Search Results - "Lee, Diana Y."

A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations by Sharma, Sreenath V., Lee, Diana Y., Li, Bihua, Quinlan, Margaret P., Takahashi, Fumiyuki, Maheswaran, Shyamala, McDermott, Ultan, Azizian, Nancy, Zou, Lee, Fischbach, Michael A., Wong, Kwok-Kin, Brandstetter, Kathleyn, Wittner, Ben, Ramaswamy, Sridhar, Classon, Marie, Settleman, Jeff

“…Accumulating evidence implicates heterogeneity within cancer cell populations in the response to stressful exposures, including drug treatments. While modeling…”
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Neuregulin-1-Mediated Autocrine Signaling Underlies Sensitivity to HER2 Kinase Inhibitors in a Subset of Human Cancers by Wilson, Timothy R., Lee, Diana Y., Berry, Leanne, Shames, David S., Settleman, Jeff

“…HER2 kinase inhibitors, such as lapatinib, have demonstrated clinical efficacy in HER2-amplified breast cancers. By profiling nearly 700 human cancer cell…”
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Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma by Montagut, Clara, Sharma, Sreenath V, Shioda, Toshi, McDermott, Ultan, Ulman, Matthew, Ulkus, Lindsey E, Dias-Santagata, Dora, Stubbs, Hannah, Lee, Diana Y, Singh, Anurag, Drew, Lisa, Haber, Daniel A, Settleman, Jeffrey

“…Activating BRAF kinase mutations arise in approximately 7% of all human tumors, and preclinical studies have validated the RAF-mitogen-activated…”
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A common signaling cascade may underlie “addiction” to the Src, BCR-ABL, and EGF receptor oncogenes by Sharma, Sreenath V., Gajowniczek, Patrycja, Way, Inna P., Lee, Diana Y., Jiang, Jane, Yuza, Yuki, Classon, Marie, Haber, Daniel A., Settleman, Jeffrey

“…“Oncogene addiction” describes an unexplained dependency of cancer cells on a particular cellular pathway for survival or proliferation. We report that…”
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Predicting the capsid architecture of phages from metagenomic data by Lee, Diana Y., Bartels, Caitlin, McNair, Katelyn, Edwards, Robert A., Swairjo, Manal A., Luque, Antoni

“…[Display omitted] Tailed phages are viruses that infect bacteria and are the most abundant biological entities on Earth. Their ecological, evolutionary, and…”
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The Missing Tailed Phages: Prediction of Small Capsid Candidates by Luque, Antoni, Benler, Sean, Lee, Diana Y, Brown, Colin, White, Simon

“…Tailed phages are the most abundant and diverse group of viruses on the planet. Yet, the smallest tailed phages display relatively complex capsids and large…”
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Differential gene expression analysis reveals generation of an autocrine loop by a mutant epidermal growth factor receptor in glioma cells by RAMNARAIN, Deepti B, PARK, Seongmi, JULIAN WU, ELLIOTT, Robert, EABIB, Amyn A, LEE, Diana Y, HATANPAA, Kimmo J, SCOGGIN, Shane O, OTU, Hasan, LIBERMANN, Towia A, RAISANEN, Jack M, ASHFAQ, Raheela, WONG, Eric T

“…The epidermal growth factor receptor (EGFR) gene is commonly amplified and rearranged in glioblastoma multiforme leading to overexpression of wild-type and…”
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Preoperative Imaging in Cochlear Implants by Lee, Andrew Y, Lee, Diana Y, Saunders, James E

“…To determine the utility of computed tomography (CT) and magnetic resonance imaging (MRI) in cochlear implant candidates. Retrospective case review. Tertiary…”
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Learning to fail: Predicting fracture evolution in brittle material models using recurrent graph convolutional neural networks by Schwarzer, Max, Rogan, Bryce, Ruan, Yadong, Song, Zhengming, Lee, Diana Y., Percus, Allon G., Chau, Viet T., Moore, Bryan A., Rougier, Esteban, Viswanathan, Hari S., Srinivasan, Gowri

“…[Display omitted] We propose a machine learning approach to address a key challenge in materials science: predicting how fractures propagate in brittle…”
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Spatially adaptive unsupervised multispectral nonlocal filtering for improved cerebral blood flow mapping using arterial spin labeling magnetic resonance imaging by Bouhrara, Mustapha, Lee, Diana Y., Rejimon, Abinand C., Bergeron, Christopher M., Spencer, Richard G.

