Search Results - "Lee, Der‐Yen"

Recent advances in LC-MS-based metabolomics for clinical biomarker discovery by Chen, Chao-Jung, Lee, Der-Yen, Yu, Jiaxin, Lin, Yu-Ning, Lin, Tsung-Min

“…The employment of liquid chromatography-mass spectrometry (LC-MS) untargeted and targeted metabolomics has led to the discovery of novel biomarkers and…”
Get full text

Metabolism modulation in rat tissues in response to point specificity of electroacupuncture by Lee, Der-Yen, Jiu, Yu-Rung, Hsieh, Ching-Liang

“…Zusanli (ST36) and Neiguan (PC6) are acupoints along two meridians. To demonstrate point specificity, we investigated the effects of ST36 and PC6 in…”
Get full text

H2S- and Redox-State-Mediated PTP1B S-Sulfhydration in Insulin Signaling by Lin, Yu-Chin, Zeng, Wan-Ting, Lee, Der-Yen

“…Because hydrogen sulfide (H2S) is classified as a gaseous signaling molecule, protein S-sulfhydration is known to be one of the mechanisms by which H2S signals…”
Get full text

Electroacupuncture at Zusanli and at Neiguan characterized point specificity in the brain by metabolomic analysis by Lee, Der-Yen, Jiu, Yu-Rung, Hsieh, Ching-Liang

“…Different point stimulations can induce brain activity in specific regions, and however whether these stimulations affect unique neurotransmitter transmission…”
Get full text

METTL4-mediated nuclear N6-deoxyadenosine methylation promotes metastasis through activating multiple metastasis-inducing targets by Hsu, Kai-Wen, Lai, Joseph Chieh-Yu, Chang, Jeng-Shou, Peng, Pei-Hua, Huang, Ching-Hui, Lee, Der-Yen, Tsai, Yu-Cheng, Chung, Chi-Jung, Chang, Han, Chang, Chao-Hsiang, Chen, Ji-Lin, Pang, See-Tong, Hao, Ziyang, Cui, Xiao-Long, He, Chuan, Wu, Kou-Juey

“…DNA N6-methyldeoxyadenosine (6mA) is rarely present in mammalian cells and its nuclear role remains elusive. Here we show that hypoxia induces nuclear 6mA…”
Get full text

The Effects of a Curcumin Derivative and Osimertinib on Fatty Acyl Metabolism and Mitochondrial Functions in HCC827 Cells and Tumors by Hsieh, Min-Tsang, Lee, Pei-Chih, Chiang, Yi-Ting, Lin, Hui-Yi, Lee, Der-Yen

“…Drug combination therapy is a key approach in cancer treatments, aiming to improve therapeutic efficacy and overcome drug resistance. Evaluation of…”
Get full text

Synthesis and Characterization of the Ethylene-Carbonate-Linked L-Valine Derivatives of 4,4-Dimethylcurcumin with Potential Anticancer Activities by Lee, Der-Yen, Lin, Hui-Yi, Ramasamy, Manickavasakam, Kuo, Sheng-Chu, Lee, Pei-Chih, Hsieh, Min-Tsang

“…Natural phenolic products from herbal medicines and dietary plants constitute the main source of lead compounds for the development of the new drug…”
Get full text

An invertebrate Warburg effect: a shrimp virus achieves successful replication by altering the host metabolome via the PI3K-Akt-mTOR pathway by Su, Mei-An, Huang, Yun-Tzu, Chen, I-Tung, Lee, Der-Yen, Hsieh, Yun-Chieh, Li, Chun-Yuan, Ng, Tze Hann, Liang, Suh-Yuen, Lin, Shu-Yu, Huang, Shiao-Wei, Chiang, Yi-An, Yu, Hon-Tsen, Khoo, Kay-Hooi, Chang, Geen-Dong, Lo, Chu-Fang, Wang, Han-Ching

“…In this study, we used a systems biology approach to investigate changes in the proteome and metabolome of shrimp hemocytes infected by the invertebrate virus…”
Get full text

Docosahexaenoic Acid Alleviates Trimethylamine- N -oxide-mediated Impairment of Neovascularization in Human Endothelial Progenitor Cells by Syu, Jia-Ning, Lin, Hung-Yu, Huang, Tun Yu, Lee, Der-Yen, Chiang, En-Pei Isabel, Tang, Feng-Yao

“…Human endothelial progenitor cells (hEPCs), originating from hemangioblasts in bone marrow (BM), migrate into the blood circulation, differentiate into…”
Get full text

Electroacupuncture Relieves CCI-Induced Neuropathic Pain Involving Excitatory and Inhibitory Neurotransmitters by Hsieh, Ching-Liang, Lee, Der-Yen, Lin, Yi-Wen, Huang, Chun-Ping

“…Neuropathic pain caused by peripheral tissue injuries to the higher brain regions still has no satisfactory therapy. Disruption of the balance of excitatory…”
Get full text

