Search Results - "Lee, Dennis S.W."

Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10 by Rojas, Olga L., Pröbstel, Anne-Katrin, Porfilio, Elisa A., Wang, Angela A., Charabati, Marc, Sun, Tian, Lee, Dennis S.W., Galicia, Georgina, Ramaglia, Valeria, Ward, Lesley A., Leung, Leslie Y.T., Najafi, Ghazal, Khaleghi, Khashayar, Garcillán, Beatriz, Li, Angela, Besla, Rickvinder, Naouar, Ikbel, Cao, Eric Y., Chiaranunt, Pailin, Burrows, Kyle, Robinson, Hannah G., Allanach, Jessica R., Yam, Jennifer, Luck, Helen, Campbell, Daniel J., Allman, David, Brooks, David G., Tomura, Michio, Baumann, Ryan, Zamvil, Scott S., Bar-Or, Amit, Horwitz, Marc S., Winer, Daniel A., Mortha, Arthur, Mackay, Fabienne, Prat, Alexandre, Osborne, Lisa C., Robbins, Clinton, Baranzini, Sergio E., Gommerman, Jennifer L.

“…Plasma cells (PC) are found in the CNS of multiple sclerosis (MS) patients, yet their source and role in MS remains unclear. We find that some PC in the CNS of…”
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Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10 by Rojas, Olga L., Pröbstel, Anne-Katrin, Porfilio, Elisa A., Wang, Angela A., Charabati, Marc, Sun, Tian, Lee, Dennis S.W., Galicia, Georgina, Ramaglia, Valeria, Ward, Lesley A., Leung, Leslie Y.T., Najafi, Ghazal, Khaleghi, Khashayar, Garcillán, Beatriz, Li, Angela, Besla, Rickvinder, Naouar, Ikbel, Cao, Eric Y., Chiaranunt, Pailin, Burrows, Kyle, Robinson, Hannah G., Allanach, Jessica R., Yam, Jennifer, Luck, Helen, Campbell, Daniel J., Allman, David, Brooks, David G., Tomura, Michio, Baumann, Ryan, Zamvil, Scott S., Bar-Or, Amit, Horwitz, Marc S., Winer, Daniel A., Mortha, Arthur, Mackay, Fabienne, Prat, Alexandre, Osborne, Lisa C., Robbins, Clinton, Baranzini, Sergio E., Gommerman, Jennifer L.

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Age-dependent gray matter demyelination is associated with leptomeningeal neutrophil accumulation by Zuo, Michelle, Fettig, Naomi M, Bernier, Louis-Philippe, Pössnecker, Elisabeth, Spring, Shoshana, Pu, Annie, Ma, Xianjie I, Lee, Dennis Sw, Ward, Lesley A, Sharma, Anshu, Kuhle, Jens, Sled, John G, Pröbstel, Anne-Katrin, MacVicar, Brian A, Osborne, Lisa C, Gommerman, Jennifer L, Ramaglia, Valeria

“…People living with multiple sclerosis (MS) experience episodic CNS white matter lesions instigated by autoreactive T cells. With age, patients with MS show…”
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B cell depletion therapies in autoimmune disease: advances and mechanistic insights by Lee, Dennis S. W., Rojas, Olga L., Gommerman, Jennifer L.

“…In the past 15 years, B cells have been rediscovered to be not merely bystanders but rather active participants in autoimmune aetiology. This has been fuelled…”
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Three-Dimensional Imaging of Transparent Tissues via Metal Nanoparticle Labeling by Syed, Abdullah Muhammad, Sindhwani, Shrey, Wilhelm, Stefan, Kingston, Benjamin R, Lee, Dennis S. W, Gommerman, Jennifer L, Chan, Warren C. W

“…Chemical probes are key components of the bioimaging toolbox, as they label biomolecules in cells and tissues. The new challenge in bioimaging is to design…”
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Complement-associated loss of CA2 inhibitory synapses in the demyelinated hippocampus impairs memory by Ramaglia, Valeria, Dubey, Mohit, Malpede, M. Alfonso, Petersen, Naomi, de Vries, Sharon I., Ahmed, Shanzeh M., Lee, Dennis S. W., Schenk, Geert J., Gold, Stefan M., Huitinga, Inge, Gommerman, Jennifer L., Geurts, Jeroen J. G., Kole, Maarten H. P.

