors. However, some luminal-A…”
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Context-aware multi-token concept recognition of biological entities by Kim, Kwangmin, Lee, Doheon

“…Concept recognition is a term that corresponds to the two sequential steps of named entity recognition and named entity normalization, and plays an essential…”
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Predicting Pharmacodynamic Drug-Drug Interactions through Signaling Propagation Interference on Protein-Protein Interaction Networks by Park, Kyunghyun, Kim, Docyong, Ha, Suhyun, Lee, Doheon

“…As pharmacodynamic drug-drug interactions (PD DDIs) could lead to severe adverse effects in patients, it is important to identify potential PD DDIs in drug…”
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Combining empirical knowledge, in silico molecular docking and ADMET profiling to identify therapeutic phytochemicals from Brucea antidysentrica for acute myeloid leukemia by Bultum, Lemessa Etana, Tolossa, Gemechu Bekele, Lee, Doheon

“…Acute myeloid leukemia (AML) is one of the deadly cancers. Chemotherapy is the first-line treatment and the only curative intervention is stem cell…”
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Drug repurposing for Parkinson’s disease by biological pathway based edge-weighted network proximity analysis by Han, Manyoung, Jung, Seunghwan, Lee, Doheon

“…Parkinson’s disease is the second most frequent neurodegenerative disease, and its severity is increasing with extended life expectancy. Most of current…”
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Discovering Health Benefits of Phytochemicals with Integrated Analysis of the Molecular Network, Chemical Properties and Ethnopharmacological Evidence by Yoo, Sunyong, Kim, Kwansoo, Nam, Hojung, Lee, Doheon

“…Identifying the health benefits of phytochemicals is an essential step in drug and functional food development. While many in vitro screening methods have been…”
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Normalization of Tumor Vessels by Tie2 Activation and Ang2 Inhibition Enhances Drug Delivery and Produces a Favorable Tumor Microenvironment by Park, Jin-Sung, Kim, Il-Kug, Han, Sangyeul, Park, Intae, Kim, Chan, Bae, Jeomil, Oh, Seung Ja, Lee, Seungjoo, Kim, Jeong Hoon, Woo, Dong-Cheol, He, Yulong, Augustin, Hellmut G., Kim, Injune, Lee, Doheon, Koh, Gou Young

“…A destabilized tumor vasculature leads to limited drug delivery, hypoxia, detrimental tumor microenvironment, and even metastasis. We performed a side-by-side…”
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Genome-Wide Analysis of Genes Targeted by PHYTOCHROME INTERACTING FACTOR 3-LIKE5 during Seed Germination in Arabidopsis by Oh, Eunkyoo, Kang, Hyojin, Yamaguchi, Shinjiro, Park, Jeongmoo, Lee, Doheon, Kamiya, Yuji, Choi, Giltsu

“…PHYTOCHROME INTERACTING FACTOR 3-LIKE5 (PIL5) is a basic helix-loop-helix transcription factor that inhibits seed germination by regulating the expression of…”
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Literature mining for context-specific molecular relations using multimodal representations (COMMODAR) by Lee, Jaehyun, Lee, Doheon, Lee, Kwang Hyung

“…Abstract Biological contextual information helps understand various phenomena occurring in the biological systems consisting of complex molecular relations…”
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Topological motifs populate complex networks through grouped attachment by Choi, Jaejoon, Lee, Doheon

“…Network motifs are topological subgraph patterns that recur with statistical significance in a network. Network motifs have been widely utilized to represent…”
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Network-based classification of breast cancer metastasis by Ideker, Trey, Chuang, Han-Yu, Lee, Eunjung, Liu, Yu-Tsueng, Lee, Doheon

“…Mapping the pathways that give rise to metastasis is one of the key challenges of breast cancer research. Recently, several large‐scale studies have shed light…”
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Computational Discovery of Cancer Immunotherapy Targets by Intercellular CRISPR Screens by Yim, Soorin, Hwang, Woochang, Han, Namshik, Lee, Doheon

“…Cancer immunotherapy targets the interplay between immune and cancer cells. In particular, interactions between cytotoxic T lymphocytes (CTLs) and cancer…”
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In silico activity and ADMET profiling of phytochemicals from Ethiopian indigenous aloes using pharmacophore models by Bultum, Lemessa Etana, Tolossa, Gemechu Bekele, Kim, Gwangmin, Kwon, Ohhyeon, Lee, Doheon

“…In silico profiling is used in identification of active compounds and guide rational use of traditional medicines. Previous studies on Ethiopian indigenous…”
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Inferring pathway activity toward precise disease classification by Lee, Eunjung, Chuang, Han-Yu, Kim, Jong-Won, Ideker, Trey, Lee, Doheon

“…The advent of microarray technology has made it possible to classify disease states based on gene expression profiles of patients. Typically, marker genes are…”
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feature-based approach to modeling protein-protein interaction hot spots by Cho, Kyu-il, Kim, Dongsup, Lee, Doheon

“…Identifying features that effectively represent the energetic contribution of an individual interface residue to the interactions between proteins remains…”
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Compositional and functional differences of the mucosal microbiota along the intestine of healthy individuals by Vaga, Stefania, Lee, Sunjae, Ji, Boyang, Andreasson, Anna, Talley, Nicholas J., Agréus, Lars, Bidkhori, Gholamreza, Kovatcheva-Datchary, Petia, Park, Junseok, Lee, Doheon, Proctor, Gordon, Ehrlich, Stanislav Dusko, Nielsen, Jens, Engstrand, Lars, Shoaie, Saeed

“…Gut mucosal microbes evolved closest to the host, developing specialized local communities. There is, however, insufficient knowledge of these communities as…”
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Phytochromes promote seedling light responses by inhibiting four negatively-acting phytochrome-interacting factors by Shin, Jieun, Kim, Keunhwa, Kang, Hyojin, Zulfugarov, Ismayil S, Bae, Gabyong, Lee, Choon-Hwan, Lee, Doheon, Choi, Giltsu

“…PIF3 is a phytochrome-interacting basic helix-loop-helix transcription factor that negatively regulates light responses, including hypocotyl elongation,…”
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Identification of common coexpression modules based on quantitative network comparison by Jo, Yousang, Kim, Sanghyeon, Lee, Doheon

“…Finding common molecular interactions from different samples is essential work to understanding diseases and other biological processes. Coexpression networks…”
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A systematic approach to identify therapeutic effects of natural products based on human metabolite information by Noh, Kyungrin, Yoo, Sunyong, Lee, Doheon

“…Natural products have been widely investigated in the drug development field. Their traditional use cases as medicinal agents and their resemblance of our…”
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NaCTR: Natural product-derived compound-based drug discovery pipeline from traditional oriental medicine by search space reduction by Jung, Seunghwan, Kim, Kwansoo, Wang, Seunghyun, Han, Manyoung, Lee, Doheon

“…The drug discovery pipelines require enormous time and cost, albeit their infamously high risk of failures. Reducing such risk has therefore been the utmost…”
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