Docosahexaenoic acid inhibits the proliferation of Kras/TP53 double mutant pancreatic ductal adenocarcinoma cells through modulation of glutathione level and suppression of nucleotide synthesis by Hung, Wei-Chia, Lee, Der-Yen, Chiang, En-Pei Isabel, Syu, Jia-Ning, Chao, Che-Yi, Yang, Mei-Due, Tsai, Shu-Yao, Tang, Feng-Yao

“…The treatment of cancer cells obtained by blocking cellular metabolism has received a lot of attention recently. Previous studies have demonstrated that Kras…”
Get full text

Synthesis, Anticancer Activity, and Preliminary Pharmacokinetic Evaluation of 4,4-Disubstituted Curcuminoid 2,2-bis(Hydroxymethyl)Propionate Derivatives by Lee, Der-Yen, Hou, Yu-Chi, Yang, Jai-Sing, Lin, Hui-Yi, Chang, Tsu-Yuan, Lee, Kuo-Hsiung, Kuo, Sheng-Chu, Hsieh, Min-Tsang

“…Compound is a curcumin di- -2,2-bis(hydroxymethyl)propionate that shows significant in vitro and in vivo inhibitory activity against MDA-MB-231 cells with…”
Get full text

Afatinib Exerts Immunomodulatory Effects by Targeting the Pyrimidine Biosynthesis Enzyme CAD by Tu, Hsin-Fang, Ko, Chun-Jung, Lee, Ching-Tai, Lee, Cheng-Fan, Lan, Shao-Wei, Lin, Hsin-Hsien, Lin, Hsin-Ying, Ku, Chia-Chi, Lee, Der-Yen, Chen, I-Chun, Chuang, Ya-Hui, Del Caño-Ochoa, Francisco, Ramón-Maiques, Santiago, Ho, Chao-Chi, Lee, Ming-Shyue, Chang, Geen-Dong

“…Current clinical trials of combined EGFR-tyrosine kinase inhibitors (TKI) and immune checkpoint blockade (ICB) therapies show no additional effect. This raises…”
Get full text

Changes in Acupuncture-Induced Specific Acupoint Neurotransmitters are Possibly Related to Their Physiological Functions in Rats by Nguyen, Huong Thi Mai, Lee, Der-Yen, Liu, Chung-Hsiang, Hsieh, Ching-Liang

“…This study investigated changes in neurotransmitters induced by the application of electroacupuncture (EA) at Zusanli (ST36) and Neiguan (PC6). A total of 30…”
Get full text

4,4‐Diallyl curcumin bis(2,2‐hydroxymethyl)propanoate ameliorates nonalcoholic steatohepatitis in methionine‐choline‐deficient diet and Western diet mouse models by Yang, Li‐Chan, Wang, Chih‐Chiang, Lee, Der‐Yen, Lin, Wen‐Chuan, Kuo, Sheng‐Chu, Juang, Shin‐Hun, Hsieh, Min‐Tsang

“…Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease (NAFLD) that causes severe liver damage, fibrosis, and scarring…”
Get full text

A Novel Chinese Herbal and Corresponding Chemical Formula for Cancer Treatment by Targeting Tumor Maintenance, Progression, and Metastasis by Song, Ying-Chyi, Lee, Der-Yen, Yeh, Pei-Yen

“…We characterized a so-called "heirloom recipe" Chinese herbal formula (temporarily named Formula X) that contains five Chinese medical botanical drugs,…”
Get full text

White Spot Syndrome Virus Triggers a Glycolytic Pathway in Shrimp Immune Cells (Hemocytes) to Benefit Its Replication by Ng, Yen Siong, Lee, Der-Yen, Liu, Chun-Hung, Tung, Cheng-Yi, He, Shu-Ting, Wang, Han-Ching

“…White spot syndrome virus (WSSV) is the causative agent of a shrimp disease that inflicts in huge economic losses in shrimp-farming industry. WSSV triggers…”
Get full text

Development of Novel Rhodacyanine-Based Heat Shock Protein 70 Inhibitors by Chang, Chih-Shiang, Kumar, Vathan, Lee, Der-Yen, Chen, Yeh, Wu, Yu-Chieh, Gao, Jing-Yan, Chu, Po-Chen

“…A growing body of evidence suggests that Hsp70, which is overexpressed in human breast tumors, plays a role in tumorigenesis and tumor progression in breast…”
Get more information

Glutamine Metabolism in Both the Oxidative and Reductive Directions Is Triggered in Shrimp Immune Cells (Hemocytes) at the WSSV Genome Replication Stage to Benefit Virus Replication by He, Shu-Ting, Lee, Der-Yen, Tung, Cheng-Yi, Li, Chun-Yuan, Wang, Han-Ching

“…White spot syndrome virus (WSSV) is the causative agent of a shrimp disease that has caused huge global economic losses. Although its pathogenesis remains…”
Get full text

Effect of electrode configuration in electroacupuncture on ischemic stroke treatment in rats by Liu, Chung-Hsiang, Nguyen, Huong Thi Mai, Lee, Der-Yen, Hsieh, Ching-Liang

“…Background and aim: This study investigated the effect of the electrode configuration on EA treating ischemic stroke. Experimental procedure: An ischemic…”
Get full text