“…The complement system is implicated in synapse loss in the MS hippocampus, but the functional consequences of synapse loss remain poorly understood. Here, in…”
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Complement-associated Synaptic Reorganization in the Hippocampal CA2 Subfield in Multiple Sclerosis and Cuprizone-induced Myelin Loss (4554) by Ramaglia, Valeria, Dubey, Mohit, Malpede, Alfonso, Petersen, Naomi, de Vries, Sharon, Lee, Dennis S.W., Schenk, Geert, Huitinga, Inge, Gommerman, Jennifer L., Geurts, Jeroen J.G., Kole, Maarten H.P.

“…Abstract only…”
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CCR6 Expression on B Cells Is Not Required for Clinical or Pathological Presentation of MOG Protein–Induced Experimental Autoimmune Encephalomyelitis despite an Altered Germinal Center Response by Lee, Dennis S. W., Yam, Jennifer Y., Grasmuck, Camille, Dasoveanu, Dragos, Michel, Laure, Ward, Lesley A., Rojas, Olga L., Zandee, Stephanie, Bourbonnière, Lyne, Ramaglia, Valeria, Bar-Or, Amit, Prat, Alexandre, Gommerman, Jennifer L.

“…Abstract B cells have been implicated in the pathogenesis of multiple sclerosis, but the mechanisms that guide B cell activation in the periphery and…”
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The Impact of IgA and the Microbiota on CNS Disease by Pu, Annie, Lee, Dennis S W, Isho, Baweleta, Naouar, Ikbel, Gommerman, Jennifer L

“…Although anatomically distant from the central nervous system (CNS), gut-derived signals can dynamically regulate both peripheral immune cells and CNS-resident…”
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Isotype-Switched Autoantibodies Are Necessary To Facilitate Central Nervous System Autoimmune Disease in Aicda -/- and Ung -/- Mice by Galicia, Georgina, Lee, Dennis S W, Ramaglia, Valeria, Ward, Lesley A, Yam, Jennifer Y, Leung, Leslie Y T, Li, Rui, Handy, Marcus, Zhang, Junxian, Drohomyrecky, Paulina C, Lancaster, Eric, Bar-Or, Amit, Martin, Alberto, Gommerman, Jennifer L

“…B cell-depleting therapies have been shown to ameliorate symptoms in multiple sclerosis (MS) patients; however, the mechanism of action remains unclear…”
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Age-dependent gray matter demyelination is associated with leptomeningeal neutrophil accumulation by Zuo, Michelle, Fettig, Naomi M, Bernier, Louis-Philippe, Pössnecker, Elisabeth, Spring, Shoshana, Pu, Annie, Ma, Xianjie I, Lee, Dennis Sw, Ward, Lesley A, Sharma, Anshu, Kuhle, Jens, Sled, John G, Pröbstel, Anne-Katrin, MacVicar, Brian A, Osborne, Lisa C, Gommerman, Jennifer L, Ramaglia, Valeria

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Siponimod therapy implicates Th17 cells in a preclinical model of subpial cortical injury by Ward, Lesley A, Lee, Dennis Sw, Sharma, Anshu, Wang, Angela, Naouar, Ikbel, Ma, Xianjie I, Pikor, Natalia, Nuesslein-Hildesheim, Barbara, Ramaglia, Valeria, Gommerman, Jennifer L

“…Subpial demyelination is a specific hallmark of multiple sclerosis and a correlate of disease progression. Although the mechanism(s) that mediate pathogenesis…”
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