“…•We applied the NESMA filter to improve cerebral blood flow (CBF) mapping from ASL MRI data.•The NESMA-ASL filter outperforms other advanced filters in terms…”
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Rapid B 1 field mapping at 3 T using the 180° signal null method with extended flip angle by Rejimon, Abinand C, Lee, Diana Y, Bergeron, Christopher M, Zhuo, You, Qian, Wenshu, Spencer, Richard G, Bouhrara, Mustapha

“…To extend the null signal method (NSM) for B mapping to 3 T magnetic resonance imaging (MRI). The NSM operates in the steady state regime and exploits the…”
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Anatomic Considerations for Temporomandibular Joint Vascularized Composite Allotransplantation by Khavanin, Nima, Davidson, Edward H, Lee, Diana Y, Byrne, Patrick, Dorafshar, Amir H

“…Concomitant temporomandibular joint (TMJ) transplantation is an obvious advancement in the reconstructive armamentarium for face transplantation in scenarios…”
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Rapid B1 field mapping at 3 T using the 180° signal null method with extended flip angle by Rejimon, Abinand C., Lee, Diana Y., Bergeron, Christopher M., Zhuo, You, Qian, Wenshu, Spencer, Richard G., Bouhrara, Mustapha

“…To extend the null signal method (NSM) for B1 mapping to 3 T magnetic resonance imaging (MRI). The NSM operates in the steady state regime and exploits the…”
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Ligand-Dependent Platelet-Derived Growth Factor Receptor (PDGFR)-α Activation Sensitizes Rare Lung Cancer and Sarcoma Cells to PDGFR Kinase Inhibitors by MCDERMOTT, Ultan, AMES, Rachel Y, LUCIEN, Laury, BRANNIGAN, Brian W, ULKUS, Lindsey E, MA, Xiao-Jun, ERLANDER, Mark G, HABER, Daniel A, SHARMA, Sreenath V, SETTLEMAN, Jeffrey, IAFRATE, A. John, MAHESWARAN, Shyamala, STUBBS, Hannah, GRENINGER, Patricia, MCCUTCHEON, Kaitlin, MILANO, Randy, TAM, Angela, LEE, Diana Y

“…Platelet-derived growth factor (PDGF) receptors (PDGFR) and their ligands play critical roles in several human malignancies. Sunitinib is a clinically approved…”
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Impact of nuchal cord on fetal outcomes, mode of delivery, and management: a questionnaire survey of pregnant women by Kong, C W, Lee, Diana H Y, Chan, L W, To, William W K

“…To explore pregnant women's views on the impact of nuchal cord on fetal outcomes, mode of delivery, and management. Questionnaire survey. Antenatal clinic of…”
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CAT‐2003: A novel sterol regulatory element‐binding protein inhibitor that reduces steatohepatitis, plasma lipids, and atherosclerosis in apolipoprotein E3‐Leiden mice by Zimmer, Michael, Bista, Pradeep, Benson, Ericka L., Lee, Diana Y., Liu, Feng, Picarella, Dominic, Vega, Rick B., Vu, Chi B., Yeager, Maisy, Ding, Min, Liang, Guosheng, Horton, Jay D., Kleemann, Robert, Kooistra, Teake, Morrison, Martine C., Wielinga, Peter Y., Milne, Jill C., Jirousek, Michael R., Nichols, Andrew J.

“…CAT‐2003 is a novel conjugate of eicosapentaenoic acid (EPA) and niacin designed to be hydrolyzed by fatty acid amide hydrolase to release EPA inside cells at…”
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Influence of Age on Salvia Divinorum Use: Results of an Internet Survey by Nyi, Pearl P., Lai, Emily P., Lee, Diana Y., Biglete, Shannon A., Torrecer, Gilsky I., Anderson, Ilene B.

“…An Internet-based survey of Salvia divinorum ("salvia") users was conducted to identify correlates surrounding its use. Salvia-knowledgeable persons were…”
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Reaching Across the Divide: Tools for Bridging Structural and Viral Genomics Using a Combination of Biophysical Principles and Machine Learning by Lee, Diana Y

“…Bacteriophages are the most ubiquitous biological entity on the planet, but most viruses found in nature cannot be cultured in the laboratory and encode genes…”
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Rapid B1 field mapping at 3T using the 180° signal null method with extended flip angle range by Rejimon, Abinand C., Lee, Diana Y., Bergeron, Christopher M., Zhuo, You, Qian, Wenshu, Spencer, Richard G., Bouhrara, Mustapha

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Ligand-dependent PDGF receptor-alpha activation sensitizes rare lung cancer and sarcoma cells to PDGF receptor kinase inhibitors by McDermott, Ultan, Ames, Rachel Y., Iafrate, A. John, Maheswaran, Shyamala, Stubbs, Hannah, Greninger, Patricia, McCutcheon, Kaitlin, Milano, Randy, Tam, Angela, Lee, Diana Y., Lucien, Laury, Brannigan, Brian W., Ulkus, Lindsey E., Ma, Xiao-Jun, Erlander, Mark G., Haber, Daniel A., Sharma, Sreenath V., Settleman, Jeffrey

“…Platelet-derived growth factor receptors (PDGFR) and their ligands play critical roles in several human malignancies. Sunitinib is a clinically-approved…”
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